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Your search keyword '"Marine Jarbeau"' showing total 2 results
Start Over Author "Marine Jarbeau" Topic 030104 developmental biology
2 results on '"Marine Jarbeau"'

1. Modeling undernutrition with enteropathy in mice

Author

Moutaz Aziz, E. Salameh, Mamane Zeilani, Marine Jarbeau, Pierre Déchelotte, Rachel Marion-Letellier, Fanny B. Morel, Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Nutriset, Service d'Anatomie et Cytologie Pathologique [CHU Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU), Service de nutrition [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), and douville, sabine

Subjects
Male, 0301 basic medicine, medicine.medical_specialty, Science, Inflammation, Article, Mice, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Intestine, Small, medicine, Animals, Enteropathy, Gastrointestinal models, Wasting, Growth Disorders, Feces, Caloric Restriction, 2. Zero hunger, Multidisciplinary, Intestinal permeability, business.industry, Malnutrition, medicine.disease, Pathophysiology, 3. Good health, Mice, Inbred C57BL, Disease Models, Animal, Intestinal Diseases, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, 030104 developmental biology, Endocrinology, Medicine, 030211 gastroenterology & hepatology, medicine.symptom, Calprotectin, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Abstract

Undernutrition is a global health issue leading to 1 out 5 all deaths in children under 5 years. Undernutrition is often associated with environmental enteric dysfunction (EED), a syndrome associated with increased intestinal permeability and gut inflammation. We aimed to develop a novel murine model of undernutrition with these EED features. Post-weaning mice were fed with low-protein diet (LP) alone or combined with a gastrointestinal insult trigger (indomethacin or liposaccharides). Growth, intestinal permeability and inflammation were assessed. LP diet induced stunting and wasting in post-weaning mice but did not impact gut barrier. We therefore combined LP diet with a single administration of indomethacin or liposaccharides (LPS). Indomethacin increased fecal calprotectin production while LPS did not. To amplify indomethacin effects, we investigated its repeated administration in addition to LP diet and mice exhibited stunting and wasting with intestinal hyperpermeability and gut inflammation. The combination of 3-weeks LP diet with repeated oral indomethacin administration induced wasting, stunting and gut barrier dysfunction as observed in undernourished children with EED. As noninvasive methods for investigating gut function in undernourished children are scarce, the present pre-clinical model provides an affordable tool to attempt to elucidate pathophysiological processes involved in EED and to identify novel therapeutic strategies.

Published
2020
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2. Glutamine, but Not Branched-Chain Amino Acids, Restores Intestinal Barrier Function during Activity-Based Anorexia

Author

Wafa Bahlouli, C. L’Huillier, Jean-Luc do Rego, S. Nobis, Alexis Goichon, Pierre Déchelotte, Marine Jarbeau, Najate Achamrah, Asma Amamou, E. Salameh, Moïse Coëffier, L. Belmonte, Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université (NU), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de nutrition [CHU Rouen], Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Service Commun d'Analyse Comportementale (SCAC), Normandie Université (NU)-Normandie Université (NU)-Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), GOICHON, Alexis, Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-High-tech Research Infrastructures for Life Sciences (HeRacLeS), and Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0301 basic medicine, Male, Anorexia nervosa, Mice, Protein biosynthesis, Intestinal Mucosa, Barrier function, 2. Zero hunger, chemistry.chemical_classification, Nutrition and Dietetics, Chemistry, digestive, oral, and skin physiology, food and beverages, Branched-chain amino acids, 3. Good health, Amino acid, Anorexia, Paracellular transport, Body Composition, glutamine, medicine.symptom, lcsh:Nutrition. Foods and food supply, medicine.medical_specialty, Colon, lcsh:TX341-641, Intestinal permeability, digestive system, Article, Permeability, Activity-Based Anorexia, 03 medical and health sciences, Internal medicine, medicine, Animals, 030109 nutrition & dietetics, fungi, Feeding Behavior, medicine.disease, Glutamine, Mice, Inbred C57BL, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, 030104 developmental biology, Endocrinology, Protein Biosynthesis, Dietary Supplements, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Amino Acids, Branched-Chain, Food Science
Abstract

Background: During activity-based anorexia (ABA) in mice, enhanced paracellular permeability and reduced protein synthesis have been shown in the colon while the gut&ndash, brain axis has received increasing attention in the regulation of intestinal and mood disorders that frequently occur during anorexia nervosa, a severe eating disorder for which there is no specific treatment. In the present study, we assessed the effects of oral glutamine (Gln) or branched-chain amino acids (BCAA) supplementation during ABA to target intestinal functions, body composition and feeding behavior. Methods: C57BL/6 male mice were randomized in Control (CTRL) and ABA groups. After ABA induction, mice received, or not, either 1% Gln or 2.5% BCAA (Leu, Ile, Val) for one week in drinking water. Results: Neither Gln nor BCAA supplementation affected body weight and body composition, while only Gln supplementation slightly increased food intake. ABA mice exhibited increased paracellular permeability and reduced protein synthesis in the colonic mucosa. Oral Gln restored colonic paracellular permeability and protein synthesis and increased the mucin-2 mRNA level, whereas BCAA did not affect colonic parameters. Conclusion: In conclusion, oral Gln specifically improves colonic response during ABA. These data should be further confirmed in AN patients.

Published
2019
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