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This is a preliminary study of a material comprising gelatin (Gel), silver nanoparticles (AgNPs) and curcumin (Cur) aimed for wound-healing treatment. Gelatin was used to stabilize AgNPs and encapsulate curcumin to form a therapeutic composite (GelCurAg) for their strong bactericidal and antioxidant properties. GelCurAg formulations with different gelatin concentrations were characterized to attain information about their physiochemical properties and the loading efficiency of therapeutic agents. In vitro assessment of GelCurAg focused on antibacterial, antioxidant and cytotoxic aspects. The results suggested that Gel1CurAg (synthesized from 1% gelatin solution) could be utilized as potential therapeutic agents in treating infectious wound owing to its bactericidal and antioxidant effects and low toxicity for clinical uses., GRAPHICAL ABSTRACT

Titanium (Ti) abutment is a supporting structure of dental implant which anchors and provides retention for fixed or removable tooth restoration. However, bio-inert property of Ti leaves the soft tissue to detach from the abutment, partly leading to implant failure. Meanwhile previous studies have mainly focused on enhancing the osseointegration of Ti implant, the dislocation and imbalance of dental implant still occur since the connective tissue defect at the abutment. This study aimed to investigate the interaction between fibroblast and the modified Ti in which type 1 collagen (Col-1) was modified on Ti surface. Ti/Col-1 modification was performed by electrochemical deposition (ECD) based on the polyelectrolyte property of Col-1 and conductivity of Ti under electric field. Parameters optimized for ECD were investigated including Col-1 concentration, pH of electrolyte, and deposition potential. Fibroblast's cell adhesion/spreading, and cell viability/proliferation assays were analyzed between the coated Ti/Col-1 with optimized ECD conditions and uncoated Ti. Scanning Electron Microscope (SEM) observation indicated that Col-1 was modified successfully on Ti while fibroblast cell adhered and proliferated well in Ti/Col-1 compared with the uncoated Ti. This study suggested the influence of Col-1 modification on the attachment of fibroblast cells around the Ti abutment.