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1. HemoTypeSC point-of-care testing shows high sensitivity with alkaline cellulose acetate hemoglobin electrophoresis for screening hemoglobin SS and SC genotypes

Author: Samuel Ademola Adegoke, Alex Ifeoluwa Akinwumi, O I Oladimeji, Morenike Agnes Akinlosotu, and Kayode Ademola Matthew
Subjects: medicine.medical_specialty, Hemoglobin electrophoresis, business.industry, Point-of-care testing, Hematology, Disease, 030204 cardiovascular system & hematology, medicine.disease, Cellulose acetate, Sickle cell anemia, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, Internal medicine, Cohort, Genotype, Immunology and Allergy, Medicine, business, Malaria, 030215 immunology
Abstract: Introduction By providing timely actionable results for prompt management, point-of-care testing (POCT) kits have revolutionised medical care for various diseases, ranging from infectious diseases like malaria to genetic disorders, such as sickle cell disease (SCD). They are, however, underutilised in the diagnosis of SCD in developing countries, where the need is greatest. Objective The study was aimed at assessing the sensitivity of HemoTypeSC POCT among a cohort of children with SCD, previously diagnosed by Alkaline cellulose acetate hemoglobin electrophoresis (ACAE), with or without high-performance liquid chromatography (HPLC). Methods In this descriptive cross-sectional study, HemoTypeSC test was conducted on all participants and its sensitivity was determined by comparing results with those obtained using ACAE. Discordance was verified with HPLC. Results One hundred and forty-five children aged one to 19 years were studied. There were 84 males and 61 females (male: female ratio = 1.4: 1). The HemoTypeSC was able to correctly diagnose sickle cell anemia (SCA) and hemoglobin SC in all (100%) of the children tested. Conclusion The HemoTypeSC shows high sensitivity in detecting SCA and hemoglobin SC. Hence, it is useful for targeted screening of individuals suspected of having SCD, leading to rapid diagnosis of these hemoglobinopathies, even in resource-constrained settings.
Published: 2022
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2. Urban Poor Community Settings' Knowledge and Screening Practices for Cervical Cancer in Ibadan, Nigeria

Author: Oladimeji Oladepo, Mojisola Oluwasanu, and Yetunde O. John-Akinola
Subjects: Cervical cancer, Health Knowledge, Attitudes, Practice, Cancer Research, business.industry, Nigeria, Uterine Cervical Neoplasms, ORIGINAL REPORTS, Urban poor, medicine.disease, Cancer Prevention and Control, 03 medical and health sciences, Cross-Sectional Studies, 0302 clinical medicine, Oncology, Surveys and Questionnaires, 030220 oncology & carcinogenesis, Environmental health, medicine, Humans, Community setting, Female, 030212 general & internal medicine, business, Early Detection of Cancer
Abstract: PURPOSE This study investigated knowledge and screening practices for cervical cancer among two urban poor community settings in Ibadan, Nigeria. METHODS A cross-sectional design was used. ODK tool was used to collect quantitative data among a sample size of 500 respondents. Data were analyzed using IBM SPSS version 21 for descriptive and inferential statistics. Scores for knowledge were on a scale of 0-39 points (0-18 low, 19-23 fair, and 24-39 high knowledge). RESULTS A majority of respondents (77.2%) had low knowledge of cervical cancer and were not aware (93.6%) of the Papanicolaou test (Pap smear test) or cervical cancer screening (91.2%). Very few women (10%) were aware of the human papillomavirus vaccine for the prevention of cervical cancer, 4% had been screened with the Papanicolaou test, and one woman (0.3%) with visual inspection with acetic acid. Four (1.1%) women had taken human papillomavirus vaccine before. CONCLUSION The findings of this study have underscored a necessity for increased awareness creation through health promotion interventions and strategies to alleviate low knowledge, prevention, and screening practices for cervical cancer in poor community settings in Nigeria.
Published: 2021
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3. Pregnancy-related anxiety symptoms and associated factors amongst pregnant women attending a tertiary hospital in south-west Nigeria

Author: Badejoko O. Olalekan, Adesanmi Akinsulore, Akinfenwa M. Temidayo, Oladimeji B. Yetunde, and Ibidunni Olapeju Oloniniyi
Subjects: lcsh:RC435-571, media_common.quotation_subject, Nigeria, lcsh:RZ400-408, Miscarriage, 03 medical and health sciences, Social support, 0302 clinical medicine, lcsh:Psychiatry, medicine, 030212 general & internal medicine, Big Five personality traits, media_common, Original Research, Pregnancy, 030219 obstetrics & reproductive medicine, Extraversion and introversion, business.industry, gynaecology, lcsh:Mental healing, medicine.disease, anxiety, Psychiatry and Mental health, Anxiety, pregnancy, women, medicine.symptom, Worry, business, Psychosocial, Demography
Abstract: Background: Pregnancy can be associated with anxiety symptoms because of anticipated uncertainty. Aim: This study investigated pregnancy-related anxiety symptoms (PRASs) and their associated factors amongst pregnant women. Setting: Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria. Methods: This cross-sectional survey involved 230 pregnant women attending antenatal clinic at a tertiary teaching hospital in Nigeria. Pregnancy- related anxiety symptoms, maternal worries, personality traits and social support were measured by using Perinatal Anxiety Screening Scale (PASS), Cambridge Worry Scale (CWS), Big Five Personality Inventory (BFI10) and Maternal Social Support Scale (MSSS) respectively. Socio-demographic and obstetric details were also obtained. The Chi-square, t-test and logistic regression were used. Results: Respondents’ mean age was 28.2 ± 5.4 years, whilst 192 (83.5%) were of Yoruba ethnicity. Twenty-four respondents (10.4%) were in the first trimester, 85 (37.0%) in the second and 121 (52.6%) in the third trimester. Some 154 (67.0%) were parous. The prevalence of PRAS and major maternal worries were 43.5% and 55.7% respectively. The socio-demographic factors significantly associated with PRAS were age (p = 0.004), ethnicity (p = 0.001), educational level (p = 0.011) and living arrangement (p = 0.029). Associated obstetric factors include trimester (p = 0.01), hypertension (p = 0.006), past miscarriage(s) (p = 0.013) and past pregnancy complication (p = 0.030). Significant psychosocial factors were partner social support (p = 0.038), maternal worries (p < 0.001) and extraversion (p = 0.016). Factors that contributed significantly to regression models were older maternal age and socio-medical worries. Conclusion: High level of PRAS and major maternal worries were common amongst antenatal clinic attendees of a tertiary teaching hospital in Nigeria. Older maternal age and socio-medical maternal worries are important predictors of PRAS.&nbsp
Published: 2023

4. Practice, Perception, and Associations of Peer Learning Among Resident Doctors in Nigeria: Charting Study

Author: Oladimeji Adebayo, Martin Igbokwe, Kehinde Kanmodi, Abimbola Amoo, Olusegun Olaopa, Sebastine Oiwoh, Selekeowei Peter Kespi Kpuduwei, Elizabeth Grillo, Rereloluwa Babalola, Gbenga Popoola, Florence Anne Oladimeji, Ayanfe Omololu, Oluwaseyi Ogunsuji, Francis Fagbule, Babalola Adeniyi Ibisola, Oluwafemi Efuntoye, Makinde Adeniyi Adebayo, Dabota Yvonne Buowari, and Aliyu Sokomba
Subjects: 03 medical and health sciences, Medical education, 0302 clinical medicine, 020205 medical informatics, Perception, media_common.quotation_subject, 0202 electrical engineering, electronic engineering, information engineering, 030212 general & internal medicine, 02 engineering and technology, Peer learning, Psychology, media_common
Abstract: Introduction: Peer learning is an important component of the postgraduate medical curriculum, and it is considered as an integral part of learning in some countries. The practice of peer learning among postgraduate trainees, especially the resident doctors, is an area that has not been explored in Nigeria and other third world countries. This study aims to examine the practice, perception, and drivers of peer-to-peer training in Nigeria. Methodology: This study was a national multi-centre and multi-disciplinary cross-sectional survey, conducted among resident doctors in Nigeria. Semi-structured questionnaires were used to obtain respondents’ biodata, perception and practice on peer learning. Data were analysed using SPSS version 23 software. Results were presented as frequency table and proportion, means, and standard deviation. Inferential statistics such as bivariate analysis was performed. Results: Majority, 287 (73.2%), considered the peer education programme as an appropriate learning practice, 173 (45.9%) considered peer education programme integrated part of the training, while 350/383 (88.2%) engaged in a peer education programme. Statistically, a significant association was found between those who considered peer training as appropriate (p = 0.038) and those who considered peer education as an integral part of postgraduate medical training curriculum (p =0.009). Conclusion: Peer learning is popular among resident doctors in Nigeria. Concerted efforts are needed to re-structure the residency training curriculum in order to maximize the benefits of this learning approach for an effective training programme.
Published: 2020
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5. Bioactive Constituents and Potency of Aqueous-Methanolic Extract of Asclepias syriaca on Plasmodium falciparum Infected Albino Rats

Author: Iwuji Samuel Chidi, Uzoechi Samuel Chidiebere, Emmanuel Tochukwu Chibuike, Azeez Taofik Oladimeji, Ajuogu Eno, Ejeta Kennedy Oghenenyore, and Okafor Loretta Afoma
Subjects: Microbiology (medical), 0303 health sciences, Aqueous solution, Asclepias syriaca, biology, Traditional medicine, 030306 microbiology, 030231 tropical medicine, Immunology, Plasmodium falciparum, biology.organism_classification, 03 medical and health sciences, 0302 clinical medicine, parasitic diseases, Immunology and Allergy, Potency
Abstract: High mortality rate couple with the economic effect of deadlyPlasmodium falciparumcaused by malaria necessitated this study. Evaluation of bioactive constituents and antimalarial properties of the aqueous-methanolic extract ofAsclepias syriaca (A. syriaca) was investigated. Bioactive constituents were determined by GC-MS analytical detector. Albino rats were five in each group of six groups (A-E) in which group A was non-infected withP. falciparum(negative control). Groups B, C, D, E were infected with 1×107/mlP. falciparumwithout treated, treated with standard drugs of 20mg of chloroquine/kg, 100, 200 and 400mg of extractedA. syriaca/kg, respectively.Hematological and biochemical parameters ofPlasmodium falciparuminfected albino rats were determined. Aqueous-methanolic extract ofA. syriacaleaf made up of high content of pyrimidine, quinolone and silane derivatives with synergetic properties with potency for therapeutic of malarial and viral infectious diseases. MCV, PLA, RBC, total protein and albumin were significantly elevated upon infectedP. falciparumand gradually increases with dosage and time when treated with chloroquine andA.syriacaleaf extract but vice visa for the case WBC and creatinine. Parasitemia level significantly declined when administered with chloroquine andA, syriacaleaf extract for 36 hours. Hence serves as an effective medication in place of chloroquine due to its availability, avoidable and as a source of relevant medications toPlasmodium sppand viral infectious diseases.
Published: 2021
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6. Human health risk assessment of essential and non-essential metals in vegetables (Jute Mallow, Onions, Celosia, Spinach and Tomatoes) from Ogun, Lagos and Oyo states, southwestern Nigeria

Author: Osayande J. Avan, Patricia K. Ogunkoya, Gbolahan Oladimeji, Abibat O. Jimoh, Kofoworola A. Olatunde, Al-Amin Adenekan, Ebunoluwa R. Lawal, Mukaila B. Adekola, Adewale Matthew Taiwo, and Karimat L. Abdullahi
Subjects: 0106 biological sciences, 0301 basic medicine, Cadmium, Health risk assessment, biology, chemistry.chemical_element, Plant Science, Zinc, Contamination, biology.organism_classification, 01 natural sciences, Hazard quotient, Toxicology, 03 medical and health sciences, 030104 developmental biology, chemistry, Spinach, Celosia, Risk assessment, 010606 plant biology & botany
Abstract: Vegetables are important sources of essential minerals and vitamins required for healthy living. However, contamination of vegetables with inorganic and organic substances may pose severe or irreversible health risk. The present study assessed the health risk of metals in vegetables from three states in southwestern Nigeria. A total of 180 vegetable samples (Jute Mallow, Onions, Celosia, Spinach and Tomatoes) were collected and analyzed for essential {copper (Cu), iron (Fe), nickel (Ni) and zinc (Zn)}, and nonessential {cadmium (Cd) and lead (Pb)} metals using the standard method. The health risk assessment was evaluated for hazard quotient (HQ), hazard index (HI) and cancer risk (CR). Results showed the highest concentrations of Fe in vegetable samples ranging from 4.9 mg kg−1 in jute mallow from Ogun to 558 mg kg−1 in spinach from Lagos. The spinach samples were more enriched in Fe and Zn than any other vegetables. The abundance pattern of metals in vegetables followed the order of Fe > Zn > Cu > Pb > Ni > Cd. The health risk assessment study revealed HQ and HI of metals greater than 1.0 in many vegetable samples indicating non-carcinogenic adverse health effects. The average CR values for Cd and Ni in vegetables were generally higher than the acceptable limit of 1.0 × 10–4, while the mean CR data for Pb were greater than the priority limit of 1.0 × 10–6. These CR values suggested possible cancer development through consumption of vegetables from the study area.
Published: 2021
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7. Combine effect of exposure to petrol, kerosene and diesel fumes: On hepatic oxidative stress and haematological function in rats

Author: Uche O Arunsi, Bidemi Noah Oladimeji, Tobiloba C. Elebiyo, and Solomon E. Owumi
Subjects: Blood Glucose, Male, Diesel exhaust, Health, Toxicology and Mutagenesis, 010501 environmental sciences, Disease pathogenesis, Toxicology, medicine.disease_cause, 01 natural sciences, Kerosene, Leukocyte Count, 03 medical and health sciences, Occupational Exposure, medicine, Animals, Humans, Gasoline, 030304 developmental biology, 0105 earth and related environmental sciences, 0303 health sciences, Platelet Count, Chemistry, Public Health, Environmental and Occupational Health, Petroleum exploration, Rats, Oxidative Stress, Petroleum, Hematocrit, Environmental chemistry, Models, Animal, Organic component, Chemical and Drug Induced Liver Injury, Biomarkers, Oxidative stress
Abstract: Petroleum product fumes (PPFs) containing toxic organic components are pervasive in the environment, emanating from anthropogenic activities, including petroleum exploration and utilization by end-user activities from petrol–gasoline stations. Petrol station attendants are exposed to PPF through inhalation and dermal contact with consequent toxicological implications. We investigated the effects of chronic exposure (60 and 90 days) to petrol (P), kerosene (K) and diesel (D) alone and combined exposure to petrol, kerosene and diesel (PKD) fumes on hepatotoxicity, haematological function and oxidative stress in rats. Following sacrifice, we evaluated hepatic damage biomarkers, blood glucose, oxidative stress and haematological function. Chronic exposure to PPF significantly increased organo-somatic indices, blood glucose, biomarkers of hepatic toxicity and oxidative stress in an exposure duration-dependent manner. There was a simultaneous decrease in the protective capacity of antioxidants. Furthermore, exposure to PPF increased pro-inflammatory biomarkers in rats (90 > 60 days). Regardless of exposure duration, plateletcrit, mean platelet volume, platelet distribution width and red cell distribution width in the coefficient of variation increased, whereas red blood cell count, haemoglobin, packed cell volume, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, white blood cell, lymphocyte, monocyte–basophil–eosinophil mixed counts and platelet count decreased after 60 and 90 days exposure. Microscopic examination of the liver demonstrated hepatic pathological changes paralleling the duration of exposure to PKD fumes. However, the injury observed was lesser to that of rats treated with the diethylnitrosamine – positive control. Our results expanded previous findings and further demonstrated the probable adverse effect on populations’ health occasioned by persistent exposure to PPF. Individuals chronically exposed by occupation to PPF may be at greater risk of developing disorders promoted by continuous oxido-inflammatory perturbation and suboptimal haematological–immunologic function – thereby enabling a permissive environment for pathogenesis notwithstanding the limitation of quantifying PPF absolute values in our model system.
Published: 2021
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8. Growth performance, carcass characteristics and cost benefit of feeding broilers with diets containing high quality cassava peel (HQCP)

Author: O. Bamidele, A. A. Adebayo, S. O. Oladimeji, T. E. Odekunle, O. Olasusi, T. A. Amole, A. B. Adekeye, and A. A. Raji
Subjects: 0303 health sciences, 030309 nutrition & dietetics, 0402 animal and dairy science, Broiler, Live weight, 04 agricultural and veterinary sciences, Body weight, 040201 dairy & animal science, Feed conversion ratio, Cost savings, 03 medical and health sciences, Animal science, medicine, Cost benefit, medicine.symptom, General Agricultural and Biological Sciences, Weight gain, Completely randomized design, Mathematics
Abstract: A feeding trial was conducted to evaluate the effect of isonitrogenous and isocaloric diets containing varying levels of high-quality cassava peel (HQCP) fine mash on broilers’ performance, carcass characteristics, and cost benefit. A feeding trial was carried out using four hundred (400) 21-day old Arbor Acres broiler chicks weighing 570 – 630 g (live weight). The chicks were randomly allocated to five dietary treatments (T); (T1- 0 kg/t of HQCP, T2- 150 kg/t of HQCP, T3- 200 kg/t of HQCP, T4- 250 kg/t of HQCP and T5- 300 kg/t of HQCP) for 21 days in a completely randomized design. Data on live performance, carcass characteristics, and feeding costs were collected. The results showed significant (P
Published: 2021
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9. Factors associated with age-disparate sexual partnerships among males and females in South Africa: a multinomial analysis of the 2012 national population-based household survey data

Author: Inbarani Naidoo, Leickness C. Simbayi, Musawenkosi Mabaso, Khangelani Zuma, Buyisile Chibi, Lehlogonolo Makola, Olanrewaju Oladimeji, Yogandra Naidoo, Lungelo Mlangeni, Department of Psychiatry and Mental Health, and Faculty of Health Sciences
Subjects: medicine.medical_specialty, Epidemiology, Population, Age-disparate, Sexual partnerships, 030312 virology, law.invention, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, South Africa, Condom, law, medicine, lcsh:RC109-216, education, Socioeconomic status, 0303 health sciences, education.field_of_study, Poverty, Public health, 05 social sciences, Stepwise regression, 050902 family studies, Cluster sampling, 0509 other social sciences, Psychology, Multinomial analysis, Demography, Research Article
Abstract: Background In South Africa, age-disparate to sexual relationships where the age difference between partners is 5 years or greater is an important contributor to the spread of HIV. However, little is known about the predictors of age-disparate sexual relationships. This study investigates factors associated with age-disparate sexual relationships among males and females in South Africa. Methods This analysis used the 2012 nationally representative population-based household survey conducted using multi-stage stratified cluster sampling design. Multivariate multinomial stepwise logistic regression models were used to determine factors associated with age-disparate sexual relationships. Results Of 15,717 participants, who responded to the question on age-disparate sexual relationships, 62% males versus 58.5% females had partners within 5 years older or younger, 34.7% of males versus 2.7% of females had partners at least 5 years younger and 3.3% of males versus 38.8% of females had partners at least 5 years older. Among both males and females predictors of age-disparate sexual relationships were education, employment, socioeconomic status, locality type, age at sexual debut, condom use at last sexual act and HIV status while race was also an additional predictor for among females. Including unprotected sex and risk of HIV infection among adolescent girls and young women with sexual partners 5 years older their age. Conclusions This study suggest that there is a need for reprioritizing the combination of behavioural and structural interventions to address risky sexual behaviours, unprotected sex, poverty, limited education and gender inequitable norms related to age-disparate sexual relationships and HIV.
Published: 2021

10. Detection and characterization of chicken astrovirus associated with hatchery disease in commercial day-old turkeys in southwestern Nigeria

Author: V J Smyth, Daniel Oladimeji Oluwayelu, A I Adebiyi, and Kerry Mcilwaine
Subjects: medicine.medical_specialty, Turkeys, viruses, Population, Nigeria, Infectious bronchitis virus, Avian nephritis virus, Disease, Biology, law.invention, 03 medical and health sciences, Medical microbiology, law, Virology, Astroviridae Infections, medicine, Animals, Animal Husbandry, education, Clade, Polymerase chain reaction, Phylogeny, Poultry Diseases, 030304 developmental biology, 0303 health sciences, education.field_of_study, 030306 microbiology, General Medicine, Hatchery, Avastrovirus, Original Article
Abstract: Infectious diseases are a major obstacle to profitable poultry production in Nigeria due to the mortality and severe economic losses they cause. In particular, they are a potent threat to attainment of the food security goals of government and national self-sufficiency in food production. Thus, there is a need for continuous monitoring of the nation's poultry population for these diseases. As part of an ongoing investigation of enteric viruses associated with poor performance or hatchery diseases in commercial poultry in southwestern Nigeria, intestinal contents from 97 condemned or runted day-old commercial turkey poults were examined for turkey astroviruses, infectious bronchitis virus, chicken astrovirus (CAstV), avian nephritis virus, avian rotavirus, avian reovirus, fowl adenovirus, and chicken parvovirus by virus isolation, electron microscopy (EM), polymerase chain reaction (PCR), and reverse transcription PCR. The samples were collected from five commercial hatcheries and five farms located in southwestern Nigeria. While all samples tested negative for other viruses, CAstV was detected in the majority (83.5%) of the birds, although some pleomorphic virus-like particles with surface projections that appeared fringed or fimbriated were observed in five of the cell culture samples by EM. Phylogenetic analysis revealed these CAstV strains belonged to the Bi clade. These findings not only implicate CAstV as the major cause of hatchery condemnations in commercial turkeys in southwestern Nigeria but also highlight the need for experimental studies to further establish its role in this disease condition.
Published: 2021

11. Triglyceride-Glucose Index and Related Parameters Predicted Metabolic Syndrome in Nigerians

Author: Joseph O Fadare, Ebenezer Adekunle Ajayi, Oladimeji Akande Ajayi, TH Raimi, Samuel Ayokunle Dada, David Daisi Ajayi, and Bolade Folashade Dele-Ojo
Subjects: Adult, Blood Glucose, Male, cardiovascular risk factors, obesity, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Nigeria, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, TyG index, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Internal Medicine, medicine, Health Status Indicators, Humans, Mass index, Hospitals, Teaching, Triglycerides, Metabolic Syndrome, anthropometry, Receiver operating characteristic, business.industry, Nigerians, Original Articles, Middle Aged, Anthropometry, Stepwise regression, medicine.disease, Obesity, Confidence interval, Cross-Sectional Studies, Female, Metabolic syndrome, business, Biomarkers
Abstract: Background: Triglyceride-glucose (TyG) index, a product of triglyceride and fasting plasma glucose, is a novel tool that can identify people with metabolic syndrome (MS). It is unknown if TyG index can identify MS among Nigerians. Methods: Cross-sectional health screening conducted between August and December 2018, among staff and students of Ekiti State University/Ekiti State University Teaching Hospital, Nigeria, Ado-Ekiti. The analysis included 473 participants, aged ≥18 years. Anthropometric indices and blood pressure were measured by standard protocol. Fasting lipid profile and blood glucose were determined. TyG index and product of TyG and anthropometric indices were calculated, and MS defined according to the harmonized criteria. The diagnostic ability of TyG index and related parameters to identify people with MS was determined with the area under curve (AUC) of receiver operating characteristic curves. Stepwise logistic regression analyses were used to generate odd ratios (ORs) for prediction of MS. Results: The mean age of the participants was 39.2 (11.4) years and there were 173 (36.6%) men. In all participants, TyG-waist to height ratio (TyG-WHtR) shows the largest AUC for MS detection (0.863, 95% confidence interval, CI: 0.828–0.892) followed by TyG-waist circumference (TyG-WC) (0.858, 95% CI: 0.823–0.888), TyG-body mass index (TyG-BMI) (0.838, 95% CI: 0.802–0.870), TyG index (0.796, 95% CI: 0.757–0.831), WHtR (0.791, 95% CI: 0.752–0.827), and TyG-waist-to-hip ratio (TyG-WHpR) (0.771, 95% CI: 0.730–0.808) in that order. Gender analysis revealed that TyG-WC and TyG-WHtR have largest AUC in both genders. Before and after adjustment, TyG-WHtR (OR: 6.86, 95% CI: 3.94–11.93) and TyG index (OR: 5.91, 95% CI: 3.01–11.59) presented the highest OR in all participants, respectively. Conclusions: TyG index is effective in identifying MS in this cross-sectional study, and the product of TyG index and anthropometric indices improved identification and prediction of MS.
Published: 2021
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12. Optimization of ultraviolet irradiation of Clarias gariepinus (Burchell, 1822) eggs for androgen production

Author: Mhd Ikhwanuddin, Haziqah Jumahat Nursyaza, Ambok Bolong Abol-Munafi, Abraham Sunday Oladimeji, A. Hassan, Victor Tosin Okomoda, Ijabo Oga Samuel, and Korede Isaiah Alabi
Subjects: Clarias gariepinus, 0303 health sciences, biology, medicine.drug_class, Chemistry, Unfertilized Eggs, 04 agricultural and veterinary sciences, Cell Biology, Androgen, biology.organism_classification, Sperm, 03 medical and health sciences, Animal science, 040102 fisheries, medicine, Ultraviolet irradiation, 0401 agriculture, forestry, and fisheries, Irradiation, Ploidy, 030304 developmental biology, Developmental Biology, Catfish
Abstract: SummaryThe optimum distance and duration of ultraviolet (UV) irradiation for the complete inactivation of African catfish Clarias gariepinus egg nucleus was investigated in this study. The UV light was suspended above the unfertilized eggs at four distances (5, 10, 20 and 30 cm) and for five durations (1, 2, 3, 4 and 5 min). Then, the irradiated eggs were activated with sperm from diploid C. gariepinus and cold shocked at 5°C for 5 min just moments before cell cleavage. Ploidy analysis was performed using karyotype chromosome counting. The results obtained suggested that the further the distance, the better the hatchability rate, however prolonged duration seemed to significantly reduced hatchability. All treatments with surviving progenies at the end of the study showed evidence of successfully diploid gynogen (2n = 56) induction at different percentages. However, the optimal protocol that gave a moderately high hatchability/survival rate and completely induced gynogens was exposure of the eggs to UV irradiation at 20 cm for 1 min. It was concluded that the distance and duration of UV irradiation affects gynogenetic induction in African catfish C. gariepinus.
Published: 2021
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13. Predictors of institutional delivery service utilization among women of reproductive age in Senegal: a population-based study

Author: Dina Idriss-Wheelr, Sanni Yaya, Betregiorgis Zegeye, Bright Opoku Ahinkorah, Olanrewaju Oladimeji, and Comfort Z. Olorunsaiye
Subjects: medicine.medical_specialty, Global health, 1117 Public Health and Health Services, 03 medical and health sciences, 0302 clinical medicine, Health facility, Reproductive age, Childbirth, Medicine, Women, 030212 general & internal medicine, Social determinants of health, Institutional delivery, Socioeconomic status, Health policy, 030219 obstetrics & reproductive medicine, Sub-Saharan Africa, business.industry, Research, Public health, lcsh:Public aspects of medicine, Public Health, Environmental and Occupational Health, Health services research, lcsh:RA1-1270, medicine.disease, Senegal, Maternal death, Public Health, Maternal health, business, Demography
Abstract: BackgroundIn Senegal, sub-Saharan Africa, many women continue to die from pregnancy and childbirth complications. Even though health facility delivery is a key intervention to reducing maternal death, utilization is low. There is a dearth of evidence on determinants of health facility delivery in Senegal. Therefore, this study investigated the predictors of health facility-based delivery utilization in Senegal.MethodsData from the 2017 Senegal Continuous Survey were extracted for this study, and approximately 11,487 ever-married women aged 15–49 years participated. Chi-square test was used to select significant variables and multivariable logistic regression analysis was performed to identify statistically significant predictors at a 95% confidence interval with a 0.05p-value using Stata version 14 software.ResultsFacility-based delivery utilization was 77.7% and the main predictors were maternal educational status (primary school Adjusted Odds Ratio [aOR] = 1.44, 95% CI; 1.14–1.83; secondary school aOR = 1.62, 95% CI; 1.17–2.25), husband’s educational status (primary school aOR = 1.65, 95% CI; 1.24–2.20, secondary school aOR = 2.17, 95% CI; 1.52–3.10), maternal occupation (agricultural-self-employed aOR = 0.77, 95% CI; 0.62–0.96), ethnicity (Poular aOR = 0.74, 95% CI; 0.56–0.97), place of residence (rural aOR = 0.57, 95% CI; 0.43, 0.74), media exposure (yes aOR = 1.26, 95% CI; 1.02–1.57), economic status (richest aOR = 5.27, 95% CI; 2.85–9.73), parity (seven and above aOR =0.46, 95% CI; 0.34–0.62), wife beating attitude (refuse aOR =1.23, 95% CI; 1.05–1.44) and skilled antenatal care (ANC) (yes aOR = 4.34, 95% CI; 3.10–6.08).ConclusionUptake of health facility delivery services was seen among women who were educated, exposed to media, wealthy, against wife-beating, attended ANC by skilled attendants and had educated husbands. On the other hand, women from ethnic groups like Poular, those working in agricultural activities, living in rural setting, and those who had more delivery history were less likely to deliver at a health facility. Therefore, there is the need to empower women by encouraging them to use skilled ANC services in order for them to gain the requisite knowledge they need to enhance their utilization of health facility delivery, whiles at the same time, removing socio-economic barriers to access to health facility delivery that occur from low education, poverty and rural dwelling.
Published: 2021

14. Randomized control trial of oral arginine therapy for children with sickle cell anemia hospitalized for pain in <scp>Nigeria</scp>

Author: Peter A. Cooper, Oniyangi O Oluseyi, Alice U Ayodele-Kehinde, Barend Christiaan Vorster, Nnebe-Agumadu Uche, Claudia R. Morris, Antoinette Cilliers, Victoria D Onalo, Oladimeji M Damilare, Janet Figueroa, Richard Onalo, and Yunusa Zubairu
Subjects: Male, medicine.medical_specialty, Adolescent, Arginine, Analgesic, Administration, Oral, Nigeria, Placebo, law.invention, 03 medical and health sciences, 0302 clinical medicine, Double-Blind Method, Randomized controlled trial, law, Internal medicine, Acute Chest Syndrome, medicine, Humans, Prospective Studies, Child, Adverse effect, Prospective cohort study, business.industry, Hematology, Length of Stay, medicine.disease, Sickle cell anemia, Clinical trial, Child, Preschool, 030220 oncology & carcinogenesis, Female, business, 030215 immunology
Abstract: Low arginine bioavailability is associated with vaso-occlusive painful crisis (VOC) severity in sickle cell anemia (SCA) and predicts need for pediatric hospitalization. Intravenous arginine therapy has opioid-sparing effects and was found to significantly decrease pain scores in children hospitalized with SCA-VOC in a phase-two randomized placebo-controlled trial (RCT). Efficacy of oral arginine is unknown. Our objective was to determine the safety and efficacy of oral arginine therapy in Nigerian children with SCA. A double-blind RCT of oral L-arginine-hydrochloride (100 mg/kg TID) was conducted in children with SCA-VOC, aged 5-17 years, hospitalized at two Nigerian sites. The primary outcome measure was analgesic usage, quantified by difference in the mean Analgesic Medication Quantification Scale (MQS). Secondary outcomes included daily pain scores, time-to-crisis-resolution and length-of-hospital-stay. An intention-to-treat analysis was performed. Sixty-eight children (age 5-17 years, mean 10.6 ± 0.4 years; 56% male), were randomized to receive L-arginine (35 patients) or placebo (33 patients). The mean total MQS for the arginine group was 73.4 (95% CI, 62.4-84.3) vs 120.0 (96.7-143.3) for placebo (P < .001). The mean rate of decline in worst pain scores was faster in the arginine arm vs placebo (1.50 [1.23-1.77] vs 1.09 [0.94-1.24] point/d, P = .009). Children receiving arginine had a shorter time-to-crisis-resolution (P = .02), shorter hospital-stay (P = .002) and experienced no serious adverse event. Pain control was more rapid, total analgesic requirement was significantly reduced, and most notably, time-to-crisis-resolution and length-of-hospital-stay were shorter in children with SCA-VOC receiving arginine vs placebo. Given the established safety and low cost, oral arginine is a promising adjuvant therapy for SCA-VOC management.
Published: 2020
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15. Knowledge and Prevalence of Heart Disease Risk Factors Among Staff of a Tertiary Institution in Nigeria

Author: Ebenezer Adekunle Ajayi, O. D Ojo, J.A. Ogunmodede, David Daisi Ajayi, Oladimeji Akande Ajayi, Bolade Folashade Dele-Ojo, TH Raimi, Samuel Ayokunle Dada, and Joseph O Fadare
Subjects: Adult, Male, Health Knowledge, Attitudes, Practice, medicine.medical_specialty, Health (social science), Alcohol Drinking, Universities, Heart disease, Cardiovascular risk factors, Nigeria, Disease, 030204 cardiovascular system & hematology, Education, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Diabetes Mellitus, Prevalence, medicine, Humans, 030212 general & internal medicine, Intensive care medicine, Heart disease risk, business.industry, Smoking, Public Health, Environmental and Occupational Health, Tertiary institution, General Medicine, Middle Aged, medicine.disease, Cross-Sectional Studies, Cardiovascular Diseases, Heart Disease Risk Factors, Obesity, Abdominal, Hypertension, Female, business
Abstract: Background Cardiovascular disease is the most common cause of mortality worldwide. Hence, awareness of cardiovascular risk factors is an essential step towards effective reduction of the disease burden. This study determined the knowledge and prevalence of cardiovascular risk factors among Staff of Ekiti State University. Ado-Ekiti, Nigeria. Methods A cross-sectional study which comprised of 223 members of staff. Results There were 103 males (46.2%). Low knowledge of heart disease risk factors was found in 68.6% of the respondents. The prevalence of hypertension, diabetes mellitus, overweight, obesity, physical inactivity was 35.4%, 12.1%, 31.8%, 23.3%, and 83% respectively. Family history of hypertension was a predictor of a high level of knowledge. Conclusion A low level of knowledge and increasing prevalence of cardiovascular risk factors existed among staff of Ekiti State University, Nigeria. Hence, there should be a step-up of awareness campaigns and promotion of healthy lifestyle among this category of people.
Published: 2020
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16. HPLC techniques for phytochemistry

Author: MF Valan and Ashaolu Victoria Oladimeji
Subjects: 010404 medicinal & biomolecular chemistry, 03 medical and health sciences, 0302 clinical medicine, Phytochemistry, Qualitative analysis, Phytochemical, Computer science, 030220 oncology & carcinogenesis, Plant species, Biochemical engineering, 01 natural sciences, 0104 chemical sciences, Plant Sources
Abstract: There are some drawbacks to existing methods in use for plant content estimation, including large quantities of solvents and long study time. For thousands of years, nature has been a source of therapeutic agents, and an impressive number of modern medicines have been isolated from natural plant sources. Phytochemicals are referred to as the biologically active compounds found in plants. In the cure and treatment of various diseases, these phytochemicals play a major role. It is necessary to have the means available to carry out a characterization of the crude extract to gain access to the therapeutic benefits of these plant species. As a key response to the challenge of detection, characterization and purification of compounds, this paper examines the advances in the high-pressure liquid chromatographic process. This paper focuses on HPLC, an important qualitative and quantitative technique that is commonly used for pharmaceutical and biological sample estimation.
Published: 2020
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17. Nanomedicines for Subcellular Targeting: The Mitochondrial Perspective

Author: Olakunle Oladimeji, Moganavelli Singh, and Jude Akinyelu
Subjects: Pharmacology, 0303 health sciences, business.industry, Organic Chemistry, Drug administration, 02 engineering and technology, Computational biology, 021001 nanoscience & nanotechnology, Biochemistry, Mitochondria, 03 medical and health sciences, Drug Delivery Systems, Nanomedicine, Therapeutic index, Neoplasms, Drug Discovery, Tumor Microenvironment, Humans, Nanoparticles, Molecular Medicine, Medicine, Nanocarriers, 0210 nano-technology, business, 030304 developmental biology
Abstract: Background: Over the past decade, there has been a surge in the number of mitochondrialactive therapeutics for conditions ranging from cancer to aging. Subcellular targeting interventions can modulate adverse intracellular processes unique to the compartments within the cell. However, there is a dearth of reviews focusing on mitochondrial nano-delivery, and this review seeks to fill this gap with regards to nanotherapeutics of the mitochondria. Methods: Besides its potential for a higher therapeutic index than targeting at the tissue and cell levels, subcellular targeting takes into account the limitations of systemic drug administration and significantly improves pharmacokinetics. Hence, an extensive literature review was undertaken and salient information was compiled in this review. Results: From literature, it was evident that nanoparticles with their tunable physicochemical properties have shown potential for efficient therapeutic delivery, with several nanomedicines already approved by the FDA and others in clinical trials. However, strategies for the development of nanomedicines for subcellular targeting are still emerging, with an increased understanding of dysfunctional molecular processes advancing the development of treatment modules. For optimal delivery, the design of an ideal carrier for subcellular delivery must consider the features of the diseased microenvironment. The functional and structural features of the mitochondria in the diseased state are highlighted and potential nano-delivery interventions for treatment and diagnosis are discussed. Conclusion: This review provides an insight into recent advances in subcellular targeting, with a focus on en route barriers to subcellular targeting. The impact of mitochondrial dysfunction in the aetiology of certain diseases is highlighted, and potential therapeutic sites are identified.
Published: 2020
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18. Evaluating the Relationship between Duty Hours and Quality of Life of Nigerian Early Career Doctors

Author: Olayinka Stephen Ilesanmi, R.N. Babalola, KA Durowade, Abimbola Amoo, M.C. Igbokwe, Olusegun Olaopa, Aliyu Sokomba, Oladimeji Adebayo, Olayinka Atilola, and Oluwaseyi Ogunsuji
Subjects: Adult, Male, Gerontology, Time Factors, genetic structures, Duty hours, Nigeria, Workload, 03 medical and health sciences, 0302 clinical medicine, Quality of life, Physicians, Surveys and Questionnaires, medicine, Humans, Attrition, 030212 general & internal medicine, Early career, Potential impact, business.industry, 030503 health policy & services, Shift Work Schedule, Brain drain, General Medicine, Middle Aged, medicine.disease, Mental health, humanities, Workforce, Quality of Life, Female, 0305 other medical science, business
Abstract: This study explored association between early career doctors (ECDs) duty hours and their quality of life (QoL). Information was collected on socio-demographics, duty hours and QoL of 391 Nigerian ECDs. Results showed median of 70 duty-hours weekly, 10 call-days monthly and 6 sleep-hours daily. Weekly duty-hours and daily sleep-hours were significantly negatively and positively correlated respectively with all four domains of WHOQoL. QoL potentially affects health of ECDs especially mental health. Policies targeted at improving ECDs workforce, working conditions should improve QoL and curtail the potential impact of brain drain and attrition among ECDs in Nigeria.
Published: 2020
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19. Conflict and Conflict Resolutions Experienced by Early Career Doctors in the Nigerian Health Sector: a Qualitative Report

Author: Ibiyemi Oduyemi, Sebastine Oiwoh, Aliyu Sokomba, Oluwaseyi Ogunsuji, Makinde Adebayo Adeniyi, KA Durowade, Olusegun Olaopa, Iyanu Adufe, Elizabeth O. Grillo, Oluwafemi Efuntoye, and Oladimeji Adebayo
Subjects: 03 medical and health sciences, Medical education, 0302 clinical medicine, business.industry, Health care, 030212 general & internal medicine, 030206 dentistry, Early career, business, Business management, Health sector
Abstract: Background. Conflicts across professional workgroup and hierarchies inundate the clinical workplace. Early Career Doctors (ECDs) are also affected either as victims or as a provocateur/perpetrator. The effects of conflict at their workplaces have both significant positive and negative dimensions and impacts on ECDs. Little has been reported about conflict among ECDs in Nigeria. Thus, this study explored the issue of conflict and conflict resolution among ECDs in Nigeria, in a bid to elicit information on the causes, consequences, perpetrators and victims. Method. This was a qualitative study, using Focus Group Discussions (FGD) to explore information on conflict and conflict management among purposively selected key respondents (n = 14) from seven tertiary hospitals in Nigeria. The respondents are ECDs who were leaders and representatives of other ECDs in their various hospitals. Two FGDs were conducted. Results. The result showed that conflict is inescapable in clinical settings and occurred at different levels. The perpetrators are varieties of health workers, and most are task-related conflicts, although there are relational ones. The conflicts with the government on labour-related issues are also frequent. The lack of job description and specification and power struggle among others were highlighted as the drivers of conflicts between ECDs and other health-workers. Conclusion. The findings of the study were discussed, and suggestions were made to reduce its effect, which would require structural solutions to mitigate at different levels and the diverse players in the health sectors.
Published: 2020
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20. Environmental effects on the oxygen consumption rate in juvenile Epinephelus fuscoguttatus (Forsskal, 1775)

Author: Chukwuemeka Onwuka Martins, Ambok Bolong Abol-Munafi, Mhd Ikhwanuddin, Anil Chatterji, A. Hassan, S. Mithun, K.I. Alabi, M. A. W. Effendy, Victor Tosin Okomoda, and A.S. Oladimeji
Subjects: Salinity, Time Factors, Physiology, Acclimatization, Photoperiod, chemistry.chemical_element, Aquaculture, Environment, Aquatic Science, Biochemistry, Oxygen, 03 medical and health sciences, chemistry.chemical_compound, Oxygen Consumption, Animal science, Respiration, Animals, Urea, Juvenile, Seawater, 030304 developmental biology, photoperiodism, Analysis of Variance, 0303 health sciences, Epinephelus fuscoguttatus, biology, Malaysia, Temperature, 04 agricultural and veterinary sciences, General Medicine, Hydrogen-Ion Concentration, biology.organism_classification, chemistry, FISH EXPOSURE, 040102 fisheries, 0401 agriculture, forestry, and fisheries, Bass
Abstract: This study was designed to optimize the culture conditions of juvenile Epinephelus fuscoguttatus (Forsskål, 1775) under laboratory conditions. To this effect, the rate of oxygen consumption was monitored as an index of stress under different temperature, salinity, pH, photoperiod, and urea concentrations. The result obtained after 12 h of exposure suggests the preference of the juvenile E. fuscoguttatus to a temperature range of 15-25 °C and salinity of 30 ppt. Based on this study, temperature was found to be the most lethal as 100% mortality was observed after 6 h in fish exposure to temperatures above the optimal (≥ 30 °C). However, the oxygen consumption rate was similar under the different pH, photoperiod, and urea concentration tested. It was concluded that water temperature was most critical in terms of respiration physiology of the juvenile E. fuscoguttatus given the range and levels of environmental factors tested in this study.
Published: 2020
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21. Strategies for mitigating burnout among early career doctors in Nigeria: lessons learnt from the qualitative CHARTING study

Author: Ibiyemi Oduyemi, Ayanfe Omololu, R.N. Babalola, Omotayo Francis Fagbule, Abimbola Amoo, M.C. Igbokwe, Oladimeji Adebayo, Oluwaseyi Ogunsuji, Iyanu Adufe, Dabota Yvonne Buowari, Adeniyi Makinde Adebayo, Olusegun Olaopa, Yahya Abdulmajid Ibrahim, Sebastine Oiwoh, Ifeanyichukwu Kelvin Egbuchulem, Elizabeth O. Grillo, Kehinde Kazeem Kanmodi, and Wasinda Francis Umar
Subjects: 03 medical and health sciences, Medical education, 0302 clinical medicine, 0502 economics and business, 05 social sciences, 030212 general & internal medicine, Early career, Burnout, 050203 business & management
Abstract: Background Early career doctors (ECDs) are faced with many challenges due to their transition from undergraduate medical/dental studentship to being postgraduate doctors and being in an early phase of their career. The specific factors that affect ECDs in their careers and endeavors at the workplace range from poor remuneration, particularly in developing countries, to psychosocial problems (such as burnout [BO] syndrome). There is a dearth of information on BO among ECDs in Nigeria. This qualitative study aims to explore the opinions of ECDs in Nigeria on the causal/predisposing factors of BO, effects of BO, and strategies for mitigating BO among ECDs in Nigeria. Method Using purposive sampling method, two sessions of focus group discussions (FGDs) involving 14 ECDs (key informants) holding key leadership positions and who were delegates of other ECDs in Nigeria were conducted to explore their experiences on psychological issues among ECDs. Data collected were transcribed and analyzed thematically. Results BO is an issue of serious concern among ECDs in Nigeria. The causes of BO are diverse, some of which include low staff strength, prolonged work hours, wrong counseling, lack of job description and specification, and abuse of powers by trainers. In order to mitigate the issue of BO among ECDs, the respondents recommended that work policy review, medical workforce strengthening, stakeholder dialog on ECDs’ welfare, regular psychological review of ECDs, and provision of free yearly medicals need to be looked into. Conclusion: Our findings revealed that the participants considered BO issues among ECDs to be common, and it affected their performance and the overall quality of care in Nigeria health system. Based on our findings, there is an urgent need to mitigate the problem of emotional exhaustion among ECDs in Nigeria.
Published: 2020
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22. An Evaluation of the Effects of Pyridoxal Phosphate in Chlorpromazineinduced Parkinsonism using Mice

Author: Samad Oladimeji, Covenant I Balogun, Adejoke Y. Onaolapo, Anthony Tope Olofinnade, Adetunji M Fatoki, Olakunle J. Onaolapo, and Tolulope M Onaolapo
Subjects: medicine.medical_specialty, Chlorpromazine, medicine.medical_treatment, Motor Activity, Catalepsy, 01 natural sciences, Antioxidants, Antiparkinson Agents, Levodopa, Eating, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Dopamine, Internal medicine, medicine, Animals, Parkinson Disease, Secondary, Pyridoxal phosphate, Saline, Pyridoxal, Behavior, Animal, 010405 organic chemistry, business.industry, General Neuroscience, Parkinsonism, Body Weight, Carbidopa, medicine.disease, Micronutrient, Grooming, Diet, 0104 chemical sciences, Drug Combinations, Neuropsychology and Physiological Psychology, Endocrinology, chemistry, Pyridoxal Phosphate, Molecular Medicine, Lipid Peroxidation, business, 030217 neurology & neurosurgery, Antipsychotic Agents, medicine.drug
Abstract: Background: Parkinsonism is a neurodegenerative disorder with a heavy disease burden, despite the discovery and application of drugs. Current research is beginning to suggest the possible crucial roles of micronutrients such as pyridoxal phosphate in the prevention or management of neurodegenerative disorders. Objectives: We investigated the possible protective effects of supplemental pyridoxal phosphate in Chlorpromazine (CPZ)-induced Parkinsonism-like changes in mice. Methods: Mice were assigned to eight groups of 30 mice each. Groups included Vehicle control (fed standard diet (SD), and administered intraperitoneal ip injection of saline and saline per orem), levodopa-carbidopa (LD) group (SD, saline ip and LD per orem), two groups fed pyridoxal phosphate-supplemented diet (at 100 and 200 mg/kg of feed), and administered saline both ip and orally, CPZ group (SD, CPZ ip and saline per orem), CPZ/LD group (SD, CPZ ip and LD per orem) and finally two groups fed pyridoxal phosphate -supplemented diet (at 100 and 200 mg/kg of feed) and administered CPZ ip plus saline per orem. Treatments were administered daily for a period of 21 days to allow for the induction of Parkinsonism features. Body weight and food intake were measured weekly while neurobehavioural and biochemical tests were assessed at the end of the experimental period. Results: Pyridoxal phosphate supplementation was associated with a reduction in CPZ-induced suppression of open-field horizontal locomotion and rearing; and a significant increase in grooming activity. Administration of pyridoxal phosphate-supplemented diet was also associated with improvements in working-memory in CPZ-treated mice; and there was reduction in the index of anxiety and catalepsy score. Conclusion: Pyridoxal phosphate supplementation was associated with significant benefits in CPZ-induced Parkinsonism-like changes in mice.
Published: 2020
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23. Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017

Author: Hassan Haghparast Bidgoli, Young Eun Kim, Duduzile Ndwandwe, Marilita M Moschos, Diego De Leo, Mark A. Stokes, Faris Lami, Lorenzo Monasta, Amit Arora, Hamid Asayesh, Dhirendra N Sinha, Ferrán Catalá-López, Ana Maria Nogales Vasconcelos, Swayam Prakash, Rafael Tabarés-Seisdedos, Melkamu Merid Mengesha, Yuichiro Yano, Olalekan A. Uthman, Amir Radfar, Manasi Kumar, Kamarul Imran Musa, Babak Moazen, Spencer L. James, Ahmad Daryani, Achala Upendra Jayatilleke, Siavash Rahimi, Carl Abelardo T. Antonio, Morteza Abdullatif Khafaie, Meysam Behzadifar, Dan J. Stein, Kathryn H. Jacobsen, Jiabin Shen, Rajesh Kumar Rai, Ehimario U. Igumbor, Amir Kasaeian, Ali Kabir, Morteza Shamsizadeh, Ziad El-Khatib, Sharareh Eskandarieh, Sorin Hostiuc, Jarnail Singh Thakur, Takeshi Fukumoto, Shai Linn, João Pedro Silva, Olayinka Stephen Ilesanmi, Gizachew Assefa Tessema, Naohiro Yonemoto, Jacek Jerzy Jozwiak, Masood Ali Shaikh, Seyyed Meysam Mousavi, Syed Mohamed Aljunid, Azeem Majeed, Alexandra Brazinova, Nader Jahanmehr, Yuming Guo, Sonia Saxena, Juanita A. Haagsma, Devasahayam J. Christopher, Lorainne Tudor Car, Shamsa Zafar, Roghayeh Mohammadibakhsh, Khanh Bao Tran, Reza Malekzadeh, Martha Híjar, Addisu Melese, Tinuke O Olagunju, Guoqing Hu, Yousef Khader, Olatunde Aremu, Yahya Salimi, Corina Benjet, Seyed-Mohammad Fereshtehnejad, Julio Cesar Campuzano Rincon, Rizwan Kalani, Bach Xuan Tran, Serge Resnikoff, Félix Carvalho, Suzanne Barker-Collo, Basema Saddik, Abraham Getachew Kelbore, Chris D Castle, Andre Pascal Kengne, Joan B. Soriano, Aliasghar Ahmad Kiadaliri, Derrick A Bennett, Pedro R. Olivares, Ali Bijani, Shanshan Li, Srinivas Murthy, Dragos Virgil Davitoiu, Farid Najafi, Seyed Sina Naghibi Irvani, Maziar Moradi-Lakeh, Adauto Martins Soares Filho, Vasily Vlassov, Alessandra C. Goulart, Alireza Ahmadi, Theo Vos, Heather Orpana, Narayan Bahadur Mahotra, Dillon O Sylte, Tuomo J. Meretoja, Ireneous N. Soyiri, Susan M Sawyer, Nauman Khalid, Louisa Degenhardt, Kebede Embaye Gezae, Ubai Alsharif, Richard C. Franklin, Shane D. Morrison, Randah R. Hamadeh, G. K. Mini, Naznin Hossain, Zachary V Dingels, Kate Dolan, Florian Fischer, Atte Meretoja, Yasir Waheed, Milena M Santric Milicevic, Ai Koyanagi, Sadaf G. Sepanlou, Manisha Dubey, Michael Phillips, Koustuv Dalal, Maysaa El Sayed Zaki, Elena Varavikova, Rahul Gupta, Rajaa Al-Raddadi, Sergey Soshnikov, David Laith Rawaf, Zoubida Zaidi, David C. Schwebel, Hassan Magdy Abd El Razek, Jost B. Jonas, Flávia Ribeiro Machado, Yoshan Moodley, Stefania Mondello, Nicholas L S Roberts, N. Bedi, Amrit Banstola, Yong Zhao, Vladimir I. Starodubov, Beatriz Paulina Ayala Quintanilla, Juan Jesus Carrero, Manzoor Ahmad Malik, George C Patton, André Faro, In-Hwan Oh, Anwar Rafay, Simon I. Hay, Deborah Carvalho Malta, Erin B Hamilton, Man Mohan Mehndiratta, Suliman Alghnam, Olanrewaju Oladimeji, Sojib Bin Zaman, Ratilal Lalloo, Zichen Liu, Mahmood Moosazadeh, Isabela M. Benseñor, Muluken Azage Yenesew, Ivy Shiue, Hilton Lam, Soraya Seedat, Mete Saylan, Eduarda Fernandes, Khalid A Altirkawi, Chuanhua Yu, Jasvinder A. Singh, Pascual R. Valdez, Jan-Walter De Neve, Guilherme Borges, Seth Christopher Yaw Appiah, Linh Phuong Doan, Christopher S. Crowe, Andualem Henok, Carlos A Castañeda-Orjuela, Mina Anjomshoa, Bruno Ramos Nascimento, Paul S. F. Yip, Samath D Dharmaratne, Ayman Grada, Christian Lycke Ellingsen, Zulfiqar A Bhutta, Gurudatta Naik, Shahrzad Bazargan-Hejazi, Tomislav Mestrovic, Long Hoang Nguyen, Karen M. Tabb, Kebede Deribe, Mustafa Z. Younis, Yuan-Pang Wang, Van C. Lansingh, Felix Akpojene Ogbo, Mihajlo Jakovljevic, Till Bärnighausen, Naser Mohammad Gholi Mezerji, Kiana Ramezanzadeh, Muhammed Magdy Abd El Razek, Rasmus Havmoeller, Konrad Pesudovs, Salman Rawaf, Walter Mendoza, Smita Pakhale, Mahesh P A, Ted R. Miller, Rebecca Ivers, Gabrielle deVeber, Pallab K. Maulik, Ali H. Mokdad, Burcu Kucuk Bicer, Andre M. N. Renzaho, Muhammad Aziz Rahman, Fares Alahdab, Vafa Rahimi-Movaghar, Dipan Bose, Alireza Rafiei, Payman Salamati, Engida Yisma, Huong Lan Thi Nguyen, Juan Sanabria, Priyanka Yadav, Andrew T Olagunju, Ejaz Ahmad Khan, Irina Filip, Shahab Rezaeian, Ghobad Moradi, Mohammad Zamani, Rosario Cárdenas, Delia Hendrie, Yogesh Sabde, Marek Majdan, Mariam Molokhia, Adnan Kisa, Jacob E. Sunshine, Narayanaswamy Venketasubramanian, Mahdi Sharif-Alhoseini, Sanjay Zodpey, Ashish Awasthi, Rahman Shiri, Zahra Jorjoran Shushtari, Shivanthi Balalla, Samer Hamidi, Hailemariam Abiy Alemu Meheretu, Raimundas Lunevicius, Suzanne Polinder, Tomasz Miazgowski, Sheikh Mohammed Shariful Islam, Tim Driscoll, Son Hoang Nguyen, Mika Shigematsu, Bryan L. Sykes, Arash Tehrani-Banihashemi, Dina Nur Anggraini Ningrum, Josep Maria Haro, Leonardo Roever, Gholamreza Roshandel, Andrea Sylvia Winkler, Mehran Shams-Beyranvand, Ilais Moreno Velásquez, Luca Ronfani, Arvin Haj-Mirzaian, Arya Haj-Mirzaian, Jee-Young Jasmine Choi, Mohammad Ali Mansournia, Daniel Kim, Maheswar Satpathy, Ionut Negoi, Michael K. Hole, Miloud Taki Eddine Aichour, Erkin M. Mirrakhimov, Barthelemy Kuate Defo, Alan D. Lopez, Masoud Behzadifar, Rohan Borschmann, Ana-Laura Manda, Ione Jayce Ceola Schneider, Lydia R. Lucchesi, Trang Huyen Nguyen, Mu'awiyyah Babale Sufiyan, Janet L Leasher, Shafiu Mohammed, Lidia Morawska, Getenet Dessie, Reza Assadi, Tiffany K. Gill, Francesco Saverio Violante, Monika Sawhney, Enayatollah Homaie Rad, Yirga Legesse Nirayo, Muktar Beshir Ahmed, Oladimeji Adebayo, Mikk Jürisson, Soumyadeep Bhaumik, Hadi Hassankhani, Stanislav S. Otstavnov, Aziz Sheikh, Benjamin Uzochukwu, Aman Yesuf Endries, Eun-Kee Park, Jack T Fox, Abdallah M. Samy, Richard Ofori-Asenso, Ravi Prakash Jha, Inbal Salz, Benjamin B. 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Subjects: Epidemiology, burden of disease, descriptive epidemiology, epidemiology, ECONOMIC-DEVELOPMENT, 1106 Human Movement and Sports Sciences, Poison control, Global Health, Global Burden of Disease, 0302 clinical medicine, Quality-Adjusted Life Year, Global health, 030212 general & internal medicine, 10. No inequality, 1. No poverty, Burden of disease, DALYS, 3142 Public health care science, environmental and occupational health, ddc, 3. Good health, Descriptive epidemiology, Epidemiological transition, REGISTRATION, Disabled Person, Public Health, Human, medicine.medical_specialty, DEATHS, Adolescent, 1117 Public Health and Health Services, 03 medical and health sciences, Life Expectancy, Injury prevention, SYSTEMATIC ANALYSIS, medicine, Disability-adjusted life year, Disease burden, Estimation, burden of disease, descriptive epidemiology, epidemiology, MORTALITY, Public health, EPIDEMIOLOGIC TRANSITION, Public Health, Environmental and Occupational Health, 030208 emergency & critical care medicine, TRENDS, EXPECTANCY HALE, 1701 Psychology, Wounds and Injuries, Human medicine, Demography
Abstract: Incluye: Correction: Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017. Inj Prev. 2020 Oct;26(Supp 1):i164. doi: 10.1136/injuryprev-2019-043296corr1. Epub 2020 Sep 28. PMID: 32989004 Background: The epidemiological transition of non-communicable diseases replacing infectious diseases as the main contributors to disease burden has been well documented in global health literature. Less focus, however, has been given to the relationship between sociodemographic changes and injury. The aim of this study was to examine the association between disability-adjusted life years (DALYs) from injury for 195 countries and territories at different levels along the development spectrum between 1990 and 2017 based on the Global Burden of Disease (GBD) 2017 estimates. Methods: Injury mortality was estimated using the GBD mortality database, corrections for garbage coding and CODEm-the cause of death ensemble modelling tool. Morbidity estimation was based on surveys and inpatient and outpatient data sets for 30 cause-of-injury with 47 nature-of-injury categories each. The Socio-demographic Index (SDI) is a composite indicator that includes lagged income per capita, average educational attainment over age 15 years and total fertility rate. Results: For many causes of injury, age-standardised DALY rates declined with increasing SDI, although road injury, interpersonal violence and self-harm did not follow this pattern. Particularly for self-harm opposing patterns were observed in regions with similar SDI levels. For road injuries, this effect was less pronounced. Conclusions: The overall global pattern is that of declining injury burden with increasing SDI. However, not all injuries follow this pattern, which suggests multiple underlying mechanisms influencing injury DALYs. There is a need for a detailed understanding of these patterns to help to inform national and global efforts to address injury-related health outcomes across the development spectrum. Funding for GBD 2017 was provided by the Bill and Melinda Gates Foundation. Sí
Published: 2020
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24. Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990-2019: a systematic analysis from the Global Burden of Disease Study 2019

Author: Reitsma, Marissa B., Kendrick, Parkes J., Ababneh, Emad, Abbafati, Cristiana, Abbasi-Kangevari, Mohsen, Abdoli, Amir, Abedi, Aidin, Abhilash, E.S., Abila, Derrick Bary, Aboyans, Victor, Abu-Rmeileh, Niveen M.E., Adebayo, Oladimeji M., Advani, Shailesh M., Aghaali, Mohammad, Ahinkorah, Bright Opoku, Ahmad, Sohail, Ahmadi, Keivan, Ahmed, Haroon, Aji, Budi, Akunna, Chisom Joyqueenet, Al-Aly, Ziyad, Alanzi, Turki M., Alhabib, Khalid F., Ali, Liaqat, Alif, Sheikh Mohammad, Alipour, Vahid, Aljunid, Syed Mohamed, Alla, François, Allebeck, Peter, Alvis-Guzman, Nelson, Amin, Tarek Tawfik, Amini, Saeed, Amu, Hubert, Amul, Gianna Gayle Herrera, Ancuceanu, Robert, Anderson, Jason A., Ansari-Moghaddam, Alireza, Antonio, Carl Abelardo T., Antony, Benny, Anvari, Davood, Arabloo, Jalal, Arian, Nicholas D., Arora, Monika, Asaad, Malke, Ausloos, Marcel, Awan, Asma Tahir, Ayano, Getinet, Aynalem, Getie Lake, Azari, Samad, B, Darshan B., Badiye, Ashish D., Baig, Atif Amin, Bakhshaei, Mohammad Hossein, Banach, Maciej, Banik, Palash Chandra, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barqawi, Hiba Jawdat, Basu, Sanjay, Bayati, Mohsen, Bazargan-Hejazi, Shahrzad, Behzadifar, Masoud, Bekuma, Tariku Tesfaye, Bennett, Derrick A., Bensenor, Isabela M., Berfield, Kathleen S. 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Tovani-Palone, M, Tran, B, Tripathy, J, Tsegaye, G, Tsilimparis, N, Tymeson, H, Ullah, A, Ullah, S, Unim, B, Updike, R, Vacante, M, Valdez, P, Vardavas, C, Varona Pérez, P, Vasankari, T, Venketasubramanian, N, Verma, M, Vetrova, M, Vo, B, Vu, G, Waheed, Y, Wang, Y, Welding, K, Werdecker, A, Whisnant, J, Wickramasinghe, N, Yamagishi, K, Yandrapalli, S, Yatsuya, H, Yazdi-Feyzabadi, V, Yeshaw, Y, Yimmer, M, Yonemoto, N, Yu, C, Yunusa, I, Yusefzadeh, H, Zahirian Moghadam, T, Zaman, M, Zamanian, M, Zandian, H, Zar, H, Zastrozhin, M, Zastrozhina, A, Zavala-Arciniega, L, Zhang, J, Zhang, Z, Zhong, C, Zuniga, Y, and Gakidou, E
Subjects: 030204 cardiovascular system & hematology, 0302 clinical medicine, HV, GBD 2019 Tobacco Collaborators, Prevalence, Global health, Medicine, 030212 general & internal medicine, 610 Medicine & health, 11 Medical and Health Sciences, RISK, Tobacco control, 1. No poverty, Public Health, Global Health, Social Medicine and Epidemiology, General Medicine, Articles, Tobacco smoking, 3142 Public health care science, environmental and occupational health, 3. Good health, A990 Medicine and Dentistry not elsewhere classified, Life Sciences & Biomedicine, HAZARDS, 03 medical and health sciences, Medicine, General & Internal, Environmental health, General & Internal Medicine, Tobacco, Premature Deaths, Population growth, Medicine [Science], Global Burden, Attributable Diseases, Risk factor, Mortality, PROGRESS, Disease burden, Estimation, Science & Technology, business.industry, Smoking Tobacco, MORTALITY, Former Smoker, GOAL, REDUCTION, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, 3121 General medicine, internal medicine and other clinical medicine, PREMATURE DEATHS, business, RA, RC
Abstract: Background Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally. Methods We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk Factors Study. We modelled multiple smoking-related indicators from 3625 nationally representative surveys. We completed systematic reviews and did Bayesian meta-regressions for 36 causally linked health outcomes to estimate non-linear dose-response risk curves for current and former smokers. We used a direct estimation approach to estimate attributable burden, providing more comprehensive estimates of the health effects of smoking than previously available. Findings Globally in 2019, 1·14 billion (95% uncertainty interval 1·13–1·16) individuals were current smokers, who consumed 7·41 trillion (7·11–7·74) cigarette-equivalents of tobacco in 2019. Although prevalence of smoking had decreased significantly since 1990 among both males (27·5% [26·5–28·5] reduction) and females (37·7% [35·4–39·9] reduction) aged 15 years and older, population growth has led to a significant increase in the total number of smokers from 0·99 billion (0·98–1·00) in 1990. Globally in 2019, smoking tobacco use accounted for 7·69 million (7·16–8·20) deaths and 200 million (185–214) disability-adjusted life-years, and was the leading risk factor for death among males (20·2% [19·3–21·1] of male deaths). 6·68 million [86·9%] of 7·69 million deaths attributable to smoking tobacco use were among current smokers. Interpretation In the absence of intervention, the annual toll of 7·69 million deaths and 200 million disability-adjusted life-years attributable to smoking will increase over the coming decades. Substantial progress in reducing the prevalence of smoking tobacco use has been observed in countries from all regions and at all stages of development, but a large implementation gap remains for tobacco control. Countries have a clear and urgent opportunity to pass strong, evidence-based policies to accelerate reductions in the prevalence of smoking and reap massive health benefits for their citizens. Funding Bloomberg Philanthropies and the Bill & Melinda Gates Foundation.
Published: 2021
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25. Subnational mapping of HIV incidence and mortality among individuals aged 15-49 years in sub-Saharan Africa, 2000-18: a modelling study

Author: Sartorius, B., VanderHeide, J.D., Yang, M., Goosmann, E.A., Hon, J., Haeuser, E., Cork, M.A., Perkins, S., Jahagirdar, D., Schaeffer, L.E., Serfes, A.L., LeGrand, K.E., Abbastabar, H., Abebo, Z.H., Abosetugn, A.E., Abu-Gharbieh, E., Accrombessi, M.M.K., Adebayo, O.M., Adegbosin, A.E., Adekanmbi, V., Adetokunboh, O.O., Adeyinka, D.A., Ahinkorah, B.O., Ahmadi, K., Ahmed, M.B., Akalu, Y., Akinyemi, O.O., Akinyemi, R.O., Aklilu, A., Akunna, C.J., Alahdab, F., Al-Aly, Z., Alam, N., Alamneh, A.A., Alanzi, T.M., Alemu, B.W., Alhassan, R.K., Ali, T., Alipour, V., Amini, S., Ancuceanu, R., Ansari, F., Anteneh, Z.A., Anvari, D., Anwer, R., Appiah, S.C.Y., Arabloo, J., Asemahagn, M.A., Asghari Jafarabadi, M., Asmare, W.N., Atnafu, D.D., Atout, M.M.W., Atreya, A., Ausloos, M., Awedew, A.F., Ayala Quintanilla, B.P., Ayanore, M.A., Aynalem, Y.A., Ayza, M.A., Azari, S., Azene, Z.N., Babar, Z.-U.-D., Baig, A.A., Balakrishnan, S., Banach, M., Bärnighausen, T.W., Basu, S., Bayati, M., Bedi, N., Bekuma, T.T., Bezabhe, W.M.M., Bhagavathula, A.S., Bhardwaj, P., Bhattacharyya, K., Bhutta, Z.A., Bibi, S., Bikbov, B., Birhan, T.A., Bitew, Z.W., Bockarie, M.J., Boloor, A., Brady, O.J., Bragazzi, N.L., Briko, A.N., Briko, N.I., Burugina Nagaraja, S., Butt, Z.A., Cárdenas, R., Carvalho, F., Charan, J., Chatterjee, S., Chattu, S.K., Chattu, V.K., Chowdhury, M.A.K., Chu, D.-T., Cook, A.J., Cormier, N.M., Cowden, R.G., Culquichicon, C., Dagnew, B., Dahlawi, S.M.A., Damiani, G., Daneshpajouhnejad, P., Daoud, F., Daryani, A., das Neves, J., Davis Weaver, N., Derbew Molla, M., Deribe, K., Desta, A.A., Deuba, K., Dharmaratne, S.D., Dhungana, G.P., Diaz, D., Djalalinia, S., Doku, P.N., Dubljanin, E., Duko, B., Eagan, A.W., Earl, L., Eaton, J.W., Effiong, A., El Sayed Zaki, M., El Tantawi, M., Elayedath, R., El-Jaafary, S.I., Elsharkawy, A., Eskandarieh, S., Eyawo, O., Ezzikouri, S., Fasanmi, A.O., Fasil, A., Fauk, N.K., Feigin, V.L., Ferede, T.Y., Fernandes, E., Fischer, F., Foigt, N.A., Folayan, M.O., Foroutan, M., Francis, J.M., Fukumoto, T., Gad, M.M., Geberemariyam, B.S., Gebregiorgis, B., Gebremichael, B., Gesesew, H.A., Getacher, L., Ghadiri, K., Ghashghaee, A., Gilani, S.A., Ginindza, T.G., Glagn, M., Golechha, M., Gona, P.N., Gubari, M.I.M., Gugnani, H.C., Guido, D., Guled, R.A., Hall, B.J., Hamidi, S., Handiso, D.W., Hargono, A., Hashi, A., Hassanipour, S., Hassankhani, H., Hayat, K., Herteliu, C., de Hidru, H.D., Holla, R., Hosgood, H.D., Hossain, N., Hosseini, M., Hosseinzadeh, M., Househ, M., Hwang, B.-F., Ibitoye, S.E., Ilesanmi, O.S., Ilic, I.M., Ilic, M.D., Irvani, S.S.N., Iwu, C.C.D., Iwu, C.J., Iyamu, I.O., Jain, V., Jakovljevic, M., Jalilian, F., Jha, R.P., Johnson, K.B., Joshua, V., Joukar, F., Jozwiak, J.J., Kabir, A., Kalankesh, L.R., Kalhor, R., Kamath, A., Kamyari, N., Kanchan, T., Karami Matin, B., Karch, A., Karimi, S.E., Kasa, A.S., Kassahun, G., Kayode, G.A., Kazemi Karyani, A., Keiyoro, P.N., Kelkay, B., Khalid, N., Khan, G., Khan, J., Khan, M.N., Khatab, K., Khazaei, S., Kim, Y.J., Kisa, A., Kisa, S., Kochhar, S., Kopec, J.A., Kosen, S., Koulmane Laxminarayana, S., Koyanagi, A., Krishan, K., Kuate Defo, B., Kugbey, N., Kulkarni, V., Kumar, M., Kumar, N., Kurmi, O.P., Kusuma, D., Kuupiel, D., Kyu, H.H., La Vecchia, C., Lal, D.K., Lam, J.O., Landires, I., Lasrado, S., Lazarus, J.V., Lazzar-Atwood, A., Lee, P.H., Leshargie, C.T., Li, B., Liu, X., Lopukhov, P.D., Amin, H.I.M., Madi, D., Mahasha, P.W., Majeed, A., Maleki, A., Maleki, S., Mamun, A.A., Manafi, N., Mansournia, M.A., Martins-Melo, F.R., Masoumi, S.Z., Mayala, B.K., Meharie, B.G., Meheretu, H.A.A., Meles, H.G., Melku, M., Mendoza, W., Mengesha, E.W., Meretoja, T.J., Mersha, A.M., Mestrovic, T., Miller, T.R., Mirica, A., Mirzaei-Alavijeh, M., Mohamad, O., Mohammad, Y., Mohammadian-Hafshejani, A., Mohammed, J.A., Mohammed, S., Mokdad, A.H., Mokonnon, T., Molokhia, M., Moradi, M., Moradi, Y., Moradzadeh, R., Moraga, P., Mosser, J.F., Munro, S.B., Mustafa, G., Muthupandian, S., Naderi, M., Nagarajan, A.J., Naghavi, M., Naveed, M., Nayak, V.C., Nazari, J., Ndejjo, R., Nepal, S., Netsere, H.B., Ngalesoni, F.N., Nguefack-Tsague, G., Ngunjiri, J.W., Nigatu, Y.T., Nigussie, S.N., Nnaji, C.A., Noubiap, J.J., Nuñez-Samudio, V., Oancea, B., Odukoya, O.O., Ogbo, F.A., Oladimeji, O., Olagunju, A.T., Olusanya, B.O., Olusanya, J.O., Omer, M.O., Omonisi, A.E.E., Onwujekwe, O.E., Orisakwe, O.E., Otstavnov, N., Owolabi, M.O., Mahesh, P.A., Padubidri, J.R., Pakhale, S., Pana, A., Pandi-Perumal, S.R., Patel, U.K., Pathak, M., Patton, G.C., Pawar, S., Peprah, E.K., Pokhrel, K.N., Postma, M.J., Pottoo, F.H., Pourjafar, H., Pribadi, D.R.A., Quazi Syed, Z., Rafiei, A., Rahim, F., Rahman, M.H.U., Rahmani, A.M., Ram, P., Rana, J., Ranabhat, C.L., Rao, S., Rao, S.J., Rathi, P., Rawaf, D.L., Rawaf, S., Rawassizadeh, R., Renjith, V., Reta, M.A., Rezaei, N., Rezapour, A., Ribeiro, A.I., Ross, J.M., Rumisha, S.F., Sagar, R., Sahu, M., Sajadi, S.M., Salem, M.R., Samy, A.M., Sathian, B., Schutte, A.E., Seidu, A.-A., Sha, F., Shafaat, O., Shahbaz, M., Shaikh, M.A., Shaka, M.F., Sheikh, A., Shibuya, K., Shin, J.I., Shivakumar, K.M., Sidemo, N.B., Singh, J.A., Skryabin, V.Y., Skryabina, A.A., Soheili, A., Soltani, S., Somefun, O.D., Sorrie, M.B., Spurlock, E.E., Sufiyan, M.B., Taddele, B.W., Tadesse, E.G., Tamir, Z., Tamiru, A.T., Tanser, F.C., Taveira, N., Tehrani-Banihashemi, A., Tekalegn, Y., Tesfay, F.H., Tessema, B., Tessema, Z.T., Thakur, B., Tolani, M.A., Topor-Madry, R., Torrado, M., Tovani-Palone, M.R., Traini, E., Tsai, A.C., Tsegaye, G.W., Ullah, I., Ullah, S., Umeokonkwo, C.D., Unnikrishnan, B., Vardavas, C., Violante, F.S., Vo, B., Wado, Y.D., Waheed, Y., Wamai, R.G., Wang, Y., Ward, P., Werdecker, A., Wickramasinghe, N.D., Wijeratne, T., Wiysonge, C.S., Wondmeneh, T.G., Yamada, T., Yaya, S., Yeshaw, Y., Yeshitila, Y.G., Yilma, M.T., Yip, P., Yonemoto, N., Yosef, T., Yusefzadeh, H., Zaidi, S.S., Zaki, L., Zamanian, M., Zastrozhin, M.S., Zastrozhina, A., Zewdie, D.T., Zhang, Y., Zhang, Z.-J., Ziapour, A., Hay, S.I., Dwyer-Lindgren, L., LBD HIV Incidence Mortality Collaborators, Instituto de Saúde Pública da Universidade do Porto, Khatab, Khaled, Sartorius B., VanderHeide J.D., Yang M., Goosmann E.A., Hon J., Haeuser E., Cork M.A., Perkins S., Jahagirdar D., Schaeffer L.E., Serfes A.L., LeGrand K.E., Abbastabar H., Abebo Z.H., Abosetugn A.E., Abu-Gharbieh E., Accrombessi M.M.K., Adebayo O.M., Adegbosin A.E., Adekanmbi V., Adetokunboh O.O., Adeyinka D.A., Ahinkorah B.O., Ahmadi K., Ahmed M.B., Akalu Y., Akinyemi O.O., Akinyemi R.O., Aklilu A., Akunna C.J., Alahdab F., Al-Aly Z., Alam N., Alamneh A.A., Alanzi T.M., Alemu B.W., Alhassan R.K., Ali T., Alipour V., Amini S., Ancuceanu R., Ansari F., Anteneh Z.A., Anvari D., Anwer R., Appiah S.C.Y., Arabloo J., Asemahagn M.A., Asghari Jafarabadi M., Asmare W.N., Atnafu D.D., Atout M.M.W., Atreya A., Ausloos M., Awedew A.F., Ayala Quintanilla B.P., Ayanore M.A., Aynalem Y.A., Ayza M.A., Azari S., Azene Z.N., Babar Z.-U.-D., Baig A.A., Balakrishnan S., Banach M., Barnighausen T.W., Basu S., Bayati M., Bedi N., Bekuma T.T., Bezabhe W.M.M., Bhagavathula A.S., Bhardwaj P., Bhattacharyya K., Bhutta Z.A., Bibi S., Bikbov B., Birhan T.A., Bitew Z.W., Bockarie M.J., Boloor A., Brady O.J., Bragazzi N.L., Briko A.N., Briko N.I., Burugina Nagaraja S., Butt Z.A., Cardenas R., Carvalho F., Charan J., Chatterjee S., Chattu S.K., Chattu V.K., Chowdhury M.A.K., Chu D.-T., Cook A.J., Cormier N.M., Cowden R.G., Culquichicon C., Dagnew B., Dahlawi S.M.A., Damiani G., Daneshpajouhnejad P., Daoud F., Daryani A., das Neves J., Davis Weaver N., Derbew Molla M., Deribe K., Desta A.A., Deuba K., Dharmaratne S.D., Dhungana G.P., Diaz D., Djalalinia S., Doku P.N., Dubljanin E., Duko B., Eagan A.W., Earl L., Eaton J.W., Effiong A., El Sayed Zaki M., El Tantawi M., Elayedath R., El-Jaafary S.I., Elsharkawy A., Eskandarieh S., Eyawo O., Ezzikouri S., Fasanmi A.O., Fasil A., Fauk N.K., Feigin V.L., Ferede T.Y., Fernandes E., Fischer F., Foigt N.A., Folayan M.O., Foroutan M., Francis J.M., Fukumoto T., Gad M.M., Geberemariyam B.S., Gebregiorgis B., Gebremichael B., Gesesew H.A., Getacher L., Ghadiri K., Ghashghaee A., Gilani S.A., Ginindza T.G., Glagn M., Golechha M., Gona P.N., Gubari M.I.M., Gugnani H.C., Guido D., Guled R.A., Hall B.J., Hamidi S., Handiso D.W., Hargono A., Hashi A., Hassanipour S., Hassankhani H., Hayat K., Herteliu C., de Hidru H.D., Holla R., Hosgood H.D., Hossain N., Hosseini M., Hosseinzadeh M., Househ M., Hwang B.-F., Ibitoye S.E., Ilesanmi O.S., Ilic I.M., Ilic M.D., Irvani S.S.N., Iwu C.C.D., Iwu C.J., Iyamu I.O., Jain V., Jakovljevic M., Jalilian F., Jha R.P., Johnson K.B., Joshua V., Joukar F., Jozwiak J.J., Kabir A., Kalankesh L.R., Kalhor R., Kamath A., Kamyari N., Kanchan T., Karami Matin B., Karch A., Karimi S.E., Kasa A.S., Kassahun G., Kayode G.A., Kazemi Karyani A., Keiyoro P.N., Kelkay B., Khalid N., Khan G., Khan J., Khan M.N., Khatab K., Khazaei S., Kim Y.J., Kisa A., Kisa S., Kochhar S., Kopec J.A., Kosen S., Koulmane Laxminarayana S., Koyanagi A., Krishan K., Kuate Defo B., Kugbey N., Kulkarni V., Kumar M., Kumar N., Kurmi O.P., Kusuma D., Kuupiel D., Kyu H.H., La Vecchia C., Lal D.K., Lam J.O., Landires I., Lasrado S., Lazarus J.V., Lazzar-Atwood A., Lee P.H., Leshargie C.T., Li B., Liu X., Lopukhov P.D., Amin H.I.M., Madi D., Mahasha P.W., Majeed A., Maleki A., Maleki S., Mamun A.A., Manafi N., Mansournia M.A., Martins-Melo F.R., Masoumi S.Z., Mayala B.K., Meharie B.G., Meheretu H.A.A., Meles H.G., Melku M., Mendoza W., Mengesha E.W., Meretoja T.J., Mersha A.M., Mestrovic T., Miller T.R., Mirica A., Mirzaei-Alavijeh M., Mohamad O., Mohammad Y., Mohammadian-Hafshejani A., Mohammed J.A., Mohammed S., Mokdad A.H., Mokonnon T., Molokhia M., Moradi M., Moradi Y., Moradzadeh R., Moraga P., Mosser J.F., Munro S.B., Mustafa G., Muthupandian S., Naderi M., Nagarajan A.J., Naghavi M., Naveed M., Nayak V.C., Nazari J., Ndejjo R., Nepal S., Netsere H.B., Ngalesoni F.N., Nguefack-Tsague G., Ngunjiri J.W., Nigatu Y.T., Nigussie S.N., Nnaji C.A., Noubiap J.J., Nunez-Samudio V., Oancea B., Odukoya O.O., Ogbo F.A., Oladimeji O., Olagunju A.T., Olusanya B.O., Olusanya J.O., Omer M.O., Omonisi A.E.E., Onwujekwe O.E., Orisakwe O.E., Otstavnov N., Owolabi M.O., Mahesh P.A., Padubidri J.R., Pakhale S., Pana A., Pandi-Perumal S.R., Patel U.K., Pathak M., Patton G.C., Pawar S., Peprah E.K., Pokhrel K.N., Postma M.J., Pottoo F.H., Pourjafar H., Pribadi D.R.A., Quazi Syed Z., Rafiei A., Rahim F., Rahman M.H.U., Rahmani A.M., Ram P., Rana J., Ranabhat C.L., Rao S., Rao S.J., Rathi P., Rawaf D.L., Rawaf S., Rawassizadeh R., Renjith V., Reta M.A., Rezaei N., Rezapour A., Ribeiro A.I., Ross J.M., Rumisha S.F., Sagar R., Sahu M., Sajadi S.M., Salem M.R., Samy A.M., Sathian B., Schutte A.E., Seidu A.-A., Sha F., Shafaat O., Shahbaz M., Shaikh M.A., Shaka M.F., Sheikh A., Shibuya K., Shin J.I., Shivakumar K.M., Sidemo N.B., Singh J.A., Skryabin V.Y., Skryabina A.A., Soheili A., Soltani S., Somefun O.D., Sorrie M.B., Spurlock E.E., Sufiyan M.B., Taddele B.W., Tadesse E.G., Tamir Z., Tamiru A.T., Tanser F.C., Taveira N., Tehrani-Banihashemi A., Tekalegn Y., Tesfay F.H., Tessema B., Tessema Z.T., Thakur B., Tolani M.A., Topor-Madry R., Torrado M., Tovani-Palone M.R., Traini E., Tsai A.C., Tsegaye G.W., Ullah I., Ullah S., Umeokonkwo C.D., Unnikrishnan B., Vardavas C., Violante F.S., Vo B., Wado Y.D., Waheed Y., Wamai R.G., Wang Y., Ward P., Werdecker A., Wickramasinghe N.D., Wijeratne T., Wiysonge C.S., Wondmeneh T.G., Yamada T., Yaya S., Yeshaw Y., Yeshitila Y.G., Yilma M.T., Yip P., Yonemoto N., Yosef T., Yusefzadeh H., Zaidi S.S., Zaki L., Zamanian M., Zastrozhin M.S., Zastrozhina A., Zewdie D.T., Zhang Y., Zhang Z.-J., Ziapour A., Hay S.I., Dwyer-Lindgren L., Local Burden of Disease HIV Collaborators, Duko, Bereket, Yeshaw, Yigizie, Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Value, Affordability and Sustainability (VALUE), Microbes in Health and Disease (MHD), Bill & Melinda Gates Foundation, HUS Comprehensive Cancer Center, and Clinicum
Subjects: 0301 basic medicine, sub-Saharan Africa, Male, HIV Antibodie, Epidemiology, HIV incidences, HIV Infections, mortality rate, HIV Antibodies, Modelling study, Human immunodeficiency virus prevalence, 0302 clinical medicine, Africa, Northern, RA0421, Seroepidemiologic Studies, Medicine, Northern, HIV Infection, 030212 general & internal medicine, Young adult, 10. No inequality, uncertainty, Mozambique, 11 Medical and Health Sciences, HIV mortality, Mortality rate, Incidence (epidemiology), Incidence, 1. No poverty, Hiv incidence, article, Mauritania, Human immunodeficiency virus infected patient, Articles, tracking, Middle Aged, health care planning, 3. Good health, Lesotho, AIDS, Infectious Diseases, QR180, A990 Medicine and Dentistry not elsewhere classified, Female, prenatal care, anti human immunodeficiency virus agent, seroepidemiology, Human, Adult, Adolescent, Anti-HIV Agents, Immunology, antiretroviral therapy, Unit (housing), 03 medical and health sciences, Young Adult, blood, Human immunodeficiency virus infection, Virology, Seroprevalence, Humans, human, Developing Countries, Estimation, Acquired Immunodeficiency Syndrome, Subnational mappings, business.industry, Seroepidemiologic Studie, HIV, Anti-HIV Agent, PREVENTION, 030112 virology, mortality, monitoring, 3121 General medicine, internal medicine and other clinical medicine, Human immunodeficiency virus antibody, Africa, business, HIV incidence, Subnational mapping, Sub-Saharan Africa, Local burden of disease, Public health, Demography
Abstract: Background. High-resolution estimates of HIV burden across space and time provide an important tool for tracking and monitoring the progress of prevention and control efforts and assist with improving the precision and efficiency of targeting efforts. We aimed to assess HIV incidence and HIV mortality for all second-level administrative units across sub-Saharan Africa. Methods. In this modelling study, we developed a framework that used the geographically specific HIV prevalence data collected in seroprevalence surveys and antenatal care clinics to train a model that estimates HIV incidence and mortality among individuals aged 15–49 years. We used a model-based geostatistical framework to estimate HIV prevalence at the second administrative level in 44 countries in sub-Saharan Africa for 2000–18 and sought data on the number of individuals on antiretroviral therapy (ART) by second-level administrative unit. We then modified the Estimation and Projection Package (EPP) to use these HIV prevalence and treatment estimates to estimate HIV incidence and mortality by second-level administrative unit. Findings. The estimates suggest substantial variation in HIV incidence and mortality rates both between and within countries in sub-Saharan Africa, with 15 countries having a ten-times or greater difference in estimated HIV incidence between the second-level administrative units with the lowest and highest estimated incidence levels. Across all 44 countries in 2018, HIV incidence ranged from 2·8 (95% uncertainty interval 2·1–3·8) in Mauritania to 1585·9 (1369·4–1824·8) cases per 100 000 people in Lesotho and HIV mortality ranged from 0·8 (0·7–0·9) in Mauritania to 676·5 (513·6–888·0) deaths per 100 000 people in Lesotho. Variation in both incidence and mortality was substantially greater at the subnational level than at the national level and the highest estimated rates were accordingly higher. Among second-level administrative units, Guijá District, Gaza Province, Mozambique, had the highest estimated HIV incidence (4661·7 [2544·8–8120·3]) cases per 100 000 people in 2018 and Inhassunge District, Zambezia Province, Mozambique, had the highest estimated HIV mortality rate (1163·0 [679·0–1866·8]) deaths per 100 000 people. Further, the rate of reduction in HIV incidence and mortality from 2000 to 2018, as well as the ratio of new infections to the number of people living with HIV was highly variable. Although most second-level administrative units had declines in the number of new cases (3316 [81·1%] of 4087 units) and number of deaths (3325 [81·4%]), nearly all appeared well short of the targeted 75% reduction in new cases and deaths between 2010 and 2020. Interpretation. Our estimates suggest that most second-level administrative units in sub-Saharan Africa are falling short of the targeted 75% reduction in new cases and deaths by 2020, which is further compounded by substantial within-country variability. These estimates will help decision makers and programme implementers expand access to ART and better target health resources to higher burden subnational areas. This work was primarily supported by the Bill & Melinda Gates Foundation (grant OPP1132415). Additionally, O Adetokunboh acknowledges the support of the Department of Science and Innovation, and National Research Foundation of South Africa. M Ausloos, A Pana, and C Herteliu are partially supported by a grant of the Romanian National Authority for Scientific Research and Innovation, Executive Agency for Higher Education, Research, Development and Innovation Funding (Romania; project number PN-III-P4-ID-PCCF-2016-0084). T W Bärnighausen was supported by the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor award, funded by the German Federal Ministry of Education and Research. M J Bockarie is supported by the European and Developing Countries Clinical Trials Partnership. F Carvalho and E Fernandes acknowledge support from Portuguese national funds (Fundação para a Ciência e Tecnologia and Ministério da Ciência, Tecnologia e Ensino Superior; UIDB/info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB/50006/2020/PT, UIDB/04378/2020, and UIDP/04378/2020. K Deribe is supported by the Wellcome Trust (grant 201900/Z/16/Z) as part of his International Intermediate Fellowship. B-F Hwang was partially supported by China Medical University (CMU107-Z-04), Taichung, Taiwan. M Jakovljevic acknowledges support of the Serbia Ministry of Education Science and Technological Development (grant OI 175 014). M N Khan acknowledges the support of Jatiya Kabi Kazi Nazrul Islam University, Bangladesh. Y J Kim was supported by the Research Management Centre, Xiamen University Malaysia, Malaysia, (XMUMRF/2020-C6/ITCM/0004). K Krishnan is supported by University Grants Commission Centre of Advanced Study, (CAS II), awarded to the Department of Anthropology, Panjab University, Chandigarh, India. M Kumar would like to acknowledge National Institutes of Health and Fogarty International Cente (K43TW010716). I Landires is a member of the Sistema Nacional de Investigación, which is supported by the Secretaría Nacional de Ciencia, Tecnología e Innovación, Panama. W Mendoza is a program analyst in population and development at the UN Population Fund Country Office in Peru, which does not necessarily endorse this study. M Phetole received institutional support from the Grants, Innovation and Product Development Unit, South African Medical Research Council. O Odukoya acknowledges support from the Fogarty International Center of the US National Institutes of Health (K43TW010704). The content is solely the responsibility of the authors and does not necessarily represent the official views of the US National Institutes of Health. O Oladimeji is grateful for the support from Walter Sisulu University, Eastern Cape, South Africa, the University of Botswana, Botswana, and the University of Technology of Durban, Durban, South Africa. J R Padubidri acknowledges support from Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, India. G C Patton is supported by an Australian Government National Health and Medical Research Council research fellowship. P Rathi acknowledges Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal India. A I Ribeiro was supported by National Funds through Fundação para a Ciência e Tecnologia, under the programme of Stimulus of Scientific Employment–Individual Support (info:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND/02386/2018/CP1538/CT0001/PT). A M Samy acknowledges the support of the Egyptian Fulbright Mission Program. F Sha was supported by the Shenzhen Social Science Fund (SZ2020C015) and the Shenzhen Science and Technology Program (KQTD20190929172835662). A Sheikh is supported by Health Data Research UK. N Taveira acknowledges partial funding by Fundação para a Ciência e Tecnologia, Portugal, and Aga Khan Development Network—Portugal Collaborative Research Network in Portuguese-speaking countries in Africa (332821690), and by the European and Developing Countries Clinical Trials Partnership (RIA2016MC-1615). C S Wiysonge is supported by the South African Medical Research Council. Y Zhang was supported by the Science and Technology Research Project of Hubei Provincial Department of Education (Q20201104) and Open Fund Project of Hubei Province Key Laboratory of Occupational Hazard Identification and Control (OHIC2020Y01).
Published: 2021

26. Mapping 123 million neonatal, infant and child deaths between 2000 and 2017

Author: Mohsen Bayati, Arvin Haj-Mirzaian, Mehran Asadi-Aliabadi, Maziar Moradi-Lakeh, Nasir Salam, Mohamad-Hani Temsah, Fatemeh Heydarpour, Davide Rasella, Kavumpurathu Raman Thankappan, Ghulam Mustafa, Sergey Konstantinovitch Vladimirov, Fereshteh Ansari, Dina Nur Anggraini Ningrum, Leonardo Roever, Oghenowede Eyawo, Koustuv Dalal, Ana-Laura Manda, Ritesh G. Menezes, Molly K. Miller-Petrie, Javad Yoosefi Lebni, Gebreamlak Gebremedhn Gebremeskel, Aziz Eftekhari, Oleguer Plana-Ripoll, Jon Wakefield, Sanjay Zodpey, Birhanu Geta, Amaha Kahsay, Edris Hasanpoor, Brijesh Sathian, Kala M. Mehta, Moritz U. G. Kraemer, Saeed Amini, Hesham M. Al-Mekhlafi, Abbas Yadegar, João Pedro Silva, Desmond Kuupiel, Anvar Asadi, Hamid Sharifi, Ebrahim Babaee, Dessalegn Ajema Berbada, Taddese Alemu Zerfu, Ian Davis, Mostafa Qorbani, Fatemeh Rajati, Samer Hamidi, Parvaiz A Koul, Foad Abd-Allah, Mojisola Oluwasanu, Syed Mohamed Aljunid, Elias Merdassa Roro, Mihaela Hostiuc, Robert S. Bernstein, Vahid Yazdi-Feyzabadi, Gebre Teklemariam Demoz, Irina Filip, Mu'awiyyah Babale Sufiyan, Amir Khater, Lidia Morawska, Sangram Kishor Patel, Robert C. Reiner, Joshua O. Akinyemi, Telma Zahirian Moghadam, Ali Akbar Fazaeli, Reza Malekzadeh, Olatunde Aremu, Mohammad Reza Salahshoor, Irfan Ullah, Gabrielle B. Britton, Gelin Xu, Nathaniel J Henry, Thomas R. Hird, Ronny Westerman, Vera Marisa Costa, Reza Assadi, Tiffany K. Gill, Chhabi Lal Ranabhat, Meysam Olfatifar, Sezer Kisa, Grant Rodgers Kemp, Mahmoud Yousefifard, Aleksandra Barac, Simon I. Hay, Walter Mendoza, Mohammad Zamani, Nader Jafari Balalami, Mahdi Safdarian, Manfred S. Green, Mahesh P A, Nahid Neamati, Pallab K. Maulik, Ali H. Mokdad, Joshua Longbottom, Somayeh Bohlouli, Ahmad Daryani, Ibrahim Abdollahpour, Mostafa Hosseini, Deborah Carvalho Malta, Nick Golding, Sheikh Mohammed Shariful Islam, Shirin Nosratnejad, Haidong Wang, Shadi Rahimzadeh, Pushpendra Kumar, Mehdi Noroozi, Andre M. N. Renzaho, Brent Bell, Huong Lan Thi Nguyen, Khaled Khatab, Meghdad Pirsaheb, Yousef Veisani, Katie R Nielsen, Ionut Negoi, Seyyed Meysam Mousavi, Amir Ashraf-Ganjouei, Mohammad Hassan Emamian, Joseph L Ward, Sharath Burugina Nagaraja, Songhomitra Panda-Jonas, Ettore Beghi, Azeem Majeed, Ivy Shiue, Delia Hendrie, Roghiyeh Faridnia, Seyed Mostafa Mir, Moslem Soofi, Ghobad Moradi, Mahsa Ghajarzadeh, Chandrashekhar T Sreeramareddy, Milad Hasankhani, Mohamed I Hegazy, Mika Shigematsu, Bryan L. Sykes, Vahid Alipour, Ruth W Kimokoti, Afshin Maleki, Nafiseh Baheiraei, Noore Alam, Jalal Arabloo, Mariam Molokhia, Kimberly B. Johnson, Amber Sligar, Nicole Davis Weaver, Kerem Shuval, Malede Mequanent Sisay, Paul H. Lee, Reza Ghadimi, Mahbobeh Faramarzi, Natalia V. Bhattacharjee, Ehsan Sadeghi, Brandon V. Pickering, Animika Pandey, Ana Isabel Ribeiro, Felix Greaves, Sameer Vali Gopalani, Joel M. Francis, Alyssa N. Sbarra, Yun Jin Kim, Agus Sudaryanto, Hebat Allah Salah A. Yousof, Hadi Pourjafar, Tomohide Yamada, Alireza Rafiei, Rosario Cárdenas, Mohammad Khazaei, Hasan Yusefzadeh, Rahman Shiri, Girmay Teklay Weldesamuel, Zahra Jorjoran Shushtari, Michael Collison, Stanislav S. Otstavnov, Narayanaswamy Venketasubramanian, Yahya Salimi, Naohiro Yonemoto, Ahmad Ghashghaee, Soewarta Kosen, Al Artaman, Surendra Karki, Tariq Jamal Siddiqi, Lorenzo Monasta, Amit Arora, Christopher S Yilgwan, Ahamarshan Jayaraman Nagarajan, Adnan Kisa, Gholamreza Roshandel, Vahid Rashedi, Daniel Diaz, Amir Vahedian-Azimi, Erkin M. Mirrakhimov, Nuworza Kugbey, Zohreh Arefi, Benjamin B. Massenburg, Robert G. Weintraub, Lauren E. Schaeffer, Alexandre C. Pereira, Mehdi Hosseinzadeh, Milena M Santric Milicevic, Ai Koyanagi, Mehran Shams-Beyranvand, Salman Khazaei, Olalekan A. Uthman, Mohamed Hsairi, Nuno Taveira, Masoud Foroutan, Jayendra Sharma, Hanna Demelash Desyibelew, Max Roser, Keivan Ahmadi, Yousef Khader, Hamideh Salimzadeh, Ali Bijani, Shanshan Li, Mehran Alijanzadeh, Florian Fischer, Aziz Sheikh, Eun-Kee Park, Stefan Listl, Smita Pakhale, Brian J. Hall, Alireza Zangeneh, Ravi Mehrotra, Kidu Gidey Weldegwergs, Mahdi Afshari, Son Hoang Nguyen, Francisco Rogerlândio Martins-Melo, Rupak Desai, Aziz Rezapour, Hassan Magdy Abd El Razek, Gillian I. Hollerich, Reza Saeedi, Iman El Sayed, Olayinka Stephen Ilesanmi, Ben Lacey, Soheil Ebrahimpour, Laura Dwyer-Lindgren, Roya Ebrahimi, Bolajoko O. Olusanya, Tommi Vasankari, Siamak Sabour, Theo Vos, Tuomo J. Meretoja, Job F M van Boven, Nataliya Foigt, Mojtaba Hoseini-Ghahfarokhi, Saleh Salehi Zahabi, Mehdi Fazlzadeh, Neeraj Bedi, Hamed Mirjalali, Payman Salamati, P N Sylaja, Ted R. Miller, George J. Milne, Alaa Badawi, Muhammad Usman, Amir Hasanzadeh, Michelle L. Bell, Giang Thu Vu, Masoud Behzadifar, Manasi Kumar, Mona M. Khater, Josip Car, Nafis Sadat, Mostafa Leili, Mehdi Sharif, Hadi Hassankhani, Mowafa Househ, Joshua A. Salomon, Morteza Mansourian, G Anil Kumar, João C. Fernandes, Tufa Kolola, Arya Haj-Mirzaian, Masood Ali Shaikh, Keyghobad Ghadiri, Andrew T Olagunju, Bahram Armoon, Beatriz Paulina Ayala Quintanilla, Samantha Perkins, Mohsen Mazidi, Stefan Lorkowski, Sagnik Dey, Edward J Mills, Ali Kabir, Maryam Khazaei-Pool, Mohammad Rabiee, Arianna Maever L. Amit, John S. Ji, Sivan Yegnanarayana Iyer Saraswathy, Fares Alahdab, Vafa Rahimi-Movaghar, Martin McKee, Hadi Parsian, Ejaz Ahmad Khan, Amirhossein Sahebkar, Paramjit Gill, Dara K. Mohammad, Naznin Hossain, Karen M. Tabb, Annie J. Browne, Abdallah M. Samy, Elham Ehsani-Chimeh, Nelson G.M. Gomes, Destallem Gebremedhin Gebre, Fakher Rahim, Sheetal D. Lad, Rajat Das Gupta, Yash Jobanputra, Rajesh Sharma, Davoud Adham, Richard Ofori-Asenso, Farah Daoud, Aso Mohammad Darwesh, Meghnath Dhimal, Pranab Chatterjee, Javad Javidnia, Shafiu Mohammed, Amir Abdoli, Josep Maria Haro, Stefanie Watson, Behnam Nabavizadeh, Masoumeh Abbasi, Kefyalew Addis Alene, Marzieh Nojomi, G. K. Mini, Abbas Mosapour, Cyrus Cooper, Yirga Legesse Nirayo, Jagdish Khubchandani, Muhammed Magdy Abd El Razek, Faramarz Shaahmadi, Satar Rezaei, Mahdi Sharif-Alhoseini, Francesco Saverio Violante, Eyal Oren, Erfan Zabeh, Atte Meretoja, Nicholas Graetz, Kris J. Krohn, Anthony Masaka, Oladimeji Adebayo, Mikk Jürisson, Faris Lami, Marcos Roberto Tovani-Palone, Chloe Shields, Yahya Safari, Yasir Waheed, Dilaram Acharya, Seyed Mohammad Riahi, Jan-Walter De Neve, Carlos A Castañeda-Orjuela, Alberto Ortiz, Samad Azari, Shymaa Enany, Maha Ezalarab, Salvatore Rubino, Enayatollah Homaie Rad, Roghayeh Khabiri, Seyed-Mohammad Fereshtehnejad, Yuming Guo, Sonia Saxena, Nicholas J K Breitborde, Takeshi Fukumoto, Hamid Yimam Hassen, Thomas Pilgrim, Yasser Vasseghian, Dragos Virgil Davitoiu, Farid Najafi, Sathish Thirunavukkarasu, Ali Rostami, Efat Mohamadi, Sameh Magdeldin, Hedley Quintana, Cyrus Alinia, Rodrigo Sarmiento-Suarez, Roya Safari-Faramani, Leila Doshmangir, Kewal Krishan, Karen Sliwa, Nazrul Islam, Neal Marquez, Genet Melak Alamene, Andem Effiong, Khanh Bao Tran, Amir Kasaeian, Adeladza Kofi Amegah, Hamidreza Haririan, Maha El Tantawi, Anders Larsson, André Faro, Rushdia Ahmed, Amir Shamshirian, Josephine W. Ngunjiri, Yousef Moradi, Sharareh Eskandarieh, Evanson Z. Sambala, Nelson Alvis-Guzman, Mehdi Moradinazar, Lauren Woyczynski, Parul Puri, Yunquan Zhang, Navid Manafi, Vinay Nangia, Joan B. Soriano, Victor Adekanmbi, Sofia Androudi, Carl Abelardo T. Antonio, Morteza Abdullatif Khafaie, Netsanet Fentahun, Achala Upendra Jayatilleke, David L. Smith, Solomon Sisay, Giuseppe Gorini, Meysam Behzadifar, Charles Shey Wiysonge, Bach Xuan Tran, Lal B. Rawal, Arefeh Babazadeh, Damaris K. Kinyoki, Morteza Shamsizadeh, Ziad El-Khatib, Zohreh Anbari, Abdol Sattar Pagheh, Ranjani Somayaji, Frank B. Osei, Nancy Fullman, Zahid A Butt, Ai-Min Wu, Tahereh Pashaei, Benn Sartorius, Aaron Osgood-Zimmerman, Sachin R Atre, Mehdi Ahmadi, Chalachew Genet Akal, Aubrey J. Levine, Mohammad Fareed, Quique Bassat, Khalid A Altirkawi, Ensiyeh Jenabi, Daem Roshani, Mina Anjomshoa, Jasvinder A. Singh, Yafeng Wang, Samath D Dharmaratne, Enrico Rubagotti, Ruxandra Irina Negoi, Reinhard Busse, Abdullah Al Mamun, Yoshan Moodley, Mohammed Almalki, Peter W. Gething, Alireza Khatony, Usman Iqbal, Soraya Nouraei Motlagh, Roy Burstein, Hamed Zandian, Rakhi Dandona, Mojtaba Bagherzadeh, Majid Pirestani, Jaifred Christian F. Lopez, Chuanhua Yu, Arash Ziapour, Seyed Sina Naghibi Irvani, Bárbara Niegia Garcia Goulart, Pascual R. Valdez, Amir Jalali, Chukwudi A Nnaji, Kelechi Elizabeth Oladimeji, Tomislav Mestrovic, Isidora S. Vujcic, Osayomwanbo Osarenotor, Azin Nahvijou, Chi Linh Hoang, Christopher J L Murray, Mustafa Z. Younis, Veincent Christian Filipino Pepito, Andre Rodrigues Duraes, Yuan-Pang Wang, Felix Akpojene Ogbo, Aniruddha Deshpande, Nicholas J Kassebaum, Jacek Jerzy Jozwiak, Soghra Bagheri, Paul S. F. Yip, Sree Bhushan Raju, Sadaf G. Sepanlou, Kebede Deribe, Junaid Khan, Mohammad Aghaali, Lalit Dandona, Masoud Moradi, Molly R Nixon, Bruno Piassi Sao Jose, Atalay Goshu Muluneh, Mohammad Hasan Imani-Nasab, Naser Mohammad Gholi Mezerji, Abdullah Sulieman Terkawi, Sojib Bin Zaman, Muhammad Shahzeb Khan, Maysaa El Sayed Zaki, Gebrekiros Gebremichael Meles, Suraj Bhattarai, Yared Belete Belay, Ammas Siraj Mohammed, Dawit Zewdu Wondafrash, Abbas Balouchi, Silvano Gallus, Mohammad Abdollahi, Long Hoang Nguyen, Zulfiqar A Bhutta, Jean Jacques Noubiap, Mehdi Naderi, Bernhard T. Baune, Lucas Earl, Doris D. V. Ortega-Altamirano, Michael R.M. Abrigo, Farkhonde Salehi, Hamed Kalani, Mayowa O. Owolabi, Feleke Mekonnen Demeke, Lee Ling Lim, Ulrich O Mueller, Laurie B. Marczak, Peter Njenga Keiyoro, Ehsan Ahmadpour, Navid Rabiee, Dinh-Toi Chu, Vasily Vlassov, Bradford D Gessner, Tsegaye Tewelde Gebrehiwot, Sorin Hostiuc, Bakhtiar Piroozi, Mahdieh Abbasalizad-Farhangi, Takahiro Tabuchi, Philimon Gona, Bahar Ataeinia, Azra Ramezankhani, Duduzile Ndwandwe, Obinna Onwujekwe, Zohreh Rahimi, Seyedmojtaba Seyedmousavi, Wagaye Fentahun Chanie, Neda Kianipour, Rizwan Suliankatchi Abdulkader, Dhirendra N Sinha, Young-Ho Khang, Paula Moraga, Manoochehr Karami, Solomon Olum, Rafael Tabarés-Seisdedos, Zemenu Tadesse Tessema, Amir Radfar, Kiomars Sharafi, Rohollah Kalhor, Benjamin K. Mayala, Mahmood Moosazadeh, David C. Schwebel, Jost B. Jonas, Quyen G. To, Ester Cerin, Martin Amogre Ayanore, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), Groningen Research Institute for Asthma and COPD (GRIAC), Veritati - Repositório Institucional da Universidade Católica Portuguesa, Department of Earth Observation Science, Faculty of Geo-Information Science and Earth Observation, UT-I-ITC-ACQUAL, GeoHealth, HUS Neurocenter, Department of Neurosciences, Neurologian yksikkö, Clinicum, HUS Comprehensive Cancer Center, Staff Services, Department of Surgery, University of Helsinki, Islam, Nazrul [0000-0003-3982-4325], Apollo - University of Cambridge Repository, Burstein R., Henry N.J., Collison M.L., Marczak L.B., Sligar A., Watson S., Marquez N., Abbasalizad-Farhangi M., Abbasi M., Abd-Allah F., Abdoli A., Abdollahi M., Abdollahpour I., Abdulkader R.S., Abrigo M.R.M., Acharya D., Adebayo O.M., Adekanmbi V., Adham D., Afshari M., Aghaali M., Ahmadi K., Ahmadi M., Ahmadpour E., Ahmed R., Akal C.G., Akinyemi J.O., Alahdab F., Alam N., Alamene G.M., Alene K.A., Alijanzadeh M., Alinia C., Alipour V., Aljunid S.M., Almalki M.J., Al-Mekhlafi H.M., Altirkawi K., Alvis-Guzman N., Amegah A.K., Amini S., Amit A.M.L., Anbari Z., Androudi S., Anjomshoa M., Ansari F., Antonio C.A.T., Arabloo J., Arefi Z., Aremu O., Armoon B., Arora A., Artaman A., Asadi A., Asadi-Aliabadi M., Ashraf-Ganjouei A., Assadi R., Ataeinia B., Atre S.R., Quintanilla B.P.A., Ayanore M.A., Azari S., Babaee E., Babazadeh A., Badawi A., Bagheri S., Bagherzadeh M., Baheiraei N., Balouchi A., Barac A., Bassat Q., Baune B.T., Bayati M., Bedi N., Beghi E., Behzadifar M., Belay Y.B., Bell B., Bell M.L., Berbada D.A., Bernstein R.S., Bhattacharjee N.V., Bhattarai S., Bhutta Z.A., Bijani A., Bohlouli S., Breitborde N.J.K., Britton G., Browne A.J., Nagaraja S.B., Busse R., Butt Z.A., Car J., Cardenas R., Castaneda-Orjuela C.A., Cerin E., Chanie W.F., Chatterjee P., Chu D.-T., Cooper C., Costa V.M., Dalal K., Dandona L., Dandona R., Daoud F., Daryani A., Das Gupta R., Davis I., Davis Weaver N., Davitoiu D.V., De Neve J.-W., Demeke F.M., Demoz G.T., Deribe K., Desai R., Deshpande A., Desyibelew H.D., Dey S., Dharmaratne S.D., Dhimal M., Diaz D., Doshmangir L., Duraes A.R., Dwyer-Lindgren L., Earl L., Ebrahimi R., Ebrahimpour S., Effiong A., Eftekhari A., Ehsani-Chimeh E., El Sayed I., El Sayed Zaki M., El Tantawi M., El-Khatib Z., Emamian M.H., Enany S., Eskandarieh S., Eyawo O., Ezalarab M., Faramarzi M., Fareed M., Faridnia R., Faro A., Fazaeli A.A., Fazlzadeh M., Fentahun N., Fereshtehnejad S.-M., Fernandes J.C., Filip I., Fischer F., Foigt N.A., Foroutan M., Francis J.M., Fukumoto T., Fullman N., Gallus S., Gebre D.G., Gebrehiwot T.T., Gebremeskel G.G., Gessner B.D., Geta B., Gething P.W., Ghadimi R., Ghadiri K., Ghajarzadeh M., Ghashghaee A., Gill P.S., Gill T.K., Golding N., Gomes N.G.M., Gona P.N., Gopalani S.V., Gorini G., Goulart B.N.G., Graetz N., Greaves F., Green M.S., Guo Y., Haj-Mirzaian A., Hall B.J., Hamidi S., Haririan H., Haro J.M., Hasankhani M., Hasanpoor E., Hasanzadeh A., Hassankhani H., Hassen H.Y., Hegazy M.I., Hendrie D., Heydarpour F., Hird T.R., Hoang C.L., Hollerich G., Rad E.H., Hoseini-Ghahfarokhi M., Hossain N., Hosseini M., Hosseinzadeh M., Hostiuc M., Hostiuc S., Househ M., Hsairi M., Ilesanmi O.S., Imani-Nasab M.H., Iqbal U., Irvani S.S.N., Islam N., Islam S.M.S., Jurisson M., Balalami N.J., Jalali A., Javidnia J., Jayatilleke A.U., Jenabi E., Ji J.S., Jobanputra Y.B., Johnson K., Jonas J.B., Shushtari Z.J., Jozwiak J.J., Kabir A., Kahsay A., Kalani H., Kalhor R., Karami M., Karki S., Kasaeian A., Kassebaum N.J., Keiyoro P.N., Kemp G.R., Khabiri R., Khader Y.S., Khafaie M.A., Khan E.A., Khan J., Khan M.S., Khang Y.-H., Khatab K., Khater A., Khater M.M., Khatony A., Khazaei M., Khazaei S., Khazaei-Pool M., Khubchandani J., Kianipour N., Kim Y.J., Kimokoti R.W., Kinyoki D.K., Kisa A., Kisa S., Kolola T., Kosen S., Koul P.A., Koyanagi A., Kraemer M.U.G., Krishan K., Krohn K.J., Kugbey N., Kumar G.A., Kumar M., Kumar P., Kuupiel D., Lacey B., Lad S.D., Lami F.H., Larsson A.O., Lee P.H., Leili M., Levine A.J., Li S., Lim L.-L., Listl S., Longbottom J., Lopez J.C.F., Lorkowski S., Magdeldin S., Abd El Razek H.M., Abd El Razek M.M., Majeed A., Maleki A., Malekzadeh R., Malta D.C., Mamun A.A., Manafi N., Manda A.-L., Mansourian M., Martins-Melo F.R., Masaka A., Massenburg B.B., Maulik P.K., Mayala B.K., Mazidi M., McKee M., Mehrotra R., Mehta K.M., Meles G.G., Mendoza W., Menezes R.G., Meretoja A., Meretoja T.J., Mestrovic T., Miller T.R., Miller-Petrie M.K., Mills E.J., Milne G.J., Mini G.K., Mir S.M., Mirjalali H., Mirrakhimov E.M., Mohamadi E., Mohammad D.K., Darwesh A.M., Mezerji N.M.G., Mohammed A.S., Mohammed S., Mokdad A.H., Molokhia M., Monasta L., Moodley Y., Moosazadeh M., Moradi G., Moradi M., Moradi Y., Moradi-Lakeh M., Moradinazar M., Moraga P., Morawska L., Mosapour A., Mousavi S.M., Mueller U.O., Muluneh A.G., Mustafa G., Nabavizadeh B., Naderi M., Nagarajan A.J., Nahvijou A., Najafi F., Nangia V., Ndwandwe D.E., Neamati N., Negoi I., Negoi R.I., Ngunjiri J.W., Thi Nguyen H.L., Nguyen L.H., Nguyen S.H., Nielsen K.R., Ningrum D.N.A., Nirayo Y.L., Nixon M.R., Nnaji C.A., Nojomi M., Noroozi M., Nosratnejad S., Noubiap J.J., Motlagh S.N., Ofori-Asenso R., Ogbo F.A., Oladimeji K.E., Olagunju A.T., Olfatifar M., Olum S., Olusanya B.O., Oluwasanu M.M., Onwujekwe O.E., Oren E., Ortega-Altamirano D.D.V., Ortiz A., Osarenotor O., Osei F.B., Osgood-Zimmerman A.E., Otstavnov S.S., Owolabi M.O., Mahesh P.A., Pagheh A.S., Pakhale S., Panda-Jonas S., Pandey A., Park E.-K., Parsian H., Pashaei T., Patel S.K., Pepito V.C.F., Pereira A., Perkins S., Pickering B.V., Pilgrim T., Pirestani M., Piroozi B., Pirsaheb M., Plana-Ripoll O., Pourjafar H., Puri P., Qorbani M., Quintana H., Rabiee M., Rabiee N., Radfar A., Rafiei A., Rahim F., Rahimi Z., Rahimi-Movaghar V., Rahimzadeh S., Rajati F., Raju S.B., Ramezankhani A., Ranabhat C.L., Rasella D., Rashedi V., Rawal L., Reiner Jr R.C., Renzaho A.M.N., Rezaei S., Rezapour A., Riahi S.M., Ribeiro A.I., Roever L., Roro E.M., Roser M., Roshandel G., Roshani D., Rostami A., Rubagotti E., Rubino S., Sabour S., Sadat N., Sadeghi E., Saeedi R., Safari Y., Safari-Faramani R., Safdarian M., Sahebkar A., Salahshoor M.R., Salam N., Salamati P., Salehi F., Zahabi S.S., Salimi Y., Salimzadeh H., Salomon J.A., Sambala E.Z., Samy A.M., Santric Milicevic M.M., Jose B.P.S., Saraswathy S.Y.I., Sarmiento-Suarez R., Sartorius B., Sathian B., Saxena S., Sbarra A.N., Schaeffer L.E., Schwebel D.C., Sepanlou S.G., Seyedmousavi S., Shaahmadi F., Shaikh M.A., Shams-Beyranvand M., Shamshirian A., Shamsizadeh M., Sharafi K., Sharif M., Sharif-Alhoseini M., Sharifi H., Sharma J., Sharma R., Sheikh A., Shields C., Shigematsu M., Shiri R., Shiue I., Shuval K., Siddiqi T.J., Silva J.P., Singh J.A., Sinha D.N., Sisay M.M., Sisay S., Sliwa K., Smith D.L., Somayaji R., Soofi M., Soriano J.B., Sreeramareddy C.T., Sudaryanto A., Sufiyan M.B., Sykes B.L., Sylaja P.N., Tabares-Seisdedos R., Tabb K.M., Tabuchi T., Taveira N., Temsah M.-H., Terkawi A.S., Tessema Z.T., Thankappan K.R., Thirunavukkarasu S., To Q.G., Tovani-Palone M.R., Tran B.X., Tran K.B., Ullah I., Usman M.S., Uthman O.A., Vahedian-Azimi A., Valdez P.R., van Boven J.F.M., Vasankari T.J., Vasseghian Y., Veisani Y., Venketasubramanian N., Violante F.S., Vladimirov S.K., Vlassov V., Vos T., Vu G.T., Vujcic I.S., Waheed Y., Wakefield J., Wang H., Wang Y., Wang Y.-P., Ward J.L., Weintraub R.G., Weldegwergs K.G., Weldesamuel G.T., Westerman R., Wiysonge C.S., Wondafrash D.Z., Woyczynski L., Wu A.-M., Xu G., Yadegar A., Yamada T., Yazdi-Feyzabadi V., Yilgwan C.S., Yip P., Yonemoto N., Lebni J.Y., Younis M.Z., Yousefifard M., Yousof H.-A.S.A., Yu C., Yusefzadeh H., Zabeh E., Moghadam T.Z., Bin Zaman S., Zamani M., Zandian H., Zangeneh A., Zerfu T.A., Zhang Y., Ziapour A., Zodpey S., Murray C.J.L., and Hay S.I.
Subjects: Survival, RJ101, Mortalidad Infantil, HB, UNDER-5 MORTALITY, Global Health, Pediatrics, 0302 clinical medicine, 3123 Gynaecology and paediatrics, Child death, Infant Mortality, Epidemiology, Global health, Middle income country, Nacimiento vivo, 030212 general & internal medicine, 10. No inequality, Child, POPULATION, Developing world, education.field_of_study, Public health, Multidisciplinary, Geography, Mortality rate, wa_900, 1. No poverty, SUCCESS, Pediatrik, A900 Others in Medicine and Dentistry, 3142 Public health care science, environmental and occupational health, 3. Good health, Child Mortality, Death children, VACCINATION, HEALTH, ws_100, INTERVENTIONS, AFRICA, medicine.medical_specialty, United Nations, General Science & Technology, 030231 tropical medicine, Population, Developing country, Article, Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], ITC-HYBRID, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Social Justice, Recién nacido, Neonatal deaths, medicine, SYSTEMATIC ANALYSIS, Organizational Objectives, Humans, education, Developing Countries, business.industry, Infant, Newborn, Infant, CIVIL REGISTRATION, Paediatrics, Child survival, Newborn, PREVENTION, Infant mortality, wa_320, ws_200, Child mortality, Socioeconomic Factors, ITC-ISI-JOURNAL-ARTICLE, Human medicine, Paediatrics, Public health, Developing world, business, Demography
Abstract: Since 2000, many countries have achieved considerable success in improving child survival, but localized progress remains unclear. To inform efforts towards United Nations Sustainable Development Goal 3.2—to end preventable child deaths by 2030—we need consistently estimated data at the subnational level regarding child mortality rates and trends. Here we quantified, for the period 2000–2017, the subnational variation in mortality rates and number of deaths of neonates, infants and children under 5 years of age within 99 low- and middle-income countries using a geostatistical survival model. We estimated that 32% of children under 5 in these countries lived in districts that had attained rates of 25 or fewer child deaths per 1,000 live births by 2017, and that 58% of child deaths between 2000 and 2017 in these countries could have been averted in the absence of geographical inequality. This study enables the identification of high-mortality clusters, patterns of progress and geographical inequalities to inform appropriate investments and implementations that will help to improve the health of all populations., A high-resolution, global atlas of mortality of children under five years of age between 2000 and 2017 highlights subnational geographical inequalities in the distribution, rates and absolute counts of child deaths by age.
Published: 2019
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27. Investigating the Resurgence of Malaria Prevalence in South Africa Between 2015 and 2018: A Scoping Review

Author: Babatope O. Adebiyi, Abiodun M. Adeola, Ramsès Djidjou-Demasse, Yves J. Semegni, Peter J. Witbooi, Rita O. Abiodun, Kelechi Elizabeth Oladimeji, Gbenga J. Abiodun, Alejandro B. Aceves, Olusola Samuel Makinde, Kevin Y. Njabo, Kazeem Oare Okosun, Olanrewaju Oladimeji, Liverpool School of Tropical Medicine (LSTM), Institut de Recherche pour le Développement (IRD), University of California [Los Angeles] (UCLA), University of California, and Southern Methodist University (SMU)
Subjects: Health (social science), [SDE.MCG]Environmental Sciences/Global Changes, 030231 tropical medicine, 02 engineering and technology, 03 medical and health sciences, 0302 clinical medicine, Rare Diseases, Environmental health, 0502 economics and business, parasitic diseases, 0202 electrical engineering, electronic engineering, information engineering, medicine, Climate-Related Exposures and Conditions, 030212 general & internal medicine, ComputingMilieux_MISCELLANEOUS, Community and Home Care, Prevention, 05 social sciences, Public Health, Environmental and Occupational Health, medicine.disease, 3. Good health, Malaria, Vector-Borne Diseases, Geography, Infectious Diseases, Good Health and Well Being, 020201 artificial intelligence & image processing, Malaria control, Infection, 050203 business & management
Abstract: Background: Malaria remains a serious concern in most African countries, causing nearly one million deaths globally every year. This review aims to examine the extent and nature of the resurgence of malaria transmission in South Africa. Methods: Using the Arksey and O'Malley framework, this scoping review includes articles published between the years 2015 and 2018 on the resurgence of malaria occurrence in South Africa. Articles were searched between October 2018 to January 2019 using the following electronic databases: CINAHL, Pubmed, Science Direct and SCOPUS. Grey literature from Google Scholar was also hand searched. Key search terms and subject headings such as climate variables, climate changes, climatic factors, malaria resurgence, malaria reoccurrence and malaria increase over epidemic regions in South Africa were used to identify relevant articles. Three independent reviewers performed the selection and characterization of articles, and the data collected were synthesized qualitatively. Results: A total number of 534 studies were identified. Among these, 24 studies met the inclusion criteria. The results were grouped by factors (four main themes) that influenced the malaria resurgence: Climatic, Epidemiological, Socio-economic, and Environmental factors. Climatic factors were found to be the major factor responsible for the resurgence of malaria, as more than 55% of the selected articles were climate-focused. This was followed by epidemiological, socio-economic and environmental factors, in that order. Grey literature from Google Scholar yielded no results. Conclusion: This study shows that malaria transmission in South Africa is more associated with climate. Climate-based malaria models could be used as early warning systems for malaria over the epidemic regions in South Africa. Since epidemiological factors also play significant roles in malaria transmission, regular and unrelaxed use of Indoor Residual Spraying (IRS) should be encouraged in these regions. Individuals should also be educated on the importance and the usefulness of these deliveries. While some studies have indicated that the vectors have developed resistance to insecticides, continuous research on developing new insecticides that could alter the resistance are encouraged. Furthermore, all efforts to eradicate malaria in South Africa must also target malaria-endemic neighbouring countries.
Published: 2020
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28. Prenatal care and uptake of HIV testing among pregnant women in Gambia: a cross-sectional study

Author: Olanrewaju Oladimeji, Sanni Yaya, Kelechi Elizabeth Oladimeji, and Ghose Bishwajit
Subjects: HIV test, Adult, Employment, medicine.medical_specialty, Adolescent, Cross-sectional study, Global health, HIV Infections, Antenatal care, Prenatal care, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Environmental health, Epidemiology, Humans, Mass Screening, Medicine, Maternal Health Services, Serologic Tests, 030212 general & internal medicine, Pregnancy Complications, Infectious, Socioeconomic status, 030505 public health, business.industry, lcsh:Public aspects of medicine, Public health, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Prenatal Care, Middle Aged, Patient Acceptance of Health Care, Health Surveys, Child mortality, Cross-Sectional Studies, Socioeconomic Factors, Africa, Gambia, Female, Maternal health, Pregnant Women, Rural area, Biostatistics, 0305 other medical science, business, Research Article
Abstract: Background Improving the coverage of antenatal care is regarded as an important strategy to reduce the risks of maternal and child mortality in low income settings like Gambia. Nonetheless, a large number of countries in Africa, including Gambia, are struggling to attain an optimum level of healthcare utilization among pregnant women. The role of socioeconomic inequalities in maternal healthcare uptake has received little attention in Gambia. To address this evidence gap, the present study analyses nationally representative data to explore the socioeconomic inequalities in the use of maternal healthcare. Methods Data on women aged 15–49 years (n = 5351) were extracted from the latest round of Gambia Demographic and Health Survey in 2013 for this study. The outcome measures were early and adequate antenatal visit and HIV tests during the last pregnancy. Data were analyzed using descriptive and multivariate regression methods. Socioeconomic status was assessed through the women’s education, type of employment, and household wealth quintile. Results From the total of 5351 participants included in the study, 38.7 and 78.8% of the women had early and adequate ANC visits respectively with a 65.4% HIV test coverage during ANC visits. The odds of early [OR = 1.30, 95% confidence interval (CI) =1.06, 1.59] and adequate [OR = 1.45, 95%CI = 1.15, 1.82] ANC visits were higher in the rural areas compared with urban. Women with secondary [OR = 1.24, 95%CI = 1.04, 1.48] and higher education [OR = 1.80, 95%CI = 1.20, 2.70] had higher odds of making early ANC visits. Women from richest wealth quintile households had significantly higher odds of having early [OR = 1.49, 95%CI = 1.14, 1.95] and adequate ANC visits [OR = 2.06, 95%CI = 1.48, 2.87], but not of having HIV tests. Having access to electronic media showed a positive association with adequate ANC visits [OR = 1.32, 95%CI = 1.08, 1.62] and with taking HIV test during ANC [OR = 1.48, 95%CI = 1.21, 1.80]. A fewer odds of having unintended child was associated with early ANC visit [OR = 0.70, 95%CI = 0.59, 0.84], but positively associated with taking HIV test [OR = 1.75, 95%CI = 1.42, 2.15]. Conclusion A large proportion of women in Gambia were not using antenatal care and HIV tests during pregnancy. There are important sociodemographic differences in using maternal healthcare services such as HIV testing during pregnancy. This calls for strategic direction to promote the utilization of these services.
Published: 2020
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29. Global, regional, and national burden of stroke and its risk factors, 1990–2019 : a systematic analysis for the Global Burden of Disease Study 2019

Author: Mosiur Rahman, Rehab Salah, Mario F P Peres, Licia Iacoviello, Benjamin A Stark, Mahalaqua Nazli Khatib, Amir Radfar, Kamarul Imran Musa, Yannick Béjot, Deanna Anderlini, Carlos Cantú-Brito, Feng Sha, V. E. Nwatah, Pradip Gyanwali, Boris Bikbov, Bartosz Miazgowski, Sindhura Lakshmi Koulmane Laxminarayana, Ali Bijani, Imteyaz A Khan, Yaser Mokhayeri, Bogdan Oancea, Tarang Parekh, Martin Dichgans, Linh Gia Vu, Naohiro Yonemoto, Ahmad Ghashghaee, Marcos Roberto Tovani-Palone, Gebiyaw Wudie Tsegaye, Mona Pathak, Maciej Banach, Marissa B Reitsma, Derrick A Bennett, Treska S Hassan, Allen Seylani, Gdiom Gebreheat Abady, Islam Y. Elgendy, Hassan Mehmood Lak, Ismael R. Campos-Nonato, Sorin Hostiuc, Sheikh Mohammed Shariful Islam, Alessandra C. Goulart, Silvia Schiavolin, Simona Sacco, Atif Amin Baig, Azeem Majeed, Sahar Eftekharzadeh, Badr Hasan Sobaih, Archith Boloor, Aimé Bonny, Graeme J. Hankey, Jiregna Darega Gela, Mohamed I Hegazy, Pedram Keshavarz, Segun Emmanuel Ibitoye, Maseer Khan, Hatem Abdelaziz Mohamed Wafa, Hualiang Lin, Enayet Karim Chowdhury, Simon I. Hay, Vanessa De la Cruz-Góngora, Xuefeng Liu, Arokiasamy Perianayagam, Maryam Zamanian, Sezer Kisa, Preetam Bhalchandra Mahajan, Junmei Miao Jonasson, Alberto Raggi, Shubha Jayaram, Tahira Ashraf, Ejaz Ahmad Khan, Matthias Endres, Masoumeh Sadeghi, Dominique Vervoort, Hanadi Al Hamad, Mowafa Househ, Elena V. Gnedovskaya, Johan Ärnlöv, Andrea Sylvia Winkler, Yousef Khader, Mikhail Sergeevich Zastrozhin, Yuming Guo, Yunquan Zhang, Sami Almustanyir, Lalit Dandona, Amir Masoud Rahmani, Chythra R Rao, Giancarlo Lucchetti, Irena Ilic, Suzanne Barker-Collo, Priya Rathi, Emerito Jose A. Faraon, Mohamad-Hani Temsah, Reza Ghanei Gheshlagh, Gyu Ri Kim, Carlos A Castañeda-Orjuela, Alaa Makki, Yun Jin Kim, Vida Abedi, Shanshan Li, Kewal Krishan, David Flood, Abdollah Mohammadian-Hafshejani, Michele Romoli, Gregory A. 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Schlaich, Arief Hargono, Samaneh Asgari, Ovidiu Baltatu, Ippazio Cosimo Antonazzo, Sandhya Neupane Kandel, Nizal Sarrafzadegan, Jakub Morze, Man Mohan Mehndiratta, Manjari Tripathi, Panniyammakal Jeemon, Rohollah Kalhor, Yogeshwar Kalkonde, Soraya Siabani, Sojib Bin Zaman, Seyed Sina Naghibi Irvani, Shilpa Gaidhane, Sahel Valadan Tahbaz, Yihienew Mequanint Bezabih, Samath D Dharmaratne, Ingan Ukur Tarigan, Vivek Gupta, Klara Dokova, Alireza Vakilian, Vardhmaan Jain, Akshaya Srikanth Bhagavathula, Sarah Wulf Hanson, Umar Farooque, Mohammad Ali Mansournia, Vera Marisa Costa, Alessandro Gialluisi, Valery L. Feigin, Himal Kandel, Suzanne Polinder, Nermin Ghith, Deepak Dhamnetiya, Michael H. Criqui, Asif Hanif, Ahmed Abualhasan, Veer Bala Gupta, Mahaveer Golechha, Bach Xuan Tran, Jason A. 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A., Johnson, C. O., Roth, G. A., Bisignano, C., Abady, G. G., Abbasifard, M., Abbasi-Kangevari, M., Abd-Allah, F., Abedi, V., Abualhasan, A., Abu-Rmeileh, N. M. E., Abushouk, A. I., Adebayo, O. M., Agarwal, G., Agasthi, P., Ahinkorah, B. O., Ahmad, S., Ahmadi, S., Salih, Y. A., Aji, B., Akbarpour, S., Akinyemi, R. O., Al Hamad, H., Alahdab, F., Alif, S. M., Alipour, V., Aljunid, S. M., Almustanyir, S., Al-Raddadi, R. M., Salman, R. A. -S., Alvis-Guzman, N., Ancuceanu, R., Anderlini, D., Anderson, J. A., Ansar, A., Antonazzo, I. C., Arabloo, J., Arnlov, J., Artanti, K. D., Aryan, Z., Asgari, S., Ashraf, T., Athar, M., Atreya, A., Ausloos, M., Baig, A. A., Baltatu, O. C., Banach, M., Barboza, M. A., Barker-Collo, S. L., Barnighausen, T. W., Barone, M. T. U., Basu, S., Bazmandegan, G., Beghi, E., Beheshti, M., Bejot, Y., Bell, A. W., Bennett, D. A., Bensenor, I. M., Bezabhe, W. M., Bezabih, Y. M., Bhagavathula, A. S., Bhardwaj, P., Bhattacharyya, K., Bijani, A., Bikbov, B., Birhanu, M. M., Boloor, A., Bonny, A., Brauer, M., Brenner, H., Bryazka, D., Butt, Z. A., Dos Santos, F. L. C., Campos-Nonato, I. R., Cantu-Brito, C., Carrero, J. J., Castaneda-Orjuela, C. A., Catapano, A. L., Chakraborty, P. A., Charan, J., Choudhari, S. G., Chowdhury, E. K., Chu, D. -T., Chung, S. -C., Colozza, D., Costa, V. M., Costanzo, S., Criqui, M. H., Dadras, O., Dagnew, B., Dai, X., Dalal, K., Damasceno, A. A. M., D'Amico, E., Dandona, L., Dandona, R., Gela, J. D., Davletov, K., De La Cruz-Gongora, V., Desai, R., Dhamnetiya, D., Dharmaratne, S. D., Dhimal, M. L., Dhimal, M., Diaz, D., Dichgans, M., Dokova, K., Doshi, R., Douiri, A., Duncan, B. B., Eftekharzadeh, S., Ekholuenetale, M., El Nahas, N., Elgendy, I. Y., Elhadi, M., El-Jaafary, S. I., Endres, M., Endries, A. Y., Erku, D. A., Faraon, E. J. A., Farooque, U., Farzadfar, F., Feroze, A. H., Filip, I., Fischer, F., Flood, D., Gad, M. M., Gaidhane, S., Gheshlagh, R. G., Ghashghaee, A., Ghith, N., Ghozali, G., Ghozy, S., Gialluisi, A., Giampaoli, S., Gilani, S. A., Gill, P. S., Gnedovskaya, E. V., Golechha, M., Goulart, A. C., Guo, Y., Gupta, R., Gupta, V. B., Gupta, V. K., Gyanwali, P., Hafezi-Nejad, N., Hamidi, S., Hanif, A., Hankey, G. J., Hargono, A., Hashi, A., Hassan, T. S., Hassen, H. Y., Havmoeller, R. J., Hay, S. I., Hayat, K., Hegazy, M. I., Herteliu, C., Holla, R., Hostiuc, S., Househ, M., Huang, J., Humayun, A., Hwang, B. -F., Iacoviello, L., Iavicoli, I., Ibitoye, S. E., Ilesanmi, O. S., Ilic, I. M., Ilic, M. D., Iqbal, U., Irvani, S. S. N., Islam, S. M. S., Ismail, N. E., Iso, H., Isola, G., Iwagami, M., Jacob, L., Jain, V., Jang, S. -I., Jayapal, S. K., Jayaram, S., Jayawardena, R., Jeemon, P., Jha, R. P., Johnson, W. D., Jonas, J. B., Joseph, N., Jozwiak, J. J., Jurisson, M., Kalani, R., Kalhor, R., Kalkonde, Y., Kamath, A., Kamiab, Z., Kanchan, T., Kandel, H., Karch, A., Katoto, P. D. M. C., Kayode, G. 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M., Sarrafzadegan, N., Sathian, B., Sattin, D., Schiavolin, S., Schlaich, M. P., Schmidt, M. I., Schutte, A. E., Sepanlou, S. G., Seylani, A., Sha, F., Shahabi, S., Shaikh, M. A., Shannawaz, M., Shawon, Md. S. R., Sheikh, A., Sheikhbahaei, S., Shibuya, K., Siabani, S., Silva, D. A. S., Singh, J. A., Singh, J. K., Skryabin, V. Y., Skryabina, A. A., Sobaih, B. H., Stortecky, S., Stranges, S., Tadesse, E. G., Tarigan, I. U., Temsah, M. -H., Teuschl, Y., Thrift, A. G., Tonelli, M., Tovani-Palone, M. R., Tran, B. X., Tripathi, M., Tsegaye, G. W., Ullah, A., Unim, B., Unnikrishnan, B., Vakilian, A., Tahbaz, S. V., Vasankari, T. J., Venketasubramanian, N., Vervoort, D., Vo, B., Volovici, V., Vosoughi, K., Vu, G. T., Vu, L. G., Wafa, H. A., Waheed, Y., Wang, Y., Wijeratne, T., Winkler, A. S., Wolfe, C. D. A., Woodward, M., Wu, J. H., Hanson, S. W., Xu, X., Yadav, L., Yadollahpour, A., Jabbari, S. H. Y., Yamagishi, K., Yatsuya, H., Yonemoto, N., Yu, C., Yunusa, I., Zaman, M. S., Zaman, S. 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L., Public Health, Neurosurgery, Department of Public Health, University of Helsinki, Faculty of Medicine, Helsinki Inequality Initiative (INEQ), HUS Neurocenter, Neurologian yksikkö, Helsinki University Hospital Area, Feigin, V, Stark, B, Johnson, C, Roth, G, Bisignano, C, Abady, G, Abbasifard, M, Abbasi-Kangevari, M, Abd-Allah, F, Abedi, V, Abualhasan, A, Abu-Rmeileh, N, Abushouk, A, Adebayo, O, Agarwal, G, Agasthi, P, Ahinkorah, B, Ahmad, S, Ahmadi, S, Salih, Y, Aji, B, Akbarpour, S, Akinyemi, R, Al Hamad, H, Alahdab, F, Alif, S, Alipour, V, Aljunid, S, Almustanyir, S, Al-Raddadi, R, Salman, R, Alvis-Guzman, N, Ancuceanu, R, Anderlini, D, Anderson, J, Ansar, A, Antonazzo, I, Arabloo, J, Arnlov, J, Artanti, K, Aryan, Z, Asgari, S, Ashraf, T, Athar, M, Atreya, A, Ausloos, M, Baig, A, Baltatu, O, Banach, M, Barboza, M, Barker-Collo, S, Barnighausen, T, Barone, M, Basu, S, Bazmandegan, G, Beghi, E, Beheshti, M, Bejot, Y, Bell, A, Bennett, D, Bensenor, I, Bezabhe, W, Bezabih, Y, 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Rawaf, S, Reitsma, M, Renjith, V, Renzaho, A, Rezapour, A, Rodriguez, J, Roever, L, Romoli, M, Rynkiewicz, A, Sacco, S, Sadeghi, M, Moghaddam, S, Sahebkar, A, Saif-Ur-Rahman, K, Salah, R, Samaei, M, Samy, A, Santos, I, Santric-Milicevic, M, Sarrafzadegan, N, Sathian, B, Sattin, D, Schiavolin, S, Schlaich, M, Schmidt, M, Schutte, A, Sepanlou, S, Seylani, A, Sha, F, Shahabi, S, Shaikh, M, Shannawaz, M, Shawon, M, Sheikh, A, Sheikhbahaei, S, Shibuya, K, Siabani, S, Silva, D, Singh, J, Skryabin, V, Skryabina, A, Sobaih, B, Stortecky, S, Stranges, S, Tadesse, E, Tarigan, I, Temsah, M, Teuschl, Y, Thrift, A, Tonelli, M, Tovani-Palone, M, Tran, B, Tripathi, M, Tsegaye, G, Ullah, A, Unim, B, Unnikrishnan, B, Vakilian, A, Tahbaz, S, Vasankari, T, Venketasubramanian, N, Vervoort, D, Vo, B, Volovici, V, Vosoughi, K, Vu, G, Vu, L, Wafa, H, Waheed, Y, Wang, Y, Wijeratne, T, Winkler, A, Wolfe, C, Woodward, M, Wu, J, Hanson, S, Xu, X, Yadav, L, Yadollahpour, A, Jabbari, S, Yamagishi, K, Yatsuya, H, Yonemoto, N, Yu, C, Yunusa, I, Zaman, M, Zaman, S, Zamanian, M, Zand, R, Zandifar, A, Zastrozhin, M, Zastrozhina, A, Zhang, Y, Zhang, Z, Zhong, C, Zuniga, Y, Murray, C, Value, Affordability and Sustainability (VALUE), Real World Studies in PharmacoEpidemiology, -Genetics, -Economics and -Therapy (PEGET), and Microbes in Health and Disease (MHD)
Subjects: Male, Aging, 030204 cardiovascular system & hematology, Stroke data, GUIDELINES, 3124 Neurology and psychiatry, Body Mass Index, Global Burden of Disease, 0302 clinical medicine, RA0421, Risk Factors, Epidemiology, Strokes, YOUNG-ADULTS, Prevalence, 80 and over, Aetiology, 610 Medicine & health, Stroke, POPULATION, 1103 Clinical Sciences, 1109 Neurosciences, Cause of death, Aged, 80 and over, education.field_of_study, Mortality rate, Incidence (epidemiology), Incidence, 1. No poverty, Articles, Hälsovetenskaper, Middle Aged, Stroke types, ddc, 3. Good health, ISCHEMIC-STROKE, Income, Female, Quality-Adjusted Life Years, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, GBD, Population, Clinical Sciences, Clinical Neurology, 03 medical and health sciences, Clinical Research, MIDDLE-INCOME COUNTRIES, Health Sciences, medicine, Humans, Risk factor, education, GBD 2019 Stroke Collaborators, Cerebral Hemorrhage, Aged, Ischemic Stroke, Global burden, Science & Technology, Neurology & Neurosurgery, HYPERTENSION, business.industry, MORTALITY, Prevention, 3112 Neurosciences, Neurosciences, 1103 Clinical Sciences, SERVICES, Subarachnoid Hemorrhage, medicine.disease, PREVENTION, Brain Disorders, Good Health and Well Being, Attributable risk, Human medicine, Neurology (clinical), Neurosciences & Neurology, business, 1109 Neurosciences, 030217 neurology & neurosurgery, Demography, 2.4 Surveillance and distribution, RC
Abstract: Background Regularly updated data on stroke and its pathological types, including data on their incidence, prevalence, mortality, disability, risk factors, and epidemiological trends, are important for evidence-based stroke care planning and resource allocation. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) aims to provide a standardised and comprehensive measurement of these metrics at global, regional, and national levels. Methods We applied GBD 2019 analytical tools to calculate stroke incidence, prevalence, mortality, disability-adjusted life-years (DALYs), and the population attributable fraction (PAF) of DALYs (with corresponding 95% uncertainty intervals [UIs]) associated with 19 risk factors, for 204 countries and territories from 1990 to 2019. These estimates were provided for ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and all strokes combined, and stratified by sex, age group, and World Bank country income level. Findings In 2019, there were 12·2 million (95% UI 11·0–13·6) incident cases of stroke, 101 million (93·2–111) prevalent cases of stroke, 143 million (133–153) DALYs due to stroke, and 6·55 million (6·00–7·02) deaths from stroke. Globally, stroke remained the second-leading cause of death (11·6% [10·8–12·2] of total deaths) and the third-leading cause of death and disability combined (5·7% [5·1–6·2] of total DALYs) in 2019. From 1990 to 2019, the absolute number of incident strokes increased by 70·0% (67·0–73·0), prevalent strokes increased by 85·0% (83·0–88·0), deaths from stroke increased by 43·0% (31·0–55·0), and DALYs due to stroke increased by 32·0% (22·0–42·0). During the same period, age-standardised rates of stroke incidence decreased by 17·0% (15·0–18·0), mortality decreased by 36·0% (31·0–42·0), prevalence decreased by 6·0% (5·0–7·0), and DALYs decreased by 36·0% (31·0–42·0). However, among people younger than 70 years, prevalence rates increased by 22·0% (21·0–24·0) and incidence rates increased by 15·0% (12·0–18·0). In 2019, the age-standardised stroke-related mortality rate was 3·6 (3·5–3·8) times higher in the World Bank low-income group than in the World Bank high-income group, and the age-standardised stroke-related DALY rate was 3·7 (3·5–3·9) times higher in the low-income group than the high-income group. Ischaemic stroke constituted 62·4% of all incident strokes in 2019 (7·63 million [6·57–8·96]), while intracerebral haemorrhage constituted 27·9% (3·41 million [2·97–3·91]) and subarachnoid haemorrhage constituted 9·7% (1·18 million [1·01–1·39]). In 2019, the five leading risk factors for stroke were high systolic blood pressure (contributing to 79·6 million [67·7–90·8] DALYs or 55·5% [48·2–62·0] of total stroke DALYs), high body-mass index (34·9 million [22·3–48·6] DALYs or 24·3% [15·7–33·2]), high fasting plasma glucose (28·9 million [19·8–41·5] DALYs or 20·2% [13·8–29·1]), ambient particulate matter pollution (28·7 million [23·4–33·4] DALYs or 20·1% [16·6–23·0]), and smoking (25·3 million [22·6–28·2] DALYs or 17·6% [16·4–19·0]). Interpretation The annual number of strokes and deaths due to stroke increased substantially from 1990 to 2019, despite substantial reductions in age-standardised rates, particularly among people older than 70 years. The highest age-standardised stroke-related mortality and DALY rates were in the World Bank low-income group. The fastest-growing risk factor for stroke between 1990 and 2019 was high body-mass index. Without urgent implementation of effective primary prevention strategies, the stroke burden will probably continue to grow across the world, particularly in low-income countries. Funding Bill & Melinda Gates Foundation.
Published: 2021
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30. The Homeless, Inmates and Refugees in Africa in the Face of COVID-19 Outbreak

Author: Francis Leonard Mpotte Hyera, Jabu A Mbokazi, Olanrewaju Oladimeji, and Bamidele Paul Atiba
Subjects: Community and Home Care, Economic growth, Health (social science), Human rights, 030503 health policy & services, media_common.quotation_subject, Refugee, Public Health, Environmental and Occupational Health, 03 medical and health sciences, Intervention (law), 0302 clinical medicine, Hygiene, Political science, Pandemic, Western world, 030212 general & internal medicine, 0305 other medical science, Welfare, Mass screening, media_common
Abstract: Total well-being and care for the vulnerable, especially the homeless, inmates, and refugees during the COVID-19 pandemic, is one of the barometers to measure Africa's response. Hence in the light of this scenario, our comment is on their care during this devastating period. We compared what is currently being done in the western world with what the African countries are doing. We have posed particular challenges with the welfare packages, the implementation of physical distances, good hygiene practices, limited access to screening and testing of COVID-19, as the outbreak invasion could be overwhelming if there is no intervention to bridge this gap. There is, therefore, an urgent need to consider welfare packages, an optimum hygiene environment, decongestion, and mass screening and testing for these groups of individuals, as they also have equal human rights to be protected during this pandemic.
Published: 2020
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31. Multisectoral approach and WHO ‘Bestbuys’ in Nigeria’s nutrition and physical activity policies

Author: Mojisola Oluwasanu, Oladimeji Oladepo, and Opeyemi Oladunni
Subjects: Health (social science), Population, Psychological intervention, Nigeria, Legislation, World Health Organization, Nutrition Policy, 03 medical and health sciences, 0302 clinical medicine, Humans, 030212 general & internal medicine, Salt intake, Policy Making, education, Exercise, Government, education.field_of_study, Public economics, business.industry, 030503 health policy & services, Public Health, Environmental and Occupational Health, Policy analysis, Food processing, Thematic analysis, 0305 other medical science, business
Abstract: Unhealthy diet and physical inactivity are modifiable risk factors for non-communicable diseases. Policies formulated in line with international guidelines are required for the implementation of population-level interventions to reduce the risks. This study describes the utilization of multisectoral approach (MSA) for the formulation of nutrition and physical activity policies and the extent to which they align with the WHO ‘Best Buy Interventions’. The research utilized a descriptive case study design and the theoretical model guiding the study was the Walt and Gilson framework for policy analysis. Data were obtained through the interview of 44 key informants using pre-tested guides and document review of 17 policies and articles obtained from government institutions or through the search of electronic databases. Data were integrated and analysed using thematic analysis. Between 2000 and 2016, Nigeria had formulated 10 nutrition-related policies and 5 guidelines with actions to promote physical activity. Only three nutrition and two physical activity policies adopted a high level of MSA. In line with the WHO best buy interventions, educational interventions for the general population are proposed to reduce sugar and salt intake and replace transfat with polyunsaturated fats but there are no legal regulatory acts to support these actions. Policy documents with actions to reduce physical inactivity do not include the WHO best buys. The country should adopt a wider range of actors to formulate and review policies, integrate all the WHO best buy interventions and develop effective legislation to regulate the salt and sugar content of processed foods.
Published: 2020
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32. Exploring Issues and Challenges of Leadership among Early Career Doctors in Nigeria Using a Mixed-Method Approach: CHARTING Study

Author: Selekeowei Peter Kespi Kpuduwei, Elizabeth O. Grillo, Kehinde Kazeem Kanmodi, Oluwafemi Efuntoye, Oluwaseyi Ogunsuji, Babalola Rereloluwa, Iyanu Adufe, Ibiyemi Oduyemi, Makinde Adebayo Adeniyi, Olusegun Olaopa, M.C. Igbokwe, Oladimeji Adebayo, Ayanfe Omololu, Sebastine Oiwoh, Efosa Isibor, Ifeanyichukwu Kelvin Egbuchulem, and Onuwabuchi Egwu
Subjects: early-career doctors, organizational psychology, genetic structures, 020205 medical informatics, education, organisation, Nigeria, challenges, 02 engineering and technology, issues, Article, clinical, Dreyfus model of skill acquisition, leadership behaviour, 03 medical and health sciences, 0302 clinical medicine, Health care, 0202 electrical engineering, electronic engineering, information engineering, Developmental and Educational Psychology, 030212 general & internal medicine, Early career, Applied Psychology, Medical education, Medical setting, business.industry, Effective management, Focus group, Clinical Psychology, Medical training, Industrial and organizational psychology, business, Psychology
Abstract: (1) Background: leadership behaviour is a poorly explored phenomenon among early-career doctors (ECDs). Good leadership is vital in maximising the effective management of patients in a clinical setting. While a good number of studies, though with small sample surveys, have researched the role of leadership in clinical setting quantitatively, qualitative investigations are yet to be done in Nigeria. This study aims to explore the attitudes, skills, and experience of ECDs in Nigeria on issues pertaining to leadership in a medical setting, using a mixed-method approach. (2) Methods: we conducted two sessions of key informant focus group discussion (FGD) that involved 14 ECD leaders in Nigeria, exploring their leadership experience in a clinical setting. Furthermore, we used a self-administered questionnaire to quantitatively survey 474 ECDs from seven Nigerian teaching hospitals to explore their attitudes, skills, and experience on issues pertaining to medical leadership. (3) Results: taking on leadership roles is a common phenomenon (52.7%) among the surveyed ECDs, however, the medical leadership position can be very challenging for ECDs in Nigeria. Despite the fact that many (91.1%) of the surveyed ECDs perceived leadership skills as essential skills needed by a doctr, many (44.1%) of them were yet to be formally trained on medical leadership. About three out of every 10 (23.6%) of surveyed ECDs that have ever held leadership positions in a medical setting experienced major leadership challenges while in such office due to their lack of training on leadership skills. Leadership skill acquisition programmes are highly recommended to become an integral part of medical training programmes in Nigeria. (4) Conclusion: there is a need for a structured leadership skill acquisition programme for ECDs in Nigeria. This programme will help in the robust delivery of highly effective healthcare services in Nigeria, as effective leadership is crucial to patient care services.
Published: 2020
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33. First Report on Successful Triploidy Induction in Clarias gariepinus (Burchell, 1822) Using Electroporation

Author: Alabi Isaiah Korede, Chukwuemeka Onwuka Martins, Sunday Abraham Oladimeji, Sheriff Shahreza, A. Hassan, Mhd Ikhwanuddin, Lubna Aminath, Joshua A Umaru, Victor Tosin Okomoda, and Ambok Bolong Abol-Munafi
Subjects: Male, 0301 basic medicine, Clarias gariepinus, Erythrocytes, Semi-major axis, lcsh:Medicine, Article, 03 medical and health sciences, Animal science, Human fertilization, Animals, lcsh:Science, Incubation, Catfishes, Animal breeding, Animal biotechnology, Multidisciplinary, biology, Electroporation, lcsh:R, 04 agricultural and veterinary sciences, biology.organism_classification, Diploidy, Triploidy, 030104 developmental biology, Fertilization, 040102 fisheries, 0401 agriculture, forestry, and fisheries, Female, lcsh:Q, Ploidy, Catfish
Abstract: This study investigated the use of electric-shock in inducing triploidy in African catfish Clarias gariepinus. To achieve this, three voltages (9, 12, 21 V) were applied for different durations (3, 5, 10 min). The shock was initiated approximately three minutes after fertilization followed by incubation in ambient temperature. After incubation, hatchability and survival rates were determined while ploidy status of the treatment fishes was confirmed in one-month-old fingerlings using the exclusive triploid range of the erythrocyte major axis previously reported for the same species (11.9–14.9 μm) and by cytogenetic analysis of the chromosome. The results showed triploidy were achieved in 10 to 85% of the treatment groups. A consistent trend of decrease in hatchability and an increase in triploidy rate was observed with increased electroporation voltages and shock durations. The mean erythrocyte major axis length of triploid progenies (3n = 84) was observed to be between 11.3–14.6 μm and was higher than the range of 7.0–10.5 μm recorded for diploid progenies (2n = 56). It was concluded that electric shock can be used to induce triploidy in African catfish C. gariepinus.
Published: 2020
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34. Estimating global injuries morbidity and mortality

Author: Zohreh Arefi, Rasmus Havmoeller, Pietro Ferrara, Vijay Kumar Chattu, Payman Salamati, Agegnehu Bante Getenet, Seyedeh Zahra Masoumi, Alexander C. Tsai, Andrew T Olagunju, Carl Abelardo T. Antonio, Morteza Abdullatif Khafaie, Tim Driscoll, Reza Rawassizadeh, Vishnu Renjith, Taras Kavetskyy, Ejaz Ahmad Khan, Gebreamlak Gebremedhn Gebremeskel, Richard C. Franklin, Naznin Hossain, Bhaskaran Unnikrishnan, Fariborz Mansour-Ghanaei, Arash Tehrani-Banihashemi, Morteza Naserbakht, Sangram Kishor Patel, Vera Marisa Costa, Suzanne Polinder, Ziad El-Khatib, Ashish Pathak, Mika Shigematsu, Bryan L. Sykes, David M. Pigott, Zeleke Aschalew Melketsedik, Hadi Hassankhani, Nuworza Kugbey, Lal B. Rawal, Masoud Foroutan, Dejana Braithwaite, Muluken Bekele Sorrie, Grant M. A. Wyper, Joht Singh Chandan, Akbar Barzegar, Hamid Safarpour, Kate E. LeGrand, Giulio Castelpietra, Dina Nur Anggraini Ningrum, Seth Christopher Yaw Appiah, Amin Soheili, Azeem Majeed, Akshaya Srikanth Bhagavathula, Nikolay Ivanovich Briko, Vahid Yazdi-Feyzabadi, Walter Mendoza, Ghulam Mustafa, Cuong Tat Nguyen, Pengpeng Ye, Mahesh P A, Carlos Miguel Rios González, Ahmad Daryani, Ibrahim Abdollahpour, Masoud Moradi, Haileab Fekadu Wolde, Mohammad Rabiee, Jaya Prasad Tripathy, Jack T Fox, Diep Ngoc Nguyen, Pallab K. Maulik, Ai-Min Wu, Félix Carvalho, Yun Jin Kim, Fatemeh Rajati, Nathaniel J Henry, David C. Schwebel, Ali H. Mokdad, Akine Eshete Abosetugn, Leonardo Roever, Ketema Bizuwork Gebremedhin, Khalid A Altirkawi, Hayimro Edemealem Merie, Farhad Ghamari, Ramesh Holla, Arash Sarveazad, Devasahayam J. Christopher, Kedir Hussein Abegaz, Suresh Jungari, Rohan Borschmann, Irfan Ullah, Nitin Joseph, Catalina Liliana Andrei, Abdallah M. Samy, Roman Topor-Madry, Michal Grivna, Ivo Rakovac, Mohammad Zamani, Antonio Maria Borzì, Atif Amin Baig, Mohsen Bayati, Mohammad Ali Mansournia, Fatemeh Heydarpour, Juanita A. Haagsma, Segun Emmanuel Ibitoye, Mehdi Sayyah, Teshome Abegaz Kamil, Fakher Rahim, Dillon O Sylte, Feng Sha, Palash Chandra Banik, Mohan Bairwa, Mariya Vladimirovna Titova, Yong Yu, Delia Hendrie, Spencer L. James, Anusha Ganapati Bhat, Seok Jun Yoon, Siavash Rahimi, Jost B. Jonas, Michael R. Phillips, Diana Silva, Amir Hossein Goudarzian, Samath D Dharmaratne, Roba Khundkar, Jemal Abdu Mohammed, Joemer C. Maravilla, Eleonora Dubljanin, Arun Balachandran, Arman Latifi, Randah R. Hamadeh, G. K. Mini, Alessandra C. Goulart, Andreea Mirica, Fatemeh Zarei, Habte Belete, Telma Zahirian Moghadam, Maseer Khan, Morenike Oluwatoyin Folayan, Atte Meretoja, Jasvinder A. Singh, Guilherme Borges, Yasir Waheed, Fahad Alanezi, Masoud Moghadaszadeh, Guoqing Hu, Archith Boloor, Luca Ronfani, Olayinka Stephen Ilesanmi, Vahid Rashedi, Mehran Shams-Beyranvand, Trang Huyen Nguyen, Yonatal Mesfin Tefera, Yousef Khader, Adnan Kisa, Simon I. Hay, Takeshi Fukumoto, Shahrzad Bazargan-Hejazi, Yuichiro Yano, Carlos A Castañeda-Orjuela, Suzanne Barker-Collo, Ghasem Azarian, Sezer Kisa, Basema Saddik, Leake Gebremeskel, Yetunde O. John-Akinola, Jennifer Rickard, Ilais Moreno Velásquez, Priya Rathi, Ali Bijani, Smita Pakhale, Francesco Saverio Violante, Neeraj Bedi, Efat Mohamadi, Deborah Carvalho Malta, Marek Majdan, Feleke Mekonnen Demeke, Chukwudi A Nnaji, Richard Ofori-Asenso, Prateek Rastogi, Xuefeng Liu, Monika Sawhney, Ayman Grada, Prasanna Mithra, Shanshan Li, Masood Ali Shaikh, Erin B Hamilton, Hung Chak Ho, Zichen Liu, Irini Chatziralli, Paulo A. Lotufo, Yuming Guo, Daniel N. Kiirithio, Hamidreza Komaki, Aristidis Tsatsakis, Brijesh Sathian, Daniel Kim, Yoosik Youm, Kebreab Paulos, Saqib Ali, Beriwan Abdulqadir Ali, M. Mofizul Islam, Ahad Bakhtiari, Karen M. Tabb, Davood Anvari, Tomislav Mestrovic, Yunquan Zhang, Muhammad Aziz Rahman, Naohiro Yonemoto, Rupak Desai, Peter Njenga Keiyoro, Rajan Nikbakhsh, Zahra Sadat Dibaji Forooshani, Carlo La Vecchia, Amrit Banstola, Niguse Meles Alema, Shivakumar K.M. Kondlahalli, Soraya Seedat, Filippo Ariani, Chi Linh Hoang, Maziar Moradi-Lakeh, Erika Ota, Dimas Ria Angga Pribadi, Van C. Lansingh, Mohammed Madadin, Mostafa Dianati Nasab, Biniyam Sahiledengle Geberemariyam, Amanda J. Mason-Jones, Marcela Agudelo-Botero, Dinh-Toi Chu, Bach Xuan Tran, Till Bärnighausen, Mehdi Mirzaei-Alavijeh, Mohammad Ali Jahani, Bereket Duko Adema, In-Hwan Oh, Paul S. F. Yip, Ionut Negoi, Eduarda Fernandes, Reza Ghanei Gheshlagh, Kelly Jones, Mahdi Safdarian, Josep Maria Haro, Zahiruddin Quazi Syed, Diego De Leo, Khanh Bao Tran, Syed Mohamed Aljunid, Yasser S. Amer, Tommi Vasankari, Vasily Vlassov, Jose C. Adsuar, Zoubida Zaidi, Asadollah Gholamian, Theo Vos, Nauman Khalid, Malke Asaad, André Faro, Rushdia Ahmed, Tuomo J. Meretoja, Ireneous N. Soyiri, Ana Isabel Ribeiro, Hoa Thi Do, Temesgen Gebeyehu Wondmeneh, Vladimir Andreevich Korshunov, Manasi Kumar, Josip Car, Shoaib Hassan, Mukhammad David Naimzada, Gurudatta Naik, Ali Rajabpour-Sanati, Mustafa Z. Younis, Farid Najafi, Ester Cerin, Lorenzo Monasta, Amit Arora, Rizwan Suliankatchi Abdulkader, Huong Lan Thi Nguyen, Javad Nazari, Joel M. Francis, Martin Amogre Ayanore, Farahnaz Joukar, Babak Moazen, Kebede Deribe, Nithin Kumar, Seyed-Mohammad Fereshtehnejad, Getinet Ayano, Serge Resnikoff, Mark A. Stokes, Alaa Badawi, Narinder Kumar, Habibolah Khazaie, Sojib Bin Zaman, Faris Lami, Jens R. Chapman, Onome Bright Oghenetega, Dhirendra N Sinha, Engida Yisma, Aso Mohammad Darwesh, Demelash Abewa Elemineh, Junaid Khan, Shane D. Morrison, Mansour Ghafourifard, Ata Rafiee, Hadush Gebremariam, Oghenowede Eyawo, Amir Hasanzadeh, Ana Laura Manda, Muhammed Magdy Abd El Razek, Morteza Arab-Zozani, Narayana Manjunatha, Navid Manafi, Ritesh G. Menezes, Ferrán Catalá-López, Hossein Poustchi, Ghobad Moradi, Suliman Alghnam, Tinuke O Olagunju, Mohiuddin Ahsanul Kabir Chowdhury, Man Mohan Mehndiratta, Sorin Hostiuc, Jalal Arabloo, Shaun Wen Huey Lee, Chris D Castle, Joan B. Soriano, Syed Amir Gilani, Mariam Molokhia, Gaurav Gupta, Inga Dora Sigfusdottir, Isabela M. Benseñor, Desalegn Getnet Demsie, Atalay Goshu Muluneh, Young Eun Kim, Olatunde Aremu, Leeberk Raja Inbaraj, Jae Il Shin, Berhe Etsay Tesfay, Neha Chaudhary, Juan Sanabria, Soosanna Kumary Chattu, Sanni Yaya, Rekha Thapar, Biruk Wogayehu Taddele, Maciej Banach, Salman Rawaf, Nicholas L S Roberts, Jagadish Rao Padubidri, Manoochehr Karami, Derrick A Bennett, Duduzile Ndwandwe, Soheil Hassanipour, Ashish Badiye, Krittika Bhattacharyya, Obinna Onwujekwe, Kewal Krishan, João Coelho, Ahmed Abdelalim, Kerrie E. Doyle, Tomasz Miazgowski, Rahman Shiri, Demelash Woldeyohannes Handiso, Navid Rabiee, Nikita Otstavnov, Brian J. Hall, Olalekan A. Uthman, Rohollah Kalhor, Swayam Prakash, Beatriz Paulina Ayala Quintanilla, Gebre Teklemariam Demoz, Ted R. Miller, Rebecca Ivers, Chuanhua Yu, Pascual R. Valdez, Martha Híjar, Taweewat Wiangkham, Maysaa El Sayed Zaki, Rafael Tabarés-Seisdedos, Melkamu Merid Mengesha, Seyedmojtaba Seyedmousavi, Ravi Prakash Jha, Songhomitra Panda-Jonas, Aidin Abedi, Savita Lasrado, Veincent Christian Filipino Pepito, Amir Almasi-Hashiani, Burcu Kucuk Bicer, Hagazi Gebremedhin Kassaye, Yousef Veisani, Ayenew Kassie Tesema, Amir Radfar, Pawan Faris, Oladimeji Adebayo, Fares Alahdab, Heather Orpana, Narayan Bahadur Mahotra, Tripti Khanna, Girikumar Kumaresh, Alireza Rafiei, João Mauricio Castaldelli-Maia, Subramanian Senthilkumaran, Cyrus Alinia, Era Upadhyay, Stanislav S. Otstavnov, Ahmed Omar Bali, Farshad Farzadfar, Vivek Kumar, Sanghamitra Pati, Gholamreza Roshandel, Daiane Borges Machado, Yuan-Pang Wang, Rafael Alves Guimarães, Aziz Sheikh, Jeevan Pereira, Ahamarshan Jayaraman Nagarajan, Soraya Siabani, Kamarul Imran Musa, Farshad Pourmalek, Janet L Leasher, Shafiu Mohammed, Shyam Sundar Budhathoki, Mehdi Naderi, Mehdi Hosseinzadeh, Eun-Kee Park, Marwa Rashad Salem, Alireza Ansari-Moghaddam, Achala Upendra Jayatilleke, Paolo Lauriola, Amir Kasaeian, Adam Belay Wondmieneh, Tilahun Belete Mossie, Rovshan Khalilov, Milena M Santric Milicevic, Ai Koyanagi, Shailesh Advani, Felix Akpojene Ogbo, Nihad A. Almasri, Abdur Razzaque Sarker, Salman Khazaei, Narayanaswamy Venketasubramanian, Josephine W. Ngunjiri, Mihajlo Jakovljevic, Matthew Cunningham, Shaimaa I. El-Jaafary, Hosni Salem, Sharareh Eskandarieh, Muktar Beshir Ahmed, Amy E. 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Nayak, Yoshan Moodley, Venkatesh Maled, Zhi-Jiang Zhang, Arielle Wilder Eagan, Saif Ullah, Anwar Rafay, Ali Koolivand, Ibrahim A Khalil, Parul Puri, Lidia Sanchez Riera, Vinay Nangia, Tanuj Kanchan, Mu'awiyyah Babale Sufiyan, Lidia Morawska, Saeed Shahabi, Tiffany K. Gill, Traolach S. Brugha, Michael K. Hole, Vahid Alipour, Sowmya J. Rao, Pankaj Singh, Rosario Cárdenas, Abdollah Mohammadian-Hafshejani, Sanjay Zodpey, Birhanu Geta, Amaha Kahsay, Moritz U. G. Kraemer, Claudio Alberto Dávila-Cervantes, Samer Hamidi, Gbenga A. Kayode, Miloud Taki Eddine Aichour, Peter Memiah, Erkin M. Mirrakhimov, Sheikh Mohammed Shariful Islam, Sadia Bibi, Bartosz Miazgowski, Daniel Y. Cho, Keyvan Pakshir, Aziz Rezapour, R V Polibin, Sudha Jayaraman, S. Mohammad Sajadi, Amir Manafi, Berhe Gebremichael, Ali Yadollahpour, Barthelemy Kuate Defo, Alan D. Lopez, Masoud Behzadifar, Mohammad A. Mohseni Bandpei, Ali Kabir, Jee-Young Jasmine Choi, Gebretsadkan Hintsa Tekulu, Kidanemaryam Berhe, Bill & Melinda Gates Foundation, Sanofi, HUS Comprehensive Cancer Center, Clinicum, University of Helsinki, Helsinki University Hospital Area, HUS Neurocenter, James, S. L., Castle, C. D., Dingels, Z. V., Fox, J. T., Hamilton, E. B., Liu, Z., Roberts, N. L. S., Sylte, D. O., Bertolacci, G. J., Cunningham, M., Henry, N. J., Legrand, K. E., Abdelalim, A., Abdollahpour, I., Abdulkader, R. S., Abedi, A., Abegaz, K. H., Abosetugn, A. E., Abushouk, A. I., Adebayo, O. M., Adsuar, J. C., Advani, S. M., Agudelo-Botero, M., Ahmad, T., Ahmed, M. B., Ahmed, R., Aichour, M. T. E., Alahdab, F., Alanezi, F. M., Alema, N. M., Alemu, B. W., Alghnam, S. A., Ali, B. A., Ali, S., Alinia, C., Alipour, V., Aljunid, S. M., Almasi-Hashiani, A., Almasri, N. A., Altirkawi, K., Amer, Y. S. A., Andrei, C. L., Ansari-Moghaddam, A., Antonio, C. A. T., Anvari, D., Appiah, S. C. Y., Arabloo, J., Arab-Zozani, M., Arefi, Z., Aremu, O., Ariani, F., Arora, A., Asaad, M., Quintanilla, B. P. A., Ayano, G., Ayanore, M. A., Azarian, G., Badawi, A., Badiye, A. D., Baig, A. A., Bairwa, M., Bakhtiari, A., Balachandran, A., Banach, M., Banerjee, S. K., Banik, P. C., Banstola, A., Barker-Collo, S. L., Barnighausen, T. W., Barzegar, A., Bayati, M., Bazargan-Hejazi, S., Bedi, N., Behzadifar, M., Belete, H., Bennett, D. A., Bensenor, I. M., Berhe, K., Bhagavathula, A. S., Bhardwaj, P., Bhat, A. G., Bhattacharyya, K., Bhutta, Z. A., Bibi, S., Bijani, A., Boloor, A., Borges, G., Borschmann, R., Borzi, A. M., Boufous, S., Braithwaite, D., Briko, N. I., Brugha, T., Budhathoki, S. S., Car, J., Cardenas, R., Carvalho, F., Castaldelli-Maia, J. M., Castaneda-Orjuela, C. A., Castelpietra, G., Catala-Lopez, F., Cerin, E., Chandan, J. S., Chapman, J. R., Chattu, V. K., Chattu, S. K., Chatziralli, I., Chaudhary, N., Cho, D. Y., Choi, J. -Y. J., Chowdhury, M. A. K., Christopher, D. 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A., Guo, Y., Gupta, G., Haagsma, J. A., Hall, B. J., Hamadeh, R. R., Hamidi, S., Handiso, D. W., Haro, J. M., Hasanzadeh, A., Hassan, S., Hassanipour, S., Hassankhani, H., Hassen, H. Y., Havmoeller, R., Hendrie, D., Heydarpour, F., Hijar, M., Ho, H. C., Hoang, C. L., Hole, M. K., Holla, R., Hossain, N., Hosseinzadeh, M., Hostiuc, S., Hu, G., Ibitoye, S. E., Ilesanmi, O. S., Inbaraj, L. R., Irvani, S. S. N., Islam, M. M., Islam, S. M. S., Ivers, R. Q., Jahani, M. A., Jakovljevic, M., Jalilian, F., Jayaraman, S., Jayatilleke, A. U., Jha, R. P., John-Akinola, Y. O., Jonas, J. B., Jones, K. M., Joseph, N., Joukar, F., Jozwiak, J. J., Jungari, S. B., Jurisson, M., Kabir, A., Kahsay, A., Kalankesh, L. R., Kalhor, R., Kamil, T. A., Kanchan, T., Kapoor, N., Karami, M., Kasaeian, A., Kassaye, H. G., Kavetskyy, T., Kayode, G. A., Keiyoro, P. N., Kelbore, A. G., Khader, Y. S., Khafaie, M. A., Khalid, N., Khalil, I. A., Khalilov, R., Khan, M., Khan, E. 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Yazdi-Feyzabadi, V., Ye, P., Yip, P., Yisma, E., Yonemoto, N., Yoon, S.-J., Youm, Y., Younis, M.Z., Yousef, Z., Yu, C., Yu, Y., Moghadam, T.Z., Zaidi, Z., Zaman, S.B., Zamani, M., Zandian, H., Zarei, F., Zhang, Z.-J., Zhang, Y., Ziapour, A., Zodpey, S., Dandona, R., Dharmaratne, S.D., Hay, S.I., Mokdad, A.H., Pigott, D.M., Reiner, R.C., Vos, T., Instituto de Saúde Pública da Universidade do Porto, James, Spencer L, Castle, Chris D, Dingels, Zachary V, Fox, Jack T, Adema, Bereket Duko, Yisma, Engida, Vos, Theo, and Public Health
Subjects: Male, Populations/contexts, 1106 Human Movement and Sports Sciences, Global injuries, population, 030204 cardiovascular system & hematology, Global Health, contexts, context, Global Burden of Disease, 0302 clinical medicine, Quality-Adjusted Life Year, Global health, 030212 general & internal medicine, Original Research, Data, populations/contexts, Incidence (epidemiology), Incidence, methodology, 3142 Public health care science, environmental and occupational health, Female, Public Health, TERRITORIES, Quality-Adjusted Life Years, descriptive epidemiology, Human, Disabilities, 195 COUNTRIES, statistical issue, 1117 Public Health and Health Services, 03 medical and health sciences, AGE, Life Expectancy, Environmental health, Injury prevention, SYSTEMATIC ANALYSIS, statistical issues, Humans, Mortality, Estimation, SEX-SPECIFIC MORTALITY, DISABILITY, Public Health, Environmental and Occupational Health, populations, Morbidity, Wounds and Injuries, 1106 Human Movement and Sports Sciences, 1117 Public Health and Health Services, 1701 Psychology, Quality-adjusted life year, Years of potential life lost, 1701 Psychology, Life expectancy, Estimates, Human medicine, populations/context
Abstract: Background. While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of global injury burden that meet these criteria. Methods. In this study, we report and discuss the methods used in GBD 2017 for injury morbidity and mortality burden estimation. In summary, these methods included estimating cause-specific mortality for every cause of injury, and then estimating incidence for every cause of injury. Non-fatal disability for each cause is then calculated based on the probabilities of suffering from different types of bodily injury experienced. Results. GBD 2017 produced morbidity and mortality estimates for 38 causes of injury. Estimates were produced in terms of incidence, prevalence, years lived with disability, cause-specific mortality, years of life lost and disability-adjusted life-years for a 28-year period for 22 age groups, 195 countries and both sexes. Conclusions. GBD 2017 demonstrated a complex and sophisticated series of analytical steps using the largest known database of morbidity and mortality data on injuries. GBD 2017 results should be used to help inform injury prevention policy making and resource allocation. We also identify important avenues for improving injury burden estimation in the future. Seyed Aljunid acknowledges the Department of Health Policy and Management, Faculty of Public Health, Kuwait University and International Centre for Casemix and Clinical Coding, Faculty of Medicine, National University of Malaysia for the approval and support to participate in this research project. Alaa Badawi acknowledges support by the Public Health Agency of Canada. Till Bärnighausen acknowledges support by the Alexander von Humboldt Foundation through the Alexander von Humboldt Professor award, funded by the German Federal Ministry of Education and Research. Traolach Brugha received support from NatCen Social Research (http://natcen.ac.uk/) via NHS Digital and Department of Health and Social Care London, for the Adult Psychiatric Morbidity Survey (APMS) programme. Felix Carvalho received support from UID/MULTI/04378/2019 with funding from FCT/MCTES through national funds. Vera M Costa acknowledges support from grant (SFRH/BHD/110001/2015), received by Portuguese national funds through Fundação para a Ciência e Tecnologia (FCT), IP, under the Norma Transitória DL57/2016/CP1334/CT0006. Kebede Deribe is supported by a grant from the Wellcome Trust [grant number 201900] as part of his International Intermediate Fellowship. Tim Driscoll acknowledges that work on occupational risk factors was partially supported by funds from the World Health Organization. Eduarda Fernandes acknowledges support from UID/QUI/50006/2019 with funding from FCT/MCTES through national funds. Yuming Guo acknowledges support from Career Development Fellowships of the Australian National Health and Medical Research Council (numbers APP1107107 and APP1163693). Sheikh Mohammed Shariful Islam is funded by a Fellowship from National Heart Foundation of Australia and Institute for Physical Activity and Nutrition, Deakin University. Mihajlo Jakovljevic acknowledges support by the Ministry of Education Science and Technological Development of the Republic of Serbia through the Grant number OI175014; publication of results was not contingent upon Ministry's censorship or approval. Sudha Jayaraman acknowledges support from: NIH R21: 1R21TW010439-01A1 (PI); Rotary Foundation Global Grant #GG1749568 (PI); NIH P20: 1P20CA210284-01A1 (Co-PI) and DOD grant W81XWH-16-2-0040 (Co-I), during the period of this study. Yun Jin Kim acknowledges support from a grant from the Research Management Centre, Xiamen University Malaysia [grant number: XMUMRF/2018-C2/ITCM/0001]. Kewal Krishan is supported by UGC Centre of Advanced Study (CAS II) awarded to the Department of Anthropology, Panjab University, Chandigarh, India. Mansai Kumar acknowledges support from FIC/ NIH K43 1K43MH114320-01. Amanda Mason-Jones acknowledges support by the University of York. Mariam Molokhia is supported by the National Institute for Health Research Biomedical Research Center at Guy’s and St Thomas’s National Health Service Foundation Trust and King’s College London. Ilais Moreno Velasquez is supported by the Sistema Nacional de Investigación (SNI, Senacyt, Panama). Mukhammad David Naimzada acknowledges support from Government of the Russian Federation (Agreement No – 075-02-2019-967). Duduzile Ndwandwe acknowledges support from Cochrane South Africa, South African Medical Research Council. Stanislav S. Otstavnov acknowledges the support from the Government of the Russian Federation (Agreement No – 075-02-2019-967). Ashish Pathak acknowledges support from Indian Council of Medical Research (ICMR), New Delhi, India (Grant number 2013-1253). Michael R Phillips acknowledges support in part by a grant from the National Natural Science Foundation of China (No.81761128031). Abdallah M. Samy received a fellowship from the Egyptian Fulbright Mission Program. Milena Santric Milicevic acknowledges the support from the Ministry of Education, Science and Technological Development, Republic of Serbia (Contract No. 175087). Seyedmojtaba Seyedmousavi was supported by the Intramural Research Program of the National Institutes of Health, Clinical Center, Department of Laboratory Medicine, Bethesda, MD, USA. Rafael Tabarés-Seisdedos was supported in part by the national grant PI17/00719 from ISCIII-FEDER. Sojib Bin Zaman acknowledges support from an "Australian Government Research Training Program (RTP) Scholarship.
Published: 2020
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35. KANSL2 and MBNL3 are regulators of pancreatic ductal adenocarcinoma invasion

Author: Peter Oladimeji, William C. Wright, Jesse Bakke, and Taosheng Chen
Subjects: endocrine system diseases, lcsh:Medicine, Biology, Article, Metastasis, Small hairpin RNA, Gene Knockout Techniques, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, Cell Line, Tumor, medicine, Carcinoma, Humans, CRISPR, Neoplasm Invasiveness, RNA, Small Interfering, lcsh:Science, Histone Acetyltransferases, 030304 developmental biology, Regulation of gene expression, 0303 health sciences, Multidisciplinary, Cell growth, lcsh:R, High-throughput screening, RNA-Binding Proteins, Cancer, Pancreatic cancer, medicine.disease, digestive system diseases, 3. Good health, Gene Expression Regulation, Neoplastic, Pancreatic Neoplasms, Cell culture, 030220 oncology & carcinogenesis, Cancer research, lcsh:Q, CRISPR-Cas Systems, Carcinoma, Pancreatic Ductal
Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer. One major reason for this is that PDAC quickly metastasizes to other organs, thereby making its treatment difficult. The molecular machinery driving PDAC metastasis is still poorly understood. In this study, we applied an unbiased approach using CRISPR screening to identify genes that strongly regulate invasion (based on an in vitro assessment of their metastatic potential) in PANC-1, a PDAC cell line. Through CRISPR screening, we identified MBNL3 and KANSL2 as strong regulators of invasion in PANC-1 cells. We further validated MBNL3 and KANSL2 as regulators of PANC-1 cell invasion by using the doxycycline-inducible shRNA system. We also showed that MBNL3 and KANSL2 do not affect cell proliferation. Through our efforts, we have established a process to identify genes that regulate cell invasion and can be further investigated as potential targets for therapeutic intervention.
Published: 2020
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36. Prevalence of Antibodies to Crimean-Congo Hemorrhagic Fever Virus in Ruminants, Nigeria, 2015

Author: A I Adebiyi, Daniel Oladimeji Oluwayelu, Tomoki Yoshikawa, Masayuki Saijo, Oyewale Tomori, Anitha Varghese, Park Eunsil, Shuetsu Fukushi, Roger Hewson, Shigeru Morikawa, Babak Afrough, and E.J. Neumann
Subjects: Microbiology (medical), Crimean–Congo hemorrhagic fever, Epidemiology, 030231 tropical medicine, prevalence, lcsh:Medicine, Nigeria, Human pathogen, Prevalence of Antibodies to Crimean-Congo Hemorrhagic Fever Virus in Ruminants, Nigeria, 2015, Antibodies, Viral, Virus, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, 0302 clinical medicine, Seroepidemiologic Studies, CCHF, antibodies Crimean-Congo hemorrhagic fever virus, Medicine, antibodies, Animals, lcsh:RC109-216, viruses, 030212 general & internal medicine, biology, business.industry, lcsh:R, Dispatch, Ruminants, Hemorrhagic fever virus, medicine.disease, Virology, Crimean-Congo hemorrhagic fever virus, zoonoses, Infectious Diseases, CCHFV, Hemorrhagic Fever Virus, Crimean-Congo, biology.protein, Crimean-Congo hemorrhagic fever, Cattle, Hemorrhagic Fever, Crimean, Antibody, business, Crimean Congo hemorrhagic fever virus
Abstract: Crimean-Congo hemorrhagic fever virus (CCHFV) is a highly transmissible human pathogen. Infection is often misdiagnosed, in part because of poor availability of data in disease-endemic areas. We sampled 150 apparently healthy ruminants throughout Nigeria for virus seropositivity and detected virus-specific IgG in cattle (24%) and goats (2%), highlighting the need for further investigations.
Published: 2020

37. Oxidative Stress Induced DNA Damage and Reproductive Toxicity in Male Albino Mice Orally Exposed to Sorbitol

Author: Okunola A. Alabi, Lanre R. Oladimeji, Yetunde M Adeoluwa, and Adewale A. Sorungbe
Subjects: 0301 basic medicine, History, 030102 biochemistry & molecular biology, DNA damage, 04 agricultural and veterinary sciences, Pharmacology, Biology, medicine.disease_cause, 040401 food science, Computer Science Applications, Education, 03 medical and health sciences, chemistry.chemical_compound, 0404 agricultural biotechnology, chemistry, medicine, Sorbitol, Reproductive toxicity, Oxidative stress
Abstract: In this study, the potential DNA damage and reproductive toxicity of sorbitol was investigated using bone marrow micronucleus (MN), sperm morphology, and sperm count in mice. Five doses of 90, 45, 20, 10 and 1 mg/kg/day, defined by allometry, and approximately corresponding to 1.5g, 750mg, 330mg, 165mg and 16mg of sorbitol daily consumption by a 70kg human, respectively, were used. MN analysis showed a dose-dependent induction of micronucleated polychromatic erythrocytes and other nuclear abnormalities across the treatment groups. Assessment of sperm shape showed a significant (p < 0.05) increase in sperm abnormalities with significant (p < 0.05) decrease in mean sperm count in treated groups. The result of the oxidative stress biomarkers showed induction of significant (p < 0.05) increase in liver catalase, MDA and serum ALT and AST activities with concomitant decrease in SOD activities in exposed mice. A significant increase in weight of exposed mice were recorded when compared with the negative control. The results of this study showed the genotoxicity and reproductive effects of sorbitol.
Published: 2019
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38. Electronic Cigarette Use among Survivors of Smoking-Related Cancers in the United States

Author: Oladimeji Akinboro, Jamie S. Ostroff, Olatunde Ola, Oluseyi Balasire, Stanley Madu Nwabudike, and Rawad Elias
Subjects: Adult, Male, 0301 basic medicine, Adolescent, Epidemiology, Cross-sectional study, medicine.medical_treatment, law.invention, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Cancer Survivors, law, Neoplasms, Surveys and Questionnaires, Prevalence, medicine, Humans, National Health Interview Survey, Young adult, Aged, business.industry, Vaping, Smoking, Middle Aged, Prognosis, Former Smoker, United States, Confidence interval, Cross-Sectional Studies, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Relative risk, Smoking cessation, Female, Smoking Cessation, Self Report, business, Electronic cigarette, Follow-Up Studies, Demography
Abstract: Background: The prevalence of electronic cigarette (e-cigarette) use and its impact on smoking cessation among cancer survivors in the United States is largely unknown. We sought to estimate the prevalence of e-cigarette use and examine its associations with cigarette smoking and smoking quit attempts among smoking-related cancer survivors in the United States. Methods: We obtained data from the 2014–2017 annual cycles of the National Health Interview Survey for participants with self-reported history of smoking-related cancer(s). We calculated the prevalence of current e-cigarette use and utilized multinomial logistic regression in examining the independent association between e-cigarette use and cigarette smoking. Appropriate survey weights were applied in estimating the prevalence rates, relative risk ratios (RRR), ORs, and confidence intervals (CI). Results: Our sample comprised 3,162 smoking-related cancer survivors. The prevalence of current e-cigarette use was 3.18% (95% CI, 2.40–3.96). Current e-cigarette users were 83 times as likely as never users to be current cigarette smokers (RRR, 82.89; 95% CI, 16.54–415.37). Among those with a history of cigarette smoking, current e-cigarette users were 90% less likely to be former smokers (OR, 0.10; 95% CI, 0.05–0.18). No association was seen between current e-cigarette use and a smoking quit attempt in the prior year. Conclusions: E-cigarette use among cigarette ever smokers was associated with a lower likelihood of being a former smoker/having quit smoking, and e-cigarette use was not associated with smoking quit attempts. Impact: Our findings do not provide evidence that e-cigarette use facilitates smoking cessation among smoking-related cancer survivors.
Published: 2019
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39. Nigerian rural mothers’ knowledge of routine childhood immunizations and attitudes about use of reminder text messages for promoting timely completion

Author: Oladimeji Oladepo, Opeyemi Oladunni, and Isaac Oluwafemi Dipeolu
Subjects: Adult, Rural Population, medicine.medical_specialty, Reminder Systems, Nigeria, Mothers, Federal capital territory, Rural areas, 03 medical and health sciences, 0302 clinical medicine, Intervention (counseling), Environmental health, medicine, Humans, 030212 general & internal medicine, Immunization Schedule, Medical sociology, Text Messaging, 030505 public health, Descriptive statistics, Health Policy, Public health, Public Health, Environmental and Occupational Health, Infant, Newborn, Infant, Focus group, Routine immunization, Mobile phone reminder text messages, Cross-Sectional Studies, Family medicine, Original Article, Female, Rural area, Willingness to accept, 0305 other medical science, Psychology
Abstract: Mothers’ poor knowledge and attitudes about routine immunization impede child- hood immunization completion. This study assessed mothers’ knowledge in rural communities about routine immunization and acceptability of mobile phone reminder text messages as an intervention for improving uptake and timely completion of routine immunization. The study adopted a descriptive cross-sectional design among 3440 consenting mothers of infants in six randomly selected Nigerian states and in the Federal Capital Territory (FCT). We used a Focus Group Discussion guide and validated questionnaire to collect data; we analysed data using a thematic approach and descriptive statistics. Respondents’ ages were 26.7 ± 5.5 years. Knowl- edge of routine immunization was poor; attitudinal disposition was positive. Most (90.5%) indicated willingness to accept reminder text messages for routine immu- nization and 91.5% opined that mobile phones can be effective in providing such information. Mothers’ willingness to accept the use of SMS reminder text messages for promoting routine immunization completion requires well-designed and culture- sensitive persuasive messages.
Published: 2019

40. Predictors of Safer Conception Practices Among HIV-Infected Women in Northern Nigeria

Author: Musa Babashani, Auwalu U. Gajida, Hadiza S Galadanci, Muktar H. Aliyu, Alfa I Oladimeji, and Zubairu Iliyasu
Subjects: Adult, Counseling, Health (social science), hiv/aids, Leadership and Management, media_common.quotation_subject, Social Stigma, Breastfeeding, Nigeria, HIV Infections, Fertility, Management, Monitoring, Policy and Law, Cohort Studies, northern nigeria, 03 medical and health sciences, 0302 clinical medicine, Health Information Management, Acquired immunodeficiency syndrome (AIDS), SAFER, Humans, Medicine, 030212 general & internal medicine, Heterosexuality, media_common, 030219 obstetrics & reproductive medicine, Reproductive Rights, business.industry, Health Policy, lcsh:Public aspects of medicine, lcsh:RA1-1270, medicine.disease, Risk perception, Sexual Partners, Fertilization, Serodiscordant, Marital status, Female, Pre-Exposure Prophylaxis, Original Article, women, Serostatus, business, safer conception practice, Demography
Abstract: Background Persons living with HIV often face discrimination in safe sex and reproductive choices, especially in lowresource settings. This study assessed fertility desires and intentions, risk perception and correlates of ever use of at least one safer conception method among HIV-infected women attending a tertiary health facility in Kano, Nigeria. Methods Structured questionnaires were administered to a cross section of 328 of 427 eligible HIV-infected women. Fertility desires and intentions, risk perception and safer conception practice were analyzed. Logistic regression was employed to assess for predictors. Results Of the 328 respondents, 150 respondents (45.7%) wanted more children. The proportions of respondents aware of their transmission risk during pregnancy, delivery, and breastfeeding were 69.5%, 75.3%, and 78.9%, respectively. Further, 68.9% of respondents were aware of the prospects of bearing HIV-negative children without infecting their partners. About 64.8% of women were aware of at least one safer conception method. Safer conception methods everused by the participants include: antiretroviral therapy (ART) (36.7%), timed unprotected intercourse with (10.9%), and without pre-exposure prophylaxis (PrEP) (17.2%), intravaginal insemination (7.3%) and intrauterine insemination (4.7%). Safer conception practice was predicted by marital status (married versus single, adjusted odds ratio [AOR] = 1.50, 95% CI = 1.10-3.55), parity (2-4 versus 0, AOR = 12.1, 95% CI = 3.7-39.8), occupation (civil servants versus traders, AOR = 0.37, 95% CI = 0.16-0.86), husband’s serostatus (seroconcordant versus serodiscordant) (AOR = 1.51, 95% CI = 1.13-4.64), couple contraceptive use (users versus non-users) (AOR = 1.62, 95% CI = 1.16-5.83) and transmission risk perception (high risk versus low/no risk) (AOR = 2.14, 95% CI = 1.18-3.90). Conclusion We found high levels of fertility desires and intentions and moderate risk perception among a cohort of HIV-infected women in urban Kano, Nigeria. The use of safer conception practices was not common. Our findings underscore the need for healthcare provider capacity building to enhance safer conception counseling and service delivery.
Published: 2019

41. Comparative effectiveness of convolutional neural network (CNN) and recurrent neural network (RNN) architectures for radiology text report classification

Author: Matthew C. Chen, N Moradzadeh, Imon Banerjee, Matthew P. Lungren, Daniel L. Rubin, Yuan Ling, David A. Mong, Timothy J. Amrhein, Oladimeji Farri, Sadid A. Hasan, Brian E. Chapman, and Curtis P. Langlotz
Subjects: medicine.medical_specialty, Computer science, Population, Information Storage and Retrieval, Medicine (miscellaneous), Convolutional neural network, Article, 03 medical and health sciences, Deep Learning, 0302 clinical medicine, Artificial Intelligence, Medical imaging, medicine, Humans, AdaBoost, education, 030304 developmental biology, 0303 health sciences, education.field_of_study, Artificial neural network, business.industry, Deep learning, Support vector machine, Recurrent neural network, Radiography, Thoracic, Neural Networks, Computer, Artificial intelligence, Radiology, Pulmonary Embolism, business, 030217 neurology & neurosurgery
Abstract: This paper explores cutting-edge deep learning methods for information extraction from medical imaging free text reports at a multi-institutional scale and compares them to the state-of-the-art domain-specific rule-based system - PEFinder and traditional machine learning methods - SVM and Adaboost. We proposed two distinct deep learning models - (i) CNN Word - Glove, and (ii) Domain phrase attention-based hierarchical recurrent neural network (DPA-HNN), for synthesizing information on pulmonary emboli (PE) from over 7,370 clin-ical thoracic computed tomography (CT) free-text radiology reports collected from four major healthcare centers. Our proposed DPA-HNN model encodes domain-dependent phrases into an attention mechanism and represents a radiology report through a hierarchical RNN structure composed of word-level, sentence-level and document-level representations. Experimental results suggest that the performance of the deep learning models that are trained on a single institutional dataset, are better than rule-based PEFinder on our multi-institutional test sets. The best F1 score for the presence of PE in an adult patient population was 0.99 (DPA-HNN) and for a pediatrics population was 0.99 (HNN) which shows that the deep learning models being trained on adult data, demonstrated generalizability to pediatrics population with comparable accuracy. Our work suggests feasibility of broader usage of neural network models in automated classification of multi-institutional imaging text reports for a variety of applications including evaluation of imaging utilization, imaging yield, clinical decision support tools, and as part of automated classification of large corpus for medical imaging deep learning work.
Published: 2019
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42. Genome-wide CRISPR screen reveals PSMA6 to be an essential gene in pancreatic cancer cells

Author: Robert J Autry, Taosheng Chen, Jesse Bakke, Jeremy Chase Crawford, Peter Oladimeji, Paul G. Thomas, Anthony E. Zamora, William E. Evans, Christopher Trent Brewer, and William C. Wright
Subjects: 0301 basic medicine, Cancer Research, Proteasome Endopeptidase Complex, endocrine system diseases, Cell Survival, Cell, PSMA6, Biology, Essential genes, lcsh:RC254-282, CRISPR screen, Bortezomib, 03 medical and health sciences, 0302 clinical medicine, Pancreatic cancer, Cell Line, Tumor, Spheroids, Cellular, Genetics, medicine, CRISPR, Humans, Clustered Regularly Interspaced Short Palindromic Repeats, RNA, Small Interfering, Pancreas, Cell Proliferation, Genome, Human, Cancer, PDAC, Genomics, Oncogenes, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, 3. Good health, Pancreatic Neoplasms, 030104 developmental biology, medicine.anatomical_structure, Oncology, Essential gene, 030220 oncology & carcinogenesis, Cancer research, Proteasome inhibitor, Proteasome Inhibitors, medicine.drug, Research Article, Carcinoma, Pancreatic Ductal
Abstract: Background Despite its relatively low incidence, pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer deaths because of the aggressive growth/metastasis of the tumor, the lack of early symptoms, and the poor treatment options. Basic research to identify potential therapeutic targets for PDAC is greatly needed. Methods We used a negative-selection genome-wide CRISPR screen to identify essential genes in the PANC-1 human pancreatic carcinoma cell line. We validated the top hits with follow-up siRNA screens, using the HPNE, HPAF-II, AsPC-1, and Mia PaCa-2 cell lines. Results The PSMA6 gene was an identified candidate hit after the CRISPR screen, siRNA validation screen, and siRNA deconvolution screen. Spheroid formation assays and flow cytometry analysis showed that PSMA6 is critical for survival in many pancreatic ductal carcinoma cell models. Lastly, as PSMA6 protein is a proteosomal subunit of the 20S core complex, we showed that bortezomib, a proteasome inhibitor, was especially toxic in PANC-1 cells. Conclusions Further study of PSMA6 and the proteasome subunit that it encodes, along with other hits identified in our CRISPR screens, may provide valuable insights into potential therapeutic targets for PDAC. Electronic supplementary material The online version of this article (10.1186/s12885-019-5455-1) contains supplementary material, which is available to authorized users.
Published: 2019
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43. Knowledge of malaria prevention among pregnant women and non-pregnant mothers of children aged under 5 years in Ibadan, South West Nigeria

Author: Joyce Mahlako Tsoka-Gwegweni, Samuel Tassi Yunga, Kelechi Elizabeth Oladimeji, and Elizabeth Ojewole
Subjects: Adult, medicine.medical_specialty, Health Knowledge, Attitudes, Practice, Multivariate analysis, lcsh:Arctic medicine. Tropical medicine, Non-pregnant mothers of children aged under 5 years, Cross-sectional study, lcsh:RC955-962, 030231 tropical medicine, Mothers, Nigeria, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Malaria prevention and control, Environmental health, parasitic diseases, Medicine, Humans, lcsh:RC109-216, 030212 general & internal medicine, business.industry, Public health, Research, Pregnant women, Infant, Newborn, Infant, medicine.disease, Educational attainment, Malaria, Infectious Diseases, Cross-Sectional Studies, Child, Preschool, Tropical medicine, Multivariate Analysis, Population study, Marital status, Parasitology, business
Abstract: Background Adequate knowledge of malaria prevention and control can help in reducing the growing burden of malaria among vulnerable groups, particularly pregnant women and children aged under 5 years living in malaria endemic settings. Similar studies have been conducted but with less focus on these vulnerable groups. This study assessed knowledge of malaria prevention and control among the pregnant women and non-pregnant mothers of children aged under 5 years in Ibadan, Oyo State, South West Nigeria. Methods In this cross sectional study, data on socio-demographic, clinical and knowledge on malaria prevention was collected using interviewer administered questionnaires from consenting study participants attending Adeoyo maternity hospital between May and November 2016. Data was described using percentages and compared across the two maternal groups in the study population. Knowledge scoring from collected data was computed using the variables on causes, symptoms and prevention of malaria and thereafter dichotomised. Multivariate analyses were used to assess the interactive effect of socio demographic and clinical characteristics with malaria knowledge. Level of statistical significance was set at p
Published: 2019
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44. Inhibition of PGE2/EP4 receptor signaling enhances oxaliplatin efficacy in resistant colon cancer cells through modulation of oxidative stress

Author: Oladimeji Aladelokun, Takayasu Ideta, Lee M. Ellis, Huakang Huang, Daniel W. Rosenberg, and Charles Giardina
Subjects: 0301 basic medicine, Colorectal cancer, Prostaglandin E2 receptor, lcsh:Medicine, medicine.disease_cause, 03 medical and health sciences, 0302 clinical medicine, medicine, Receptor, lcsh:Science, neoplasms, Gene knockdown, Multidisciplinary, biology, Chemistry, CD44, lcsh:R, medicine.disease, digestive system diseases, 3. Good health, Oxaliplatin, 030104 developmental biology, Apoptosis, Cancer research, biology.protein, lipids (amino acids, peptides, and proteins), lcsh:Q, 030217 neurology & neurosurgery, Oxidative stress, medicine.drug
Abstract: The platinum-based chemotherapeutic agent, oxaliplatin, is used to treat advanced colorectal cancer (CRC). Unfortunately, nearly all patients acquire resistance to oxaliplatin after long-term use, limiting its therapeutic efficacy. Since COX-2 and PGE2 signaling can impact colon cancer cell proliferation and survival, we examined how this pathway was affected in an oxaliplatin resistant colon cancer cell line. PGE2 levels were significantly elevated in oxaliplatin-resistant HT29 cells (OXR) compared to naïve parental HT29 cells (PAR). This increase was associated with elevated COX-2 (17.9-fold; P = 0.008) and reduced 15-hydroxyprostaglandin dehydrogenase (2.9-fold; P 2 synthesis, sensitized OXR cells to oxaliplatin. Downstream effects of PGE2 in OXR cells were also examined. Selective inhibition of the EP4 PGE2 receptor by the small molecule inhibitor, L-161,982 enhanced oxaliplatin-induced apoptosis in OXR cells. L-161,982 also reduced expression of the colonic stem cell markers, CD133 and CD44, and inhibited tumor sphere formation. The accumulation of intracellular reactive oxygen species (ROS), a key component of oxaliplatin cytotoxicity, was significantly increased by EP4 inhibition (2.4 -fold; P 2/EP4 signaling axis in oxaliplatin resistance via regulation of oxidative stress.
Published: 2019
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45. Malaria testing and treatment knowledge among selected rural patent and proprietary medicine vendors (PPMV) in Nigeria

Author: Iorwakwagh Apera, Sarah M. Burnett, Adedayo O. Adeyemi, Michael Alliu, Oladimeji Oladepo, Abisoye Oyeyemi, Opeyemi Oladunni, and Musibau A. Titiloye
Subjects: Adult, Male, Rural Population, medicine.medical_specialty, lcsh:Arctic medicine. Tropical medicine, lcsh:RC955-962, 030231 tropical medicine, Nigeria, Pharmacists, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Professional Competence, Health facility, Pregnancy, Environmental health, Surveys and Questionnaires, parasitic diseases, Diagnosis, medicine, Humans, Patent and proprietary medicine vendors, lcsh:RC109-216, 030212 general & internal medicine, Malaria treatment, Aged, Rapid diagnostic test, Under-five, Descriptive statistics, business.industry, Public health, Research, Rapid diagnostic tests, Infant, Newborn, Infant, Middle Aged, medicine.disease, Malaria, Infectious Diseases, Cross-Sectional Studies, Child, Preschool, Tropical medicine, Parasitology, Female, Rural area, business
Abstract: Background Malaria is a leading cause of illness and death in Nigeria, but access of poor people to quality anti-malarial services remains low especially in the rural areas. Patent and proprietary medicine vendors (PPMVs) provide the majority of malaria treatment in rural areas, but little is known about their knowledge of malaria testing and treatment of uncomplicated malaria as recommended in the 2011 National Malaria Control Programme policy. Methods A cross-sectional survey was conducted in two purposively selected states (Oyo and Bayelsa) in Nigeria with each state representing a different geographic and linguistic–ethnic region in the southern part of the country. Two rural LGAs were randomly selected from each state and data were collected from 160 randomly selected PPMVS (40 per LGA) using a structured questionnaire. Data were analysed using descriptive statistics. Results The 2011 National Policy on Malaria Diagnosis and Treatment is mostly unknown to PPMVs. Although most PPMVs (89%) knew that artemisinin-based combination therapy (ACT) is recommended in the national policy, 91% also thought non-ACT were endorsed. The proportion of PPMVs who stated they would treat a malaria case with an artemisinin-based combination at the correct dose was 33% for a child under five, 47% for an adult male and 14% for a pregnant woman in her second trimester. The proportion of PPMVs who reported they would diagnose a case of malaria prior to treatment using a malaria rapid diagnostic test (RDT) kit was 1.9% for children under five, 7.5% for adult males and 3.1% for pregnant women in their first trimester due to lack of knowledge. Almost two-thirds (65.6%) would correctly refer children with severe malaria to health facility. Conclusions Substantial knowledge gaps on the use of RDTs and treatment with artemisinin-based combinations exist among rural PPMVs. Given existing evidence regarding the effectiveness of private retail outlets in malaria case management, PPMVs should be provided with competency-based training and supervision to improve the quality of care they provide.
Published: 2019
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46. Frequency and Factors Associated with Post-Stroke Seizures in a large multicenter study in West Africa

Author: Godwin Osaigbovo, Arti Singh, Adeniyi Abdulwasiu, Oladimeji Adebayo, Onasanya Akinola, Arnette Donna, Lambert Appiah, Carolyn Jenkins, Joshua O. Akinyemi, Ezinne Uvere, Albert Akpalu, Y. B. Mensah, Fred Stephen Sarfo, Lukman Owolabi, Okechukwu S Ogah, Rufus Akinyemi, Kolawole Wahab, Edward O. Komolafe, Bruce Ovbiagele, Benedict Calys-Tagoe, Godwin Ogbole, Adekunle Fakunle, Oyedunni Arulogun, Olayemi Balogun, Mayowa O. Owolabi, Osi Adeleye, Philip Adebayo, Imbo Fawale, Reginald Obiako, Joseph Yaria, Luqman Ogunjimi, and Tiwari Hemant
Subjects: Adult, medicine.medical_specialty, Adolescent, Nigeria, Logistic regression, Ghana, Article, 03 medical and health sciences, Epilepsy, 0302 clinical medicine, stomatognathic system, Risk Factors, Seizures, Internal medicine, Medicine, Humans, cardiovascular diseases, 030212 general & internal medicine, Stroke, Cerebral Hemorrhage, Intracerebral hemorrhage, business.industry, Symptomatic seizures, Odds ratio, Middle Aged, medicine.disease, eye diseases, Confidence interval, stomatognathic diseases, Neurology, Multicenter study, Neurology (clinical), business, 030217 neurology & neurosurgery
Abstract: BACKGROUND: Post-stroke seizures (PSS) are associated with significant morbidity and mortality across the globe. There is a paucity of data on PSS in Africa. PURPOSE: To assess the frequency and factors associated with PSS by stroke types across 15 hospitals in Nigeria and Ghana. METHODS: We analyzed data on all stroke cases recruited into the Stroke Investigative Research and Educational Network (SIREN). We included adults aged ≥18 years with radiologically confirmed ischemic stroke (IS) or intracerebral hemorrhage (ICH). PSS were defined as acute symptomatic seizures occurring at stroke onset and/or during acute hospitalization up until discharge. We used logistic regression to estimate adjusted odds ratios (aOR) with 95% Confidence Interval. RESULTS: Among 3,344 stroke patients, 499 (14.9%) had PSS (95% CI: 13.7 – 16.2%). The mean duration of admission in days for those with PSS vs no PSS was 17.4 ± 28.6 vs 15.9 ± 24.7, p=0.72. There were 294(14.1%) PSS among 2091 ischemic strokes and 159(17.7%) among 897 with ICH, p=0.01. The factors associated with PSS occurrence were age
Published: 2021

47. Dengue Vector Population Forecasting Using Multisource Earth Observation Products and Recurrent Neural Networks

Author: Oladimeji Mudele, Alejandro Frery, Lucas Zanandrez, Alvaro Eiras, and Paolo Gamba
Subjects: Atmospheric Science, Earth observation, 010504 meteorology & atmospheric sciences, Geophysics. Cosmic physics, Population, computer.software_genre, 01 natural sciences, Data modeling, remote sensing, 03 medical and health sciences, Aedes+aegypti<%2Fitalic>%22">Aedes aegypti, Computers in Earth Sciences, Time series, education, Cluster analysis, TC1501-1800, 030304 developmental biology, 0105 earth and related environmental sciences, 0303 health sciences, education.field_of_study, QC801-809, business.industry, Deep learning, dengue risk, Random forest, Ocean engineering, Recurrent neural network, Artificial intelligence, Data mining, business, computer, satellite images
Abstract: This article introduces a technique for using recurrent neural networks to forecast Ae. aegyptimosquito (Dengue transmission vector) counts at neighborhood-level, using Earth Observation data inputs as proxies to environmental variables. The model is validated using in situdata in two Brazilian cities, and compared with state-of-the-art multioutput random forest and k-nearest neighbor models. The approach exploits a clustering step performed before the model definition, which simplifies the task by aggregating mosquito count sequences with similar temporal patterns.
Published: 2021
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48. Factors Driving the Acquisition of University Postgraduate Degrees among Resident Doctors in Nigeria

Author: Olayinka Stephen Ilesanmi, Oladimeji Adebayo, Olayinka Atilola, Oluwaseyi Ogunsuji, M.C. Igbokwe, Aliyu Sokomba, Rereoluwa Babalola, Kehinde Kazeem Kanmodi, Ugo U. Enebeli, Mojisola A. Makinde, and KA Durowade
Subjects: 03 medical and health sciences, Medical education, 0302 clinical medicine, Universities, 030503 health policy & services, Surveys and Questionnaires, Humans, Nigeria, 030212 general & internal medicine, General Medicine, 0305 other medical science, Psychology, Residency training
Abstract: The study examined the characteristics and factors driving the acquisition of postgraduate academic degrees among resident doctors in Nigeria. About 10% of the respondents had a form of university postgraduate degree with majority being master's degree. Having more than seven years of professional practice was the only factor predicting the acquisition of postgraduate academic degrees amongst the respondents [AOR: 0.243 (95% CI: 0.069,0.856
Published: 2021

49. Identification of a Putative Novel Genotype of Avian Hepatitis E Virus from Apparently Healthy Chickens in Southwestern Nigeria

Author: Patrycja Klink, Fisayo Temilade Osamudiamen, Olusola Aanuoluwapo Akanbi, Steffen Zander, Daniel Oladimeji Oluwayelu, and Claus-Thomas Bock
Subjects: 0301 basic medicine, Genotype, 040301 veterinary sciences, Nigeria, Spleen, Genome, Viral, hepatitis E virus, Biology, medicine.disease_cause, Microbiology, novel genotype, Article, Hepevirus, avian HEV, 0403 veterinary science, 03 medical and health sciences, Open Reading Frames, RNA Virus Infections, Hepatitis E virus, Virology, medicine, Animals, ddc:610, Gene, Feces, Phylogeny, Poultry Diseases, Phylogenetic tree, Nucleic acid sequence, 04 agricultural and veterinary sciences, QR1-502, 030104 developmental biology, Infectious Diseases, medicine.anatomical_structure, Capsid, Hepatitis, Viral, Animal, RNA, Viral, 610 Medizin und Gesundheit, Chickens, layer chickens
Abstract: Avian hepatitis E virus (aHEV) is the major etiological agent of hepatitis-splenomegaly syndrome (HSS), big liver and spleen disease (BLSD), and hepatic rupture hemorrhage syndrome (HRHS) in chickens. Infections with aHEV cause a significant decrease in egg production and increased mortality in chickens worldwide. However, studies on the prevalence of aHEV in Nigeria are scarce. In this study, serum (n = 88) and fecal samples (n = 110) obtained from apparently healthy layer chickens from three states in southwestern Nigeria were analyzed by nested reverse transcription-polymerase chain reaction (nRT-PCR) targeting the helicase and capsid gene for the presence of aHEV. Avian HEV was detected in 12.5% (n = 11/88) of serum samples and 9.1% (n = 10/110) of fecal samples tested. Phylogenetic analysis showed that five of the twelve identified aHEV sequences belonged to genotype 2. The remaining seven sequences were only distantly related to other known aHEV isolates. After amplification of the near-complete ORF2 fragment (1618 bp) and part of the ORF1 (582 bp) of isolate YF40_aHEV_NG phylogenetic analysis revealed a nucleotide sequence identity between 79.0 and 82.6% and 80.1 and 83.5%, respectively, to other known aHEV strains, indicating that the Nigerian isolate YF40_aHEV_NG belongs to a novel aHEV genotype. This is the first report of co-circulation of aHEV genotypes in chickens in Nigeria.
Published: 2021
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50. Modified Gold Nanoparticles for Efficient Delivery of Betulinic Acid to Cancer Cell Mitochondria

Author: Olakunle Oladimeji, Aliscia Daniels, Moganavelli Singh, and Jude Akinyelu
Subjects: Metal Nanoparticles, Apoptosis, 02 engineering and technology, Mitochondrion, HeLa, chemistry.chemical_compound, 0302 clinical medicine, Drug Delivery Systems, Betulinic acid, Neoplasms, mitochondrial targeting, Biology (General), Spectroscopy, Caspase, biology, Cell Cycle, General Medicine, Cell cycle, 021001 nanoscience & nanotechnology, Computer Science Applications, Mitochondria, Chemistry, 030220 oncology & carcinogenesis, Drug delivery, MCF-7 Cells, 0210 nano-technology, Pentacyclic Triterpenes, QH301-705.5, Catalysis, Article, cancer chemotherapy, Inorganic Chemistry, 03 medical and health sciences, betulinic acid, Humans, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, Cell Proliferation, Organic Chemistry, biology.organism_classification, chemistry, gold nanoparticles, Cancer cell, drug delivery, biology.protein, Cancer research, Gold, Caco-2 Cells, laminin receptor, HeLa Cells
Abstract: Advances in nanomedicine have seen the adaptation of nanoparticles (NPs) for subcellular delivery for enhanced therapeutic impact and reduced side effects. The pivotal role of the mitochondria in apoptosis and their potential as a target in cancers enables selective induction of cancer cell death. In this study, we examined the mitochondrial targeted delivery of betulinic acid (BA) by the mitochondriotropic TPP+-functionalized epigallocatechin gallate (EGCG)-capped gold NPs (AuNPs), comparing the impact of polyethylene glycol (PEG) and poly-L-lysine-graft-polyethylene glycol (PLL-g-PEG) copolymer on delivery efficacy. This included the assessment of their cellular uptake, mitochondrial localization and efficacy as therapeutic delivery platforms for BA in the human Caco-2, HeLa and MCF-7 cancer cell lines. These mitochondrial-targeted nanocomplexes demonstrated significant inhibition of cancer cell growth, with targeted nanocomplexes recording IC50 values in the range of 3.12–13.2 µM compared to that of the free BA (9.74–36.31 µM) in vitro, demonstrating the merit of mitochondrial targeting. Their mechanisms of action implicated high amplitude mitochondrial depolarization, caspases 3/7 activation, with an associated arrest at the G0/G1 phase of the cell cycle. This nano-delivery system is a potentially viable platform for mitochondrial-targeted delivery of BA and highlights mitochondrial targeting as an option in cancer therapy.
Published: 2021

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