1. Non-invasive radiofrequency therapy modulated histone acetylation status without change heat shock proteins in healthy women
- Author
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Daniela Pochmann, Ivy Reichert Vital da Silva, Rafael Perin Arpini, Caroline Dani, Viviane Rostirola Elsner, Víctor García Gimenez, Rafael Sánchez Borrego, and Mariana Sponchiado Arpini
- Subjects
Adult ,medicine.medical_specialty ,040301 veterinary sciences ,Thermal effect ,Adipose tissue ,Histones ,0403 veterinary science ,03 medical and health sciences ,Histone H3 ,Internal medicine ,Heat shock protein ,medicine ,Humans ,Histone H3 acetylation ,Heat-Shock Proteins ,030304 developmental biology ,0303 health sciences ,biology ,business.industry ,Non invasive ,Acetylation ,04 agricultural and veterinary sciences ,Radiofrequency Therapy ,Surgery ,Histone ,Endocrinology ,biology.protein ,Female ,business - Abstract
Non-invasive radiofrequency acts through an electromagnetic field that generates a thermal effect on adipose tissue without contact with the skin. The temperature in the subcutaneous reaches between 44°C to 45°C, which after 45 minutes of intervention causes apoptosis of adipocytes. The objective of this study is investigate the impact of non-invasive radiofrequency (RF) on global histone H3 acetylation and heat shock proteins (HSPs) 47 and 60 levels in the peripheral blood of healthy women. The participants were divided in control/sedentary (n = 10) and exercised/physically active (n = 10) groups and were submitted to 4 sessions of RF intervention (once a week; 45 min each session, total 4 sessions). In order to analyze the acute and long term effects, blood samples for biomarkers analysis were taken in 3 moments: before (T1), after the first session (T2) and after the last session (T3), while anthropometric measurements were taken before and after the treatment protocol. The intervention was not able to modulate the HSPs in both groups at any time, while a significant increase on global histone H3 levels was observed at T2 compared to T1 (p=0.047) in exercised group. Regarding anthropometric measurements, we observed a significant reduction in body mass and adipose mass in the exercised group in T3 when compared to T1. Non-invasive RF is able to improve anthropometric measurements in physically active healthy women. This response might be related to acute histone H3 hyperacetylation status and is not associated with the modulation of HSPs 47 and 60.
- Published
- 2021