1. Towards More Predictive, Physiological and Animal-free In Vitro Models: Advances in Cell and Tissue Culture 2020 Conference Proceedings
- Author
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Prospero Civita, Hayley McMillan, Catia Neto, Sheree Smith, Vivian Monteban, Lauri Paasonen, Victoria Kearns, Bhumika Singh, Kerri Palmer, Mohamed Essameldin Abdelgawad, Julia Katharina Metz, Martin J. D. Clift, Samuel Constant, Jarrod Bailey, Claus-Michael Lehr, Ipsita Roy, Adriele Prina-Mello, Karen Pilkington, Geoffrey J. Pilkington, Dania Movia, Melissa Anne Tutty, Tony Kiuru, Elisa Budyn, Zulfiqur Ali, John Malcolm Wilkinson, Tomasz Kostrzewski, Victoria Marsh Durban, Carla Owen, Jonathan Sheard, Helena Kandarova, Clive Roper, Eirini Velliou, John T. Connelly, Janette Ellen Turner, Marius Hittinger, Sebastian Kress, and HIPS, Helmholtz-Institut für Pharmazeutische Forschung Saarland, Universitätscampus E8.1 66123 Saarbrücken, Germany.
- Subjects
0301 basic medicine ,animal replacement ,media_common.quotation_subject ,organoid ,Toxicology ,Organ-on-a-chip ,General Biochemistry, Genetics and Molecular Biology ,Session (web analytics) ,3Rs ,03 medical and health sciences ,0302 clinical medicine ,Promotion (rank) ,microphysiological system ,media_common ,organ-on-a-chip ,Animal Welfare (journal) ,animal-free ,3-D ,in vitro ,General Medicine ,Human physiology ,tissue microenvironment ,Three Rs ,Variety (cybernetics) ,Medical Laboratory Technology ,030104 developmental biology ,030220 oncology & carcinogenesis ,Engineering ethics ,new approach methodologies ,Psychology - Abstract
Experimental systems that faithfully replicate human physiology at cellular, tissue and organ level are crucial to the development of efficacious and safe therapies with high success rates and low cost. The development of such systems is challenging and requires skills, expertise and inputs from a diverse range of experts, such as biologists, physicists, engineers, clinicians and regulatory bodies. Kirkstall Limited, a biotechnology company based in York, UK, organised the annual conference, Advances in Cell and Tissue Culture (ACTC), which brought together people having a variety of expertise and interests, to present and discuss the latest developments in the field of cell and tissue culture and in vitro modelling. The conference has also been influential in engaging animal welfare organisations in the promotion of research, collaborative projects and funding opportunities. This report describes the proceedings of the latest ACTC conference, which was held virtually on 30th September and 1st October 2020, and included sessions on in vitro models in the following areas: advanced skin and respiratory models, neurological disease, cancer research, advanced models including 3-D, fluid flow and co-cultures, diabetes and other age-related disorders, and animal-free research. The roundtable session on the second day was very interactive and drew huge interest, with intriguing discussion taking place among all participants on the theme of replacement of animal models of disease.
- Published
- 2021