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Your search keyword '"Gregory R.C. Blass"' showing total 2 results
Start Over Author "Gregory R.C. Blass" Topic 03 medical and health sciences
2 results on '"Gregory R.C. Blass"'

1. Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat

Author

Ole Eigenbrod, Wiebke Hamann, Richard D. Minshall, Tetiana Kosten, Christin Zasada, Victoria M Gavaghan, Michael Gotthardt, Stefan Kempa, Gary R. Lewin, Bethany L. Peterson, John Larson, Heike Lutermann, Nigel C. Bennett, P. Henning J. L. Kuich, Vince G. Amoroso, Thomas J. Park, Ewan St. John Smith, Daniel T. Applegate, Brigitte M. Browe, Michael H. Radke, Vidya Govind, Jane Reznick, Gregory R.C. Blass, Damir Omerbašić, Valérie Bégay, Smith, Ewan St John [0000-0002-2699-1979], and Apollo - University of Cambridge Repository

Subjects
0301 basic medicine, Sucrose, 02 engineering and technology, Fructose, Biology, Fructokinases, 03 medical and health sciences, chemistry.chemical_compound, Mice, Respiration, medicine, Animals, Glycolysis, Anaerobiosis, Lactic Acid, Naked mole-rat, Multidisciplinary, Glucose Transporter Type 5, Mole Rats, Myocardium, Brain, Hypoxia (medical), 021001 nanoscience & nanotechnology, biology.organism_classification, Adaptation, Physiological, Oxygen, 030104 developmental biology, chemistry, Biochemistry, biology.protein, medicine.symptom, 0210 nano-technology, Anaerobic exercise, GLUT5, Phosphofructokinase
Abstract

Safe anaerobic metabolism Naked mole-rats live in large colonies deep underground in hypoxic conditions. Park et al. found that these animals fuel anaerobic glycolysis with fructose by a rewired pathway that avoids tissue damage (see the Perspective by Storz and McClelland). These results provide insight into the adaptations that this strange social rodent has to make for life underground. They also have implications for medical practice, particularly for understanding how to protect tissues from hypoxia. Science , this issue p. 307 ; see also p. 248

Published
2017

2. Absence of histamine-induced itch in the African naked mole-rat and 'rescue' by Substance P

Author

Ewan St. John Smith, Gregory R.C. Blass, Thomas J. Park, Gary R. Lewin, Smith, Ewan St John [0000-0002-2699-1979], and Apollo - University of Cambridge Repository

Subjects
Male, medicine.medical_specialty, Population, TRPV1, Short Report, Substance P, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Mice, 0302 clinical medicine, Internal medicine, medicine, lcsh:Pathology, Animals, education, Naked mole-rat, 030304 developmental biology, 0303 health sciences, education.field_of_study, biology, Mole Rats, Pruritus, Scratching, biology.organism_classification, Spinal cord, Rats, Mice, Inbred C57BL, Posterior Horn Cells, Anesthesiology and Pain Medicine, Endocrinology, medicine.anatomical_structure, chemistry, nervous system, Spinal Cord, Nociceptor, Molecular Medicine, Calcium, Function and Dysfunction of the Nervous System, Neuroscience, 030217 neurology & neurosurgery, Histamine, lcsh:RB1-214
Abstract

Recent research has proposed a pathway in which sensory neurons expressing the capsaicin activated ion channel TRPV1 are required for histamine-induced itch and subsequent scratching behavior. We examined histamine-induced itch in the African naked mole-rat (Heterocephalus glaber) and found that although naked mole-rats display innate scratching behavior, histamine was unable to evoke increased scratching as is observed in most mouse strains. Using calcium imaging, we examined the histamine sensitivity of naked mole-rat dorsal root ganglia (DRG) neurons and identified a population of small diameter neurons activated by histamine, the majority of which are also capsaicinsensitive. This suggested that naked mole-rat sensory neurons are activated by histamine, but that spinal dorsal horn processing of sensory information is not the same as in other rodents. We have previously shown that naked mole-rats naturally lack substance P (SP) in cutaneous C-fibers, but that the neurokinin-1 receptor is expressed in the superficial spinal cord. This led us to investigate if SP deficiency plays a role in the lack of histamine-induced scratching in this species. After intrathecal administration of SP into the spinal cord we observed robust scratching behavior in response to histamine injection. Our data therefore support a model in which TRPV1-expressing sensory neurons are important for histamine-induced itch. In addition, we demonstrate a requirement for active, SP-induced post-synaptic drive to enable histamine sensitive afferents to drive itch-related behavior in the naked mole-rat. These results illustrate that it is altered dorsal horn connectivity of nociceptors that underlies the lack of itch and pain-related behavior in the naked mole-rat., This work was supported by the Alexander von Humboldt Foundation (EStJS) and NSF grant 0744979 (TJP).

Published
2010

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