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4 results on '"CDTN/CNEN"'

1. Modifying internal organization and surface morphology of siRNA lipoplexes by sodium alginate addition for efficient siRNA delivery

Author

Céline Hoffmann, Valérie Trichet, Waldemar A. A. Macedo, Armando da Silva Cunha, Angelo Malachias de Souza, Ismael González, Luis A. Córdova, Gracielle Ferreira Andrade, Stéphanie Finet, Danielle Campiol Arruda, Virginie Escriou, Pascal Bigey, Universidade Federal de Minas Gerais [Belo Horizonte] (UFMG), Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS - UM 4 (UMR 8258 / U1022)), Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Centro de Desenvolvimento da Tecnologia Nuclear (CDTN), Institut de minéralogie, de physique des matériaux et de cosmochimie (IMPMC), Muséum national d'Histoire naturelle (MNHN)-Institut de recherche pour le développement [IRD] : UR206-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Universidad de Chile, Physiopathologie de la résorption osseuse et thérapie des tumeurs osseuses primitives, Université de Nantes (UN)-IFR26-Institut National de la Santé et de la Recherche Médicale (INSERM), Equipe Labellisée LIGUE 2012 [Nantes], Centro de Desenvolvimento da Tecnologia NuclearCDTN/CNEN, CDTN/CNEN, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Universidade Federal de Minas Gerais (UFMG), Universidade Federal de Minas Gerais, Department of Oral and Maxillofacial Surgery [Santiago, Chile], Universidad de Chile = University of Chile [Santiago] (UCHILE)-San Borja Arriarán University Hospital - Faculty of Dentistry [Santiago, Chile], Sarcomes osseux et remodelage des tissus calcifiés - INSERM U1238 (Phy-Os), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bretagne Loire (UBL)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Universidad de Chile = University of Chile [Santiago] (UCHILE), and ESCRIOU, Virginie

Subjects
[CHIM.POLY] Chemical Sciences/Polymers, Small interfering RNA, [SDV.BIO]Life Sciences [q-bio]/Biotechnology, Morphology (linguistics), Alginates, Static Electricity, cationic lipid, Nanoparticle, 02 engineering and technology, delivery system, 010402 general chemistry, 01 natural sciences, Cell Line, Biomaterials, RNA interference, Colloid and Surface Chemistry, Cations, Animals, structure, Particle Size, RNA, Small Interfering, Sodium alginate, Chemistry, nanoparticle, Gene Transfer Techniques, anionic polymer, [SDV.SP]Life Sciences [q-bio]/Pharmaceutical sciences, 021001 nanoscience & nanotechnology, Lipids, [SDV.BIO] Life Sciences [q-bio]/Biotechnology, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, [SDV.SP] Life Sciences [q-bio]/Pharmaceutical sciences, Mice, Inbred C57BL, [CHIM.POLY]Chemical Sciences/Polymers, Liposomes, Biophysics, Female, Cytokine secretion, 0210 nano-technology, Internal organization, Intracellular
Abstract

International audience; Vectorized small interfering RNAs (siRNAs) are widely used to induce specific mRNA degradation in the intracellular compartment of eukaryotic cells. Recently, we developed efficient cationic lipid-based siRNA vectors (siRNA lipoplexes or siLex) containing sodium alginate (Nalg-siLex) with superior efficiency and stability properties than siLex. In this study, we assessed the physicochemical and some biological properties of Nalg-siLex compared to siLex. While no significant differences in size, ζ potential and siRNA compaction were detected, the addition of sodium alginate modified the particle morphology, producing smoother and heterogeneous particles characterized by transmission electron microscopy. We also noted that Nalg-siLex have surface differences observed by X-ray photoelectron spectroscopy. These differences could arise from an internal reorganization of components induced by the addition of sodium alginate, that is indicated by Small-Angle X-ray Scattering results. Moreover, Nalg-siLex did not trigger significant hepatotoxicity nor inflammatory cytokine secretion compared to siLex. Taken together these results suggest that sodium alginate played a key role by structuring and reinforcing siRNA lipoplexes, leading to more stable and efficient delivery vector.

Published
2019
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2. Observation of magnons in Mn 2 Au films by inelastic Brillouin and Raman light scattering

Author

L. E. Fernandez-Outon, D. Givord, Sergio M. Rezende, V. M. T. S. Barthem, D. S. Maior, W. A. A. Macedo, Joaquim Mendes, M. Arana, A. Azevedo, F. Estrada, Universidade Federal de Pernambuco [Recife] (UFPE), Universidade Federal do Rio de Janeiro (UFRJ), Universidade Federal de Vicosa (UFV), Centro de Desenvolvimento da Tecnologia NuclearCDTN/CNEN, CDTN/CNEN, Micro et NanoMagnétisme (MNM ), Institut Néel (NEEL), and Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])

Subjects
Materials science, Physics and Astronomy (miscellaneous), Spintronics, Condensed matter physics, Magnon, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Light scattering, Brillouin zone, Condensed Matter::Materials Science, symbols.namesake, Magnetic anisotropy, [PHYS.COND.CM-GEN]Physics [physics]/Condensed Matter [cond-mat]/Other [cond-mat.other], 0103 physical sciences, symbols, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Condensed Matter::Strongly Correlated Electrons, 010306 general physics, 0210 nano-technology, Anisotropy, Raman spectroscopy, Néel temperature, ComputingMilieux_MISCELLANEOUS
Abstract

The intermetallic antiferromagnetic compound Mn2Au has been attracting considerable interest for antiferromagnetic spintronics due to its high Neel temperature and strong spin–orbit coupling. We report on the experimental investigation of the zero-wave number magnon frequencies in Mn2Au films using Brillouin and Raman inelastic light scattering techniques. The derived effective anisotropy field values are in close agreement with theoretical calculations. With the values of the anisotropy and exchange fields, the full magnon dispersion curves in Mn2Au were calculated. Due to the weak in-plane anisotropy, the k ∼ 0 frequency of the lower magnon branch, 121 GHz, is among the lowest for 3D antiferromagnets, suggesting that Mn2Au is a good candidate for realizing the generation of spin currents by antiferromagnetic resonance driven spin-pumping, as proposed theoretically.

Published
2017
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3. Significant Dzyaloshinskii-Moriya interaction at graphene-ferromagnet interfaces due to the Rashba effect

Author

Hongxin Yang, Gong Chen, Alexandre A. C. Cotta, Alpha T. N’Diaye, Sergey A. Nikolaev, Edmar A. Soares, Waldemar A. A. Macedo, Kai Liu, Andreas K. Schmid, Albert Fert, Mairbek Chshiev, SPINtronique et TEchnologie des Composants (SPINTEC), Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Unité mixte de physique CNRS/Thales (UMPhy CNRS/THALES), THALES-Centre National de la Recherche Scientifique (CNRS), Ningbo Institute of Technology (NIT), Lawrence Berkeley National Laboratory [Berkeley] (LBNL), University of California [Davis] (UC Davis), University of California, Centro de Desenvolvimento da Tecnologia NuclearCDTN/CNEN, CDTN/CNEN, Departamento de Fisica, Universidade Federal de Minas Gerais, ANR-14-CE26-0012,ULTRASKY,Skyrmions dans les couches magnétiques ultraminces en vue d'une spintronique basse consommation(2014), ANR-13-BS10-0005,SOspin,Courants de spin et couple de transfert de spin produits par des effets spin-orbites(2013), European Project: 696656,H2020,H2020-Adhoc-2014-20,GrapheneCore1(2016), THALES [France]-Centre National de la Recherche Scientifique (CNRS), University of California (UC), and Universidade Federal de Minas Gerais [Belo Horizonte] (UFMG)

Subjects
Materials science, FOS: Physical sciences, 02 engineering and technology, 01 natural sciences, law.invention, law, 0103 physical sciences, Mesoscale and Nanoscale Physics (cond-mat.mes-hall), General Materials Science, 010306 general physics, Spin-½, Condensed Matter - Materials Science, Condensed Matter - Mesoscale and Nanoscale Physics, Spintronics, Condensed matter physics, Graphene, Mechanical Engineering, Skyrmion, Materials Science (cond-mat.mtrl-sci), General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Coupling (physics), Ferromagnetism, Mechanics of Materials, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], Condensed Matter::Strongly Correlated Electrons, 0210 nano-technology, Chirality (chemistry), Rashba effect
Abstract

The possibility of utilizing the rich spin-dependent properties of graphene has attracted great attention in pursuit of spintronics advances. The promise of high-speed and low-energy consumption devices motivates a search for layered structures that stabilize chiral spin textures such as topologically protected skyrmions. Here we demonstrate that chiral spin textures are induced at graphene/ferromagnetic metal interfaces. This is unexpected because graphene is a weak spin-orbit coupling material and is generally not expected to induce sufficient Dzyaloshinskii-Moriya interaction to affect magnetic chirality. We demonstrate that graphene induces a new type of Dzyaloshinskii-Moriya interaction due to a Rashba effect. First-principles calculations and experiments using spin-polarized electron microscopy show that this graphene-induced Dzyaloshinskii-Moriya interaction can have similar magnitude as at interfaces with heavy metals. This work paves a new path towards two-dimensional material based spin orbitronics., Comment: 21 pages, 4 figures

Published
2016
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4. Solutions of Negatively Charged Graphene Sheets and Ribbons

Author

Maoshuai He, Clascídia A. Furtado, Alain Pénicaud, Hassan Saadaoui, Carlos Drummond, Olivier Roubeau, Cristina Vallés, Marc Monthioux, Luca Ortolani, Centre de recherches Paul Pascal (CRPP), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN), Desenvolvimento da Tecnologia Nuclear, Istituto per la Microelettronica e i Microsistemi [Bologna] (IMM), National Research Council of Italy | Consiglio Nazionale delle Ricerche (CNR), Centre d'élaboration de matériaux et d'études structurales (CEMES), Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut National des Sciences Appliquées (INSA)-Université de Toulouse (UT)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Nanotubes, Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Consiglio Nazionale delle Ricerche (CNR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Institut de Chimie du CNRS (INC)-Institut National des Sciences Appliquées - Toulouse (INSA Toulouse), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)

Subjects
Ribbons, Graphene sheets, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Biochemistry, Catalysis, law.invention, Graphite intercalation compound, chemistry.chemical_compound, Colloid and Surface Chemistry, law, Wafer, Composite material, Graphene oxide paper, Chemistry, Graphene, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Interferometry, Sarfus, Mica, 0210 nano-technology, Graphene nanoribbons
Abstract

International audience; Negatively charged graphene layers from a graphite intercalation compound spontaneously dissolve in N-methylpyrrolidone, without the need for any sonication, yielding stable, air-sensitive, solutions of laterally extended atom-thick graphene sheets and ribbons with dimensions over tens of micrometers. These can be deposited on a variety of substrates. Height measurements showing single-atom thickness were performed by STM, AFM, multiple beam interferometry, and optical imaging on Sarfus wafers, demonstrating deposits of graphene flakes and ribbons. AFM height measurements on mica give the actual height of graphene (ca. 0.4 nm).

Published
2008
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