1. The landscape of small cell lung cancer metastases: Organ specificity and timing
- Author
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Ferenc Rényi-Vámos, Melinda Rezeli, Viktoria Laszlo, János Fillinger, Anna Schwendenwein, Orsolya Pipek, Bernadett Tallosy, Mir Alireza Hoda, Christian Lang, Judit Moldvay, Thomas Klikovits, Zsolt Megyesfalvi, and Balazs Dome
- Subjects
Adult ,Male ,0301 basic medicine ,Pulmonary and Respiratory Medicine ,Oncology ,medicine.medical_specialty ,Lung Neoplasms ,survival ,lcsh:RC254-282 ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Neoplasm Metastasis ,Aged ,Retrospective Studies ,Aged, 80 and over ,Lung ,Adrenal gland ,business.industry ,Significant difference ,Original Articles ,General Medicine ,Middle Aged ,medicine.disease ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Small Cell Lung Carcinoma ,Primary tumor ,Peripheral ,respiratory tract diseases ,Cross-Sectional Studies ,030104 developmental biology ,medicine.anatomical_structure ,Organ Specificity ,030220 oncology & carcinogenesis ,Female ,Original Article ,Non small cell ,small cell lung cancer ,metastasis pattern ,business - Abstract
Background Early metastasis is a hallmark of small cell lung cancer (SCLC). However, the mechanisms and resulting patterns of SCLC dissemination are unclear. Our aim was thus to investigate the organ specificity and timing of blood‐borne metastases in a comprehensive large cohort of SCLC patients. Methods In this retrospective non‐interventional cross‐sectional study of 1009 Caucasian SCLC patients, we investigated the correlation between the distinct locations of the primary tumor and metastatic sites. Results The onset of bone (p, In this study, our aim was to examine the organ specificity and timing of blood‐borne metastases in a comprehensive large cohort of Caucasian SCLC patients (n =1009). We report here that the onset of bone, brain, and pericardial metastases are late events, whereas adrenal gland and liver metastases occur earlier during tumor progression. We also show that several metastatic sites, such as bone and liver, and brain and adrenal gland intend to co‐metastasize preferentially. Of note, however, no significant associations were observed with regards to the timing and organ preference of distant metastases when comparing central and peripheral primary tumors.
- Published
- 2021