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13 results on '"Laboratoire Mémoire et Cognition"'

1. How to change your memory of an object with a posture and a verb

Author

Valérie Gyselinck, Xavière Dahiez, Léo Dutriaux, Laboratoire Mémoire et Cognition, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), Université Sorbonne Paris Cité (USPC), Université Paris Descartes – Institut de psychologie (UPD5 Psychologie), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Psychologie des Comportements et des Mobilités (IFSTTAR/AME/LPC), and Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR)

Subjects
Adult, Male, Memory, Long-Term, Physiology, Posture, Object (grammar), Experimental and Cognitive Psychology, Context (language use), Verb, Representation (arts), Motor Activity, 050105 experimental psychology, Association, Young Adult, [SCCO]Cognitive science, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Humans, Attention, PSYCHOLOGIE, 0501 psychology and cognitive sciences, Control (linguistics), General Psychology, Language, Long-term memory, MEMORY, 05 social sciences, General Medicine, MEMOIRE, Neuropsychology and Physiological Psychology, Action (philosophy), Embodied cognition, Mental Recall, COGNITION, Female, Cues, EMBODIEMENT, Psychology, Psychomotor Performance, 030217 neurology & neurosurgery, Cognitive psychology
Abstract

According to grounded cognition, the format of representation of knowledge is sensorimotor. This means that long-term memory shares processing resources with the sensorimotor system. The main objective of this work is to provide new evidence in favour of two claims from the embodied cognition framework: (1) memory is grounded on the sensorimotor system, that is, memory shares processing resources with the sensorimotor system, and (2) memory serves at least in part to support action. For this purpose, the present experiment aimed to show that the action context modulates the motor simulation and, consequently, the memory of manipulable objects. Participants were presented with short phrases comprising the name of a manipulable object, and an action verb (“To take a cup”) or an attentional verb (“To see a cup”). During this phase, they had to put their hands in front of them in the control condition, whereas they had to keep them behind their back in the interfering condition. A cued recall test followed after a short distractive letter-matching task, with the verbs serving as cues. Results showed that memory of the words denoting manipulable objects was impaired by the interfering posture when associated with an action verb, but not when associated with an attentional verb. This suggests that a context which does not favour action interferes with motor simulation and thus decreases the memory of manipulable objects. These results provide strong evidence for a grounded account of memory and language.

Published
2018
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2. Subsyndromal and syndromal depressive symptoms among older adults with schizophrenia spectrum disorder: Prevalence and associated factors in a multicenter study

Author

Céline Béra-Potelle, Astrid Chevance, Rachel Pascal de Raykeer, Kibby McMahon, Hugo Peyre, Nicolas Hoertel, Christine Cuervo-Lombard, Frédéric Limosin, Claire Jaffré, Sarah Barrière, Christophe Portefaix, Arthur Kaladjian, Guillaume Airagnes, Christophe Guerin-Langlois, Yvonne Blumenstock, Delphine Raucher-Chéné, Cédric Lemogne, Assistance publique-Hôpitaux de Paris - Espace éthique (AP-HP Espace éthique), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire Mémoire et Cognition, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), Duke University [Durham], Centre de Recherche en Sciences et Technologies de l'Information et de la Communication - EA 3804 (CRESTIC), Université de Reims Champagne-Ardenne (URCA), École normale supérieure - Paris (ENS Paris), and Université Paris sciences et lettres (PSL)

Subjects
Male, medicine.medical_specialty, Psychosis, Comorbidity, Antipsychotic, Cohort Studies, 03 medical and health sciences, Benzodiazepines, 0302 clinical medicine, Elderly, Quality of life, Risk Factors, medicine, Prevalence, Humans, Psychiatry, Depression (differential diagnoses), Aged, Not evaluated, Psychiatric Status Rating Scales, Depressive Disorder, business.industry, Depression, Depressive symptoms, Antidepressants, Middle Aged, medicine.disease, Antidepressive Agents, 030227 psychiatry, 3. Good health, Treatment, Psychiatry and Mental health, Clinical Psychology, Older, Cross-Sectional Studies, Psychotic Disorders, Schizophrenia, Cohort, Quality of Life, Female, business, 030217 neurology & neurosurgery, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Schizophrenia spectrum
Abstract

International audience; BackgroundFew studies have examined the prevalence and correlates of subsyndromal and syndromal depressive symptoms (SSSD) among older adults with schizophrenia spectrum disorder. In this report, we examined the prevalence of SSSD and their associations with sociodemographic characteristics, clinical characteristics of schizophrenia, comorbidity, psychotropic medications, quality of life, functioning and mental health care utilization in a large, multicenter sample of older adults with schizophrenia spectrum disorder.MethodsData from the Cohort of individuals with Schizophrenia Aged 55 years or more (CSA) were used to examine the prevalence of SSSD, defined using the Center of Epidemiologic Studies Depression (CESD) scale. Clinical characteristics associated with SSSD were explored.ResultsAmong 343 older adults with schizophrenia spectrum disorder, 78.1% had either subsyndromal (30.6%) or syndromal (47.5%) depressive symptoms. SSSD were independently associated with positive and negative symptoms, lower quality of life, non-late-onset psychosis, benzodiazepine use and urbanicity. There were no significant associations of SSSD with other sociodemographic characteristics and psychotropic medications, or with general medical conditions. We found no significant differences in the proportion of participants who were treated with antidepressants between those with syndromal depressive symptoms and those without depression (22.1% vs. 20.0%, p = 0.89). SSSD were not associated with higher mental health care utilization.LimitationsData were cross-sectional and depression was not evaluated with a semi-structured interview.ConclusionSSSD may be highly prevalent and under-assessed and/or undertreated among older adults with schizophrenia spectrum disorder. Our findings should alert clinicians about the need to assess systematically and regularly depression in this vulnerable population.

Published
2018
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3. Extensive and severe CNS demyelination associated with golimumab therapy

Author

Elisabeth Maillart, C. Mellerio, Céline Louapre, Anne Bertrand, Catherine Lubetzki, Caroline Papeix, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire Mémoire et Cognition, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Algorithms, models and methods for images and signals of the human brain (ARAMIS), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Inria de Paris, Service de Neuroradiologie [CHU Pitié-Salpêtrière], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Inria de Paris, Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Département de Neurologie [Paris], Assistance publique - Hôpitaux de Paris (AP-HP)-IFR70-Hôpital de la Salpétrière, CHU Pitié-Salpêtrière [APHP], Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Algorithms, models and methods for images and signals of the human brain ( ARAMIS ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute ( ICM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique ( CNRS ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique ( CNRS ) -Inria de Paris, Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute ( ICM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique ( CNRS ), Service de neuro-radiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Inria de Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) - IFR70 - Hôpital de la Salpétrière, Institut du Cerveau et de la Moëlle Epinière (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU Pitié-Salpêtrière [APHP] - Centre National de la Recherche Scientifique (CNRS), Service d'Explorations Fonctionnelles Neurologie [CHU Pitié-Salpétrière], CHU Pitié-Salpêtrière [APHP] - Assistance publique - Hôpitaux de Paris (AP-HP), Laboratoire Mémoire & Cognition, Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS), Université Pierre et Marie Curie - Paris 6 (UPMC) - Institut du Cerveau et de la Moëlle Epinière (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU Pitié-Salpêtrière [APHP] - Centre National de la Recherche Scientifique (CNRS) - Université Pierre et Marie Curie - Paris 6 (UPMC) - Institut National de la Santé et de la Recherche Médicale (INSERM) - CHU Pitié-Salpêtrière [APHP] - Centre National de la Recherche Scientifique (CNRS) - Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria) - Institut National de Recherche en Informatique et en Automatique (Inria), and Assistance publique - Hôpitaux de Paris (AP-HP) - CHU Pitié-Salpêtrière [APHP]

Subjects
medicine.medical_specialty, Pathology, Neurology, [SDV.IB.IMA]Life Sciences [q-bio]/Bioengineering/Imaging, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, CNS demyelination, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, [ INFO.INFO-CV ] Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], 03 medical and health sciences, 0302 clinical medicine, [ INFO.INFO-TI ] Computer Science [cs]/Image Processing, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Golimumab therapy, Medicine, [ SDV.IB.IMA ] Life Sciences [q-bio]/Bioengineering/Imaging, ComputingMilieux_MISCELLANEOUS, Neuroradiology, 030203 arthritis & rheumatology, [SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, [ INFO.INFO-IM ] Computer Science [cs]/Medical Imaging, business.industry, [INFO.INFO-CV]Computer Science [cs]/Computer Vision and Pattern Recognition [cs.CV], 3. Good health, [SDV.MHEP.OS] Life Sciences [q-bio]/Human health and pathology/Sensory Organs, [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [INFO.INFO-TI]Computer Science [cs]/Image Processing [eess.IV], Neurology (clinical), business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing, 030217 neurology & neurosurgery
Abstract

International audience; Our case emphasizes a very particular and uncommon course of tumefactive lesions of the central nervous system and their subsequent cavitation in the context of TNF-alpha antagonists. Such evolution must be recognized to initiate active disease-modifying treatments aiming to prevent further neurological relapses and subsequent disability for those patients with rheumatologic diseases.

Published
2016
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4. The role of verbal and visuo-spatial working memory in the encoding of virtual routes by children and adults

Author

Marion Nys, Maya Hickmann, Valérie Gyselinck, Laboratoire Mémoire et Cognition, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Structures Formelles du Langage (SFL), Université Paris 8 Vincennes-Saint-Denis (UP8)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Lumières (UPL), Laboratoire de Psychologie des Comportements et des Mobilités (IFSTTAR/AME/LPC), Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), and Université Paris 8 Vincennes-Saint-Denis (UP8)-Centre National de la Recherche Scientifique (CNRS)- Université Paris Lumières, Académie de Créteil, Campus Condorcet (UPLUM)

Subjects
SPATIAL COGNITION, Working memory, 05 social sciences, Experimental and Cognitive Psychology, CHILDREN, REPRESENTATION SPATIALE, Child development, Spatial memory, 050105 experimental psychology, 03 medical and health sciences, [SCCO]Cognitive science, 0302 clinical medicine, ENFANT, REALITE VIRTUELLE, Encoding (memory), 0501 psychology and cognitive sciences, Spatial representation, WORKING MEMORY, Psychology, 030217 neurology & neurosurgery, Cognitive psychology
Abstract

This study aims to understand the role of verbal and visual-spatial components of working memory in children's encoding of virtual routes. Children aged 8 and 10 years and adults memorised virtual routes in three conditions involving either a secondary task (visuo-spatial or verbal) or no such task (control). The learning phase was followed by four tasks evaluating their spatial representation: producing a description of the route, verbally and visually recognising landmarks, and choosing directions. Results first supported an increase with age in the quantity and quality of landmarks and directions mentioned and recognised in both verbal and visuo-spatial tasks. Second, both concurrent tasks were detrimental to spatial memory although this was more striking for the visuo-spatial task. Moreover, interference effects depended on age and on the format used for retrieval. Overall, our results provide a novel contribution to our understanding of the development of spatial models.

Published
2018
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5. Hyperfrontality and hypoconnectivity during refreshing in schizophrenia

Author

Catherine Oppenheim, Franck Baylé, Marie-Laure Grillon, Anne-Dominique Devauchelle, F. Charbonneau, Marie-Odile Krebs, Gaël Varoquaux, Caroline Huron, Bertrand Thirion, Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Mémoire et Cognition, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Psychiatry Générale, CHUV, Centre Hospitalier Universitaire Vaudois [Lausanne] (CHUV), Service de neuroradiologie [Paris], Hôpital Sainte-Anne, Modelling brain structure, function and variability based on high-field MRI data (PARIETAL), Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Service NEUROSPIN (NEUROSPIN), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de Neuroimagerie Assistée par Ordinateur (LNAO), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Neuroimagerie cognitive - Psychologie cognitive expérimentale (UNICOG-U992), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Saclay (COmUE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Chaire Psychologie cognitive expérimentale, Collège de France (CdF (institution)), Service de psychiatrie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Hôpital Sainte-Anne, Service NEUROSPIN (NEUROSPIN), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Collège de France - Chaire Psychologie cognitive expérimentale, Centre de Psychiatrie et Neurosciences ( CPN - U894 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre Hospitalier Universitaire Vaudois [Lausanne] ( CHUV ), service de neuroradiologie [Paris], Modelling brain structure, function and variability based on high-field MRI data ( PARIETAL ), Service NEUROSPIN ( NEUROSPIN ), Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) ( DRF (CEA) ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Université Paris-Saclay-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique ( Inria ) -Institut National de Recherche en Informatique et en Automatique ( Inria ), Laboratoire de Neuroimagerie Assistée par Ordinateur ( LNAO ), Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ), Neuroimagerie cognitive ( UNICOG-U992 ), Université Paris-Sud - Paris 11 ( UP11 ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris-Saclay, Collège de France ( CDF ), Collège de France ( CdF ), Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Descartes - Paris 5 ( UPD5 ) -Hôpital Sainte-Anne, Centre de Psychiatrie et Neurosciences (U894), and Varoquaux, Gaël

Subjects
Adult, Male, Neuroscience (miscellaneous), Neuropsychological Tests, Verbal learning, Brain mapping, 050105 experimental psychology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Neural Pathways, Outpatients, Image Processing, Computer-Assisted, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Prefrontal cortex, Cerebral Cortex, Brain Mapping, Memory Disorders, medicine.diagnostic_test, Working memory, [SCCO.NEUR]Cognitive science/Neuroscience, [SCCO.NEUR] Cognitive science/Neuroscience, 05 social sciences, Verbal Learning, Executive functions, medicine.disease, Magnetic Resonance Imaging, Oxygen, Psychiatry and Mental health, Memory, Short-Term, medicine.anatomical_structure, Cerebral cortex, Schizophrenia, Case-Control Studies, [ SCCO.NEUR ] Cognitive science/Neuroscience, Female, Functional magnetic resonance imaging, Psychology, Neuroscience, 030217 neurology & neurosurgery
Abstract

Anomalous activations of the prefrontal cortex (PFC) and posterior cerebral areas have been reported in previous studies of working memory in schizophrenia. Several interpretations have been reported: e.g., neural inefficiency, the use of different strategies and differences in the functional organization of the cerebral cortex. To better understand these abnormal activations, we investigated the cerebral bases of a working memory component process, namely refreshing (i.e., thinking briefly of a just-activated representation). Fifteen patients with schizophrenia and 15 control subjects participated in this functional magnetic resonance imaging (fMRI) study. Participants were told that whenever they saw a word on the screen, they had to read it silently to themselves (read and repeat conditions), and when they saw a dot, they had to think of the just-previous word (refresh condition). The refresh condition (in comparison with the read condition) was associated with significantly increased activation in the left inferior frontal gyrus and significantly decreased connectivity within the prefrontal cortex and between the prefrontal and parietal cortices in patients with schizophrenia in comparison with control subjects. These results suggest that prefrontal dysfunctions in schizophrenia might be related to a defective ability to initiate (rather than to execute) specific cognitive processes.

Published
2013
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6. Increases of SET level and translocation are correlated with tau hyperphosphorylation at ser202/thr205 in CA1 of Ts65Dn mice

Author

Chantal Guihenneuc-Jouyaux, Christelle Albac, Lucie Gorisse-Hussonnois, Emilie Dorard, Bernadette Allinquant, Marie-Claude Potier, Laboratoire Mémoire et Cognition, Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Epidémiologie Environnementale : Impact Sanitaire des Pollutions ( EA 4064 ), Université Paris Descartes - Paris 5 ( UPD5 ), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute ( ICM ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -CHU Pitié-Salpêtrière [APHP]-Centre National de la Recherche Scientifique ( CNRS ), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Epidémiologie Environnementale : Impact Sanitaire des Pollutions (EA 4064), Université Paris Descartes - Paris 5 (UPD5), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS), and HAL-UPMC, Gestionnaire

Subjects
Male, Threonine, 0301 basic medicine, Cytoplasm, Aging, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Gene Expression, Hippocampus, Amyloid beta-Protein Precursor, Mice, 0302 clinical medicine, Serine, Amyloid precursor protein, Molecular Targeted Therapy, Protein Phosphatase 2, Phosphorylation, Caspase, Oncogene Proteins, biology, Kinase, General Neuroscience, Brain, Transport protein, Cell biology, DNA-Binding Proteins, Protein Transport, Biochemistry, [ SDV.NEU.NB ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Tau hyperphosphorylation, Hyperphosphorylation, Mice, Inbred Strains, tau Proteins, 03 medical and health sciences, Caspase cleaved APP, Animals, Histone Chaperones, CA1 Region, Hippocampal, SET translocation, Sirolimus, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, Protein phosphatase 2, Disease Models, Animal, 030104 developmental biology, Ts65Dn mice, biology.protein, Neurology (clinical), Down Syndrome, Geriatrics and Gerontology, 030217 neurology & neurosurgery, Developmental Biology
Abstract

International audience; SET is a multifunctional protein, but when present in the cytoplasm, acts as a powerful inhibitor of phosphatase 2A. We previously observed that in CA1 of Down syndrome (DS) patients, the level of SET is increased, and SET is translocated to the cytoplasm and associated with the hyperphosphorylation of tau at ser202/thr205. The presence of SET in the cytoplasm in DS brains may play a role in the progression of the disease. Here, we show that in CA1 of 3-month-old Ts65Dn mice modeling DS, SET level is increased, and SET is translocated to the cytoplasm and associated with tau hyperphosphorylations at ser202/ thr205 and with amyloid precursor protein caspase cleaved as observed in Alzheimer disease brains. Tau hyperphosphorylation at ser356 and activation of other phosphatase 2A targets such as the mammalian target of rapamycin and adenosine monophosphate protein kinases were also observed, suggesting deleterious mechanisms. We propose Ts65Dn mice as a model for therapeutic approaches focused on SET overexpression and its cytoplasmic translocation to slow down disease progression.

Published
2016
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7. New Insights in Anorexia Nervosa

Author

Sergueï O. Fetissov, Nicolas Ramoz, Carole Rovere-Jovene, Pierre Déchelotte, Nicolas Chartrel, Jean-Claude Melchior, Corinne Blanchet-Collet, Nathalie Godart, Odile Viltart, Philip Gorwood, Virginie Tolle, Mouna Hanachi, Jacques Epelbaum, Jeanne Duclos, Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Sainte Anne [Paris], Maison de Solenn [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Mutualiste de Montsouris (IMM), Cognition, Santé, Société (C2S), SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Maison des Sciences Humaines de Champagne-Ardenne (MSH-URCA), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA), Nutrition, inflammation et dysfonctionnement de l'axe intestin-cerveau (ADEN), Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologies appliquées (END-ICAP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Raymond Poincaré [AP-HP], Institut de pharmacologie moléculaire et cellulaire (IPMC), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U1172 Inserm - U837 (JPArc), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Lille Nord de France (COMUE)-Université de Lille, Clinique des maladies mentales et de l'encéphale (CMME - Service de psychiatrie), Hôpital Sainte-Anne-Université Paris Descartes - Paris 5 (UPD5), Université Sorbonne Paris Cité (USPC), Laboratoire Mémoire et Cognition, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institute for Research and Innovation in Biomedicine (IRIB), Normandie Université (NU)-Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), douville, sabine, Université Paris Descartes - Paris 5 (UPD5)-Hôpital Sainte-Anne, Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA), Université Nice Sophia Antipolis (1965 - 2019) (UNS), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA)-Maison des Sciences Humaines de Champagne-Ardenne (MSH-URCA), Centre de Psychiatrie et Neurosciences (U894), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], Dept. of Psychiatry for Adolescents and Young Adults, Faculté de Médecine, Site Institut Mutualiste Montsouris, Université Paris Descartes - Paris 5 (UPD5), Appareil Digestif Environnement Nutrition (ADEN), Normandie Université (NU)-Normandie Université (NU), AP-HP Hôpital Raymond Poincaré [Garches], Analyse Phenotypique, Developpementale et Genetique des Comportements Addictifs, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), CRM J-P Aubert INSERM UMR 837, and Université de Lille

Subjects
0301 basic medicine, reward system adaptations, Lateral hypothalamus, autoantibodies, [SDV]Life Sciences [q-bio], mental homeostasis, Review, eating disorders, Gut flora, Developmental psychology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Neuroimaging, Orexigenic, medicine, microbiota, ComputingMilieux_MISCELLANEOUS, biology, General Neuroscience, Cognition, biology.organism_classification, medicine.disease, 3. Good health, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, Eating disorders, 030104 developmental biology, Anorexia nervosa (differential diagnoses), susceptibility factors, Abnormality, Psychology, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Neuroscience, 030217 neurology & neurosurgery, medicine.drug
Abstract

International audience; Anorexia nervosa (AN) is classically defined as a condition in which an abnormally low body weight is associated with an intense fear of gaining weight and distorted cognitions regarding weight, shape, and drive for thinness. This article reviews recent evidences from physiology, genetics, epigenetics, and brain imaging which allow to consider AN as an abnormality of reward pathways or an attempt to preserve mental homeostasis. Special emphasis is put on ghrelino-resistance and the importance of orexigenic peptides of the lateral hypothalamus, the gut microbiota and a dysimmune disorder of neuropeptide signaling. Physiological processes, secondary to underlying, and premorbid vulnerability factors—the “pondero-nutritional-feeding basements”- are also discussed.

Published
2016
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8. Retrieval of recent autobiographical memories is associated with slow-wave sleep in early AD.: Recent autobiographical memory in Alzheimer's disease

Author

Géraldine eRAUCHS, Pascale ePiolino, Françoise eBertran, Vincent ede La Sayette, Fausto eViader, Francis eEustache, Béatrice eDesgranges, Neuropsychologie cognitive et neuroanatomie fonctionnelles de la mémoire humaine, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Mémoire et Cognition, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Explorations Fonctionnelles Neurologiques [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de Neurologie [CHU Caen], Université de Caen Normandie ( UNICAEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -École pratique des hautes études ( EPHE ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre de Psychiatrie et Neurosciences ( CPN - U894 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service des Explorations Fonctionnelles Neurologiques [Caen], Normandie Université ( NU ) -Normandie Université ( NU ) -CHU Caen, and Service de Neurologie [Caen]

Subjects
medicine.medical_specialty, Cognitive Neuroscience, Precuneus, Polysomnography, Audiology, 050105 experimental psychology, Developmental psychology, lcsh:RC321-571, Angular gyrus, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Retrosplenial cortex, medicine, 0501 psychology and cognitive sciences, positron emission tomography (PET), sleep, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Slow-wave sleep, Original Research, Recall, medicine.diagnostic_test, Autobiographical memory, 05 social sciences, autobiographical memory, Alzheimer's disease, medicine.anatomical_structure, Neuropsychology and Physiological Psychology, memory consolidation, PET, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Memory consolidation, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Psychology, Alzheimer’s disease, 030217 neurology & neurosurgery, Neuroscience
Abstract

International audience; Autobiographical memory is commonly impaired in Alzheimer's disease (AD). However, little is known about the very recent past which is though highly important in daily life adaptation. In addition, the impact of sleep disturbances, also frequently reported in AD, on the consolidation and retrieval of autobiographical memories remains to be assessed. Using an adaptation of the TEMPau task, we investigated the neural substrates of autobiographical memory for recent events and the potential relationship with sleep in 14 patients with mild AD. On day 1, autobiographical memory was explored across 3 periods: remote (18-30 years), the last two years and the last month. After testing, sleep was recorded using polysomnography. The next day, AD patients benefited a resting state 18FDG-PET scan and a second exploration of autobiographical memory, focusing on the very recent past (today and yesterday). Total recall and episodic recall scores were obtained. In addition, for all events recalled, Remember responses justified by specific factual, spatial and temporal details were measured using the Remember/Know paradigm. Retrieval of autobiographical memories was impaired in AD, but recall of young adulthood and very recent events was relatively better compared to the two intermediate periods. Recall of recent events (experienced the day and the day preceding the assessment) was correlated with brain glucose consumption in the precuneus and retrosplenial cortex, the calcarine region, the angular gyrus and lateral temporal areas. AD patients also provided more Justified Remember responses for events experienced the previous day than for those experienced the day of the assessment. Moreover, Justified Remember responses obtained for events experienced before sleep were positively correlated with the amount of slow-wave sleep. These data provide the first evidence of an association between the ability to retrieve recent autobiographical memories and sleep in mild AD patients.

Published
2013

9. Autobiographical memory in semantic dementia: new insights from two patients using fMRI

Author

Francis Eustache, Armelle Viard, Vanessa Matuszewski, Serge Belliard, Karine Lebreton, Béatrice Desgranges, Pascale Piolino, Vincent de La Sayette, Neuropsychologie cognitive et neuroanatomie fonctionnelles de la mémoire humaine, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Pontchaillou, CHU Pontchaillou [Rennes], Institut de psychiatrie et neurosciences (U894 / UMS 1266), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Mémoire et Cognition, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), This work was supported by the Fondation pour la Recherche sur le Cerveau (FRC)., Université de Caen Normandie ( UNICAEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -École pratique des hautes études ( EPHE ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre de Psychiatrie et Neurosciences ( CPN - U894 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), and Eustache, Francis

Subjects
Male, MESH : Oxygen, MESH : Aged, Hippocampal formation, MESH: Magnetic Resonance Imaging, Behavioral Neuroscience, 0302 clinical medicine, MESH: Aged, 80 and over, MESH : Frontotemporal Dementia, Image Processing, Computer-Assisted, MESH : Female, Episodic memory, MESH: Aged, Aged, 80 and over, 05 social sciences, Brain, MESH: Memory Disorders, MESH: Image Processing, Computer-Assisted, Magnetic Resonance Imaging, MESH: Memory, Episodic, MESH : Memory, Episodic, Frontotemporal Dementia, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Female, Psychology, MESH : Image Processing, Computer-Assisted, MESH: Oxygen, Mental image, Cognitive Neuroscience, MESH : Male, Memory, Episodic, Semantic dementia, MESH: Frontotemporal Dementia, Experimental and Cognitive Psychology, 050105 experimental psychology, 03 medical and health sciences, MESH: Brain, Atrophy, Neuroimaging, MESH : Magnetic Resonance Imaging, medicine, MESH : Memory Disorders, Humans, 0501 psychology and cognitive sciences, [SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], MESH : Aged, 80 and over, Aged, Memory Disorders, MESH: Humans, Recall, Autobiographical memory, MESH : Humans, medicine.disease, MESH: Male, Oxygen, MESH : Brain, [ SDV.NEU ] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neuroscience, MESH: Female, 030217 neurology & neurosurgery
Abstract

International audience; Episodic autobiographical memory (EAM) consists of personal events embedded within a specific spatiotemporal context. Patients with semantic dementia (SD) generally show preserved recent EAMs, but a controversy remains concerning their ability to retrieve remote ones. Only one fMRI study examined remote autobiographical memory in SD through a longitudinal case study (Maguire, Kumaran, Hassabis, & Kopelman, 2010). Here, we propose a cross-sectional study to test the hippocampo-neocortical up-regulation hypothesis, through a multimodal approach (gray matter volume, activation, connectivity analyses), directly comparing recent and remote autobiographical memory retrieval and collecting data to asses phenomelogical re-experiencing. EAM retrieval recruits a distributed network of brain regions, notably the hippocampus which is shown to be atrophied in SD, although some studies report no hippocampal atrophy in SD. Using fMRI, we examined recent and remote EAM retrieval in two SD patients with different profiles of hippocampal atrophy, compared to 12 healthy elders (HE). JPL presented severe bilateral hippocampal atrophy, while EP showed sparing of both hippocampi. Behaviourally, JPL was impaired at retrieving EAMs from both life periods and showed poorer use of visual mental imagery than HE, while EP retrieved memories which were as episodic as those of HE for both periods and relied on greater use of visual mental imagery than HE. Neuroimaging results showed that, for JPL, hyperactivations of the residual hippocampal tissue and of frontal, lateral temporal, occipital and parietal cortices did not efficiently compensate his autobiographical memory deficit. EP however presented hyperactivations in similar neocortical regions which appeared to be more efficient in compensating for atrophy elsewhere, since EP's EAM retrieval was preserved. Functional connectivity analyses focusing on the hippocampus showed how the residual hippocampal activity was connected to other brain areas. For JPL, recent autobiographical retrieval was associated with connectivity between the posterior hippocampus and middle occipital gyrus, while for EP, connectivity was detected between the anterior hippocampus and numerous regions (medial temporal, occipital, temporal, frontal, parietal) for both recent and remote periods. These findings suggest that intensification of hippocampal atrophy in SD strongly affects both recent and remote autobiographical recollection. Up-regulation of neocortical regions and functional hippocampal-neocortical connectivity within the autobiographical network may be insufficient to compensate the lifelong episodic memory deficit for patients with extensive hippocampal atrophy.

Published
2013
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10. L’effet de fréquence dans l’accès aux propriétés phonologiques des noms d’objets

Author

Juan Segui, Laura Manoiloff, Pierre A. Hallé, Universidad Nacional de Córdoba [Argentina], Laboratoire Mémoire et Cognition, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de psychologie expérimentale (LPE - UMR8581), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-École pratique des hautes études (EPHE), ANR-11-IDEX-0005-02/10-LABX-0083,EFL,Empirical Foundations of Linguistics : data, methods, models(2011), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Centre National de la Recherche Scientifique (CNRS), ANR-11-IDEX-0005,USPC,Université Sorbonne Paris Cité(2011), Schiattarella, Valentina, Université Sorbonne Paris Cité - - USPC2011 - ANR-11-IDEX-0005 - IDEX - VALID, Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS), École pratique des hautes études (EPHE) - Université Paris Descartes - Paris 5 (UPD5) - Centre National de la Recherche Scientifique (CNRS), and ANR-10-LABX-0083, Labex EFL, Programme 'Investissements d’avenir' géré par l’Agence Nationale de la Recherche ANR-10-LABX-0083 (Labex EFL)

Subjects
Philosophy, 05 social sciences, Frequency effect, Lexical access, [SCCO] Cognitive science, [SHS.LANGUE] Humanities and Social Sciences/Linguistics, 050105 experimental psychology, [SHS]Humanities and Social Sciences, 03 medical and health sciences, psycholinguistique, [SCCO]Cognitive science, 0302 clinical medicine, Arts and Humanities (miscellaneous), [SCCO.PSYC] Cognitive science/Psychology, [SCCO.PSYC]Cognitive science/Psychology, 0501 psychology and cognitive sciences, [SHS] Humanities and Social Sciences, [SHS.LANGUE]Humanities and Social Sciences/Linguistics, Humanities, 030217 neurology & neurosurgery, General Psychology, Picture naming, ComputingMilieux_MISCELLANEOUS
Abstract

EnglishPicture naming is a highly popular task in language production research. In particular, the frequency effect obtained in picture naming is generally considered as the signature of lexical access in speech production. However, it is quite well established that picture naming is very sensitive to the phonetic properties of the word to be produced, imposing some limitations in using this task. In this paper, we look for a frequency effect in the lexical access to picture names, by means of a phoneme-monitoring task. This task requires access to the object name’s phonological representation but not its actual articulation. We found a robust frequency effect. Two additional experiments—visual object identification and semantic categorization—allow us to assume that the locus for the frequency effect is lexical. francaisLa denomination d’images est une procedure privilegiee pour l’etude de la production du langage. En particulier, l’effet de frequence en denomination a ete considere comme la signature de l’acces au lexique mental. Toutefois, en raison de sa nature articulatoire, la reponse de denomination est tres sensible aux proprietes phonetiques du mot a produire, ce qui contraint son utilisation. Dans cet article, nous examinons l’effet de frequence dans l’acces lexical aux noms d’image en utilisant une tâche de detection de phoneme. Cette tâche necessite l’acces a la representation phonologique du nom de l’objet, mais pas son articulation. Nous trouvons un effet robuste de frequence. Deux experiences complementaires –identification d’objet visuel et categorisation semantique – nous permettent de supposer que le locus de l’effet de frequence est lexical.

Published
2013

11. Depression, anxiety and personality dimensions in female first-degree relatives of alcohol-dependent probands

Author

Jean-Pierre Kahn, Renaud Cohen, Christine-Vanessa Cuervo-Lombard, Fabien Gierski, Arthur Kaladjian, Delphine Raucher-Chéné, Frédéric Limosin, Céline Béra-Potelle, Bérengère Hübsch, Université de Reims Champagne-Ardenne (URCA), Service de Psychiatrie pour Adultes [CHU Reims], Centre Hospitalier Universitaire de Reims (CHU Reims), Cognition, Santé, Société (C2S), SFR CAP Santé (Champagne-Ardenne Picardie Santé), Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Université de Reims Champagne-Ardenne (URCA)-Université de Picardie Jules Verne (UPJV)-Maison des Sciences Humaines de Champagne-Ardenne (MSH-URCA), Université de Reims Champagne-Ardenne (URCA)-Université de Reims Champagne-Ardenne (URCA), Psychiatrie et Psychologie Clinique de Liaison [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Université Sorbonne Paris Cité (USPC), Laboratoire Mémoire et Cognition, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Corentin Celton [Issy-les-Moulineaux], Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Université de Reims Champagne-Ardenne (URCA)-SFR CAP Santé (Champagne-Ardenne Picardie Santé)

Subjects
Adult, medicine.medical_specialty, media_common.quotation_subject, Comorbidity, Anxiety, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Surveys and Questionnaires, medicine, Prevalence, Personality, Humans, First-degree relatives, Psychiatry, media_common, Family Health, [SHS.STAT]Humanities and Social Sciences/Methods and statistics, Depression, [SCCO.NEUR]Cognitive science/Neuroscience, Alcohol dependence, Cooperativeness, Obstetrics and Gynecology, Middle Aged, medicine.disease, Self Concept, 030227 psychiatry, Psychiatry and Mental health, Alcoholism, Mental Health, Reward dependence, [SCCO.PSYC]Cognitive science/Psychology, Women's Health, Temperament, Female, France, medicine.symptom, Psychology, [STAT.ME]Statistics [stat]/Methodology [stat.ME], 030217 neurology & neurosurgery, Clinical psychology, Agoraphobia
Abstract

International audience; A total of 136 with or without first-degree relatives with alcohol dependence were compared according to lifetime prevalence of psychiatric disorders and personality dimensions. Family history positive women showed significant higher prevalence rates of depression and agoraphobia, and exhibited lower scores on Reward Dependence, Self-Directedness and Cooperativeness dimensions.

Published
2012
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12. The awareness of body orientation modulates the perception of visual vertical

Author

Adolfo M. Bronstein, Dominic Pérennou, Julien Barra, Michael A. Gresty, Kail V. Thilo, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications [Grenoble] (TIMC-IMAG), Université Joseph Fourier - Grenoble 1 (UJF) - Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP) - IMAG - Centre National de la Recherche Scientifique (CNRS) - Université Grenoble Alpes (UGA), Department of Medicine, Imperial College London, Clinique Universitaire de Médecine Physique et Réadaptation, CHU Grenoble, Laboratoire Mémoire et Cognition, Université Paris Descartes - Paris 5 (UPD5) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS), SPM, Université Joseph Fourier - Grenoble 1 (UJF) - Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP) - IMAG - Centre National de la Recherche Scientifique (CNRS) - Université Grenoble Alpes (UGA) - Université Joseph Fourier - Grenoble 1 (UJF) - Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP) - IMAG - Centre National de la Recherche Scientifique (CNRS) - Université Grenoble Alpes (UGA) - Department of Medicine, Imperial College London - Imperial College London - Clinique Universitaire de Médecine Physique et Réadaptation, CHU Grenoble - CHU Grenoble, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Department of Medicine, Imperial College London-Imperial College London-Clinique Universitaire de Médecine Physique et Réadaptation, CHU Grenoble-CHU Grenoble, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-IMAG-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Department of Medicine

Subjects
Male, MESH: Awareness, Audiology, Neuropsychological Tests, Body awareness, Behavioral Neuroscience, User-Computer Interface, 0302 clinical medicine, MESH: Models, Psychological, MESH : Female, media_common, MESH : Models, Psychological, 05 social sciences, MESH : Awareness, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences, MESH: Neuropsychological Tests, MESH: Posture, MESH : Adult, Awareness, MESH : Neuropsychological Tests, Body orientation, Visual Perception, Female, Psychology, MESH : Space Perception, Social psychology, MESH : Visual Perception, MESH : Orientation, Adult, medicine.medical_specialty, Cognitive Neuroscience, media_common.quotation_subject, MESH : Male, MESH: Space Perception, Posture, Posterior parietal cortex, MESH: Orientation, Experimental and Cognitive Psychology, Sensory system, Models, Psychological, 050105 experimental psychology, 03 medical and health sciences, Perception, Orientation, medicine, MESH : User-Computer Interface, Humans, 0501 psychology and cognitive sciences, Visual vertical, Postural vertical, MESH: User-Computer Interface, MESH: Humans, MESH: Visual Perception, MESH : Humans, Body position, MESH : Posture, MESH: Adult, MESH: Male, Space Perception, Insula, MESH: Female, 030217 neurology & neurosurgery, [SDV.NEU.SC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences
Abstract

International audience; It is established that the body position influences verticality perception. In contrast, the possible influence of the awareness of the body orientation on verticality perception has never been investigated. This hypothesis, explored in the present study, is supported by the role played by the parietal cortex and the insula in both body position awareness and verticality perception. Nine subjects were asked to estimate the direction of the visual vertical (VV) by 12 adjustments of a luminous line in three conditions: (1) a control condition (subjects were upright and aware of their position), (2) a condition of congruence between the lateral body tilt and the awareness of this tilt, and (3) a condition of dissociation of subjective and objective orientations (tilted subjects who felt upright). The dissociation between objective and subjective orientations was obtained by inducing experimentally a postural vertical (PV) bias through 5 min of lateral body tilt at 30° in darkness in a motorized flight simulator (mean 8.8° ± 4; min 6.2°; max 17.4°). VV orientation and variability were measured (expressed below in this order). As compared to the upright condition (0.3° ± 0.2; 0.8° ± 0.5), subjects showed similar VV orientation (0.1° ± 0.6; p=0.82) but an increased variability (1.4°±0.5; p

Published
2012
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13. Effect of exposure to 1,800 MHz electromagnetic fields on heat shock proteins and glial cells in the brain of developing rats

Author

Philippe Lévêque, Michel Mallat, Thérèse M. Jay, Jean-Marc Edeline, Aurélie Watilliaux, Laboratoire Mémoire et Cognition, Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Equipe 6 : Plasticité Sensorielle, Code Neuronal et Perception Auditive, Centre de Neurosciences Paris-Sud (CNPS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), XLIM (XLIM), Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Male, Amino Acid Transport System X-AG, Central nervous system, Racemases and Epimerases, Cell Count, Biology, Toxicology, 03 medical and health sciences, Electromagnetic Fields, 0302 clinical medicine, Pregnancy, Heat shock protein, Glial Fibrillary Acidic Protein, medicine, Animals, Rats, Wistar, Heat-Shock Proteins, 030304 developmental biology, 0303 health sciences, Microglia, Glial fibrillary acidic protein, General Neuroscience, Age Factors, Brain, Gene Expression Regulation, Developmental, Embryo, Mammalian, Rats, Cell biology, medicine.anatomical_structure, Animals, Newborn, Biochemistry, Serine racemase, biology.protein, Neuroglia, Female, HSP60, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], 030217 neurology & neurosurgery, Astrocyte
Abstract

International audience; The increasing use of mobile phones by children raise issues about the effects of electromagnetic fields (EMF) on the immature Central Nervous System (CNS). In the present study, we quantified cell stress and glial responses in the brain of developing rats one day after a single exposure of 2 h to a GSM 1,800 MHz signal at a brain average Specific Absorption Rate (SAR) in the range of 1.7 to 2.5 W/kg. Young rats, exposed to EMF on postnatal days (P) 5 (n = 6), 15 (n = 5) or 35 (n = 6), were compared to pseudo-exposed littermate rats (n = 6 at all ages). We used western blotting to detect heat shock proteins (HSPs) and cytoskeleton- or neurotransmission-related proteins in the developing astroglia. The GSM signal had no significant effect on the abundance of HSP60, HSC70 or HSP90, of serine racemase, glutamate transporters including GLT1 and GLAST, or of glial fibrillary acid protein (GFAP) in either total or soluble tissue extracts. Imunohistochemical detection of CD68 antigen in brain sections from pseudo-exposed and exposed animals did not reveal any differences in the morphology or distribution of microglial cells. These results provide no evidence for acute cell stress or glial reactions indicative of early neural cell damage, in developing brains exposed to 1,800 MHz signals in the range of SAR used in our study.

Published
2011
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