1. Guillain–Barre syndrome outbreak in Peru: Association with polymorphisms in IL‐17, ICAM1, and CD1
- Author
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Luis Jaramillo-Valverde, Pilar Mazzetti, Kelly S. Levano, Cesar Sanchez, Julio Valdivia-Silva, Isolina Villanueva, Meylin Hidalgo, Julio A. Poterico, Mario Cornejo-Olivas, Marco Cornejo, and Heinner Guio
- Subjects
0301 basic medicine ,Male ,IL‐17 ,Guillain-Barre syndrome ,030105 genetics & heredity ,Body Mass Index ,Antigens, CD1 ,ICAM1 ,Risk Factors ,Genotype ,Peru ,genetic polymorphism ,Genetics (clinical) ,reproductive and urinary physiology ,education.field_of_study ,Interleukin-17 ,Middle Aged ,Intercellular Adhesion Molecule-1 ,IL-17 ,Regression Analysis ,Original Article ,Female ,Interleukin 17 ,lcsh:QH426-470 ,Population ,Single-nucleotide polymorphism ,Biology ,Polymorphism, Single Nucleotide ,03 medical and health sciences ,Genetics ,Genetic predisposition ,medicine ,Humans ,Genetic Predisposition to Disease ,education ,Gene ,Molecular Biology ,Aged ,Genetic polymorphism ,CD1 ,Outbreak ,Original Articles ,medicine.disease ,bacterial infections and mycoses ,lcsh:Genetics ,030104 developmental biology ,Genetic marker ,Case-Control Studies ,Immunology ,purl.org/pe-repo/ocde/ford#1.06.07 [https] - Abstract
SUMMARYGuillain-Barre Syndrome (GBS) is considered a complex disorder with significant environmental effect and genetic susceptibility. Genetic polymorphisms in CD1E, CD1A, IL-17 and/or ICAM-1 genes had been proposed as susceptibility genetic variants for GBS mainly in Caucasian population. This study explores the association between selected polymorphisms in these genes and GBS susceptibility in confirmed GBS cases reported in mestizo population from northern Peru during the most recent GBS outbreak of May 2018. A total of 9 non-related cases and 11 controls were sequenced for the polymorphic regions of CD1A, CD1E, IL-17 and ICAM-1 genes. We found a significant protective association between heterozygous GA genotype in ICAM-1 gene (241Gly / Arg) and GBS (p IL-17 was monomorphic in both controls and patients. No significant differences were found in the frequency of SNPs in CD1A and CD1E between the group with GBS patients and healthy controls. Further studies with larger sample size will be required to validate these findings.
- Published
- 2019