1. Thrombotic Microangiopathy in the Setting of HIV Infection: A Case Report and Review of the Differential Diagnosis and Therapy
- Author
-
Jeffrey Laurence, Karim R. Saab, Dennis Copertino, and Sonia Elhadad
- Subjects
Thrombotic microangiopathy ,Anti-HIV Agents ,Thrombotic thrombocytopenic purpura ,HIV Infections ,030204 cardiovascular system & hematology ,Antibodies, Monoclonal, Humanized ,Diagnosis, Differential ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Acquired immunodeficiency syndrome (AIDS) ,Atypical hemolytic uremic syndrome ,medicine ,Humans ,Renal Insufficiency ,030212 general & internal medicine ,Coma ,Young adult ,Purpura, Thrombotic Thrombocytopenic ,Thrombotic Microangiopathies ,business.industry ,Public Health, Environmental and Occupational Health ,Viral Load ,Eculizumab ,medicine.disease ,ADAMTS13 ,Treatment Outcome ,Infectious Diseases ,Creatinine ,Hemolytic-Uremic Syndrome ,Immunology ,Female ,business ,Viral load ,medicine.drug - Abstract
Before the modern era of HIV/AIDS therapeutics, which enabled a cascade of early recognition of infection, prompt initiation of effective antiretroviral therapies, and close follow-up, severe forms of microvascular clotting disorders known as thrombotic microangiopathies (TMAs) were frequent in the setting of advanced HIV disease. Their incidence was as high as 7% in the period 1984-1999, but fell dramatically, to
- Published
- 2016