1. A device for high-throughput monitoring of degradation in soft tissue samples
- Author
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Tzeranis, Dimitrios S., Panagiotopoulos, I., Gkouma, S., Kanakaris, G., Georgiou, N., Vaindirlis, N., Vasileiou, G., Neidlin, M., Gkousioudi, A., Spitas, V., Macheras, G. A., Alexopoulos, L. G., Alexopoulos, L. G. [0000-0003-0425-166X], and Tzeranis, Dimitrios S. [0000-0001-8730-301X]
- Subjects
030203 arthritis & rheumatology ,Aged, 80 and over ,Materials science ,0206 medical engineering ,Rehabilitation ,Biomedical Engineering ,Biophysics ,Pilot Projects ,02 engineering and technology ,Equipment Design ,020601 biomedical engineering ,03 medical and health sciences ,0302 clinical medicine ,Cartilage ,Degradation (geology) ,Humans ,Orthopedics and Sports Medicine ,Collagenases ,Femur ,Instrument design ,Cartilage degeneration ,Throughput (business) ,Biomedical engineering ,Aged - Abstract
This work describes the design and validation of a novel device, the High-Throughput Degradation Monitoring Device (HDD), for monitoring the degradation of 24 soft tissue samples over incubation periods of several days inside a cell culture incubator. The device quantifies sample degradation by monitoring its deformation induced by a static gravity load. Initial instrument design and experimental protocol development focused on quantifying cartilage degeneration. Characterization of measurement errors, caused mainly by thermal transients and by translating the instrument sensor, demonstrated that HDD can quantify sample degradation with
- Published
- 2017