1. Antioxidant, anticholinesterase and antibacterial activities of Stachys guyoniana and Mentha aquatica
- Author
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Khadidja Aya Beladjila, Zahia Kabouche, Mehmet Emin Duru, M. Ferhat, Ebru Erol, Yunus Çetintaş, Ahmed Kabouche, Mehmet Öztürk, EROL, EBRU, MÜ, Fen Fakültesi, Kimya Bölümü, Erol, Ebru, Öztürk, Mehmet, Çetintaş, Yunus, and Duru, Mehmet Emin
- Subjects
DPPH ,Ethyl acetate ,Pharmaceutical Science ,01 natural sciences ,Ferric Compounds ,Antioxidants ,chemistry.chemical_compound ,β-carotene/linoleic acid ,metal chelating ,Drug Discovery ,Chelating Agents ,CUPRAC ,ABTS ,biology ,Traditional medicine ,Chemistry ,Cholinesterase Inhibitory Activity ,General Medicine ,Stachys ,beta Carotene ,Anti-Bacterial Agents ,Beta-Carotene/Linoleic Acid ,cuprac ,Acetylcholinesterase ,Molecular Medicine ,Antibacterial activity ,Oxidation-Reduction ,Mentha ,Microbial Sensitivity Tests ,Enterobacter aerogenes ,dpph ,Microbiology ,Linoleic Acid ,abts+ ,cholinesterase inhibitory activity ,Chlorides ,Picrates ,Metal Chelating ,Benzothiazoles ,Pharmacology ,Plants, Medicinal ,Bacteria ,010405 organic chemistry ,Plant Extracts ,lcsh:RM1-950 ,Biphenyl Compounds ,Plant Components, Aerial ,biology.organism_classification ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,lcsh:Therapeutics. Pharmacology ,Complementary and alternative medicine ,Agar Dilution ,Butyrylcholinesterase ,Solvents ,Lamiaceae ,Cholinesterase Inhibitors ,Sulfonic Acids ,Morganella morganii ,Copper ,agar dilution ,Phytotherapy - Abstract
WOS: 000390846600032 PubMed ID: 27927090 Context: Stachys guyoniana Noe ex. Batt. and Mentha aquatica L. are two Algerian Lamiaceae used in folk medicine. Objective: To investigate their antioxidant, anticholinesterase and antibacterial activities. Material and methods: n-Butanol (BESG), ethyl acetate (EESG) and chloroform (CESG) extracts of S. guyoniana and methanol (MEMA) and chloroform (CEMA) aerial part extracts of M. aquatica and methanol (MERMA) and acetone (AERMA) roots extracts of M. aquatica were evaluated for their antioxidant activity by the beta-carotene-linoleic acid, DPPH center dot and ABTS(center dot+) scavenging, CUPRAC and metal chelating assays. The anticholinesterase activity was tested against AChE and BChE. The antibacterial activity was assessed by MICs determination against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Salmonella heidelberg, Klebsiella pneumoniae, Enterobacter aerogenes and Morganella morganii strains. Results: In the b-carotene test, the CESG (IC50: 2.3 +/- 1.27 mu g/mL) exhibited the highest activity. The BESG was the best scavenger of DPPH center dot (IC50: 2.91 +/- 0.14 mu g/mL). In the ABTS test, AERMA was the most active (IC50: 4.21 +/- 0.28 mu g/mL). However, with the CUPRAC, the BESG exhibited the best activity (A(0.50): 0.15 +/- 0.05 mu g/mL) and was active in metal chelating assay with 48% inhibition at 100 mu g/mL. The BESG was the best AChE inhibitor (IC50: 5.78 +/- 0.01 mu g/mL) however, the AERMA showed the highest BChE inhibitory activity (IC50: 19.23 +/- 1.42 mu g/mL). The tested extracts exhibited a good antibacterial activity. Conclusion: This study demonstrated good antioxidant, anticholinesterase and antibacterial potential of S. guyoniana and M. aquatica, which fits in well with their use in folk medicine. MESRS-Algeria; Mugla Sitki Kocman University, Department of ChemistryMugla Sitki Kocman University The authors thank the MESRS-Algeria and the Mugla Sitki Kocman University, Department of Chemistry for financial support.
- Published
- 2016