1. Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse
- Author
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Natalia Mitin, Judith Campisi, Alexis Valdovinos, Norman E. Sharpless, Jianhui Chang, Boshi Wang, Hyman B. Muss, Shani Alston, Kristin Koenig, Allison M. Deal, Brian K. Kennedy, Alain de Bruin, Sumner Kilmarx, Fatouma Alimirah, Catherine H. Le, Simon Melov, Monique N. O’Leary, Lijian Shao, Emmeline C. Academia, Daohong Zhou, Su Liu, Marco Demaria, Damage and Repair in Cancer Development and Cancer Treatment (DARE), and Restoring Organ Function by Means of Regenerative Medicine (REGENERATE)
- Subjects
BIOMARKER ,EXPRESSION ,0301 basic medicine ,Senescence ,DOXORUBICIN ,CLEARANCE ,medicine.medical_treatment ,Oncology and Carcinogenesis ,Antineoplastic Agents ,Breast Neoplasms ,Mice, Transgenic ,Biology ,Systemic inflammation ,THERAPY ,FATIGUE ,Transgenic ,Article ,Proinflammatory cytokine ,Mice ,03 medical and health sciences ,P16(INK4A) ,medicine ,Animals ,Humans ,Doxorubicin ,Senolytic ,IN-VIVO ,Cellular Senescence ,Cyclin-Dependent Kinase Inhibitor p16 ,Cell Proliferation ,Chemotherapy ,Cancer ,medicine.disease ,Neoplasm Recurrence ,030104 developmental biology ,Local ,Oncology ,Bone marrow suppression ,CELLS ,Immunology ,SECRETION ,Female ,Neoplasm Recurrence, Local ,medicine.symptom ,medicine.drug - Abstract
Cellular senescence suppresses cancer by irreversibly arresting cell proliferation. Senescent cells acquire a proinflammatory senescence-associated secretory phenotype. Many genotoxic chemotherapies target proliferating cells nonspecifically, often with adverse reactions. In accord with prior work, we show that several chemotherapeutic drugs induce senescence of primary murine and human cells. Using a transgenic mouse that permits tracking and eliminating senescent cells, we show that therapy-induced senescent (TIS) cells persist and contribute to local and systemic inflammation. Eliminating TIS cells reduced several short- and long-term effects of the drugs, including bone marrow suppression, cardiac dysfunction, cancer recurrence, and physical activity and strength. Consistent with our findings in mice, the risk of chemotherapy-induced fatigue was significantly greater in humans with increased expression of a senescence marker in T cells prior to chemotherapy. These findings suggest that senescent cells can cause certain chemotherapy side effects, providing a new target to reduce the toxicity of anticancer treatments. Significance: Many genotoxic chemotherapies have debilitating side effects and also induce cellular senescence in normal tissues. The senescent cells remain chronically present where they can promote local and systemic inflammation that causes or exacerbates many side effects of the chemotherapy. Cancer Discov; 7(2); 165–76. ©2016 AACR. This article is highlighted in the In This Issue feature, p. 115
- Published
- 2017