1. Co-templating Synthesis of Bimodal Mesoporous Silica for Potential Drug Carrier
- Author
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Dong R. Peng, Victor Malgras, Yusuke Yamauchi, Malay Pramanik, Shiao W. Kuo, Wei C. Chu, Saad M. Alshehri, Tansir Ahamad, and Bishnu Prasad Bastakoti
- Subjects
Materials science ,010405 organic chemistry ,Scattering ,General Chemistry ,Mesoporous silica ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,Mesoporous organosilica ,Chemical engineering ,Transmission electron microscopy ,Copolymer ,medicine ,Organic chemistry ,Self-assembly ,Swelling ,medicine.symptom ,Drug carrier - Abstract
Bimodal mesoporous silica is prepared by co-templating method using PEO-b-PLA diblock copolymer and F127 triblock copolymer. The pore size distribution of the mesoporous silica is bimodal, based on small angle X-ray scattering, transmission electron microscopy, and nitrogen adsorption-desorption isotherms analyses, and can be divided into the larger pores, originating from PEO-b-PLA, and the smaller pores, originating from F127. In addition, we are able to ascertain that the F127 triblock copolymer not only produces the smaller pores, but also acts as a swelling agent in the formation of the larger pores. This novel bimodal mesoporous silica is further successfully employed as a drug-carrier for doxorubicin in ambient conditions.
- Published
- 2016