1. A Review of Drug Repositioning Based Chemical-induced Cell Line Expression Data
- Author
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Fei Wang, Xiujuan Lei, and Fang-Xiang Wu
- Subjects
0301 basic medicine ,Pharmacology ,Databases, Factual ,Computer science ,Drug candidate ,Organic Chemistry ,Drug Repositioning ,Computational Biology ,Computational biology ,Biochemistry ,Cell Line ,03 medical and health sciences ,Drug repositioning ,030104 developmental biology ,0302 clinical medicine ,Expression data ,Cell culture ,Drug Discovery ,Molecular Medicine ,Transcriptome ,Gene ,030217 neurology & neurosurgery - Abstract
Drug repositioning is an important area of biomedical research. The drug repositioning studies have shifted to computational approaches. Large-scale perturbation databases, such as the Connectivity Map and the Library of Integrated Network-Based Cellular Signatures, contain a number of chemical-induced gene expression profiles and provide great opportunities for computational biology and drug repositioning. One reason is that the profiles provided by the Connectivity Map and the Library of Integrated Network-Based Cellular Signatures databases show an overall view of biological mechanism in drugs, diseases and genes. In this article, we provide a review of the two databases and their recent applications in drug repositioning. more...
- Published
- 2020
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