1. Impact of genetic mutations and nutritional status on the survival of patients with colorectal cancer
- Author
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Luísa Jacques Sauer, Katia Barão, Carla Caroline Dias Ribeiro, Sarhan Sydney Saad, Mariana Abe Vicente Cavagnari, Tiago Donizetti Silva, David Carlos Shigueoka, Marco Antonio Haddad Pereira, and Nora Manoukian Forones
- Subjects
0301 basic medicine ,Oncology ,Male ,Cancer Research ,medicine.medical_specialty ,Sarcopenia ,Colorectal cancer ,Nutritional Status ,Gene mutation ,Intra-Abdominal Fat ,Lower risk ,medicine.disease_cause ,lcsh:RC254-282 ,Body composition ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Tumor supressor gene ,Genetics ,Medicine ,Humans ,Oncogene ,Aged ,business.industry ,Hazard ratio ,Odds ratio ,Middle Aged ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Prognosis ,Survival Analysis ,Neoplasm Proteins ,Phase angle ,030104 developmental biology ,Visceral adipose tissue ,030220 oncology & carcinogenesis ,Relative risk ,Mutation ,Female ,KRAS ,business ,Colorectal Neoplasms ,Research Article - Abstract
Background The prognosis of colorectal cancer (CRC) patients can be influenced by genetic mutations and nutritional status. The relationship between these variables is unclear. The objective of the study was to verify the variables involved in the nutritional status and genetic mutations, which correlate with survival of CRC patients. Methods Patients with surgical intervention for tumor resection were evaluated using body mass index, nutritional screening, patient self-produced global subjective assessment, phase angle, and computed tomography to calculate the areas of visceral adipose tissue (VAT) and subcutaneous adipose tissue, and muscle mass for the determination of sarcopenia. Ten gene mutations involved in CRC carcinogenesis were studied (PIK3CA, KRAS, BRAF, EGFR, NRAS, TP53, APC, PTEN, SMAD4, and FBXW7). DNA was extracted from fresh tumor or paraffin tissues. Results Of the 46 patients, 29 (64.4%) were at nutritional risk and 21 (45.7%) were moderately malnourished. However, there was a high percentage of VAT in 24 (61.5%) and sarcopenia in 19 (48.7%) patients. These variables were associated with a higher risk of mortality. Nutritional risk, moderate or severe malnutrition, phase angle
- Published
- 2019