1. Clinical implication of minimal presence of solid or micropapillary subtype in early‐stage lung adenocarcinoma
- Author
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Seung Ick Cha, Jaehee Lee, Shin Young Jeong, Chang Ho Kim, Hyewon Seo, Kyung Min Shin, Won Kee Lee, Sun Ha Choi, Yangki Seok, Yong Hoon Lee, Eung Bae Lee, Sunji Park, Jieun Park, Seung Soo Yoo, Tae-In Park, Shin Yup Lee, Ji Yun Jeong, Jae Yong Park, and Young Woo Do
- Subjects
0301 basic medicine ,Pulmonary and Respiratory Medicine ,Lung adenocarcinoma ,Adult ,Male ,medicine.medical_specialty ,Poor prognosis ,Lung Neoplasms ,stage IA ,Adenocarcinoma of Lung ,Gastroenterology ,Complete resection ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Humans ,Stage (cooking) ,Aged ,Neoplasm Staging ,Aged, 80 and over ,Lung ,business.industry ,General Medicine ,Original Articles ,Middle Aged ,medicine.disease ,micropapillary ,Prognosis ,Clinical trial ,030104 developmental biology ,Lymphatic system ,medicine.anatomical_structure ,Oncology ,Time to recurrence ,solid ,030220 oncology & carcinogenesis ,Adenocarcinoma ,Original Article ,Female ,business - Abstract
Background We investigated the clinical features and surgical outcomes of lung adenocarcinoma with minimal solid or micropapillary (S/MP) components, with a focus on stage IA. Methods We enrolled 506 patients with lung adenocarcinoma who underwent curative resection in this study. Clinical features and surgical outcomes were compared between the groups with and without the S/MP subtype (S/MP+ and S/MP−, respectively), and between the group with an S/MP proportion of ≤5% (S/MP5) and the S/MP−. Results The S/MP subtype was present in 247 patients (48.8%); 129 (25.5%) were grouped as the S/MP5 group. The S/MP+ and S/MP5 groups had larger tumors, higher frequency of lymph node metastasis, and more advanced stages of disease than the S/MP− group (P, We demonstrated that only minimal presence of solid or micropapillary component was profoundly associated with aggressive clinicopathological features and poor prognosis after complete resection even in stage IA lung adenocarcinoma. Our results suggest that minimal presence of these subtypes is a strong prognostic factor which should be taken into account in the risk assessment for adjuvant chemotherapy in lung adenocarcinoma.
- Published
- 2020