1. Genetic mapping of the autosomal region involved in XX sex-reversal and horn development in goats
- Author
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Eduardo Manfredi, Marc Fellous, Daniel Vaiman, A. Oustry, O Koutita, Jean-Michel Elsen, Edmond-Paul Cribiu, ProdInra, Migration, Unité de recherche Génétique Biochimique et Cytogénétique (LGBC), Institut National de la Recherche Agronomique (INRA), and Station d'Amélioration Génétique des Animaux (SAGA)
- Subjects
Male ,Sex Determination Analysis ,X Chromosome ,Chromosome Disorders ,[SDV.GEN] Life Sciences [q-bio]/Genetics ,Biology ,03 medical and health sciences ,symbols.namesake ,Gene mapping ,Genetic linkage ,Genetics ,Animals ,X chromosome ,ComputingMilieux_MISCELLANEOUS ,Horns ,030304 developmental biology ,Chromosome Aberrations ,0303 health sciences ,[SDV.GEN]Life Sciences [q-bio]/Genetics ,Autosome ,Goats ,0402 animal and dairy science ,Chromosome Mapping ,04 agricultural and veterinary sciences ,Sex reversal ,040201 dairy & animal science ,Human genetics ,Pedigree ,Mendelian inheritance ,symbols ,Microsatellite ,Cattle ,Female ,Microsatellite Repeats - Abstract
Contrary to other genetic disorders, the genetic study of sex determination anomalies in humans stumbles over the difficulty in observing large pedigrees. In goats, abnormalities in sex determination are intimately linked to a dominant Mendelian gene coding for the "polled" (hornless) character, which could render this species an interesting animal model for the rare human cases of SRY-negative XX males. In this report, we describe genetic linkage between the polled/intersex synchome (PIS) and four microsatellite markers of the distal region of goat Chromosome 1 (CHI1), quite distinct from the bovine "polled" region. According to comparative mapping data, no sex-determining gene has been described so far in homologous regions in the human. This genetic localization constitutes a first step towards identifying a new autosomal sex-determining gene in mammals.
- Published
- 1996