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This paper report the use of Carapa guianensis Abul. (Meliaceae) oil and derivates [fatty acid ethyl ester (FAEE’s) and free fatty acid (FFA’s)] associate with silk fibroin (SF), and its activity against the larvae of the vector Aedes aegypti. The emulsions FFA2-SF derived from AO2, that mostly contained unsaturated fatty acids, presented the best results against the larvae of Ae. aegypti after a 48 h period (LC50 = 16.79 mg.mL−1), causing structural alterations to the vector. It is suggested that the biopolymeric matrix of silk fibroin increases the biodistribution and bioavailability of active in medium aqueous. This is the first work of its type which has pointed larvicidal activity of the free fatty acid from C. guianensis, associate with silk fibroin against Aedes aegypti.

The Aedes aegypti mosquito is a vector that causes various diseases such as chikungunya fever, dengue and Zika, and therefore constitutes a public health problem. The present study was carried out to evaluate the larvicidal activity of different crude extracts (methanolic, hydroethanolic and hexanic) from leaves of Acmella oleracea solubilized in fibroin solution, as an alternative to the organic solvents that are used against Aedes aegypti. Using the Probit analysis, the hexane extract showed LC50 of 2.23 μg/mL after 24 h, whereas the hydroethanolic and the methanolic extracts showed LC50 of 28.42 μg/mL and 39.67 μg/mL, respectively. These extracts also did not show toxicity towards Chlorella vulgaris after 30 days, which suggests that they can be used without causing environmental damage. Thus, A. oleracea extract dissolved in fibroin solution could be an alternative for controlling Ae. aegypti without causing damage to the environment.