19 results on '"Masanori Masui"'
Search Results
2. A case of langerhans cell histiocytosis of the mandible that spontaneously regressed after biopsy in a child
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Kyoichi Obata, Shoji Ryumon, Tatsuo Okui, Kisho Ono, Yuki Kunisada, Tomoya Nakamura, Soichiro Ibaragi, Masanori Masui, and Akira Sasaki
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general surgery ,Medicine (General) ,medicine.medical_specialty ,dentistry ,medicine.diagnostic_test ,business.industry ,Mandible ,Case Report ,Case Reports ,General Medicine ,030204 cardiovascular system & hematology ,medicine.disease ,Surgery ,03 medical and health sciences ,R5-920 ,0302 clinical medicine ,Langerhans cell histiocytosis ,030220 oncology & carcinogenesis ,oncology ,Rare case ,Biopsy ,Medicine ,business - Abstract
In younger patients of LCH, we should consider that the effectiveness of follow‐up without aggressive treatment for SS‐type LCH in the oral and maxillofacial bone. However, there are very rare case in which an SS‐type LCH recurred after showing a healing tendency. Regular follow‐up must be performed even after healing., In younger patients of LCH, we should consider that the effectiveness of follow‐up without aggressive treatment for SS‐type LCH in the oral and maxillofacial bone. However, there are very rare case in which an SS‐type LCH recurred after showing a healing tendency. Regular follow‐up must be performed even after healing
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- 2021
3. A retrospective comparative study of mandibular fracture treatment with internal fixation using reconstruction plate versus miniplates
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Yoshihiko Furuki, Masanori Masui, Tsukasa Kishimoto, Ai Sato, Yuka Sukegawa-Takahashi, Shintaro Sukegawa, and Takahiro Kanno
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Male ,medicine.medical_treatment ,Mandibular fracture ,Treatment outcome ,Clinical success ,Condyle ,Fracture Fixation, Internal ,03 medical and health sciences ,0302 clinical medicine ,Mandibular Fractures ,medicine ,Humans ,Internal fixation ,Fractures, Comminuted ,Retrospective Studies ,Orthodontics ,Mandible Fracture ,business.industry ,Mandible ,030206 dentistry ,medicine.disease ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Fracture (geology) ,Female ,Surgery ,Oral Surgery ,business ,Bone Plates - Abstract
This study compared the clinical success rates of mandibular fracture treatment using reconstruction plates or miniplates and clarified the selection criteria for reconstruction plates.All patients who had surgically-treated mandible fractures from 2008 to 2017 with sufficient follow-up were retrospectively analyzed for information about the fracture condition, treatment, and outcomes.A total of 126 surgically-treated mandible fractures without mandibular condylar fracture in 105 patients (76 male, 29 female) were included. Reconstruction plates were used in 32 fractures with very good postoperative occlusal function. Four cases with complications requiring reoperation were treated using only miniplates. Variables that were statistically associated with follow-up surgery included simple versus comminuted mandible fracture, and the absence of teeth that could be used for intermaxillary fixation (P 0.05). In the miniplates treatment for comminuted fracture, there was a significant difference in the treatment outcome depending on the number of free bone-fragments and the presence of bone-fragments requiring removal within 1 cm (P 0.05).Reconstruction plates provided better treatment outcomes for comminuted fractures and fractures without teeth. Selecting a reconstruction plate that is capable of sufficiently overloading is important in comminuted fractures with multiple free bone-fragments and bone-fragments requiring removal.
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- 2019
4. Is the removal of osteosynthesis plates after orthognathic surgery necessary? Retrospective long-term follow-up study
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Masanori Masui, Yuka Sukegawa-Takahashi, Yoshiki Manabe, K. Matsumoto, Takahiro Kanno, Yoshihiko Furuki, and Shintaro Sukegawa
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Long term follow up ,medicine.medical_treatment ,Orthognathic surgery ,Bone healing ,Titanium plate ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,medicine ,Humans ,Device Removal ,Retrospective Studies ,Titanium ,Osteosynthesis ,Orthognathic Surgical Procedures ,business.industry ,Retrospective cohort study ,030206 dentistry ,Middle Aged ,Surgery ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Oral and maxillofacial surgery ,Female ,Oral Surgery ,business ,Bone Plates ,Follow-Up Studies - Abstract
The removal of titanium miniplates is a controversial topic in oral and maxillofacial surgery. This retrospective study examined the timing of and reasons for titanium plate removal after orthognathic surgery. The study included 240 orthognathic surgery patients (71 male, 169 female; age range 16-55 years, mean 25.0±8.8 years) who had maxillofacial osteosynthesis plates inserted or inserted and then removed at the Division of Oral and Maxillofacial Surgery, Kagawa Prefectural Central Hospital, between April 2003 and March 2017. During the study period, a total of 717 miniplates were inserted in the 240 patients, and 71 of the patients (29.6%) had 236 plates (32.9%) removed. Ten patients (14.1%) had their plates removed within a year due to early complications. Although no patient had their plate removed due to complications at 1-5 years postoperative, a further 14 patients (19.7%) had their plates removed after more than 5 years of long-term follow-up due to plate-related complications. Complications requiring plate removal were evidently biphasic, occurring within 1 year after the operation and at ≥5 years after the operation. Therefore, after confirming postoperative bone healing, it is necessary to explain to patients the risks of plate removal and the importance of long-term follow-up.
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- 2018
5. Maxillofacial Trauma Surgery Patients With Titanium Osteosynthesis Miniplates: Remove or Not?
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Hitoshi Nagatsuka, Masanori Masui, Yuka Sukegawa-Takahashi, Shintaro Sukegawa, Kiyofumi Takabatake, Hotaka Kawai, Yoshihiko Furuki, and Keisuke Nakano
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Adult ,Male ,Adolescent ,Dentistry ,Fracture site ,03 medical and health sciences ,Fracture Fixation, Internal ,Young Adult ,0302 clinical medicine ,Long period ,Fracture fixation ,Medicine ,Humans ,030223 otorhinolaryngology ,Child ,Device Removal ,Aged ,Retrospective Studies ,Aged, 80 and over ,Titanium ,Osteosynthesis ,Skull Fractures ,business.industry ,Significant difference ,Retrospective cohort study ,030206 dentistry ,General Medicine ,Middle Aged ,Surgery, Oral ,Otorhinolaryngology ,Surgery ,Female ,Maxillofacial Injuries ,Predictive variables ,business ,Trauma surgery - Abstract
The authors examined the timing and causes of titanium miniplate removal after maxillofacial trauma surgery. The authors performed a retrospective study of maxillofacial fracture patients in whom maxillofacial osteosynthesis miniplates were inserted or removed at the Kagawa Prefectural Central Hospital, between 2008 and 2017. Predictive variables were age, sex, fracture site distribution, and time to miniplate removal with or without complications in relation to primary outcome variables. Among 185 patients, 440 miniplates were inserted and 272 miniplates were removed. In total, 116 patients (73.4%) had 282 miniplates (64.1%) removed, of which 4.8% fracture sites and 5.7% miniplates were removed because of complications. The mean time to miniplate removal was 630.9 and 258.0 days in patients with and without complications, respectively. There was a statistically significant difference in miniplate removal and miniplate retention relative to age and sex. This difference was not related to the presence or absence of sex- or age-related complications. The miniplates as osteosynthesis material were safe and useful for a long period of time with relatively few complications. Because complications requiring miniplate removal occurred within 1 or after 5 years postoperatively, osteosynthesis miniplate treatments should be decided while considering the patient's age and sex. Long-term follow-up is recommended for miniplates that remain implanted for >1 year.
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- 2020
6. Evaluation of Open Reduction and Internal Fixation of Mandibular Condyle Fracture by Intraoperative Cone-Beam Computed Tomography in a Hybrid Operating Room
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Masanori Masui, Hitoshi Nakamoto, Shintaro Sukegawa, Yoshihiko Furuki, Takahiro Kanno, and Masayuki Miki
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Cone beam computed tomography ,Operating Rooms ,Image quality ,medicine.medical_treatment ,Condyle ,open reduction and internal fixation ,03 medical and health sciences ,Fixation (surgical) ,Fracture Fixation, Internal ,0302 clinical medicine ,Imaging, Three-Dimensional ,stomatognathic system ,Mandibular Fractures ,Clinical Studies ,Medicine ,Internal fixation ,Humans ,030223 otorhinolaryngology ,mandibular condyle fracture ,Aged ,Orthodontics ,Surgical approach ,business.industry ,Mandibular Condyle ,030206 dentistry ,General Medicine ,Cone-Beam Computed Tomography ,Open Fracture Reduction ,Otorhinolaryngology ,Hybrid room ,Invasive surgery ,Hybrid operating room ,Surgery ,Female ,business ,intraoperative cone-beam computed tomography - Abstract
Condylar fractures are the most common fractures of the mandible, and treatment of mandibular condylar fractures by maxillofacial surgeons is a very important procedure. However, the surgical approaches have anatomical limitations. Therefore, it is difficult to evaluate the reduction achieved in open reduction and internal fixation because of the uncertainty in securing a sufficient operative field. As a potential solution, the authors evaluated the benefits of intraoperative cone-beam computed tomography (CBCT) with high image quality performed in a hybrid operating room. Intraoperative CBCT is easy to perform in a hybrid operating room, and it is possible to quickly evaluate high-quality CT images, including 3D images. Because the state of reduction of mandibular condylar fractures also affects the prognosis of treatment, more precise reduction and fixation should improve prognoses. The use of CBCT in a hybrid operating room also avoids re-operation, and patients benefit from minimum invasive surgery. Intraoperative CBCT is a very useful strategy for evaluation of mandibular condylar fracture surgical treatment.
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- 2019
7. Low‐intensity pulsed ultrasound stimulation promotes osteoblast differentiation through hedgehog signaling
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Masanori Masui, Akira Sasaki, Masaharu Takigawa, Nobuyuki Yamanaka, Yuki Kunisada, Naito Kurio, Tatsuo Okui, Pang Pai, Kenichi Matsumoto, Soichiro Ibaragi, Kyoichi Obata, Tsuyoshi Shimo, and Yuu Horikiri
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Male ,0301 basic medicine ,animal structures ,Callus formation ,Bone healing ,Zinc Finger Protein Gli2 ,Low-intensity pulsed ultrasound ,Zinc Finger Protein GLI1 ,Biochemistry ,Mice ,03 medical and health sciences ,GLI1 ,medicine ,Animals ,Hedgehog Proteins ,Sonic hedgehog ,Molecular Biology ,Osteoblasts ,biology ,Chemistry ,Cell Differentiation ,Osteoblast ,Cell Biology ,Hedgehog signaling pathway ,Cell biology ,030104 developmental biology ,medicine.anatomical_structure ,Ultrasonic Waves ,biology.protein ,Smoothened ,Signal Transduction - Abstract
Low-intensity pulsed ultrasound (LIPUS) has been used as an adjunct to fracture healing therapies, but the mechanisms underlying its action are not known. We reported that sonic hedgehog (SHH) signaling was activated in osteoblasts at the dynamic remodeling site of a bone fracture. Mechanical stimulation is a crucial factor in bone remodeling, and it is related to the primary cilia as a sensor of hedgehog signaling. Here we observed that LIPUS promoted callus formation in accord with Gli2-positive cells after 14 days at the mouse femur fractured site compared with a control group. An immunofluorescence analysis showed that the numbers of primary cilia and cilia/osterix double-positive osteoblasts were increased at the fracture site by LIPUS. LIPUS stimulated not only the number and the length of primary cilia, but also the levels of ciliated protein, Ift88 mRNA, and SHH, Gli1, and Gli2 in MC3T3-E1 cells. Further experiments revealed that LIPUS stimulated osteogenic differentiation in the presence of smoothened agonist (SAG) treatment. These results indicate that LIPUS stimulates osteogenic differentiation and the maturation of osteoblasts by a primary cilium-mediated activation of hedgehog signaling.
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- 2018
8. Use of an intraoperative navigation system and piezoelectric surgery for styloidectomy in a patient with Eagle’s syndrome: a case report
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Masanori Masui, Takahiro Kanno, Yuka Sukegawa-Takahashi, Yoshihiko Furuki, Shintaro Sukegawa, Akio Yoshimoto, and Kenichi Matsumoto
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Male ,medicine.medical_specialty ,Stylomandibular ligament ,Radiography ,Oral Surgical Procedures ,Thiazines ,lcsh:Medicine ,Meloxicam ,Surgical planning ,Eagle's syndrome ,Resection ,03 medical and health sciences ,Imaging, Three-Dimensional ,0302 clinical medicine ,Transoral approach ,medicine.ligament ,Case report ,Humans ,Minimally Invasive Surgical Procedures ,Medicine ,Intraoperative navigation ,Piezosurgery ,030223 otorhinolaryngology ,Piezoelectric surgery ,Mouth ,Neck Pain ,business.industry ,Ossification, Heterotopic ,Anti-Inflammatory Agents, Non-Steroidal ,lcsh:R ,Temporal Bone ,030206 dentistry ,General Medicine ,Middle Aged ,Magnetic Resonance Imaging ,Osteotomy ,Surgery ,Thiazoles ,Treatment Outcome ,Intraoperative navigation system ,Tomography, X-Ray Computed ,business ,Eagle’s syndrome - Abstract
Background Elongated styloid process syndrome (Eagle’s syndrome) is the term given to the symptomatic elongation of the styloid process or the mineralization of the stylohyoid or stylomandibular ligament. The two commonly used approaches for the surgical treatment of this syndrome are the transcervical and transoral approaches. Both have their limitations and specific intraoperative risks. Here, we report the treatment of a patient with Eagle’s syndrome using the transoral approach in conjunction with piezoelectric surgery, surgical planning, and intraoperative navigation to reduce the risk of complications. Case presentation The elongated styloid process was resected in a 45-year-old Japanese man using a minimally invasive approach with an intraoperative navigation system. Preoperative preparation involved the use of a custom interocclusal splint to produce the mouth opening conditions required during surgery. Using the three-dimensional position of the navigation probe, the location of the elongated styloid process was identified. After confirmation of the resection spot via the transoral approach, the styloid process was dissected by piezoelectric surgery. Follow-up examination showed an uneventful recovery with no associated complications. Conclusion The resection of the styloid process using an intraoperative navigation system and a custom interocclusal splint during a transoral approach, together with a piezoelectric cutting device, is safe and effective for the treatment of Eagle’s syndrome.
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- 2017
9. Semaphorin 4D promotes bone invasion in head and neck squamous cell carcinoma
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Hiroyuki Takada, Guo-fu Hu, Tatsuo Okui, Masanori Masui, Akira Sasaki, Norie Yoshioka, Ayaka Morisawa, Hitoshi Nagatsuka, Hotaka Kawai, Soichiro Ibaragi, Nur Mohammad Monsur Hassan, Tsuyoshi Shimo, Takanori Eguchi, Kiyofumi Takabatake, and Kyoichi Obata
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0301 basic medicine ,Cancer Research ,Pathology ,medicine.medical_specialty ,Bone disease ,medicine.medical_treatment ,Cell ,SEMA4D ,Osteoclasts ,Bone Neoplasms ,Semaphorins ,Biology ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Antigens, CD ,Cell Movement ,Cell Line, Tumor ,medicine ,Animals ,Humans ,Neoplasm Invasiveness ,Insulin-Like Growth Factor I ,Neovascularization, Pathologic ,Oncogene ,Squamous Cell Carcinoma of Head and Neck ,Growth factor ,RANK Ligand ,Articles ,Cell cycle ,medicine.disease ,Xenograft Model Antitumor Assays ,Head and neck squamous-cell carcinoma ,Gene Expression Regulation, Neoplastic ,Oligodendroglia ,030104 developmental biology ,medicine.anatomical_structure ,Oncology ,Head and Neck Neoplasms ,RANKL ,030220 oncology & carcinogenesis ,Carcinoma, Squamous Cell ,Cancer research ,biology.protein - Abstract
Head and neck squamous cell carcinomas (HNSCCs) frequently invade the bones of the facial skeleton. Semaphorin 4D (Sema4D) is an axon guidance molecule produced by oligodendrocytes. Sema4D was also identified in the bone microenvironment and many cancer tissues including HNSCC. To date, however, the role of Sema4D in cancer-associated bone disease is still unknown. This is the first study to demonstrate the role of Sema4D in bone invasion of cancer. In the clinical tissue samples of bone lesion of HNSCC, Sema4D was detected at high levels, and its expression was correlated with insulin-like growth factor-I (IGF-I) expression. In vitro experiments showed that IGF-I regulates Sema4D expression and Sema4D increased proliferation, migration and invasion in HNSCC cells. Sema4D also regulated the expression of receptor activator of nuclear factor κβ ligand (RANKL) in osteoblasts, and this stimulated osteoclastgenesis. Furthermore, knockdown of Sema4D in HNSCC cells inhibited tumor growth and decreased the number of osteoclasts in a mouse xenograft model. Taken together, IGF-I-driven production of Sema4D in HNSCCs promotes osteoclastogenesis and bone invasion.
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- 2017
10. Pathological and Clinical Study of Japanese Ameloblastic Fibro-Odontomas
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Kenichi Matsumoto, Takahiro Kanno, Yuka Sukegawa-Takahashi, Keisuke Nakano, Masanori Masui, Yoshihiko Furuki, Shintaro Sukegawa, and Hotaka Kawai
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Pathology ,medicine.medical_specialty ,business.industry ,Ameloblastic Fibro-Odontoma ,Medicine (miscellaneous) ,Dentistry ,Odontogenic tumor ,030206 dentistry ,Cell Biology ,medicine.disease ,Biochemistry ,Biomaterials ,Clinical study ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Medicine ,Orthopedics and Sports Medicine ,business ,General Dentistry ,Pathological - Published
- 2017
11. Precision of Post-Traumatic Orbital Reconstruction Using Unsintered Hydroxyapatite Particles/Poly-L-Lactide Composite Bioactive/Resorbable Mesh Plate with and without Navigation: A Retrospective Study
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Shintaro Sukegawa, Yoshihiko Furuki, Takahiro Kanno, Kenichi Matsumoto, Yuta Koyama, Shigeto Tanaka, Yuka Sukegawa-Takahashi, and Masanori Masui
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medicine.medical_specialty ,Materials science ,Composite number ,Medicine (miscellaneous) ,030206 dentistry ,Cell Biology ,Biochemistry ,Surgery ,Biomaterials ,03 medical and health sciences ,0302 clinical medicine ,Orbital reconstruction ,030220 oncology & carcinogenesis ,Poly-L-lactide ,medicine ,Orthopedics and Sports Medicine ,Intraoperative navigation ,Orbital Fracture ,General Dentistry ,Biomedical engineering - Published
- 2017
12. Retinoic Receptor Signaling Regulates Hypertrophic Chondrocyte-specific Gene Expression
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Naito Kurio, Yuki Kunisada, Norie Yoshioka, Masanori Masui, Akira Sasaki, Eiki Koyama, Tatsuo Okui, Masahiro Iwamoto, Shoko Yoshida, Tsuyoshi Shimo, and Soichiro Ibaragi
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MAPK/ERK pathway ,Cancer Research ,medicine.drug_class ,Receptors, Retinoic Acid ,Retinoic acid ,Retinoid receptor ,Tretinoin ,p38 Mitogen-Activated Protein Kinases ,General Biochemistry, Genetics and Molecular Biology ,03 medical and health sciences ,chemistry.chemical_compound ,Mice ,0302 clinical medicine ,Chondrocytes ,Gene expression ,Matrix Metalloproteinase 13 ,medicine ,Animals ,Humans ,Retinoid ,RNA, Messenger ,Phosphorylation ,Protein kinase A ,In Situ Hybridization ,Pharmacology ,Tibia ,Kinase ,Connective Tissue Growth Factor ,Gene Expression Regulation, Developmental ,Cell Differentiation ,Chondrogenesis ,Cell biology ,Cartilage ,chemistry ,030220 oncology & carcinogenesis ,Research Article ,Collagen Type X ,Signal Transduction - Abstract
Background/aim Retinoid signaling is important for the maturation of growth-plate chondrocytes. The effect of retinoid receptor gamma (RARγ) signaling on the expression of genes in hypertrophic chondrocytes is unclear. This study investigated the role of RARγ signaling in regulation of hypertrophic chondrocyte-specific genes. Materials and methods The gene expression in mouse E17.5 tibial cartilage was examined by in situ hybridization analysis. Real-time reverse transcription-polymerase chain reaction (RT-PCR) and immunoblotting were used for analysis of mRNA and phosphorylated mitogen-activated protein kinase (MAPK). Results mRNA expression of Rarg and connective tissue growth factor (Ccn2) was detected in maturing chondrocytes throughout the cartilaginous skeletal elements. In chondrogenic ATDC5 cells, an RARγ agonist induced the gene expression of type-X collagen (Col10A1), transglutaminase-2 (Tg2), matrix metalloproteinase-13 (Mmp13), and Ccn2 mRNA, whereas a retinoic acid pan-agonist suppressed RARγ agonist-stimulated gene expression. Phosphorylated extracellular signal regulated-kinases (pERK1/2), p-p38, and phosphorylated c-Jun N-terminal kinase (pJNK) MAPK were time-dependently increased by RARγ agonist treatment. Experimental p38 inhibition led to a severe drop in the RARγ agonist-stimulated expressions of Col10A1, Tg2, Mmp13, and Ccn2 mRNA. Conclusion RARγ signaling is required for the differentiation of hypertrophic chondrocytes, with differential cooperation with p38 MAPK.
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- 2019
13. Endoscope-Assisted Resection of Intramuscular Cavernous Hemangioma Within the Temporal Muscle
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Ai Sato, Takahiro Kanno, Masanori Masui, Yoshihiko Furuki, Tsukasa Kishimoto, Naoki Katase, Yuka Sukegawa-Takahashi, and Shintaro Sukegawa
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Adult ,Male ,medicine.medical_specialty ,Nerve Paralysis ,Temporal Muscle ,Intramuscular Hemangioma ,Temporal muscle ,Hemangioma ,Lesion ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,Humans ,030223 otorhinolaryngology ,Muscle Neoplasms ,medicine.diagnostic_test ,business.industry ,Soft tissue ,Magnetic resonance imaging ,Endoscopy ,030206 dentistry ,General Medicine ,medicine.disease ,Hemangioma, Cavernous ,Otorhinolaryngology ,Zygomatic bone ,Surgery ,Radiology ,medicine.symptom ,business - Abstract
Hemangiomas are benign vascular soft tissue tumors, which most frequently occur in the skin or subcutaneous tissue. Intramuscular hemangiomas typically occur in the trunk and extremities and less frequently in the head and neck. Among these, those occurring in the temporalis muscle are extremely rare. The authors report the case of a 43-year-old Japanese male with a mass in his left temporal fossa. Computed tomography images showed no erosion of the zygomatic bone, and magnetic resonance imaging revealed an ovoid well-marginated mass within the temporal muscle. The lesion was surgically excised with an endoscopy procedure used for minimally invasive lesions and complete removal. Histopathological examination confirmed the diagnosis of intramuscular cavernous hemangioma. The postoperative clinical course was good, with no indications of temporary nerve paralysis. No signs of local recurrence were observed postoperatively. Therefore, a cavernous hemangioma should be suspected when a mass occurs in the temporal region with accompanying radiologic findings suggesting vascular origin. In surgical treatment, the endoscopy-assisted technique is very useful to achieve complete tumor resection and prevent relapse while avoiding serious complications due to surgical procedures.
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- 2018
14. Which fixation methods are better between three-dimensional anatomical plate and two miniplates for the mandibular subcondylar fracture open treatment?
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Masanori Masui, Yuka Sukegawa-Takahashi, Ai Sato, Shintaro Sukegawa, Takahiro Kanno, Yoshihiko Furuki, and Tsukasa Kishimoto
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Orthodontics ,business.industry ,Mandibular Condyle ,Fracture site ,030206 dentistry ,Bone healing ,Fixation method ,Retrospective data ,03 medical and health sciences ,Fracture Fixation, Internal ,0302 clinical medicine ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Mandibular Fractures ,Open treatment ,Fracture (geology) ,Medicine ,Simple fracture ,Humans ,Surgery ,Oral Surgery ,business ,Bone Plates ,Plate fixation ,Retrospective Studies - Abstract
To compare the clinical outcomes of a single three-dimensional (3-D) anatomical plate versus two conventional straight miniplates for the open treatment of mandibular subcondylar fractures.This retrospective clinical study included patients with mandibular subcondylar fractures treated by the retromandibular transparotid approach using a 3-D plate or two straight miniplates. Outcome variables included preoperative conditions of patients and fractures, extent of postoperative bone healing, and incidence of complications. Other variables included age, sex, fracture site, and follow-up duration. Variables were evaluated using descriptive statistics and compared between groups.Twenty-eight fractures were analyzed: 13 fractures using 3-D plate and 15 fractures using two straight miniplates. None of the assessed variables showed significant differences between the two groups (p 0.05). Unfortunately, in the 3-D plate group, reoperation was necessary for nonunion owing to plate breakage in one case with a bone defect around the fracture.The 3-D plate and two straight miniplates were equally effective for the surgical management of mandibular subcondylar fractures. Although a 3-D plate is sufficient for a typical simple fracture, in cases with a bone defect around the fracture, selection of the plate fixation method should be carefully considered.
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- 2018
15. What are the risk factors for postoperative infections of third molar extraction surgery: A retrospective clinical study-?
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Takahiro Kanno, Yuka Sukegawa-Takahashi, Yoshiki Manabe, Shintaro Sukegawa, Yoshihiko Furuki, Kyoko Yokota, and Masanori Masui
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Adult ,Male ,Molar ,medicine.medical_specialty ,Retrospective data ,Clinical study ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,stomatognathic system ,Risk Factors ,Postoperative infection ,medicine ,Humans ,Mandibular Diseases ,General Dentistry ,Retrospective Studies ,business.industry ,Research ,Mandible ,Retrospective cohort study ,Bacterial Infections ,030206 dentistry ,CIENCIAS MÉDICAS [UNESCO] ,Surgery ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Maxilla ,Tooth Extraction ,UNESCO::CIENCIAS MÉDICAS ,Female ,Molar, Third ,General health ,Oral Surgery ,business ,Third molar extraction surgery ,delayed-onset infection ,early-onset infection ,postoperative infection - Abstract
Background This study aimed to identify (1) the predilection site of postoperative infection after third molar extraction surgery, (2) risk factors associated with postoperative infection, and (3) the cause of the difference between delayed- and early-onset infections. Material and Methods This retrospective study included 1010 patients (396 male, 614 female) who had ≥1 third molars extracted (2407; 812 maxilla, 1595 mandible). The risk factors were classified as attributes, general health, anatomic, and operative. Outcome variables were delayed- and early-onset infections. Results Postoperative infection was completely absent in the maxilla, and all infections occurred in the mandible, with a probability of 1.94% (31/1595). Bivariate analysis for postoperative infection showed depth of inclusion and intraoperative hemostatic treatment to be significantly associated with the development of infections. Bivariate analysis for delayed- and early-onset infections showed simultaneous extraction of the left and right mandibular third molars to be prominent risk factors. Conclusions Postoperative infection occurs mainly in the mandible, and that in the maxilla is very rare. The risk of postoperative infection in the mandible was found to be related to the depth of inclusion and intraoperative hemostatic treatment. Simultaneous extraction of the left and right mandibular third molars appear to increase the risk of delayed-onset postoperative infection. Key words:Third molar extraction surgery, delayed-onset infection, early-onset infection, postoperative infection.
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- 2018
16. Oral Squamous Cell Carcinoma-derived Sonic Hedgehog Promotes Angiogenesis
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Hiromasa Kuroda, Koji Kishimoto, Naito Kurio, Tsuyoshi Shimo, Masanori Masui, Akira Sasaki, Kiyofumi Takabatake, Hitoshi Nagatsuka, Norie Yoshioka, Yuki Kunisada, Soichiro Ibaragi, Kyoichi Obata, Tatsuo Okui, and Kenichi Matsumoto
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0301 basic medicine ,Patched ,Cancer Research ,animal structures ,Cyclopamine ,Angiogenesis ,Mice, Nude ,Zinc Finger Protein Gli2 ,Biology ,Zinc Finger Protein GLI1 ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,GLI1 ,Cell Line, Tumor ,Animals ,Humans ,Hedgehog Proteins ,Sonic hedgehog ,Cells, Cultured ,Cell Proliferation ,Mice, Inbred BALB C ,Neovascularization, Pathologic ,Oncogene ,Veratrum Alkaloids ,General Medicine ,Immunohistochemistry ,Xenograft Model Antitumor Assays ,Hedgehog signaling pathway ,Patched-1 Receptor ,stomatognathic diseases ,030104 developmental biology ,Oncology ,PTCH1 ,chemistry ,030220 oncology & carcinogenesis ,embryonic structures ,Carcinoma, Squamous Cell ,biology.protein ,Cancer research ,Female ,Mouth Neoplasms ,Signal Transduction - Abstract
BACKGROUND Sonic hedgehog (SHH) signaling is related to the pathogenesis of oral squamous cell carcinoma (OSCC), but its role in OSCC is not yet well understood. In this study, we analyzed the role of SHH signaling in OSCC. MATERIALS AND METHODS We examined the expression pattern of SHH and its signal proteins in clinically resected OSCC samples by immunohistochemistry. We also evaluated the function of SHH signaling using the hedgehog signaling inhibitor cyclopamine in vivo and in vitro by proliferation, migration and angiogenesis analyses. RESULTS We found that SHH was highly expressed in human tongue OSCC, whereas patched (PTCH1), glioma-associated oncogene 1 (GLI1) and GLI2 proteins were expressed in the microvascular cells in the tumor invasive front. Administration of cyclopamine to mice suppressed the growth and angiogenesis of OSCC xenografts in vivo. Moreover, cyclopamine inhibited endothelial cell proliferation and migration, and reduced aorta vascular length in the rat. CONCLUSION These findings suggest that OSCC-derived SHH stimulates angiogenesis at the tumor invasive front.
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- 2017
17. Biomechanical Loading Evaluation of Unsintered Hydroxyapatite/poly-l-lactide Plate System in Bilateral Sagittal Split Ramus Osteotomy
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Yuka Sukegawa-Takahashi, Yoshiki Manabe, Yoshihiko Furuki, Masanori Masui, Kenichi Matsumoto, Shintaro Sukegawa, and Takahiro Kanno
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Materials science ,bioactive resorbable plate ,sagittal split ramus osteotomy ,unsintered hydroxyapatite/poly-, ,l-<%2Fspan>lactide+composite+plate%22">">l- lactide composite platebiomechanical loading evaluation ,tensile and shear strength evaluation ,unsintered hydroxyapatite/poly ,Mandibular first molar ,lcsh:Technology ,Article ,l-lactide+composite+plate%22">">l-lactide composite plate ,03 medical and health sciences ,0302 clinical medicine ,Sagittal Split Ramus Osteotomy ,Ultimate tensile strength ,Shear strength ,General Materials Science ,lcsh:Microscopy ,Fixation (histology) ,lcsh:QC120-168.85 ,Orthodontics ,Osteosynthesis ,lcsh:QH201-278.5 ,lcsh:T ,Mandible ,030206 dentistry ,Masticatory force ,unsintered hydroxyapatite/poly-l-lactide composite plate ,lcsh:TA1-2040 ,030220 oncology & carcinogenesis ,lcsh:Descriptive and experimental mechanics ,lcsh:Electrical engineering. Electronics. Nuclear engineering ,lcsh:Engineering (General). Civil engineering (General) ,lcsh:TK1-9971 - Abstract
OSTEOTRANS MX® (Takiron Co., Ltd., Osaka, Japan) is a bioactive resorbable maxillofacial osteosynthetic material composed of an unsintered hydroxyapatite/poly-l-lactide composite, and its effective osteoconductive capacity has been previously documented. However, the mechanical strength of this plate system is unclear. Thus, the aim of this in vitro study was to assess its tensile and shear strength and evaluate the biomechanical intensity of different osteosynthesis plate designs after sagittal split ramus osteotomy by simulating masticatory forces in a clinical setting. For tensile and shear strength analyses, three mechanical strength measurement samples were prepared by fixing unsintered hydroxyapatite/poly-l-lactide composed plates to polycarbonate skeletal models. Regarding biomechanical loading evaluation, 12 mandibular replicas were used and divided into four groups for sagittal split ramus osteotomy fixation. Each sample was secured in a jig and subjected to vertical load on the first molar teeth. Regarding shear strength, the novel-shaped unsintered hydroxyapatite/poly-l-lactide plate had significantly high intensity. Upon biomechanical loading evaluation, this plate system also displayed significantly high stability in addition to bioactivity, with no observed plate fracture. Thus, we have clearly demonstrated the efficacy of this plate system using an in vitro model of bilateral sagittal split ramus osteotomy of the mandible.
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- 2017
18. Complications of a poly-L-lactic acid and polyglycolic acid osteosynthesis device for internal fixation in maxillofacial surgery
- Author
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Yoshihiko Furuki, Yuka Sukegawa-Takahashi, Masanori Masui, Takahiro Kanno, Shintaro Sukegawa, and Kenichi Matsumoto
- Subjects
Poly l lactic acid ,Adult ,Male ,medicine.medical_specialty ,Adolescent ,medicine.medical_treatment ,Biocompatible Materials ,02 engineering and technology ,03 medical and health sciences ,0302 clinical medicine ,Postoperative Complications ,Polylactic Acid-Polyglycolic Acid Copolymer ,Absorbable Implants ,medicine ,Internal fixation ,Humans ,Child ,General Dentistry ,Aged ,Retrospective Studies ,Osteosynthesis ,business.industry ,Incidence ,Significant difference ,Retrospective cohort study ,030206 dentistry ,Middle Aged ,021001 nanoscience & nanotechnology ,Surgery ,Resorption ,Molecular Weight ,Treatment Outcome ,Oral and maxillofacial surgery ,Female ,0210 nano-technology ,Complication ,business ,Bone Plates ,Craniotomy - Abstract
The purpose of this study was to retrospectively evaluate and examine the incidence of complications using poly-l-lactic acid and polyglycolic acid (PLLA/PGA) copolymer plate system in maxillofacial osteosynthesis. The retrospective study included 87 patients (50 men, 37 women), who needed maxillofacial surgery. We examined the proportion of complications and their factors from clinical data. A comparison was also made for plate decomposition using the molecular weight of the plate without plate exposure and complications. Osteosynthesis sites healed in all patients. Ten cases (11.5%) showed plate exposure-related complications, with all occurring at intraoral surgical sites. There was no significant difference in molecular weight changes of plates in resorbable process. Statistical analysis of study variables between patients with and without exposed plates showed that the plate thickness was significantly associated with the risk of exposed plates (p
- Published
- 2017
19. Detection of sonic hedgehog in patients undergoing orthognathic surgery
- Author
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Soichiro Ibaragi, Kenichi Matsumoto, Tsuyoshi Shimo, Koji Kishimoto, Shohei Domae, Tatsuo Okui, Akiyoshi Nishiyama, Masanori Masui, Akira Sasaki, Naito Kurio, Norie Yoshioka, and Yuki Kunisada
- Subjects
0301 basic medicine ,medicine.medical_specialty ,biology ,business.industry ,medicine.medical_treatment ,Orthognathic surgery ,Sonic hedgehog ,030209 endocrinology & metabolism ,Bone healing ,Perioperative ,Osteotomy ,Surgery ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,Blood serum ,Osteoprotegerin ,Maxilla ,medicine ,biology.protein ,ELISA ,business - Abstract
PurposeSonic Hedgehog (SHH) is a regulatory protein involved in bone fracture healing. Orthognathic surgery involves surgical osteotomy of the mandible or maxilla to restore the proper anatomic and functional position in patients with dentofacial deformity. The purpose of this study was to analyze SHH local blood serum concentrations after osteotomy to gain further understanding of the molecular regulation of the initial stage of osteotomy healing.MethodsSerum samples (local drainage and peripheral venous) of 34 patients (24 females and 10 males, mean age was 23.4 (16–42) years) who underwent orthognathic surgery were isolated from patients at different time points during the perioperative period. The levels of SHH, soluble receptor activator of nuclear factor-κB ligand (sRANKL) and osteoprotegerin (OPG) were measured using ELISA.ResultsSHH was detected in the local drainage immediately after osteotomy (309.5 ± 58.2 pg/ml), and decreased for 2 days after the operation (197.5 ± 43.6 pg/ml). The sRANKL local serum concentrations were at the maximum level immediately after the operation (141.4 ± 22.6 pg/ml) and decreased for 2 days (110.1 ± 23.4 pg/ml). On the other hand, the OPG concentration in the local serum was at a minimum after osteotomy (59.4 ± 4.6 pg/ml) and reached its maximum (181.5 ± 17.8 pg/ml, P
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