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In recent years, there has been an increase in the use of spectroscopy as a diagnostic tool. This review aims to summarize the studies that have reported the use of ATR-FTIR spectroscopy for the ac...

Raman spectroscopy has the ability to provide highly specific disease diagnostic results based on intrinsic molecular signatures in biological samples. We recorded variation in spectral range (540–...

Hepatitis C virus (HCV) infection is one of the leading causes of morbidity and mortality worldwide. Mortality linked with HCV infection can be lowered with effective and prompt diagnosis in early stages of infection. In this study potential of Raman spectroscopy to differentiate between healthy and HCV infected serum samples was investigated. Clear differences were observed in the Raman spectra of HCV infected and healthy sera samples. Using the analysis of variance (ANOVA) and t-test (p 0.001) on Raman spectra of diseased and healthy samples, we observed eleven unique Raman bands at 676, 825, 853, 936, 1029, 1105, 1155, 1305, 1620, 1654 and 1757 cm

In this study, we have evaluated the potential of attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy to differentially diagnose bimolecular markers in Salmonella typhi and dengue infected freeze-dried sera samples along with healthy freeze-dried sera samples. Spectral signatures were recorded from 18 S. typhi infected, 23 dengue infected and 28 healthy freeze-dried sera samples. In order to achieve enhanced classification accuracy between the three sample classes, multivariate data classification algorithms principal component analysis (PCA) and linear discriminant analysis (LDA) were used. Outcomes of the PCA scatter plot showed 95% inter-class variation. A classification accuracy of 100% was achieved using LDA; therefore, we propose that ATR-FTIR coupled with chemo metric data classification algorithms holds substantial potential for bimolecular differentiation between S. typhi and dengue infected freeze-dried sera samples.