1. Antibiotic prophylaxis in organophosphorus poisoning: A study of health and economic outcomes
- Author
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Anantha Naik Nagappa, KE Vandana, A. Priyendu, Nishitha Prabhu, Nilima, Muralidhar Varma, and Alsha Abdul Rahim
- Subjects
medicine.medical_specialty ,medicine.drug_class ,Antibiotic resistance ,Antibiotics ,Pharmaceutical Science ,030501 epidemiology ,03 medical and health sciences ,0302 clinical medicine ,Intensive care ,Direct costs ,Medicine ,030212 general & internal medicine ,Antibiotic prophylaxis ,Medical prescription ,Intensive care medicine ,Pharmacology ,business.industry ,lcsh:RM1-950 ,Retrospective cohort study ,Antibiotic misuse ,Organophosphorous poisoning ,lcsh:Therapeutics. Pharmacology ,Pharmacy practice ,Original Article ,0305 other medical science ,business - Abstract
Objective: Organophosphorus poisoning (OPP) is a major concern for developing countries. There are no guidelines for the prophylactic use of antibiotics in the management of OPP which in such critical cases might add to the economic burden of the patients as well as antibiotic resistance. We compared the health and economic outcomes in patients prescribed with prophylactic antibiotics with respect to the patients not prescribed with any antibiotics. Methods: A retrospective observational study was carried out for two years for patients admitted to ICU with OPP. Patients were graded for severity of OPP, and divided into two groups based on prophylactic prescription and no prescription of antibiotics. The length of stay (LOS), hospitalization cost and outcomes were measured and compared between the two groups using statistical tests. Results: Out of the 254 patients observed, 108 were prescribed with prophylactic antibiotics and 94 were not prescribed with any antibiotic. There was a significant difference between LOS, cost of treatment and outcomes in the two groups (p
- Published
- 2016