1. Granulomatosis with Polyangiitis as a Cause of Sudden-Onset Bilateral Sensorineural Hearing Loss: Case Report and Recommendations for Initial Assessment
- Author
-
Benjamin R Johnson, Paul R Ratmeyer, Tania L. Kraai, and Luis P Roldan
- Subjects
Pediatrics ,medicine.medical_specialty ,Case Report ,macromolecular substances ,Disease ,03 medical and health sciences ,0302 clinical medicine ,stomatognathic system ,otorhinolaryngologic diseases ,medicine ,030223 otorhinolaryngology ,Autoimmune disease ,business.industry ,General Medicine ,medicine.disease ,Paranasal sinuses ,medicine.anatomical_structure ,Otorhinolaryngology ,RF1-547 ,030220 oncology & carcinogenesis ,Sensorineural hearing loss ,Granulomatosis with polyangiitis ,Bilateral sensorineural hearing loss ,business ,Sudden onset ,Systemic vasculitis - Abstract
Granulomatosis with polyangiitis (GPA) is a severe systemic vasculitis that commonly affects the paranasal sinuses, upper and lower respiratory tracts, and kidneys. GPA has also been associated with sensorineural hearing loss (SNHL), through inflammation of the cochlear apparatus. Early recognition, diagnostic laboratory evaluation, and appropriate treatment are essential to improve outcomes and achieve remission for patients with GPA. Here, we present a case of bilateral sudden sensorineural hearing loss (SSNHL) and distal symmetric polyneuropathy as the first presenting signs of GPA. A specific diagnostic work-up to rule out autoimmune inner-ear disease in patients with bilateral SSNHL is not clearly stated in the clinical practice guidelines from the American Academy of Otolaryngology-Head and Neck Surgery. The aim of this paper is to delineate an appropriate diagnostic work-up for patients with bilateral SSNHL when there is concern for autoimmune disease.
- Published
- 2021
- Full Text
- View/download PDF