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The investigation is to increase the cytotoxicity of soluble curcumin (SC) by loading it onto pectin and skimmed milk powder (SMP) dual layered solid lipid nanoparticles (DL-SLN). The DL-SLN exhibited significantly higher encapsulation efficiency (83.94 ± 6.16), better stability (90 days), and sustained the drug release in different gastro intestional (GI) environments upto 72 h. Molecular docking revealed that the Vander Waals (57420.669 Kcal-mol-1) and electrostatic (-197.533) bonds were involved in the DL-SLN complex formation. The in vivo toxicity of DL-SLN was performed by the zebrafish model, the cell cycle arrest at G2/M phase (64.34 %) by flow cytometry, and western blot investigation was recognized molecular level cell death using SW480 cells. Pharmacokinetic (PK) evaluation (Cmax-5.78 ± 3.26 μg/mL; Tmax-24 h) and organ distribution studies confirmed that the co-functionalized pectin based SLN could efficiently improve the oral bioavailability (up to 72 h) of curcumin (CMN) on colon-targeted release.

Artificial Intelligence (AI) is the creation of a smart machine that has human behaviour and response. AI in the education sector is able to interact, assist, and guide students through Self-Exploration Education (SEE) in Self Determined Learning (SDL) or Heutagogical technique, such as current, but semi-automatic learning systems. Malaysian higher education institutions are forced to adapt to such a radical change in order to stay competitive and fulfill their stakeholder needs. Everyone is born as a genius, with curiosity to explore the environment through experiments. This study examines the effect of SDL on SEE in Tangible Mixed-Reality Learning System until 2030. It does that under two different lenses: First, the effect on the value proposition and the business models of the SDL. Second, it identifies hurdles for the implementation and draws strategic implications for the SDL Tangible Mixed-Reality Learning System. However, in practice, SEE is still very much focused on spreading facts rather than encouraging personal exploration. Conducting exploration of learning in the classroom can be complicated for adult learning or andragogy and is limited by virtue, money and work infrastructure. But what if we can create a middle ground between learning and fiction, the world in which adults learn and explore in ways that may be impossible in real life but still true to the transfer of knowledge? The project is to craft an imaginative and accessible tool to help adults develop scientific minds and practices through self-exploration or Do-it-yourself DIY with a mixed reality learning system that empowers adults to know the invisible and investigate hard through exploration. By 2030 the likeliest scenario is that fully Self-Exploration is solely available for particularly high-value use cases, affecting the value proposition toward provision of education services, an increase of stakeholder and value-centric value propositions fostered by continuous interactions between the Heutagogical technique and the stakeholder.

A phase-locked loop (PLL) architecture is proposed for improved efficiency of power and thermal management techniques in system-on-chips (SoCs). PLL architecture introduces two techniques: a dual-stage phase-acquisition loop filter that enables fast lock time of 1.2 $\mu \text{s}$ without any frequency overshoots and a nonlinear DCO that enables a wide frequency range of 0.5–9.5 GHz and a low period jitter of ±1.25%UI p-p with a single wideband tuning. With this proposed PLL architecture, SoC can continue its operation without any interruption caused by frequency overshoots during power and thermal management techniques like dynamic core-count scaling and dynamic voltage frequency scaling. The PLL achieves 0.45 ps rms period jitter at 3.25 GHz in fractional-N mode operation, while consuming a total power of 7.1 mW.

The purpose of this study is to establish a Smartphone application for end users in Halal Brand Personality screening process that offers an option to facilitate consumers in justifying how the Halal certified brand respond to and satisfy their needs based on five Halal personality dimensions; Purity, Excitement, Safety, Sophistication, and Righteousness. The evolution of the end user application follows the waterfall development methodology. It mainly focuses on presenting the process of developing an Android application prototype using the user terminal in the electronic Halal screening system which makes it possible for users to check straightaway based on Smartphone barcode capture with the applied Halal branding database system and identify them, as well as rate the product brand using mobile devices. As for the project implementation, the functions of the end user application are introduced, and how these functions are realized is also displayed in detail. After the implementation process, the application is tested on an Android device emulator and real mobile Android devices to evaluate their performances. The version of Android 2.1 and above is chosen since most Android Smartphones operate with minimum Android 2.1. Moreover, it is tested with specialized mobile with respect to the collection of feedback. Finally, a reasonable conclusion to this project is made, including the contents reliability and security protection issues.

The aim of the study is to find out the effect of smartphone on marketing therapeutic tourist sites in Jordan. Several factors contribute to this study, including market type templates, therapeutic, demographic and their impact on tourist behavior in Jordan. We apply the technology acceptance (TAM) model to study through the incorporation of smartphone applications on marketing therapeutic tourist sites in Jordan. To achieve this, we use the quantitative research design and rely on appropriate data to test the hypothesis. We distributed questionnaire to 400 tourists as a sample of study but two hundred and four were collected. The researchers had used the structural equation modeling (PLS-SEM) for measuring relationships and correlations between variables and their impact on the behavior of tourists in Jordan. According to the study findings, there was a positive impact on market type template, therapeutic, and demographics on tourists' perceived ease of use of smartphone on marketing therapeutic tourist sites in the country. Perceived usefulness and perceived ease of use also led to an increase in tourists' intention to use smartphone.

Today's multicore processors and complex multimedia SoCs incorporate power management techniques such as dynamic frequency scaling (DFS), which dynamically changes operating frequencies, and dynamic core-count scaling (DCCS), which rapidly power cycles the cores between active and idle states. For digital clocking in such SoCs, the PLL needs to support rapid frequency change and fast locking, both without frequency overshoot, so that SoCs can continue operation without interruption during DFS and start operation right after PLL reset is released during DCCS. Moreover, digital clocking PLLs are also required to have a wide frequency range, low period jitter (JP) and low power. Conventional PLLs like [1] use coarse and fine frequency tuning to achieve both low JP, as well as wide frequency range, but may produce frequency overshoots during initial binary frequency search and during DFS, which can span over multiple coarse bands. Furthermore, a conventional proportional-integral (PI) filter [2] suffers from a tradeoff between fast locking and frequency overshoot. These conventional approaches require the SoC to stop using the PLL clock for thousands of clock cycles to mask these frequency overshoots and cause overhead in DFS and DCCS optimization [6]. Another drawback of conventional PLLs [1–4] is the use of a linearly-tuned DCO (fixed frequency steps), which is not well suited for achieving both wide frequency range and constant JP measured in clock unit-interval percentage (%UI). A constant JP (%UI) is optimal for SoC digital clocking, as a constant percentage of the clock period can be allocated for clock-uncertainties during logic synthesis at any frequency. To address these issues, two techniques are proposed in this DPLL architecture: a) a dual-stage phase-acquisition-based loop filter (DALF), which incorporates a first-order loop for phase-acquisition to achieve fast locking without frequency overshoot, and b) a nonlinear DCO (NDCO), which achieves constant JP across wide frequency range. Using these techniques, a digital PLL in 16nm CMOS achieves ±1.25%UI peak-to-peak JP (p−p JP) over a 0.5-to-9.5GHz range with a short lock-time of 1.2µs.