1. Graphene nanoribbon-based supramolecular ensembles with dual-receptor targeting function for targeted photothermal tumor therapy†
- Author
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Chen Xi Xu, Tony D. James, Hong Bo Ru, Adam C. Sedgwick, Jie Gao, Xiangfeng Luan, He Tian, Xiao-Peng He, Guo Rong Chen, Jiacheng Zhang, Yiyong Mai, Ling Zhu, Jia Li, Yi Zang, Wei Tao Dou, and Fugui Xu
- Subjects
Chemistry ,Graphene ,02 engineering and technology ,General Chemistry ,Photothermal therapy ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Ligand (biochemistry) ,medicine.disease ,01 natural sciences ,In vitro ,0104 chemical sciences ,law.invention ,Breast cancer ,In vivo ,law ,Cancer research ,medicine ,0210 nano-technology ,Receptor ,Triple-negative breast cancer - Abstract
Triple negative breast cancer (TNBC) is one of the most malignant subtypes of breast cancer. Here, we report the construction of graphene nanoribbon (GNR)-based supramolecular ensembles with dual-receptor (mannose and αvβ3 integrin receptors) targeting function, denoted as GNR-Man/PRGD, for targeted photothermal treatment (PTT) of TNBC. The GNR-Man/PRGD ensembles were constructed through the solution-based self-assembly of mannose-grafted GNRs (GNR-Man) with a pyrene-tagged αvβ3 integrin ligand (PRGD). Enhanced PTT efficacies were achieved both in vitro and in vivo compared to that of the non-targeting equivalents. Tumor-bearing live mice were administered (tail vein) with GNR-Man/PRGD and then each mice group was subjected to PTT. Remarkably, GNR-Man/PRGD induced complete ablation of the solid tumors, and no tumor regrowth was observed over a period of 15 days. This study demonstrates a new and promising platform for the development of photothermal nanomaterials for targeted tumor therapy., Dual receptor-targeting supramolecular glycomaterials are constructed based on graphene nanoribbons for the targeted photothermal therapy of triple-negative breast cancer in vivo.
- Published
- 2021