1. Nutrimetabolomics: An Integrative Action for Metabolomic Analyses in Human Nutritional Studies
- Author
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Mar Garcia-Aloy, Gianfranco Picone, Christoph H. Weinert, Claudine Manach, Edith J. M. Feskens, Beate Ott, Marynka Ulaszewska, Lieven Van Meulebroek, Samantha Riccadonna, Thomas Skurk, Bjoern Egert, René Badertscher, Joachim Kopka, Manuela J. Rist, Fulvio Mattivi, Kati Hanhineva, Rafael Llorach, Reto Portmann, Caroline Rombouts, Marta Cialiè Rosso, Francesco Capozzi, Josep Rubert, Chiara Cordero, Lorraine Brennan, Lynn Vanhaecke, Grégory Pimentel, Carole Migné, Guy Vergères, Achim Bub, Sabine E. Kulling, Franck Giacomoni, Cristina Andres Lacueva, Carl Brunius, Hannelore Daniel, Pietro Franceschi, Pedapati S. C. Sri Harsha, Alessia Trimigno, Pieter Giesbertz, Raúl González-Domínguez, Linda H. Münger, Stéphanie Durand, Rosa Vázquez-Fresno, Lieselot Hemeryck, Paola G. Ferrario, David S. Wishart, Estelle Pujos-Guillot, Marynka M. Ulaszewska, Christoph H. Weinert, Alessia Trimigno, Reto Portmann, Cristina Andres Lacueva, Rene Badertscher, Lorraine Brennan, Carl Brunius, Achim Bub, Francesco Capozzi, Marta Cialie Rosso, Chiara E. Cordero, Hannelore Daniel,Stephanie Durand, Bjoern Egert, Paola G. Ferrario, Edith J.M. Feskens, Pietro Franceschi, Mar Garcia-Aloy, Franck Giacomoni, Pieter Giesbertz, Raul Gonzalez-Domınguez,Kati Hanhineva, Lieselot Y. Hemeryck, Joachim Kopka, Sabine E. Kulling, Rafael Llorach, Claudine Manach, Fulvio Mattivi, Carole Migne, Linda H. Munger, Beate Ott, Gianfranco Picone, Gregory Pimentel, Estelle Pujos-Guillot, Samantha Riccadonna, Manuela J. Rist, Caroline Rombouts, Josep Rubert, Thomas Skurk, Pedapati S. C. Sri Harsha, Lieven Van Meulebroek, Lynn Vanhaecke, Rosa Vazquez-Fresno, David Wishart,Guy Vergeres, Department of Food Quality and Nutrition, Research and Innovation Centre, Department of Safety and Quality of Fruit and Vegetables, Federal Research Institute for Nutrition and Food, Department of Agricultural and Food Science, University of Bologna, Method Development and Analytics Research Division, Agroscope, Department of Nutrition and Food Sciences, Utah State University (USU), Universitat de Barcelona, Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable, Instituto de Salud Carlos III [Madrid] (ISC), Institute of Food and Health, University College Dublin [Dublin] (UCD), Department of Biology and Biological Engineering, Chalmers University of Technology [Göteborg], Department of Physiology and Biochemistry of Nutrition, Max Rubner-Institut, Dipartimento di Scienza e Tecnologia, Farmaco Università degli Studi di Torino, Nutritional Physiology, Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Plateforme d'Exploration du Métabolisme, Institut National de la Recherche Agronomique (INRA), Division of Human Nutrition, Wageningen University and Research [Wageningen] (WUR), Computational Biology Unit [Bergen] (CBU), University of Bergen (UiB), Molecular Nutrition Unit, Department of Clinical Nutrition, Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, University of Eastern Finland, Department of Veterinary Public Health and Food Safety, Istituto Superiore di Sanita [Rome], Ghenth University, Department of Molecular Physiology, Applied Metabolome Analysis, Max Planck Institute of Molecular Plant Physiology (MPI-MP), Max-Planck-Gesellschaft-Max-Planck-Gesellschaft, Center Agriculture Food Environment, Università degli Studi di Trento (UNITN), Food Microbial Systems Research Division, Else Kröner Fresenius Center for Nutritional Medicine, Technische Universität München, ZIEL Institute for Food and Health, Departments of Biological Sciences and Computing Science, University of Alberta, BioNH call under the Joint Programming Initiative 'A Healthy Diet for a Healthy Life' (JPI-HDHL) Ministry of Education, Universities and Research (MIUR)2075Ministry of Economy and Competitiveness (MINECO) PCIN-2014-133Agencia de Gestio D'Ajuts Universitaris de Recerca Agaur (AGAUR) 2017SGR1566CIBERFES [European Regional Development Fund (FEDER) program from the European Union (EU)] Swiss National Science Foundation (SNSF) 40HD40 160618'Juan de la Cierva' program from MINECO FJCI-2015-26590, Instituto de Salud Carlos III (ISC), Technical University of Munich (TUM), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Wageningen University and Research Centre [Wageningen] (WUR), Computational Biology Unit (BCCS), University of Bergen (UIB), University of Bologna/Università di Bologna, Università degli studi di Torino = University of Turin (UNITO), Plateforme Exploration du Métabolisme (PFEM), Institut National de la Recherche Agronomique (INRA)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-MetaboHUB-Clermont, MetaboHUB-MetaboHUB, Istituto Superiore di Sanità (ISS), Universiteit Gent = Ghent University (UGENT), Manach, Claudine, and Vergeres, G.
- Subjects
0301 basic medicine ,Settore CHIM/01 - CHIMICA ANALITICA ,Nutritional Sciences ,Computer science ,[SDV]Life Sciences [q-bio] ,Eating ,Data Mining ,GC–MS ,2. Zero hunger ,Chromatography ,Life sciences ,metabolomics ,Food Analysis ,Molecular analysis ,GC-MS, LC-MS, metabolomics, NMR, nutrition ,nutrition ,Metabolòmica ,GC-MS ,LC-MS ,NMR ,Alimentation et Nutrition ,Biotechnology ,metabolomic ,Nutritional Status ,LC–MS ,03 medical and health sciences ,Metabolomics ,Humans ,Food and Nutrition ,Expert Testimony ,VLAG ,Global Nutrition ,Electronic Data Processing ,Wereldvoeding ,Models, Statistical ,030109 nutrition & dietetics ,Clinical study design ,Reproducibility of Results ,Healthy diet ,Data science ,Biomarker (cell) ,030104 developmental biology ,Workflow ,Action (philosophy) ,Multivariate Analysis ,Ciències de la vida ,Biomarkers ,Food Science - Abstract
The life sciences are currently being transformed by an unprecedented wave of developments in molecular analysis, which include important advances in instrumental analysis as well as biocomputing. In light of the central role played by metabolism in nutrition, metabolomics is rapidly being established as a key analytical tool in human nutritional studies. Consequently, an increasing number of nutritionists integrate metabolomics into their study designs. Within this dynamic landscape, the potential of nutritional metabolomics (nutrimetabolomics) to be translated into a science, which can impact on health policies, still needs to be realized. A key element to reach this goal is the ability of the research community to join, to collectively make the best use of the potential offered by nutritional metabolomics. This article, therefore, provides a methodological description of nutritional metabolomics that reflects on the state‐of‐the‐art techniques used in the laboratories of the Food Biomarker Alliance (funded by the European Joint Programming Initiative "A Healthy Diet for a Healthy Life" (JPI HDHL)) as well as points of reflections to harmonize this field. It is not intended to be exhaustive but rather to present a pragmatic guidance on metabolomic methodologies, providing readers with useful "tips and tricks" along the analytical workflow.
- Published
- 2019
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