1. Molecular insights into the OGG1 gene, a cancer risk modifier in BRCA1 and BRCA2 mutations carriers
- Author
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Ana Osorio, Javier Benitez, Carlos Benitez-Buelga, Maria A. Blasco, Tereza Vaclova, Miguel Urioste, Nora Soberón, Sofia Ferreira, Lucía Inglada-Pérez, European Regional Development Fund (ERDF/FEDER), Spanish Research Network on Rare diseases (CIBERER), European Research Council (ERC), Ministerio de Ciencia e Innovación (España), Fundacion Botín, Fundacion Lilly (Spain), Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF), Centro de Investigación Biomédica en Red - CIBERER (Enfermedades Raras), European Research Council, Botín Foundation, and Fundación Lilly
- Subjects
0301 basic medicine ,Genome instability ,Telomerase ,endocrine system diseases ,Genotype ,Biology ,Polymorphism, Single Nucleotide ,DNA Glycosylases ,03 medical and health sciences ,0302 clinical medicine ,telomere shortening ,Risk Factors ,Humans ,SNP ,Genetic Predisposition to Disease ,skin and connective tissue diseases ,BRCA1 and BRCA2 ,Gene ,BRCA2 Protein ,Ovarian Neoplasms ,Genetics ,BRCA1 Protein ,Human genetics ,cancer risk modifier ,3. Good health ,Telomere ,Gene Expression Regulation, Neoplastic ,030104 developmental biology ,Oncology ,030220 oncology & carcinogenesis ,OGG1 polymorfism ,Mutation ,DNA damage ,Female ,Research Paper - Abstract
The Genotype-Tissue Expression (GTEx) Project was supported by the Common Fund of the Office of the Director of the National Institutes of Health. Additional funds were provided by the NCI, NHGRI, NHLBI, NIDA, NIMH, and NINDS. Donors were enrolled at Biospecimen Source Sites funded by NCI\SAIC-Frederick, Inc. (SAIC-F) subcontracts to the National Disease Research Interchange (10XS170), Roswell Park Cancer Institute (10XS171), and Science Care, Inc. (X10S172). The Laboratory, Data Analysis, and Coordinating Center (LDACC) was funded through a contract (HHSN268201000029C) to The Broad Institute, Inc. Biorepository operations were funded through an SAIC-F subcontract to Van Andel Institute (10ST1035). Additional data repository and project management were provided by SAIC-F (HHSN261200800001E). The Brain Bank was supported by a supplements to University of Miami grants DA006227 and DA033684 and to contract N01MH000028. Statistical Methods development grants were made to the University of Geneva (MH090941 & MH101814), the University of Chicago (MH090951, MH090937, MH101820, MH101825), the University of North Carolina-Chapel Hill (MH090936 & MH101819), Harvard University (MH090948), Stanford University (MH101782), Washington University St Louis (MH101810), and the University of Pennsylvania (MH101822). The data used for the analyses described in this manuscript were obtained from: [insert, where appropriate] the GTEx Portal on 01/12/2015 and/or dbGaP accession number phs000424.vN., J.B.'s laboratory is partially funded by the Spanish Ministry of Health PI12/00070 supported by FEDER funds, and the Spanish Research Network on Rare diseases (CIBERER). C.B-B is granted by the PI12/00070. M.A.B.'s laboratory is funded with the Spanish Ministry of Science and Innovation, projects SAF2008-05384 and 2007-A-200950 (TELOMARKER), European Research Council Advanced grant GA#232854, the Körber Foundation, Fundación Botín and Fundación Lilly. MU is supported by the Spanish Ministry of Health PI14/00459 with FEDER funds.
- Published
- 2016