1. Synergistic Bactericidal Effect of Chitosan/Zinc Oxide Based Nanocomposites Against Staphylococcus aureus
- Author
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Muthuvel Murugan, S. Maria Dhivya, Subramanian Mugesh, M. A. Jothi Rajan, S. M Sathiya, and Gunadhor S. Okram
- Subjects
Health (social science) ,Nanocomposite ,General Computer Science ,General Mathematics ,General Engineering ,chemistry.chemical_element ,02 engineering and technology ,Zinc ,021001 nanoscience & nanotechnology ,medicine.disease_cause ,Bactericidal effect ,030226 pharmacology & pharmacy ,Education ,Chitosan ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,General Energy ,chemistry ,Staphylococcus aureus ,medicine ,0210 nano-technology ,General Environmental Science ,Nuclear chemistry - Abstract
The biocompatible Chitosan/Zinc oxide (CS/ZnO) nanocomposites (NCs) material was synthesized via a simple and versatile microwave assisted wet synthesis method. After the incorporation of CS in the ZnO nanoparticles (NPs), the crystalline structure of the modified NPs was retained in the NCs and it was clearly exposed in the X-ray diffraction (XRD) measurements. The Zeta potential measurement of CS/ZnO nanocomposites (NCs) shows more stability than ZnO NPs. The Field Emission Scanning Electron Microscopy (FE-SEM) measurements depict the formation of cauliflower like structure after the integration of CS in the ZnO NPs. The interaction between ZnO molecules in CS becomes more compact and is confirmed in the Fourier Transform Infrared Spectroscopy (FTIR) measurement. Bacterial activity was increased gradually with the CS/ZnO content and was analytically stronger against Gram-positive cells. This study has conclusively proved that reactive oxygen species (ROS) such as •OH, •O2− , and H2O2 were significantly produced from aqueous suspension of CS/ZnO and were primarily responsible for the bactericidal activity.
- Published
- 2018
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