1. Fast Anxiolytic-Like Effect Observed in the Rat Conditioned Defensive Burying Test, after a Single Oral Dose of Natural Protein Extract Products
- Author
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Michel Boulouard, Gerald Nee, Stacy Largilliere, Sophie Corvaisier, Thomas Freret, Melanie Coolzaet, Mobilités : Vieillissement, Pathologie, Santé (COMETE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), and freret, thomas
- Subjects
Fish Proteins ,Male ,medicine.drug_class ,Protein Hydrolysates ,Pharmacology ,Anxiety ,Anxiolytic ,Hydrolysate ,Anxiolytic like ,Single oral dose ,03 medical and health sciences ,0302 clinical medicine ,Conditioning, Psychological ,medicine ,burying test ,Animals ,TX341-641 ,[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,Eating habits ,Benzodiazepine ,Nutrition and Dietetics ,Diazepam ,Behavior, Animal ,Nutrition. Foods and food supply ,business.industry ,Brief Report ,[SCCO.NEUR]Cognitive science/Neuroscience ,[SCCO.NEUR] Cognitive science/Neuroscience ,rodent ,Caseins ,[SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences ,3. Good health ,030227 psychiatry ,Rats ,[SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences ,Anti-Anxiety Agents ,fish protein hydrolysate ,[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] ,medicine.symptom ,business ,030217 neurology & neurosurgery ,Food Science ,medicine.drug - Abstract
International audience; Anxiety appears among the most frequent psychiatric disorders. During recent years, a growing incidence of anxiety disorders can be attributed, at least in part, to the modification of our eating habits. To treat anxiety disorders, clinicians use benzodiazepines, which unfortunately display many side effects. Herein, the anxiolytic-like properties of two natural products (αS1–casein hydrolysate and Gabolysat®) were investigated in rats and compared to the efficacy of benzodiazepine (diazepam). Thus, the conditioned defensive burying test was performed after a unique oral dose of 15 mg/kg, at two time-points (60 min and then 30 min post oral gavage) to show potential fast-onset of anxiolytic effect. Both natural products proved to be as efficient as diazepam to reduce the time rats spent burying the probe (anxiety level). Additionally, when investigated as early as 30 min post oral gavage, Gabolysat® also revealed a fast-anxiolytic activity. To date, identification of bioactive peptide, as well as how they interact with the gut–brain axis to sustain such anxiolytic effect, still remains poorly understood. Regardless, this observational investigation argues for the consideration of natural compounds in care pathway.
- Published
- 2021