1. Oxazole-Based Compounds As Anticancer Agents
- Author
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Salvatore V. Giofrè, Giuseppe Lanza, Roberto Romeo, Daniela Iannazzo, Ugo Chiacchio, Maria A. Chiacchio, Laura Legnani, Chiacchio, M, Lanza, G, Chiacchio, U, Giofre, S, Romeo, R, Iannazzo, D, and Legnani, L
- Subjects
Oxazolidine ,Antineoplastic Agents ,Oxazoline ,Drug Screening Assays ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Anticancer activity ,Oxazole ,Cell Line ,Synthesis ,Structure-Activity Relationship ,chemistry.chemical_compound ,Isoxazole ,Cell Line, Tumor ,Drug Discovery ,Humans ,Oxazoles ,Pharmacology ,Tumor ,010405 organic chemistry ,Drug discovery ,Synthesi ,Organic Chemistry ,Biological activity ,Antitumor ,Combinatorial chemistry ,0104 chemical sciences ,Drug Screening Assays, Antitumor ,chemistry ,Chemical diversity ,Molecular Medicine ,Anticancer activity, Isoxazole, Oxazole, Oxazolidine, Oxazoline, Synthesis - Abstract
Heterocyclic compounds represent a significant target for anti-cancer research and drug discovery, due to their structural and chemical diversity. Oxazoles, with oxygen and nitrogen atoms present in the core structure, enable various types of interactions with different enzymes and receptors, favoring the discovery of new drugs. Aim of this review is to describe the most recent reports on the use of oxazole-based compounds in anticancer research, with reference to the newly discovered iso/oxazole-based drugs, to their synthesis and to the evaluation of the most biologically active derivatives. The corresponding dehydrogenated derivatives, i.e. iso/oxazolines and iso/oxazolidines, are also reported.
- Published
- 2020
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