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Aim. Study the dynamics of immunologic parameters in patients with chronic bacterial infections during various schemes of administration of Immunovac VP-4 vaccine. Materials and methods. Parameters of systemic immunity and levels of specific antibodies of various isotypes in blood sera and saliva against vaccine antigens of Staphylococcus aureus and Klebsiella pneumoniae were evaluated in patients (20 individuals, 18 - 50 years of age) distributed into 2 groups by vaccine administration type twice (before and 0,5 - 1,5 months after vaccine therapy course). Results. Local vaccination resulted in an increase of only IgA levels in saliva and both bacterial antigens, whereas parameters of systemic immunity before and after vaccination did not differ. Subcutaneous vaccination increased the level of sera antibodies of A- and G- isotypes against both bacterial antigens, normalized the decreased level of CD8" lymphocytes and an increased value of the immune regulating index; a tendency of increase of the percentage of CD3+ T-cells and reduction of the percentage of CD4+ T-helpers was observed. Conclusion. An optimal scheme of a combined vaccine therapy should be developed to obtain a complex effect, that would allow to simultaneously reach long-term local and systemic antibacterial immunity, as well as show immune modulating effect regarding cell compartment.