1. RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence
- Author
-
Simon J. Cook, Sebastian Łukasiak, Alison Galloway, Anne E. Corcoran, Sara Ciullini Mannurita, Manuel D. Díaz-Muñoz, Martin R Turner, Elisa Monzón-Casanova, Kathryn Balmanno, Lewis S. Bell, Alexander Saveliev, Daniel J. Bolland, Helena Ahlfors, Daniel J. Hodson, and Simon Andrews
- Subjects
0301 basic medicine ,Transcription, Genetic ,B-cell receptor ,RNA-binding protein ,Biology ,Resting Phase, Cell Cycle ,S Phase ,Mice ,03 medical and health sciences ,Tristetraprolin ,Cell quiescence ,Cyclins ,Animals ,RNA, Messenger ,Selection, Genetic ,Gene ,Conserved Sequence ,S phase ,Progenitor ,Mice, Knockout ,B-Lymphocytes ,Multidisciplinary ,Immunoglobulin mu-Chains ,G1 Phase ,Nuclear Proteins ,RNA-Binding Proteins ,Cell cycle ,V(D)J Recombination ,Cell biology ,Mice, Inbred C57BL ,030104 developmental biology ,Regulon ,Gene Expression Regulation ,Pre-B Cell Receptors ,Butyrate Response Factor 1 - Abstract
Reducing the risk of rearrangement As lymphocytes develop, they rearrange their antigen receptor genes and proliferate extensively, potentially putting their genomes at risk. Galloway et al. found that two RNA-binding proteins, ZFP36L1 and ZFP36L2, ensure careful entry and exit into the cell cycle. This helps developing B lymphocytes maintain their genomic integrity. Mice deficient in ZFP36L1 and ZFP36L2 exhibited a profound block in B cell development. ZFP36L1 and ZFP36L2 suppress mRNAs that help B cells progress through the cell cycle, ensuring that cells can enter quiescence and keep their genomes safe when they undergo the risky process of rearranging their antigen receptors. Science , this issue p. 453
- Published
- 2016