1. A study of the clinical, treatment planning and dosimetric feasibility of dose painting in external beam radiotherapy of prostate cancer
- Author
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Janice Ash-Miles, Sian Curtis, Serena Hilman, Andrew Brown, Dawn Bowers, Emma Dennis, Susan Masson, Steve W. Blake, and Alison Stapleton
- Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine ,Radiotherapy planning ,lcsh:R895-920 ,medicine.medical_treatment ,Rectum ,Computer-assisted/methods ,lcsh:RC254-282 ,Prostate radiotherapy ,030218 nuclear medicine & medical imaging ,Feasibility studies ,03 medical and health sciences ,Prostate cancer ,Magnetic resonance imaging ,0302 clinical medicine ,Urethra ,Prostate ,Dose painting ,medicine ,Radiology, Nuclear Medicine and imaging ,Original Research Article ,External beam radiotherapy ,Radiation ,Radiotherapy ,medicine.diagnostic_test ,Radiotherapy dosage ,business.industry ,Focal boost ,lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,medicine.disease ,Radiation therapy ,medicine.anatomical_structure ,Intensity-modulated/methods ,030220 oncology & carcinogenesis ,Multi-parametric MRI ,Nuclear medicine ,business - Abstract
Background and purpose Radiotherapy dose painting is a promising technique which enables dose escalation to areas of higher tumour cell density within the prostate which are associated with radioresistance, known as dominant intraprostatic lesions (DILs). The aim of this study was to determine factors affecting the feasibility of radiotherapy dose painting in patients with high and intermediate risk prostate cancer. Materials & Methods Twenty patients were recruited into the study for imaging using a 3 T magnetic resonance imaging (MRI) scanner. Identified DILs were outlined and the scan registered with the planning computed tomography (CT) dataset. Intensity-modulated plans were produced and evaluated to determine the effect of the organ-at-risk constraints on the dose that could be delivered to the DILs. Measurements were made to verify that the distribution could be safely delivered. Results MRI scans were obtained for nineteen patients. Fourteen patients had one to two DILs with ten overlapping the urethra and/or rectum. The target boost of 86 Gy was achieved in seven plans but was limited to 80 Gy for five patients whose boost volume overlapped or abutted the urethra. Dosimetric measurements gave a satisfactory gamma pass rate at 3%/3 mm. Conclusions It was feasible to produce dose-painted plans for a boost of 86 Gy for approximately half the patients with DILs. The main limiting factor was the proximity of the urethra to the boost volumes. For a small proportion of patients, rigid registration between CT and MRI images was not adequate for planning purposes.
- Published
- 2020
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