1. Sleep and behavior in children and adolescents with tuberous sclerosis complex
- Author
-
Angela Peron, Aglaia Vignoli, Elena Zambrelli, Alessia Leidi, Francesca La Briola, Katherine Turner, and Maria Paola Canevini
- Subjects
Male ,Parents ,Sleep Wake Disorders ,0301 basic medicine ,congenital, hereditary, and neonatal diseases and abnormalities ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Population ,CBCL ,Child Behavior Disorders ,030105 genetics & heredity ,Cohort Studies ,03 medical and health sciences ,Tuberous sclerosis ,Tuberous Sclerosis ,Surveys and Questionnaires ,Genetics ,medicine ,Humans ,Child ,education ,Child Behavior Checklist ,Genetics (clinical) ,education.field_of_study ,Developmental age ,business.industry ,Significant difference ,medicine.disease ,Sleep in non-human animals ,030104 developmental biology ,Child, Preschool ,Cohort ,Female ,Sleep ,business - Abstract
Sleep disorders are frequent in tuberous sclerosis complex (TSC) during the developmental age but are not well characterized. Forty-six TSC patients and 46 healthy age- and sex-matched controls were enrolled. Their parents completed the Sleep Disturbances Scale for Children (SDSC) and the Child Behavior Checklist (CBCL). A total of 17.4% of the TSC patients obtained a total pathologic score at the SDSC versus 4.4% in the control group (p = 0.024). 45.7% of individuals with TSC reported a pathologic score in at least one of the factors. We found a statistically significant difference between the TSC cohort and healthy controls for most of the CBCL scales scores. A significant relationship was found between the Total SDSC score and the Total CBCL score (R-square = 0.387, p
- Published
- 2021
- Full Text
- View/download PDF