1. Immune-enhancing effects of Portulaca oleracea L.– based complex extract in cyclophosphamide-induced splenocytes and immunosuppressed rats
- Author
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Yeon Ju Park, Young-Rae Lee, Yang Gyu Kang, Deuk Seon Park, Sang-Hoon Park, Dae In Moon, Young Pill Kim, Hak Yong Lee, Okjin Kim, Oh Hong Geun, Hyang Man Lee, Hye-Jeong Yang, Min Jung Kim, Bong Gun Lee, and Young Mi Park
- Subjects
lcsh:Immunologic diseases. Allergy ,immunosuppressed rats ,medicine.medical_treatment ,spleonocyte ,Immunology ,Spleen ,Pharmacology ,01 natural sciences ,Proinflammatory cytokine ,0404 agricultural biotechnology ,Immune system ,Oral administration ,In vivo ,medicine ,Splenocyte ,cytokine ,immunostimulation ,lcsh:Agriculture (General) ,Chemistry ,010401 analytical chemistry ,04 agricultural and veterinary sciences ,040401 food science ,lcsh:S1-972 ,In vitro ,0104 chemical sciences ,medicine.anatomical_structure ,Cytokine ,portulaca oleracea l ,lcsh:RC581-607 ,Agronomy and Crop Science ,Food Science - Abstract
Portulaca oleracea L. is a traditional oriental medicine known for its pharmacological effects. The present study aimed to investigate the immunostimulatory effects of PPCE on cyclophosphamide-stimulated rat model and in isolated spleen cells. The result showed that PPCE exerted an immunostimulatory effect in vivo and in vitro. Specifically, PPCE significantly enhanced splenocyte proliferation and upregulated inflammatory cytokines (IL-2, IL-12, TNF-α, and IFN-γ) and NK cell activity in vitro. The immunostimulatory effect was further investigated through various immunological assays. Oral administration of PPCE increased the swimming time and number of immune cells in rats. Histological analysis revealed that PPCE administration exerted splenic recovery. Thus, P. oleracea L. based complex extracts may be used as an immunostimulatory agent in medicine or functional foods.
- Published
- 2019