1. Analysis of sero-epidemiological characteristics of varicella in healthy children in Jiangsu Province, China
- Author
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Fenyang Tang, Wang Ma, Peishan Lu, Minghao Zhou, Yuanbao Liu, Xiuying Deng, Xiang Sun, Lei Zhang, Ying Hu, Yong Wang, and Zhiguo Wang
- Subjects
Male ,0301 basic medicine ,China ,Herpesvirus 3, Human ,medicine.medical_specialty ,Varicella vaccine ,030106 microbiology ,Population ,Seroprevalence ,Enzyme-Linked Immunosorbent Assay ,Antibodies, Viral ,Vaccines, Attenuated ,Varicella ,lcsh:Infectious and parasitic diseases ,Chickenpox Vaccine ,03 medical and health sciences ,Chickenpox ,0302 clinical medicine ,Seroepidemiologic Studies ,Internal medicine ,Epidemiology ,medicine ,Humans ,lcsh:RC109-216 ,030212 general & internal medicine ,Child ,education ,Asymptomatic Infections ,education.field_of_study ,Immunization Programs ,business.industry ,Vaccination ,Infant ,Outbreak ,Cross-Sectional Studies ,Infectious Diseases ,Immunization ,Child, Preschool ,Tropical medicine ,Female ,Geometric antibody concentrations ,business ,Research Article - Abstract
Background In recent years, outbreaks of varicella have continued to occur, and the coverage rate of varicella vaccine in Jiangsu Province, China, remains unclear. This study aims to analyse the levels of immune antibody against varicella and obtain a comprehensive understanding of the varicella attenuated live vaccine (VarV) coverage rate in children aged 1–9 years in Jiangsu Province. Methods From June to October 2016, a cross-sectional survey was conducted to collect 3631 serum samples from healthy children aged 1–9 years in Jiangsu Province. The immunoglobulin G (IgG) antibody levels of varicella were detected by enzyme-linked immunosorbent assay (ELISA). Results The VarV coverage rate of healthy children was only 43.1% (95% CI: 41.1–44.7%). The seroprevalence after vaccination with a single dose of VarV was only 57.1%, and the overall seropositivity and geometric antibody titre (GMC) were 43.5% and 225.4 mU/ml, respectively. The seropositivity was significantly higher in girls than in boys (χ2 = 18.82, P
- Published
- 2018
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