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Your search keyword '"Dalel, Ben Nejima"' showing total 3 results
Start Over Author "Dalel, Ben Nejima" Topic 030104 developmental biology
3 results on '"Dalel, Ben Nejima"'

1. Early onset breast cancer: differences in risk factors, tumor phenotype, and genotype between North African and South European women

Author

Paul Vilquin, Virginie Galibert, Hesham El Ghazaly, Marie-Christine Picot, Paul Ihout, Helena Bertet, Asma Mouhout, Ahmed Gaballah, Karen Baudry, David Khayat, Alain Toledano, Yazid Belkacemi, Hamouda Boussen, Jean-Marc Rey, Céline Bourgier, Isabelle Coupier, Carole Corsini, Dalel Ben Nejima, Pascal Pujol, Sarra Henouda, Louise Biquard, Assia Bensalem, Faouzi Habib, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Université de Montpellier (UM), UNICANCER - Institut régional du Cancer Montpellier Val d'Aurelle (ICM), CRLCC Val d'Aurelle - Paul Lamarque, Service de radiothérapie [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Service d'Oncologie médicale [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
0301 basic medicine, Cancer Research, Genotype, [SDV]Life Sciences [q-bio], Breastfeeding, Breast Neoplasms, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Africa, Northern, Risk Factors, Humans, Medicine, Prospective Studies, Age of Onset, Neoplasm Staging, Early onset breast cancer, BRCA2 Protein, 2. Zero hunger, biology, BRCA1 Protein, business.industry, Incidence (epidemiology), North Africa, BRCA1, medicine.disease, BRCA2, 3. Good health, Phenotype, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Tumor phenotype, Ki-67, Immunology, Menarche, biology.protein, Female, France, business, Body mass index, Demography
Abstract

International audience; PURPOSE: This report compares the risk factors, the tumor phenotypes, and the BRCA1/BRCA2 genotype of early onset breast cancer (EOBC) patients between Southern Europe and North Africa. METHODS: Four hundred and fifty six women with invasive EOBC (

Published
2017
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2. Clinicopathologic and Prognostic Significance of Gelatinase A in Tunisian Colorectal Cancer: A Case-Control Study

Author

Yosr Ben Zarkouna, Dalel Ben Nejima, A. Gammoudi, Mohamed Manai, Hamouda Boussen, and Pascal Pujol

Subjects
0301 basic medicine, Oncology, Adult, Male, medicine.medical_specialty, Histology, Muscularis mucosae, Tunisia, Colorectal cancer, Gelatinase A, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Genotype, medicine, SNP, Humans, Genotyping, Aged, business.industry, Case-control study, Middle Aged, medicine.disease, Prognosis, Immunohistochemistry, Medical Laboratory Technology, 030104 developmental biology, 030220 oncology & carcinogenesis, Case-Control Studies, Matrix Metalloproteinase 2, Female, business, Colorectal Neoplasms
Abstract

Matrix metalloproteinase-2 (gelatinase A) is a well-known mediator of cancer metastasis, but it is also thought to be involved in several aspects of cancer development, including cell growth and inflammation. In the present study, we investigate whether MMP-2 SNP, MMP-2 mRNAs, and MMP-2 protein are associated with the susceptibility to colorectal cancer in the Tunisian population. The TaqMan allele discrimination assay and DNA sequencing techniques were used for genotyping; MMP-2 expression of each genotype was analyzed by semiquantitative RT-PCR, and MMP-2 protein expression was analyzed by immunohistochemistry staining. Our result showed that the levels of MMP-2 mRNA expression in patients containing the CC genotype were much higher compared with cells with the CT genotype. The frequency of the MMP-2 CC genotype was significantly higher in colorectal cancer patients when compared with controls (OR=1.94; 95% CI, 1.117-3.680). A higher intensity of staining of MMP-2 was observed in regions of invasion of the muscularis mucosa compared with superficial portions of the tumor. In addition, we found a significant progressive increase in total MMP-2 plasma levels with progression from adenomatous polyps through advancing Dukes stages (P=0.0001). Our data suggest that MMP-2 may be associated with colorectal cancer development and invasion in the Tunisian population; moreover, SNP and levels of MMP-2 could be a predictive value for colorectal cancer prevention and invasiveness.

Published
2016

3. Clinicopathologic and Prognostic Significance of Metalloproteinase Tissue Inhibitor-2 Promoters in Tunisian Colorectal Cancer: A Case-Control Study

Author

Pascal Pujol, Dalel Ben Nejima, Hamouda Boussen, Yosr Ben Zarkouna, A. Gammoudi, Mohamed Manai, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), and Université de Montpellier (UM)

Subjects
Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Tunisia, Histology, Angiogenesis, Colorectal cancer, [SDV.CAN]Life Sciences [q-bio]/Cancer, Pathology and Forensic Medicine, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Gene Frequency, Internal medicine, Genotype, medicine, [SDV.MHEP.AHA]Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO], Humans, Clinical significance, RNA, Messenger, Promoter Regions, Genetic, Genotyping, Tissue Inhibitor of Metalloproteinase-2, business.industry, Case-control study, Prognosis, medicine.disease, 3. Good health, Medical Laboratory Technology, 030104 developmental biology, Case-Control Studies, 030220 oncology & carcinogenesis, Immunohistochemistry, Female, Colorectal Neoplasms, business
Abstract

International audience; Tissue inhibitors of metalloproteinases (TIMPs) appear to affect many aspects of cancer biology, playing a crucial role in cell signaling by regulating cell growth, apoptosis, invasion, metastasis, angiogenesis, and genomic instability. In the present study, we investigate whether TIMP-2 SNP, TIMP-2 mRNAs, and TIMP-2 protein is associated with susceptibility to colorectal cancer (CRC) in Tunisian population. Taqman and DNA sequencing techniques were used for genotyping, TIMP-2 expression of each genotype was analyzed using semiquantitative RT-PCR and TIMP-2 protein expression was analyzed using immunohistochemistry staining. Our results showed that significantly elevated CRC risk was found in individuals with CC genotype (odds ratio 1.959; 95% confidence interval, 1.055-3.637). Moreover TIMP-2 mRNA expression in the colorectal cell carcinomas was significantly higher compared with the normal colorectal tissue (0.487±0.015 vs. 0.210±0.013) (P

Published
2016
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