Author: "Sabine Szunerits" / Topic: 0104 chemical sciences - Searchworks@Jio Institute Digital Library Search Results

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233 results on '"Sabine Szunerits"'

1. Electrochemical and electronic detection of biomarkers in serum: a systematic comparison using aptamer-functionalized surfaces

Author: Henri Happy, Wolfgang Knoll, Patrik Aspermair, Vladyslav Mishyn, Yann R. Leroux, Teresa Rodrigues, Rabah Boukherroub, Laura Butruille, Sabine Szunerits, David Montaigne, Eloise Woitrain, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Austrian Institute of Technology [Vienna] (AIT), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires (RNMCD - U1011), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Carbon - IEMN (CARBON - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Danube Private University [Krems, Autriche] (DPU), NanoBioInterfaces - IEMN (NBI - IEMN), Financial support from the Centre National de la Recherche Scientifique (CNRS), the University of Lille, the Hauts-de-France region and the CPER 'Photonics for Society' is gratefully acknowledged. Financial support came further from the FFG, Austria, within the Comet program., IEMN, Collection, Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), and Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U1011 (RNMCD)
Subjects: Analyte, Aptamer, [SPI] Engineering Sciences [physics], 02 engineering and technology, Biosensing Techniques, 010402 general chemistry, 01 natural sciences, Biochemistry, Graphene-based field-effect transistor, Analytical Chemistry, [SPI]Engineering Sciences [physics], Limit of Detection, Troponin I, Humans, Detection limit, Chromatography, Chemistry, Differential pulse voltammetry, Electrochemical Techniques, Aptamers, Nucleotide, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Electrochemical gas sensor, Dissociation constant, Ionic strength, cTnI, 0210 nano-technology, Biomarkers
Abstract: International audience; Sensitive and selective detection of biomarkers in serum in a short time has a significant impact on health. The enormous clinical importance of developing reliable methods and devices for testing serum levels of cardiac troponin I (cTnI), which are directly correlated to acute myocardial infarction (AMI), has spurred an unmatched race among researchers for the development of highly sensitive and cost-effective sensing formats to be able to differentiate patients with early onset of cardiac injury from healthy individuals with a mean cTnI level of 26 pg mL-1. Electronic- and electrochemical-based detection schemes allow for fast and quantitative detection not otherwise possible at the point of care. Such approaches rely largely on voltammetric and field-effect-based readouts. Here, we systematically investigate electric and electrochemical point-of-care sensors for the detection of cTnI in serum samples by using the same surface receptors, cTnI aptamer-functionalized CVD graphene-coated interdigated gold electrodes. The analytical performances of both sensors are comparable with a limit of detection (LoD) of 5.7 ± 0.6 pg mL-1(electrochemical) and 3.3 ± 1.2 pg mL-1 (electric). However, both sensors exhibit different equilibrium dissociation constant (KD) values between the aptamer-linked surface receptor and the cTnI analyte, being 160 pg mL-1 for the electrochemical and about three times lower for the electrical approach with KD = 51.4 pg mL-1. This difference is believed to be related to the use of a redox mediator in the electrochemical sensor for readout. The ability of the redox mediator to diffuse from the solution to the surface via the cTnI/aptamer interface is hindered, correlating to higher KD values. In contrast, the electric readout has the advantage of being label-free with a sensing limitation due to ionic strength effects, which can be limited using poly(ethylene) glycol surface ligands.
Published: 2022
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2. SERS characterization of aggregated and isolated bacteria deposited on silver-based substrates

Author: Lea Rosselle, Eric Larquet, Anne Chantal Gouget-Laemmel, Simion Astilean, Cristina-Cassiana Andrei, Anne Moraillon, Sabine Szunerits, Monica Potara, François Ozanam, Endre Jakab, Nadia Skandrani, Rabah Boukherroub, Julie Bouckaert, Laboratoire de physique de la matière condensée, CNRS, École polytechnique,IP Paris, Palaiseau, France, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), European Project: 690836,H2020,H2020-MSCA-RISE-2015,PANG(2016), Laboratoire de Physique de la Matière Condensée (LPMC), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université de Lille, CNRS, Laboratoire de physique de la matière condensée [LPMC], Babes-Bolyai University [Cluj-Napoca] [UBB], Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN], and Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520
Subjects: Surface-enhanced Raman scattering (SERS), Silver nanostructures, Escherichia coli, Staphylococcus aureus, Aggregated and single bacteria, Principal component analysis (PCA), Silver, Surface Properties, 02 engineering and technology, Spectrum Analysis, Raman, medicine.disease_cause, 01 natural sciences, Biochemistry, Pilus, Analytical Chemistry, Cell wall, symbols.namesake, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, medicine, Humans, Molecule, Escherichia coli Infections, biology, Chemistry, 010401 analytical chemistry, Substrate (chemistry), [CHIM.MATE]Chemical Sciences/Material chemistry, Staphylococcal Infections, 021001 nanoscience & nanotechnology, biology.organism_classification, 0104 chemical sciences, Biophysics, symbols, 0210 nano-technology, Raman spectroscopy, Bacteria, Raman scattering
Abstract: International audience; Surface-enhanced Raman scattering (SERS), based on the enhancement of the Raman signal of molecules positioned within a few nanometres from a structured metal surface, is ideally suited to provide bacterial-specific molecular fingerprints which can be used for analytical purposes. However, for some complex structures such as bacteria, the generation of reproducible SERS spectra is still a challenging task. Among the various factors influencing the SERS variability (such as the nature of SERS-active substrate, Raman parameters and bacterial specificity), we demonstrate in this study that the environment of Gram-positive and Gram-negative bacteria deposited on ultra-thin silver films also impacts the origin of the SERS spectra. In the case of densely packed bacteria, the obtained SERS signatures were either characteristic of the secretion of adenosine triphosphate for Staphylococcus aureus (S. aureus) or the cell wall and the pili/flagella for Escherichia coli (E. coli), allowing for an easy discrimination between the various strains. In the case of isolated bacteria, SERS mapping together with principal component analysis revealed some variabilities of the spectra as a function of the bacteria environment and the bactericidal effect of the silver. However, the variability does not preclude the SERS signatures of various E. coli strains to be discriminated.
Published: 2021
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3. High'Quality Carbon Nanotubes and Graphene Produced from MOFs for Supercapacitor Application

Author: Mandira Majumder, Ram Bilash Choudhary, Anukul K. Thakur, Rabah Boukherroub, Sabine Szunerits, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)
Subjects: Supercapacitor, Materials science, Graphene, Nanotechnology, 02 engineering and technology, Carbon nanotube, 010402 general chemistry, 021001 nanoscience & nanotechnology, 7. Clean energy, 01 natural sciences, 0104 chemical sciences, law.invention, Quality (physics), law, [CHIM]Chemical Sciences, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020
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4. Photothermal Activatable Mucoadhesive Fiber Mats for On-Demand Delivery of Insulin via Buccal and Corneal Mucosa

Author: Anna Voronova, Cristina Prieto, Maria Pardo-Figuerez, Jose Maria Lagaron, Amitav Sanyal, Bilal Demir, Thomas Hubert, Valerie Plaisance, Valerie Pawlowski, Séverine Vignoud-Despond, Alexandre Barras, Amar Abderrahmani, Rabah Boukherroub, Sabine Szunerits, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), European Union's Horizon 2020 Research and Innovation Staff Exchange (RISE) Marie Skłodowska-Curie Actions under grant agreement No 690836., European Project: 690836,H2020,H2020-MSCA-RISE-2015,PANG(2016), Centre National de la Recherche Scientifique (France), Université de Lille, and European commission
Subjects: Swine, Biomedical Engineering, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, reduced graphene oxide, Biomaterials, Cornea, [SPI]Engineering Sciences [physics], on-demand release, Insulin, Regular, Human, Animals, Humans, Insulin, [CHIM]Chemical Sciences, mucoadhesive buccal mucosa, Ensure healthy lives and promote well-being for all at all ages, electrospinning, Biochemistry (medical), Mouth Mucosa, Administration, Buccal, Hydrogels, General Chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, 3. Good health, Buccal mucosa, Mucoadhesive, 0210 nano-technology
Abstract: Electrospun fiber mats loaded with therapeutics have gained considerable attention as a versatile tool in the biomedical field. While these bandages are largely based on fast-dissolving polymers to release the cargo, stimuli-responsive fiber mats have the advantages of providing a timely and spatially controlled drug delivery platform, which can be refilled and reused several times. These benefits make electrospun fiber patches original platforms for painless and convenient on-demand hormone release. Because of the high need of more convenient and non-invasive methods for delivering insulin, a hormone that is currently used to treat hundred million people with diabetes worldwide, we have investigated the tremendous potential of reduced graphene oxide modified poly(acrylic acid) based fiber mats as an original platform for buccal and corneal insulin delivery on-demand. The PAA@rGO hydrogel-like fibers rendered water-insoluble by incorporating β-cyclodextrin, followed by thermal cross-linking, which showed adequate tensile strength along with high adsorption capacity of insulin at pH 7 and good recyclability. The fiber mats maintained good fibrous morphology and high loading efficiency even after five loading-release cycles. The mucoadhesive nature of the fibers allowed their application for insulin delivery via the eye cornea and the buccal mouth lining, as evidenced in ex vivo studies. Insulin loaded PAA@rGO hydrogel-like fibers showed an insulin flux via buccal lining of pigs of 16.6 ± 2.9 μg cm-2 h-1 and 24.3 ± 3.1 μg cm-2 h-1 for porcine cornea. Testing on healthy adult volunteers confirmed the excellent, mucoadhesive nature of the bandage, with three out of six volunteers feeling completely comfortable (note 8.3) while wearing the patches in the buccal cavity., The Centre National de la Recherche Scientifique (CNRS), the University of Lille, the Hauts-de-France region, and the CPER “Photonics for Society” are acknowledged for financial support. This work was partly supported by the French Renatech network. A.V. thanks the i-SITE foundation of the University of Lille for a PhD fellowship. This project has received funding from the European Union’s Horizon 2020 Research and Innovation Staff Exchange (RISE) Marie Skłodowska-Curie Actions under grant agreement No 690836.
Published: 2022
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5. Silicon nanowire-hydrogenated TiO2 core-shell arrays for stable electrochemical micro-capacitors

Author: Toufik Hadjersi, Rabah Boukherroub, Yannick Coffinier, Ahmed Addad, Mohammed A. Amin, Sabine Szunerits, Yasmina Bencheikh, Seddik El Hak Abaidia, Umesh Kumar, Pascal Roussel, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Unité Matériaux et Transformations - UMR 8207 (UMET), Institut de Chimie du CNRS (INC)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Ecole Nationale Supérieure de Chimie de Lille (ENSCL), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, Research Center for Semiconductor Technology for Energy (CRTSE), Université M'Hamed Bougara Boumerdes (UMBB), The Centre National de la Recherche Scientifique (CNRS), the University of Lille, and the Hauts-de-France region are acknowledged for financial support. The authors also thank the Taif University Researchers Supporting Project number (TURSP-2020/03), Taif University, Taif, Saudi Arabia., Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), and Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)
Subjects: Aqueous solution, Materials science, Silicon, business.industry, General Chemical Engineering, chemistry.chemical_element, 02 engineering and technology, Electrolyte, 010402 general chemistry, 021001 nanoscience & nanotechnology, Electrochemistry, 7. Clean energy, 01 natural sciences, Capacitance, Isotropic etching, 0104 chemical sciences, Atomic layer deposition, [SPI]Engineering Sciences [physics], chemistry, Electrode, Optoelectronics, 0210 nano-technology, business
Abstract: International audience; In this paper, we fabricated silicon nanowire-TiO2 core-shell arrays in a two-step process. First, silicon nanowire arrays (SiNW) were prepared in HF/AgNO3 aqueous solution using metal-assisted chemical etching of bulk silicon. Then, atomic layer deposition (ALD) technique was applied to coat a 20 nm thin shell TiO2 film. The TiO2/SiNW substrates were afterward annealed at 400°C in hydrogen atmosphere for 4 h and tested as electrode materials for electrochemical micro-capacitors. The electrochemical features of the constructed H−TiO2/SiNW electrode were assessed in an aqueous 1 M Na2SO4 electrolyte solution and revealed that the specific capacitance increased six times compared to non-annealed TiO2/SiNW and 20-fold compared to a reference SiNW electrode under the same operating conditions. Importantly, H−TiO2/SiNW also displayed a high stability over 30,000 cycles at 0.1 mA cm−2 with an overall decrease of 19% of the initial capacitance. The hydrogen treatment increased the density of hydroxyl group and enhanced the carrier density on TiO2 surface improving the capacitive properties of H−TiO2/SiNW.
Published: 2021
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6. Controlled covalent functionalization of a graphene-channel of a field effect transistor as an ideal platform for (bio)sensing applications

Author: Sabine Szunerits, Johannes Bintinger, Rabah Boukherroub, Teresa Rodrigues, Vladyslav Mishyn, Henri Happy, Wolfgang Knoll, Christoph Kleber, Yann R. Leroux, Patrik Aspermair, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Austrian Institute of Technology [Vienna] (AIT), Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Carbon - IEMN (CARBON-IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Danube University Krems, NanoBioInterfaces - IEMN (NBI - IEMN), Financial support from the Centre National de la Recherche Scientifique (CNRS) and the University of Lille is acknowledged., Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Carbon - IEMN (CARBON - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Renatech Network, and PCMP PCP
Subjects: Materials science, Fabrication, Nanotechnology, 02 engineering and technology, 010402 general chemistry, Electrochemistry, 01 natural sciences, law.invention, chemistry.chemical_compound, [SPI]Engineering Sciences [physics], law, Monolayer, Molecule, [CHIM]Chemical Sciences, General Materials Science, Electrodes, Cycloaddition Reaction, Graphene, Aryl, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, Electrode, Click Chemistry, Graphite, Field-effect transistor, Gold, 0210 nano-technology
Abstract: International audience; The controlled covalent functionalization of the graphene channel of a field effect transistor, based on interdigitated gold electrodes (source and drain), via electrochemical grafting, using specifically designed aryl diazonium species is demonstrated to allow the simple fabrication of a general platform for (bio)sensing applications. The electrochemical grafting of a protected ethynylphenyl diazonium salt leads to the deposition of only a monolayer on the graphene channel. This controlled covalent functionalization of the graphene channel results in a charge mobility of the GFET of 1739 ± 376 cm2 V−1 s−1 and 1698 ± 536 cm2 V−1 s−1 for the holes and electrons, respectively, allowing their utilization as (bio)sensors. After deprotection, a dense and compact ethynylphenyl monolayer is obtained and allows the immobilization of a wide range of (bio)molecules by a “click” chemistry coupling reaction (Huisgen 1,3-dipolar cycloaddition). This finding opens promising options for graphene-based (bio)sensing applications.
Published: 2021
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7. CoO Promoted the Catalytic Activity of Nitrogen-Doped MoS2 Supported on Carbon Fibers for Overall Water Splitting

Author: Mohammed A. Amin, Alexandre Barras, Yuan Zhang, Sabine Szunerits, Ahmed Addad, Rabah Boukherroub, Liuqing Pang, Institut de biologie de Lille - IBL (IBLI), Université de Lille, Sciences et Technologies-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille, Droit et Santé, York-Zhejiang Lab. for Cognitive Radio & Green Commun., Zhejiang University, Unité Matériaux et Transformations - UMR 8207 (UMET), Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut d’Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520 (IEMN), Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Université Polytechnique Hauts-de-France (UPHF)-Ecole Centrale de Lille-Université Polytechnique Hauts-de-France (UPHF)-Institut supérieur de l'électronique et du numérique (ISEN), Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Institut National de la Recherche Agronomique (INRA), Institut de Chimie du CNRS (INC)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Ecole Nationale Supérieure de Chimie de Lille (ENSCL), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Université de Lille, Droit et Santé-Centre National de la Recherche Scientifique (CNRS), and Institut National de la Recherche Agronomique (INRA)-Ecole Nationale Supérieure de Chimie de Lille (ENSCL)-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, Kinetics, Nitrogen doped, [CHIM.MATE]Chemical Sciences/Material chemistry, 02 engineering and technology, Electrolyte, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 0104 chemical sciences, Catalysis, Metal, Chemical engineering, visual_art, visual_art.visual_art_medium, [CHIM]Chemical Sciences, Water splitting, General Materials Science, Hydrogen evolution, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS
Abstract: Non-noble metal electrocatalysts have recently witnessed increasing attention for the hydrogen evolution reaction (HER) in acidic electrolytes. However, in alkaline electrolytes, the slow kinetics ...
Published: 2019
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8. Flower‐like nitrogen‐Co‐doped MoS2@rgo composites with excellent stability for supercapacitors

Author: Min Li, Ahmed Addad, Rabah Boukherroub, Pascal Roussel, Yuan Zhang, Mohammed A. Amin, Sabine Szunerits, Alexandre Barras, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Unité Matériaux et Transformations - UMR 8207 (UMET), Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), The authors thank the Centre National de la Recherche Scientifique (CNRS), the University of Lille, and the Hauts-de-France region for financial support. The authors acknowledge financial support from the Taif University Researchers Supporting Project number (TURSP-2020/03), Taif University, Taif, SaudiArabia., Institut de Chimie du CNRS (INC)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Ecole Nationale Supérieure de Chimie de Lille (ENSCL), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), and Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille
Subjects: Ammonium molybdate, Supercapacitor, Materials science, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 7. Clean energy, 01 natural sciences, Nitrogen, Capacitance, Catalysis, Energy storage, Hydrothermal circulation, 0104 chemical sciences, chemistry.chemical_compound, [SPI]Engineering Sciences [physics], chemistry, Electrochemistry, Composite material, 0210 nano-technology, Molybdenum disulfide, Co doped
Abstract: International audience; Nitrogen-co-doped MoS2@rGO composites (named hereafter N-MoS2@N-RGO) are prepared by the hydrothermal method using dicyandiamide or hydrazine monohydrate as the nitrogen source. N-MoS2@rGO is obtained by the hydrothermal reaction of thioacetamide, ammonium molybdate and GO precursors in the presence of dicyandiamide, while N-MoS2@N-RGO is synthesized using the same precursors in the presence of hydrazine monohydrate as the nitrogen source. On the one hand, N-MoS2@RGO displays excellent performance and good capacitance value of 335 F/g acquired at 0.5A/g and improved stability (∼94% of the original capacitance is preserved after 5000 cycles). On the other hand, compared with N-MoS2@RGO, N-MoS2@N-RGO possesses a slightly higher capacitance of 340 F/g recorded at 0.5A/g and better cycling stability (∼98% of its original value after 5000 cycles). Taken together, the results of this investigation clearly indicate that the fabricated composites have application prospect in energy storage devices.
Published: 2021
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9. A mask-based diagnostic platform for point-of-care screening of Covid-19

Author: Hiba Saada, Delphine Loze-Warot, Rabah Boukherroub, George W. Jackson, Chiu Alexander S, Ilka Engelmann, John Daniels, Quentin Pagneux, Shekhar Wadekar, Judith Ogiez, Ken DeCubellis, Sabine Szunerits, School of Materials Science and Engineering [Sydney], University of New South Wales [Sydney] (UNSW), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Institut des Sciences Chimiques de Rennes (ISCR), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA), Pathogenèse virale du diabète de type 1 - ULR 3610 (Laboratoire de Virologie), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Financial support from the Centre National de la Recherche Scientifique (CNRS), the University of Lille, I-SITE via the COVID task force and the Hauts-de-France region via ANR Resilience (CorDial-FLU) is acknowledged. The project is funded by the Horizon 2020 framework programme of the European Union under grant agreement no 101016038., ANR-21-HDF1-0003,CorDial-FLU,Dispositive portable de diagnostic pour différencier le virus la grippe de celui de Covid-19(2021), European Project: 101016038,H2020,H2020-SC1-PHE-CORONAVIRUS-2020-2-CNECT, CorDial-S(2020), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), and Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), viruses, Point-of-Care Systems, Biomedical Engineering, Biophysics, 02 engineering and technology, Biosensing Techniques, 010402 general chemistry, 01 natural sciences, Aptamers, Article, [SPI]Engineering Sciences [physics], Electrochemistry, Electrochemical biosensor, Humans, Exhaled breath condensate, Real-time reverse-transcription polymerase chain reaction (RT-PCR), skin and connective tissue diseases, Point of care, Chromatography, Chemistry, SARS-CoV-2, Exhaled breath condensate (EBC), COVID-19, General Medicine, 021001 nanoscience & nanotechnology, 3. Good health, 0104 chemical sciences, respiratory tract diseases, Detection, Turn off, Exhalation, RNA, Viral, 0210 nano-technology, Redox mediator, Biosensor, Biotechnology
Abstract: International audience; Diagnostics of SARS-CoV-2 infection using real-time reverse-transcription polymerase chain reaction (RT-PCR) on nasopharyngeal swabs is now well-established, with saliva-based testing being lately more widely implemented for being more adapted for self-testing approaches. In this study, we introduce a different concept based on exhaled breath condensate (EBC), readily collected by a mask-based sampling device, and detection with an electrochemical biosensor with a modular architecture that enables fast and specific detection and quantification of COVID-19. The face mask forms an exhaled breath vapor containment volume to hold the exhaled breath vapor in proximity to the EBC collector to enable a condensate-forming surface, cooled by a thermal mass, to coalesce the exhaled breath into a 200–500 μL fluid sample in 2 min. EBC RT-PCR for SARS-CoV-2 genes (E, ORF1ab) on samples collected from 7 SARS-CoV-2 positive and 7 SARS-CoV-2 negative patients were performed. The presence of SARS-CoV-2 could be detected in 5 out of 7 SARS-CoV-2 positive patients. Furthermore, the EBC samples were screened on an electrochemical aptamer biosensor, which detects SARS-CoV-2 viral particles down to 10 pfu mL−1 in cultured SARS-CoV-2 suspensions. Using a “turn off” assay via ferrocenemethanol redox mediator, results about the infectivity state of the patient are obtained in 10 min.
Published: 2021
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10. Non-enzymatic electrochemical cholesterol sensor based on strong host-guest interactions with a polymer of intrinsic microporosity (PIM) with DFT study

Author: Hamideh Imanzadeh, Neil B. McKeown, Mina Ghiasi, Sabine Szunerits, Mandana Amiri, Negin Jahani, Frank Marken, Rabah Boukherroub, University of Mohaghegh Ardabili, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), University of Bath [Bath], The authors received support of this work from the University ofMohaghegh Ardabili Research Council, Ardabil, Iran (grant number3051234502)., Alzahra University, Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), School of Chemistry, University of Edinburgh, University of Edinburgh, and The authors received support of this work from the University of Mohaghegh Ardabili Research Council, Ardabil, Iran (grant number 3051234502).
Subjects: Models, Molecular, Analyte, Materials science, Polymers, 02 engineering and technology, Biosensing Techniques, engineering.material, 010402 general chemistry, Electrochemistry, DFT calculations, 01 natural sciences, Biochemistry, Analytical Chemistry, [SPI]Engineering Sciences [physics], Coating, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Limit of Detection, Humans, Polymer of intrinsic microporosity (PIM), Electrodes, Density Functional Theory, Detection limit, chemistry.chemical_classification, Methylene blue, Polymer, Electrochemical Techniques, 021001 nanoscience & nanotechnology, Carbon, 0104 chemical sciences, Electrochemical gas sensor, Methylene Blue, Cholesterol, Chemical engineering, chemistry, Electrochemical sensor, Reagent, engineering, Density functional theory, 0210 nano-technology, Porosity
Abstract: Advances in materials science have accelerated the development of diagnostic tools with the last decade witnessing the development of enzyme-free sensors, owing to the improved stability, low cost and simple fabrication of component materials. However, the specificity of non-enzymatic sensors for certain analytes still represents a challenging task, for example the determination of cholesterol level in blood is vital due to its medical relevance. In this work, a reagent displacement assay for cholesterol sensing in serum samples was developed. It is based on coating of a glassy carbon electrode with a polymer of intrinsic microporosity (PIM) that forms a host-guest complex with methylene blue (MB). In the presence of cholesterol, the MB electroactive probe was displaced due to the stronger association of cholesterol guest to the PIM host. The decrease in the oxidative current was proportional to the cholesterol concentration achieving a detection limit of approximately 0.1 nM. Moreover, to further assist the experimental studies, comprehensive theoretical calculations are also performed by using density functional theory (DFT) calculations. Graphical abstract: [Figure not available: see fulltext.].
Published: 2021
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11. Enhanced electrocatalytic activity of PtRu/nitrogen and sulphur co-doped crumbled graphene in acid and alkaline media

Author: Alexandre Barras, Yuanyuan Miao, Pascal Roussel, Siddheshwar N. Bhange, Sabine Szunerits, Sreekumar Kurungot, Ahmed Addad, Rabah Boukherroub, Liuqing Pang, Mohammed A. Amin, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Unité Matériaux et Transformations - UMR 8207 (UMET), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centrale Lille Institut (CLIL), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, CSIR-National Chemical Laboratory, Council of Scientific and Industrial Research (CSIR), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)
Subjects: ORR, chemistry.chemical_element, Nanoparticle, 02 engineering and technology, Overpotential, 010402 general chemistry, Electrocatalyst, 7. Clean energy, 01 natural sciences, law.invention, Catalysis, Biomaterials, [SPI]Engineering Sciences [physics], Colloid and Surface Chemistry, law, Sulphur and nitrogen co-doped crumbled graphene, Graphene, graphene, Oxygen evolution, HER, PtRu2, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Nitrogen, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry, OER, 0210 nano-technology, Platinum, Nuclear chemistry
Abstract: International audience; The low mass activity and high price of pure platinum (Pt)-based catalysts predominantly limit their large-scale utilization in electrocatalysis. Therefore, the reduction of Pt amount while preserving the electrocatalytic efficiency represents a viable alternative. In this work, we prepared new PtRu2 nanoparticles supported on sulphur and nitrogen co-doped crumbled graphene with trace amounts of iron (PtRu2/PF) electrocatalysts. The PtRu2/PF catalysts exhibited enhanced electrocatalytic performance and stability for the hydrogen evolution reaction (HER) at pH - 0. Moreover, the prepared PtRu2/PF electrocatalyst displayed higher HER activity than commercial 20% Pt/C. The PtRu2/PF catalyst achieved a current density of 10 mA cm-2 at an overpotential value of only 22 mV for HER, performing better activity than many other Pt-based electrocatalysts. Besides, the PtRu2/PF revealed a good performance for the oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) in alkaline media. The PtRu2/PF catalyst recorded a current density of 10 mA cm-2 at an overpotential of only 270 mV for OER in KOH (1.0 M) solution and an onset potential of 0.96 V vs. RHE (at 1 mA cm-2) for ORR in KOH (0.1 M) solution.
Published: 2021
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12. Colorimetric detection of chromium (VI) ion using poly(N-phenylglycine) nanoparticles acting as a peroxidase mimetic catalyst

Author: Farnoush Faridbod, Alexandre Barras, Sabine Szunerits, Abir Swaidan, Rabah Boukherroub, Sena Ghayyem, Mathias Dolci, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), and Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)
Subjects: Chromium, Glycine, Nanoparticle, chemistry.chemical_element, 02 engineering and technology, Poly(N-phenylglycine) nanoparticles, 01 natural sciences, Analytical Chemistry, Catalysis, Absorbance, chemistry.chemical_compound, [SPI]Engineering Sciences [physics], Hexavalent chromium, Hydrogen peroxide, Chromium(VI) ion, Peroxidase, Detection limit, 010401 analytical chemistry, Substrate (chemistry), Hydrogen Peroxide, 021001 nanoscience & nanotechnology, Peroxidase-like activity, 0104 chemical sciences, Peroxidases, chemistry, Heavy metals ion, Nanoparticles, Colorimetry, 0210 nano-technology, Colorimetric detection, Nuclear chemistry
Abstract: International audience; This paper reports on enzyme-like catalytic properties of polyethylene glycol-functionalized poly(N-phenylglycine) (PNPG-PEG) nanoparticles, which have not been explored to date. The developed nanoparticles have the ability to display great inherent peroxidase-like activity at very low concentrations, and are able to catalyze the oxidation of 3,3',5,5'tetramethylbenzidine (TMB) substrate in presence of hydrogen peroxide (H2O2). The oxidized product of TMB has a deep blue color with a maximum absorbance at ~655 nm. The PNPG-PEG nanoparticles exhibit Km values of 0.2828 for TMB and 0.0799 for H2O2, indicating that TMB oxidation takes place at lower concentration of H2O2 in comparison to other nanozymes. Based on the known mechanism of H2O2 oxidation by hexavalent chromium [Cr(VI)] ions to generate hydroxyl radicals (.OH), these nanoparticles were successfully applied for the colorimetric sensing of Cr(VI) ions. The sensor achieved good performance for Cr(VI) sensing with detection limits of 0.012 μM (0.01-0.1 μM linear range) and 0.52 μM (0.05-12.5 μM linear range). The detection scheme was highly selective, and successfully applied for the detection of Cr(VI) in real water samples.
Published: 2021
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13. [1+1] Copper(II) macrocyclic Schiff base complex on rGO as a photocatalyst for reduction of nitroaromatics compounds under visible-light irradiation

Author: Mohammad Khodadadi Moghaddam, Abolfazl Bezaatpour, Saeed Nasiri Ghalebin, Sabine Szunerits, Mirabdullah Seyed Sadjadi, Moayad Hossaini Sadr, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), and Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)
Subjects: Hydrazine, Oxide, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, law.invention, Catalysis, chemistry.chemical_compound, Schiff base, Nitroaromatic, law, Materials Chemistry, [CHIM]Chemical Sciences, Reduced graphene oxide, Physical and Theoretical Chemistry, Spectroscopy, Graphene, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Copper, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, Macrocyclic cu complex, chemistry, Photocatalysis, 0210 nano-technology, Hydrate, Nuclear chemistry
Abstract: International audience; In this work, [1 + 1] macrocyclic Copper(II) Schiff base complex ([CuL](NO3)2.H2O) was synthesized and grafted on reduced graphene oxide successfully. The novel prepared sample was characterized by physico-chemical techniques and used as a photocatalyst for the reduction of nitroaromatic compounds to their amine derivatives at room temperature under visible-light irradiation with hydrazine mono hydrate. From the prepared samples, reduced graphene oxide loaded with 30% [CuL](NO3)2.H2O catalyst (rGO/CuM30) shows the best efficiency for converting different nitroaromatic compounds to the corresponding amino compounds using visible light. As-prepared catalyst illustrated excellent activity for the reduction of 2-nitrophenol to 2-aminophenol (100% conversion) in only 90 min. Finally, the catalyst could be recovered for five times and reused without decreasing of its efficiency.
Published: 2021
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14. Cathodic pre-polarization studies on the carbon felt/KOH interface: An efficient metal-free electrocatalyst for hydrogen generation

Author: Rabah Boukherroub, Alexandre Barras, Toufik Hadjersi, Sabine Szunerits, Redouane Chegroune, Madjid Ifires, Ahmed Addad, Mohammed A. Amin, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université de Lille, UDL, Centre National de la Recherche Scientifique, CNRS, and The authors gratefully acknowledge financial support from the Centre National de la Recherche Scientifique (CNRS), the University of Lille, and the Hauts-de-France region. The authors are also thankful to the Taif University Researchers Supporting Project number (TURSP-2020/03), Taif University, Taif, Saudi Arabia.
Subjects: Materials science, General Chemical Engineering, Inorganic chemistry, 02 engineering and technology, engineering.material, Overpotential, 010402 general chemistry, Electrocatalyst, Electrochemistry, 01 natural sciences, Cathodic protection, [SPI]Engineering Sciences [physics], Polarization (electrochemistry), Carbon felt, Tafel equation, Alkaline electrolytes, Chronoamperometry, 021001 nanoscience & nanotechnology, Hydrogen evolution reaction, 0104 chemical sciences, engineering, Noble metal, 0210 nano-technology, Cathodic activation, Electrocatalysis
Abstract: International audience; The recent decades have witnessed a booming research effort on the development of highly active electrode materials in electrocatalysis with the aim to replace the commonly used noble metal-based ones. Although non-noble metal electrodes can fulfill some requirements in terms of performance and price, their stability in alkaline media is generally weak. Additionally, from the environmental view point, the use of metals can cause water contamination. Therefore, the preparation of metal-free electrocatalysts represents an appealing approach to overcome the above-mentioned shortcuts. In this work, we used a simple electrochemical activation process, chronoamperometry measurements conducted in 1 M KOH at various overpotentials (−2, −2.5, −3, and −4 V vs. RHE) and pre-polarization periods (0.5, 2, 4, and 12 h), of commercially available and cheap carbon felt (CF) electrode to achieve good performance for hydrogen evolution reaction (HER) in alkaline media. Under optimized operating conditions (12 h of chronoamperometry measurement acquired at an overpotential of −4 V vs. RHE), the CF electrode exhibited an overpotential of 182 mV at 10 mA/cm2, a value surpassing that recorded for the most efficacious metal-free HER electrocatalysts published in the literature. The two CF samples exposed to 12 h of cathodic activation at −2.5 and −3.0 V vs. RHE recorded respectively Tafel slope (bc) values of 110 and 126 mV dec−1. These bc values are close to the standard bc value of 120 mV dec−1, suggesting the Volmer step as the main step controlling the HER. Increasing the applied cathodic potential to −4.0 V vs. RHE further decreased the bc value to 90 mV dec−1, referring to increased accessible active catalytic sites for the HER. The cathodically activated CF surface's morphology and composition were assessed by scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS) examinations. Raman spectroscopy was also conducted to assess the influence of the cathodic activation process on the structural defects/disorder of the CF surface. The formation of oxygen-containing groups on the CF surface after cathodic activation, as evidenced from XPS analysis, is believed to enhance water adsorption and act as active sites for hydrogen generation. The technique developed herein is simple and straightforward and can be easily implemented for almost any type of electrode.
Published: 2021
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15. Aryne cycloaddition reaction as a facile and mild modification method for design of electrode materials for high-performance symmetric supercapacitor

Author: Rabah Boukherroub, Pavel S. Postnikov, Mekhman S. Yusubov, Elizaveta Sviridova, Akira Yoshimura, Alexandre Barras, Min Li, Ahmed Addad, Viktor V. Zhdankin, Sabine Szunerits, Tomsk Polytechnic University [Russie] (UPT), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Unité Matériaux et Transformations - UMR 8207 (UMET), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centrale Lille Institut (CLIL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), and Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: Thermogravimetric analysis, Materials science, General Chemical Engineering, 02 engineering and technology, 010402 general chemistry, 7. Clean energy, 01 natural sciences, law.invention, [SPI]Engineering Sciences [physics], X-ray photoelectron spectroscopy, law, Aryne cycloaddition reaction, Electrochemistry, [CHIM]Chemical Sciences, Reduced graphene oxide, Fourier transform infrared spectroscopy, Supercapacitor, Graphene, Covalent functionalization, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Dielectric spectroscopy, Chemical engineering, Iodonium salts, Surface modification, Cyclic voltammetry, 0210 nano-technology, Symmetric supercapacitor
Abstract: International audience; Covalent modification of graphene-based materials can be considered as one of the most promising methods for tailoring their electrochemical properties and extending their application as electrode materials for supercapacitors. In this contribution, we report a facile and mild approach for the covalent functionalization of reduced graphene oxide (rGO) via aryne cycloaddition using pseudocyclic iodoxoborole as an aryne source. The structure and chemical composition of the functionalized rGO (f-rGO) were assessed by Fourier transform infrared (FTIR) spectroscopy, thermogravimetric analysis (TGA), ultraviolet-visible (UV-vis) spectrophotometry, Raman spectroscopy and X-ray photoelectron spectroscopy (XPS), which revealed the negligible influence of covalent modification on the rGO structure. Transmission electron microscopy (TEM) imaging showed an increase of the interlayer distance from 0.38 to 0.46 nm upon functionalization. The electrochemical performance of f-rGO material was studied by cyclic voltammetry (CV), galvanostatic charge-discharge (GCD) and electrochemical impedance spectroscopy (EIS) techniques in 2 M KOH aqueous solution as the electrolyte. Under optimized conditions, the f-rGO displayed a high specific capacitance of 297 F g-1 at a current density of 1 A g-1, which is much higher than that of unmodified rGO (170 F g-1 at 1 A g-1). Therefore, the f-rGO was used to construct a symmetric supercapacitor device, exhibiting an energy density of 6.7 Wh kg-1 at a power density of 685.8 W kg-1. The device exhibited good cycling stability and ability to maintain about 96% of the initial capacitance value after 10,000 cycles. Furthermore, two symmetric supercapacitor devices were successfully applied to power a home-designed windmill device for 3 s. The results obtained in the present study highlight the importance of graphene functionalization as an effective route to fabricate rGO-based materials with enhanced properties in energy storage devices.
Published: 2021
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16. Colorimetric sensing of dopamine in beef meat using copper sulfide encapsulated within bovine serum albumin functionalized with copper phosphate (CuS-BSA-Cu3(PO4)2) nanoparticles

Author: Alexandre Barras, Tayssir Hamieh, Sabine Szunerits, Abir Swaidan, Jean-Francois Tahon, Joumana Toufaily, Rabah Boukherroub, Ahmed Addad, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Unité Matériaux et Transformations - UMR 8207 (UMET), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centrale Lille Institut (CLIL), Université Libanaise, Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), and Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: Dopamine, Nanoparticle, Colorimetric Detection, 02 engineering and technology, 01 natural sciences, NANOCOMPOSITE, GLUCOSE, chemistry.chemical_compound, Colloid and Surface Chemistry, ANTIOXIDANT, Bovine serum albumin, PEROXIDASE-LIKE ACTIVITY, biology, Colorimetric, Serum Albumin, Bovine, Bovine, 021001 nanoscience & nanotechnology, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Detection, Colorimetry, 0210 nano-technology, Dopamine analysis, Peroxidase, Meat, CuS-BSA-Cu3(PO4)2, Sulfides, 010402 general chemistry, Catalysis, Phosphates, Biomaterials, Nanosensor, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Animals, Nanozymes, FLUORESCENCE, Serum Albumin, Detection limit, NANOMATERIALS, HIGH-SENSITIVITY, CAPILLARY-ELECTROPHORESIS, Substrate (chemistry), CuS-BSA-Cu-3(PO4)(2), Hydrogen Peroxide, 0104 chemical sciences, chemistry, ASCORBIC-ACID, GOLD NANOPARTICLES, Beef meat, biology.protein, Nanoparticles, Hydroxyl radical, Cattle, Copper, Nuclear chemistry
Abstract: International audience; A novel nanosensor with peroxidase enzyme-mimetic activity, based on CuS-BSA-Cu3(PO4)2 nanoparticles, was developed. CuS-BSA nanoparticles were first synthesized using a facile bio-mineralization assay. Conjugation of Cu3(PO4)2 with CuS-BSA generates CuS-BSA-Cu3(PO4)2 nanoparticles (NPs) of 10 nm in size with high catalytic activity against a peroxidase substrate, 3,3',5,5'-tetramethylbenzidine (TMB). The catalytic action was based on a remarkable color change from colorless TMB into blue oxidized product (oxTMB) with absorption maximum at 654 nm. The enzyme-mimetic activity of CuS-BSA-Cu3(PO4)2 nanoparticles was believed to occur through hydroxyl radical (HOradical dot) generation in presence of H2O2, which was inhibited upon addition of dopamine. Increasing concentrations of dopamine induced a gradual decrease of the nanoparticles' catalytic activity. The developed colorimetric sensor displayed a limit of detection of 0.13 µM for dopamine over 0.05-100 µM linear range and high specificity. The performance of the nanosensor for sensing dopamine in beef meat and blood samples was evaluated and proved to be promising for diagnostic applications without the requirement of complex and expensive instrumentation.
Published: 2021
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17. Advancements in sensor technology with innovative and significant research publications: how to write that perfect paper?

Author: Adam T. Woolley, Antje J. Baeumner, Hua Cui, Günter Gauglitz, Sabine Szunerits, María C. Moreno-Bondi, University of Science and Technology of China [Hefei] (USTC), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), NanoBioInterfaces - IEMN (NBI - IEMN), and Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)
Subjects: Engineering, business.industry, 010401 analytical chemistry, Medical laboratory, MEDLINE, Analytical Chemistry (journal), 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Biochemistry, Data science, 0104 chemical sciences, Analytical Chemistry, [SPI]Engineering Sciences [physics], 0210 nano-technology, business, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2021
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18. The role of the surface ligand on the performance of electrochemical SARS-CoV-2 antigen biosensors

Author: David Devos, Christian Cambillau, Henri Happy, Quentin Pagneux, Vladyslav Mishyn, Enagnon Kazali Alidjinou, Ilka Engelmann, Rabah Boukherroub, Abir Swaidan, Sabine Szunerits, Alain Roussel, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Architecture et fonction des macromolécules biologiques (AFMB), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Lille Neurosciences & Cognition - U 1172 (LilNCog (ex-JPARC)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Pathogenèse virale du diabète de type 1 - ULR 3610 (Laboratoire de Virologie), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Carbon - IEMN (CARBON-IEMN), Centre National de la Recherche Scientifique (CNRS)Centre National de la Recherche Scientifique (CNRS), University of Lille, I-SITE, via the COVID task force, Hauts-de-France region via ANR Resilience (CorDial-FLU), French Infrastructure for Integrated Structural Biology (FRISBI) [ANR-10-INBS-0005], ANR-10-INBS-0005,FRISBI,Infrastructure Française pour la Biologie Structurale Intégrée(2010), ANR-21-HDF1-0003,CorDial-FLU,Dispositive portable de diagnostic pour différencier le virus la grippe de celui de Covid-19(2021), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Lille Neurosciences & Cognition - U 1172 (LilNCog), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Carbon - IEMN (CARBON - IEMN), IEMN, Collection, Infrastructure Française pour la Biologie Structurale Intégrée - - FRISBI2010 - ANR-10-INBS-0005 - INBS - VALID, and Dispositive portable de diagnostic pour différencier le virus la grippe de celui de Covid-19 - - CorDial-FLU2021 - ANR-21-HDF1-0003 - PRHDF - VALID
Subjects: Coronavirus disease 2019 (COVID-19), Computer science, [SPI] Engineering Sciences [physics], Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Point-of-care testing, Point-of-Care Systems, Medical laboratory, Economic shortage, 02 engineering and technology, Review, Biosensing Techniques, point-of-care (poc) technologies, Ligands, 01 natural sciences, Biochemistry, Analytical Chemistry, [SPI]Engineering Sciences [physics], COVID-19 Testing, Health care, Humans, field effect transistors, Antigens, Viral, Disease surveillance, business.industry, 010401 analytical chemistry, COVID-19, Electrochemical Techniques, 021001 nanoscience & nanotechnology, biosensors, 0104 chemical sciences, 3. Good health, sars-cov-2, Risk analysis (engineering), electrochemistry, surface ligands, Analytics, Point-of-Care Testing, 0210 nano-technology, business
Abstract: International audience; Point-of-care (POC) technologies and testing programs hold great potential to significantly improve diagnosis and disease surveillance. POC tests have the intrinsic advantage of being able to be performed near the patient or treatment facility, owing to their portable character. With rapid results often in minutes, these diagnostic platforms have a high positive impact on disease management. POC tests are, in addition, advantageous in situations of a shortage of skilled personnel and restricted availability of laboratory-based analytics. While POC testing programs are widely considered in addressing health care challenges in low-income health systems, the ongoing pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections could largely benefit from fast, efficient, accurate, and cost-effective point-of-care testing (POCT) devices for limiting COVID-19 spreading. The unrestrained availability of SARS-CoV-2 POC tests is indeed one of the adequate means of better managing the COVID-19 outbreak. A large number of novel and innovative solutions to address this medical need have emerged over the last months. Here, we critically elaborate the role of the surface ligands in the design of biosensors to cope with the current viral outbreak situation. Their notable effect on electrical and electrochemical sensors' design will be discussed in some given examples.
Published: 2021
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19. The importance of the shape of Cu2O nanocrystals on plasmon-enhanced oxygen evolution reaction in alkaline media

Author: Robert Wojcieszak, Georgiana Sandu, Eduardo D. Vicentini, André H.B. Dourado, Franck Dumeignil, Adriano H. Braga, Antonio G. S. de Oliveira-Filho, Taissa F. Rosado, Kilaparthi Sravan Kumar, Anderson G.M. da Silva, Liuqing Pang, Dalila Meziane, Susana I. Córdoba de Torresi, Rabah Boukherroub, Sorin Melinte, Sébastien Paul, Tamazouzt Nait Saada, Sabine Szunerits, Lucas D. Germano, Guido Petretto, Ana Paula de Lima Batista, Gian-Marco Rignanese, UCL - SST/ICTM/ELEN - Pôle en ingénierie électrique, UCL - SST/IMCN - Institute of Condensed Matter and Nanosciences, UCL - SST/IMCN/MODL - Modelling, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Financial support from the Centre National de la Recherche Scientifique (CNRS), the University of Lille and the Hauts-de-France region via the dispositif STIMulE (Soutien aux travaux interdisciplinaires 2019) is acknowledged. This work was also supported by the São Paulo Research Foundation (FAPESP) (grant number 2015/26308-7) and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). S.I.C.T. and A.G.M.S. thank CNPq and FAPERJ for their research fellowships. A.G.M.S. and L.D.G. thank FAPESP for their fellowship (grant numbers FAPESP 2017/12407- 9, 2018/25567-7, and 2018/22845-6)., Financial support from the Centre National de la Recherche Sci- entifique (CNRS), the University of Lille and the Hauts-de-France region via the dispositif STIMulE (Soutien aux travaux interdisci- plinaires 2019) is acknowledged. This work was also supported by the São Paulo Research Foundation (FAPESP) (grant number 2015/26308-7) and Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ). S.I.C.T. and A.G.M.S. thank CNPq and FAPERJ for their research fellowships. A.G.M.S. and L.D.G. thank FAPESP for their fellowship (grant numbers FAPESP 2017/12407- 9, 2018/25567-7, and 2018/22845-6)., Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), and Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA)
Subjects: Cubes, Materials science, Nanostructure, Oxygen evolution reaction, General Chemical Engineering, 02 engineering and technology, Overpotential, 010402 general chemistry, Electrochemistry, 01 natural sciences, Cuprous oxide, Octahedra, Gold nanoparticles, Plasmon-enhanced electrocatalysis, Density functional theory, [CHIM]Chemical Sciences, Plasmon, Tafel equation, Oxygen evolution, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Nanocrystal, Chemical engineering, Colloidal gold, [PHYS.COND.CM-MS]Physics [physics]/Condensed Matter [cond-mat]/Materials Science [cond-mat.mtrl-sci], ELETROCATÁLISE, 0210 nano-technology
Abstract: International audience; Cu2O nanostructures of cubic or octahedral shape as well as decorated with gold nanoparticles were synthesized by a chemical process. The electrochemical activity of these nanostructures for the oxygen evolution reaction (OER) in alkaline media was assessed in the dark and under solar light irradiation. Electrodes modified with cubic-shaped Cu2O and Cu2O-Au nanostructures revealed both enhanced electrocatalytic OER activity over the octahedral-shaped ones, for which hydroxylation of the (111) surfaces might hinder the OER as supported by numerical computations. Illumination of Cu2O nanostructures with solar light did not enhance the electrocatalytic OER. Cu2O-Au nanostructures, however, showed improved OER activity with an overpotential of 200 mV (10 mA cm−2) and a Tafel slope of 97 mV dec−1. The enhanced OER activity was ascribed to increased light absorption due to the plasmonic properties of Cu2O-Au cubes.
Published: 2021
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20. Electrochemical, theoretical and surface physicochemical studies of the alkaline copper corrosion inhibition by newly synthesized molecular complexes of benzenediamine and tetraamine with π acceptor

Author: Rabah Boukherroub, Sarah Alharthi, Mohamed M. Ibrahim, Gaber A.M. Mersal, Fatma Kandemirli, Jacek Ryl, Mohammed A. Amin, Murat Saracoglu, Sabine Szunerits, Ahmed M. Fallatah, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Faculty of Electrical and Control Engineering [GUT Gdańsk] (EIA), Gdańsk University of Technology (GUT), Computer & Systems Dept., Ain Shams Univ., Egypt (COMPUTER & SYSTEMS DEPT., AIN SHAMS UNIV., EGYPT), Université Ain Shams, Deanship of Scientific Research, Taif University, Saudi Arabia [1-439-6070], and Ain Shams University (ASU)
Subjects: B3LYP, Potassium, Inorganic chemistry, chemistry.chemical_element, 02 engineering and technology, Electrolyte, 010402 general chemistry, Electrochemistry, 01 natural sciences, DFT, [SPI]Engineering Sciences [physics], X-ray photoelectron spectroscopy, Materials Chemistry, Molecule, Quantum chemical calculation, Physical and Theoretical Chemistry, Spectroscopy, Chemistry, Single crystal, Alkaline corrosion, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Acceptor, Copper, Atomic and Molecular Physics, and Optics, 0104 chemical sciences, Electronic, Optical and Magnetic Materials, Corrosion inhibitor, Erosion corrosion of copper water tubes, 0210 nano-technology, Charge transfer complexes
Abstract: International audience; Two charge transfer complexes, namely [(BDAH)(+)(PA(-))] CT1 [(BTAH)(2+) (PA(-))(2)] and CT2 (BDAH = 1,2-benzenediamine, BTAH = 1,2,4,5-benzenetetramine, and PA(-) = 2,4,6-trinitrophenolate), were synthesized and fully characterized using various spectroscopic techniques. CT1 and CT2 were tested as inhibitors to effectively control the uniform and anodic corrosion processes of copper in an alkaline electrolyte (1.0 M KOH) using various electrochemical techniques. As a reference point, results were compared with the potassium salt of the pi-acceptor potassium 2,4,6-trinitrophenolate (designated here as PA(-)K(+)). The highest inhibition efficiency (97%) was recorded for inhibitor CT2 at a concentration of 1.0 mM. The inhibition mechanism was discussed based on scanning electron microscopy and X-ray photoelectron spectroscopy results of the corroded and inhibited Cu surfaces. A theoretical study, based on quantum-chemical calculations of the synthesized compounds. performed by the DFF/B3LYP method with a 6-311++G(2d,2p) basis set by using Gaussian 09, Revision A.02 program, was also included to support experimental findings. The various quantum chemical parameters such as E-HOMO, E-LUMO, chemical hardness, and chemical softness of the investigated molecules were calculated, and their correlation with the inhibition efficiency of the synthesized compounds was discussed. (C) 2020 Elsevier B.V. All rights reserved.
Published: 2020
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21. Photothermally Active Cryogel Devices for Effective Release of Antimicrobial Peptides: On-Demand Treatment of Infections

Author: Sabine Szunerits, Julia E. Bandow, Duygu Aydin, Laura Chambre, Alexandre Barras, Suzan Gunbay, Rana Sanyal, Aleksandra Loczechin, Nadia Skandrani, Nils Metzler-Nolte, Amitav Sanyal, Rabah Boukherroub, Léa Rosselle, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), and European Project: 690836,H2020,H2020-MSCA-RISE-2015,PANG(2016)
Subjects: cryogel, Staphylococcus aureus, Materials science, Infrared Rays, Antimicrobial peptides, Peptide, 02 engineering and technology, Microbial Sensitivity Tests, Conjugated system, 010402 general chemistry, 01 natural sciences, Polyethylene Glycols, Heating, photothermal, Escherichia coli, Humans, General Materials Science, [SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/Biomaterials, Furans, chemistry.chemical_classification, Cycloaddition Reaction, Substrate (chemistry), [CHIM.MATE]Chemical Sciences/Material chemistry, Photothermal therapy, Staphylococcal Infections, 021001 nanoscience & nanotechnology, Antimicrobial, S. aureus, Combinatorial chemistry, peptide, 0104 chemical sciences, Anti-Bacterial Agents, Diels−Alder reaction, Drug Liberation, chemistry, Covalent bond, Self-healing hydrogels, antimicrobial, Methacrylates, 0210 nano-technology, Cryogels, Antimicrobial Cationic Peptides, HeLa Cells
Abstract: International audience; There has been significant interest in the use of peptides as antimicrobial agents, and peptide containing hydrogels have been proposed as biological scaffolds for various applications. Limited stability and rapid clearance of small molecular weight peptides pose challenges to their widespread implementation. As a common approach, antibacterial peptides are physically loaded into hydrogel scaffolds, which leads to continuous release through the passive mode with spatial control but provides limited control over drug dosage. Although utilization of peptide covalent linkage onto hydrogels addresses partially this problem, the peptide release is commonly too slow. To alleviate these challenges, in this work, maleimide-modified antimicrobial peptides are covalently conjugated onto furan-based cryogel (CG) scaffolds via the Diels-Alder cycloaddition at room temperature. The furan group offers a handle for specific loading of the peptides, thus minimizing passive and burst drug release. The porous nature of the CG matrix provides rapid loading and release of therapeutic peptides, apart from high water uptake. Interfacing the peptide adduct containing a CG matrix with a reduced graphene oxide-modified Kapton substrate allows “on-demand” photothermal heating upon near-infrared (NIR) irradiation. A fabricated photothermal device enables tunable and efficient peptide release through NIR exposure to kill bacteria. Apart from spatial confinement offered by this CG-based bandage, the selective ablation of planktonic Staphylococcus aureus is demonstrated. It can be envisioned that this modular “on-demand” peptide-releasing device can be also employed for other topical applications by appropriate choice of therapeutic peptides.
Published: 2020
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22. Plasmon-driven electrochemical methanol oxidation on gold nanohole electrodes

Author: Rabah Boukherroub, Sorin Melinte, Georgiana Sandu, Svetlana Heyte, Sabine Szunerits, Egon Heuson, Liuqing Pang, Hamid Oubaha, Vladyslav Mishyn, Alexandre Barras, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Transfrontalière BioEcoAgro - UMR 1158 (BioEcoAgro), Université d'Artois (UA)-Université de Liège-Université de Picardie Jules Verne (UPJV)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Renatech Network, ANR-11-EQPX-0037,REALCAT,Plateforme intégREe AppLiquée au criblage haut débit de CATalyseurs pour les bioraffineries(2011), and UCL - SST/ICTM/ELEN - Pôle en ingénierie électrique
Subjects: Materials science, Photoelectrochemistry, Localized surface plasmon resonance, Hot carriers, Electrocatalysis, Electrochemical methanol oxidation, 02 engineering and technology, 010402 general chemistry, Electrocatalyst, Electrochemistry, 7. Clean energy, 01 natural sciences, photoelectrochemistry, chemistry.chemical_compound, localized surface plasmon resonance, electrocatalysis, General Materials Science, Thin film, Plasmon, electrochemical methanol oxidation, [CHIM.CATA]Chemical Sciences/Catalysis, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Anode, Chemical engineering, chemistry, Electrode, Methanol, hot carriers, 0210 nano-technology
Abstract: International audience; Direct methanol oxidation is expected to play a central role in low-polluting future power sources. However, the sluggish and complex electro-oxidation of methanol is one of the limiting factors for any practical application. To solve this issue, the use of plasmonic is considered as a promising way to accelerate the methanol oxidation reaction. In this study, we report on a novel approach for achieving enhanced methanol oxidation currents. Perforated gold thin film anodes were decorated with Pt/Ru via electrochemical deposition and investigated for their ability for plasmon-enhanced electrocatalytic methanol oxidation in alkaline media. The novel methanol oxidation anode (AuNHs/PtRu), combining the strong light absorption properties of a gold nanoholes array-based electrode (AuNHs) with surface-anchored bimetallic Pt/Ru nanostructures, known for their high activity toward methanol oxidation, proved to be highly efficient in converting methanol via the hot holes generated in the plasmonic electrode. Without light illumination, AuNHs/PtRu displayed a maximal current density of 13.7 mA/cm2 at -0.11 V vs Ag/AgCl. Enhancement to 17.2 mA/cm2 was achieved under 980 nm laser light illumination at a power density of 2 W/cm2. The thermal effect was negligible in this system, underlining a dominant plasmon process. Fast generation and injection of charge carriers were also evidenced by the abrupt change in the current density upon laser irradiation. The good stability of the interface over several cycles makes this system interesting for methanol electro-oxidation.
Published: 2020
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23. Rapid and sensitive identification of uropathogenic Escherichia coli using a surface-enhanced-Raman-scattering-based biochip

Author: Eric Larquet, Nordin Félidj, Nao Yamakawa, Julie Bouckaert, Sabine Szunerits, François Ozanam, Cristina-Cassiana Andrei, Rabah Boukherroub, Anne Chantal Gouget-Laemmel, Anne Moraillon, Stephanie Lau, Laboratoire de physique de la matière condensée (LPMC), École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut d’Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520 (IEMN), Ecole Centrale de Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Laboratoire International associé sur les phénomènes Critiques et Supercritiques en électronique fonctionnelle, acoustique et fluidique (LIA LICS/LEMAC), Ecole Centrale de Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Ecole Centrale de Lille-Université de Lille-Université Polytechnique Hauts-de-France (UPHF)-Université Polytechnique Hauts-de-France (UPHF), Interfaces, Traitements, Organisation et Dynamique des Systèmes (ITODYS (UMR_7086)), Université Paris Diderot - Paris 7 (UPD7)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Unité de Glycobiologie Structurale et Fonctionnelle (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université de Lille, CNRS, Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 [UGSF], and Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Subjects: Principle Component Analysis (PCA), [SDV]Life Sciences [q-bio], Metal Nanoparticles, biochips, gold nanorods (Au NRs), 02 engineering and technology, Spectrum Analysis, Raman, medicine.disease_cause, 01 natural sciences, Antibodies, Analytical Chemistry, [SPI]Engineering Sciences [physics], symbols.namesake, FimA, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, medicine, Escherichia coli, Humans, Uropathogenic Escherichia coli, [CHIM]Chemical Sciences, Biochip, ComputingMilieux_MISCELLANEOUS, biology, surface-enhanced Raman spectroscopy (SERS), SERS, Cetrimonium, Chemistry, Biochips, Surface-enhanced Raman spectroscopy (SERS), Gold nanorods (Au NRs), Principle component analysis (PCA), Hydrogenated amorphous silicon (a-Si:H), 010401 analytical chemistry, E. coli, Substrate (chemistry), CTAB, 021001 nanoscience & nanotechnology, biology.organism_classification, Combinatorial chemistry, 0104 chemical sciences, Covalent bond, Pilin, symbols, biology.protein, Nanorod, Gold, hydrogenated amorphous silicon (a-Si:H), 0210 nano-technology, Raman spectroscopy, Bacteria
Abstract: International audience; Rapid, selective and sensitive sensing of bacteria remains challenging. We report on a highly sensitive and reproducible surface-enhanced Raman spectroscopy (SERS)-based sensing approach for the detection of ur-opathogenic Escherichia coli (E. coli) bacteria in urine. The assay is based on the specific capture of the bacteria followed by interaction with cetyltrimethylammonium bromide (CTAB)-stabilised gold nanorods (Au NRS) as SERS markers. High sensitivity up to 10 CFU mL-1 is achieved by optimizing the capture interface based on hydrogenated amorphous silicon a-Si:H thin films. The integration of CH 3 O-PEG750 onto a-Si:H gives the sensing interface an efficient anti-fouling character, while covalent linkage of antibodies directed against the major type-1 fimbrial pilin FimA of the human pathogen E. coli results in the specific trapping of fimbriated E. coli onto the SERS substrate and their spectral fingerprint identification.
Published: 2020
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24. High performance flexible hybrid supercapacitors based on nickel hydroxide deposited on copper oxide supported by copper foam for a sunlight-powered rechargeable energy storage system

Author: Min Li, Sabine Szunerits, Pascal Roussel, Ahmed Addad, Rabah Boukherroub, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Unité Matériaux et Transformations - UMR 8207 (UMET), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centrale Lille Institut (CLIL), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Institut d’Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520 (IEMN), Ecole Centrale de Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Laboratoire International associé sur les phénomènes Critiques et Supercritiques en électronique fonctionnelle, acoustique et fluidique (LIA LICS/LEMAC), Ecole Centrale de Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Ecole Centrale de Lille-Université de Lille-Université Polytechnique Hauts-de-France (UPHF)-Université Polytechnique Hauts-de-France (UPHF), Université de Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN], Unité Matériaux et Transformations - UMR 8207 [UMET], Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS], Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), and Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, Energy storage system, Oxide, 02 engineering and technology, 010402 general chemistry, Electrochemistry, 7. Clean energy, 01 natural sciences, Energy storage, law.invention, Biomaterials, chemistry.chemical_compound, Colloid and Surface Chemistry, law, Energy transformation, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS, Power density, Supercapacitor, Sunlight-powered, Graphene, Ni(OH)2, CuO, Copper foam, Flexible supercapacitors, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry, Chemical engineering, Electrode, 0210 nano-technology
Abstract: International audience; Herein, an integrated system combining solar cells with a hybrid supercapacitor for operating a homemade windmill device was assembled, achieving energy conversion, storage and utilization. As a candidate for positive electrode of hybrid supercapacitor devices, battery-like Ni(OH)2@CuO@Cu binder-free electrode was fabricated by a two-step process at ambient temperature. CuO@Cu was prepared by chemical oxidation method to act as the supporting electrode for electrochemical deposition of Ni(OH)2. Various deposition times (30, 50, 90, 150 and 200 s) were investigated to optimize the energy storage characteristics of the resulting Ni(OH)2@CuO@Cu electrode materials. Among all the samples, Ni(OH)2@CuO@Cu-150 exhibited the largest areal capacity of 7063 mC cm−2 at 20 mA cm−2, and was therefore chosen as the positive electrode in a hybrid supercapacitor device. Using N-doped reduced graphene oxide on nickel foam (N-rGO/NF) as the negative electrode, a hybrid supercapacitor was assembled. It displayed good flexibility, cycling stability and high areal energy density of 130.4 μWh cm−2 at a power density of 1.6 mW cm−2. Two hybrid supercapacitor devices were connected in series to successfully lighten up a red LED for 12 min 39 s, while three devices assembled in series were able to successfully power a three-digit digital display for 1 min 28 s. Interestingly, the hybrid supercapacitor device, charged by solar cells, further operated a homemade windmill device for 59 s, achieving sunlight-powered integration system. All of the findings suggested the practical application potential of the hybrid supercapacitor based on Ni(OH)2@CuO@Cu composite as energy storage device.
Published: 2020
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25. Copper‐based metal–organic framework decorated by CuO hair‐like nanostructures: Electrocatalyst for oxygen evolution reaction

Author: Ali Khodayari, Zahra Tofighi, Vladyslav Mishyn, Abolfazl Bezaatpour, Mandana Amiri, Sabine Szunerits, Rabah Boukherroub, Shabnam Sohrabnezhad, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)
Subjects: Nanostructure, Oxygen evolution, chemistry.chemical_element, 02 engineering and technology, General Chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, 010402 general chemistry, 021001 nanoscience & nanotechnology, Electrocatalyst, 01 natural sciences, Copper, 0104 chemical sciences, Inorganic Chemistry, chemistry, Chemical engineering, Metal-organic framework, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2020
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26. Preparation of boron-doped diamond nanospikes on porous Ti substrate for high-performance supercapacitors

Author: Zhi-yan Zhao, Sabine Szunerits, Jing Zhang, Alexandre Barras, Yannick Coffinier, Xiang Yu, Rabah Boukherroub, NanoBioInterfaces - IEMN (NBI - IEMN), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), and Renatech Network
Subjects: Supercapacitor, Materials science, business.industry, General Chemical Engineering, Diamond, 02 engineering and technology, Substrate (electronics), [CHIM.MATE]Chemical Sciences/Material chemistry, engineering.material, 010402 general chemistry, 021001 nanoscience & nanotechnology, 7. Clean energy, 01 natural sciences, Capacitance, 0104 chemical sciences, Electrode, Electrochemistry, engineering, Optoelectronics, Reactive-ion etching, 0210 nano-technology, business, Porosity, Current density, ComputingMilieux_MISCELLANEOUS
Abstract: The study reports on the preparation of boron-doped diamond nanospikes (BDD-NSs), supported on porous titanium (Ti) substrate, using reactive ion etching (RIE) with oxygen plasma and their investigation as an electrode material for supercapacitors. The above architecture contributes to an ideal pathway for supercapacitors with good stability and high specific capacitance. As a result, the BDD electrode etched for 5 min (BDD-NSs-5) achieved good performance with a high specific capacitance of 70.6 mF cm−2 at a current density of 0.32 mA cm−2 and a capacitance retention of 84.3% after 15,000 cycles. Moreover, the BDD-NSs-5 electrode was assembled into a symmetric supercapacitor device. The device achieved high energy and power densities of 9.24 mJ cm−2 and 1.26 mW cm−2, respectively, implying enhanced potential for real-time applications. For practical application, the BDD-NSs-5 electrode was used for rotating a home-designed windmill device and the solid-state symmetric supercapacitor device can light up a red LED for 20 s after being charged to 3.0 V.
Published: 2020
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27. High-performance flexible hybrid supercapacitor based on NiAl layered double hydroxide as a positive electrode and nitrogen-doped reduced graphene oxide as a negative electrode

Author: Mathias Dolci, Alexandre Barras, Pascal Roussel, Rabah Boukherroub, Min Li, Sabine Szunerits, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), The authors gratefully acknowledge financial support from the Centre National de la Recherche Scientifique (CNRS), the University of Lille, and the Hauts-de-France region. Min Li thanks Chinese government for the China Scholarship Council fellowship., Renatech Network, Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut d’Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520 (IEMN), Ecole Centrale de Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Laboratoire International associé sur les phénomènes Critiques et Supercritiques en électronique fonctionnelle, acoustique et fluidique (LIA LICS/LEMAC), Ecole Centrale de Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Ecole Centrale de Lille-Université de Lille-Université Polytechnique Hauts-de-France (UPHF)-Université Polytechnique Hauts-de-France (UPHF), Université de Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN], and Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Subjects: Nial, Materials science, General Chemical Engineering, Oxide, chemistry.chemical_element, 02 engineering and technology, engineering.material, 010402 general chemistry, Electrochemistry, 7. Clean energy, 01 natural sciences, law.invention, chemistry.chemical_compound, law, NiAl LDHs, Carbon spheres, Nickel foam, Flexible supercapacitors, ComputingMilieux_MISCELLANEOUS, computer.programming_language, Supercapacitor, Graphene, Layered double hydroxides, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Nickel, Chemical engineering, chemistry, Electrode, engineering, 0210 nano-technology, [CHIM.OTHE]Chemical Sciences/Other, computer
Abstract: International audience; Herein, we investigated the influence of Fe, Cr and Al incorporation in Ni-based layered double hydroxides (LDHs) supported on nickel foam (NF) electrodes, prepared through a one-step hydrothermal, on their electrochemical performance. The resulting NiFe, NiCr and NiAl (LDHs) were further coated on carbon spheres (CS) supported on NF using a facile two-step hydrothermal process to produce NiFe LDHs@CS/NF, NiCr LDHs@CS/NF and NiAl LDHs@CS/NF. The performance of the prepared materials as binder-free electrodes in supercapacitors was assessed. Among all the prepared electrodes, NiAl LDHs@CS/NF electrode material achieved the largest areal capacity (1042.2 mC cm−2 at 1 mA cm−2), as compared to the areal capacity values attained by NiFe LDHs@CS/NF (705.8 mC cm−2) and NiCr LDHs@CS/NF (814.9 mC cm−2) at 1 mA cm−2. Therefore, a hybrid supercapacitor device comprising NiAl LDHs@CS/NF as the positive electrode and N-doped reduced graphene/NF as the negative electrode was successfully fabricated. The device exhibited favorable flexibility, good mechanical properties and stability; the areal capacity remained ∼75% and ∼67% of the original value after 5000 and 10,000 cycles, respectively. The hybrid supercapacitor attained an energy density of 43 μWh cm−2 at a power density of 0.805 mW cm−2 and was applied successfully to operate a home-made windmill device continuously for 32 s. Moreover, two flexible NiAl LDHs@CS/NF//N-rGO/NF hybrid supercapacitors, connected in series, were able to light up a green, a red and a yellow LED in parallel, lasting for 37 s, 542 s and 199 s, respectively, indicating their potential application for flexible energy storage devices.
Published: 2020
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28. Formation of a Highly Stable and Nontoxic Protein Corona upon Interaction of Human α-1-Acid Glycoprotein (AGP) with Citrate-Stabilized Silver Nanoparticles

Author: Fakhrossadat Mohammadi, Rabah Boukherroub, Sabine Szunerits, Amin Sahraei, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)
Subjects: Silver, Metal Nanoparticles, Nanoparticle, Protein Corona, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Citric Acid, Silver nanoparticle, Electrochemistry, Native state, Humans, General Materials Science, Citrates, Cytotoxicity, Spectroscopy, ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, Bioconjugation, Orosomucoid, Surfaces and Interfaces, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, Binding constant, 0104 chemical sciences, Molecular Docking Simulation, chemistry, Biophysics, 0210 nano-technology, Glycoprotein
Abstract: Given the importance of protein corona in determining cellular responses to nanoparticles, numerous studies have been devoted to finding stable, biocompatible, and nontoxic protein corona. In this work, the interaction between human α-1-acid glycoprotein (AGP) and citrate-stabilized silver (Ag-CIT) nanoparticles of about 10 nm was methodically studied using molecular docking simulation approach and various experimental techniques. It could be shown that a stable Ag-CIT/AGP bioconjugate was formed with a high binding constant of 109 M-1, several orders of magnitude larger than that of other highly abundant serum proteins. Formation of AGP corona was accompanied by conserving the native conformation of the protein and further associated with a considerable decrease in the cytotoxicity of the silver nanoparticles.
Published: 2020
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29. Flow injection enzymatic biosensor for aldehydes based on a Meldola Blue-Ni complex electrochemical mediator

Author: Cristian N Mihailescu, Cristina Purcarea, Alina Vasilescu, Georgiana Necula-Petrareanu, Rabah Boukherroub, Sabine Szunerits, Ana Maria Titoiu, Diana Visinescu, Valentina Dinca, Anca Bonciu, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)
Subjects: Flow injection analysis, Detection limit, 010401 analytical chemistry, Biosensing Techniques, 02 engineering and technology, Nicotinamide adenine dinucleotide, 021001 nanoscience & nanotechnology, Electrochemistry, 01 natural sciences, Combinatorial chemistry, Amperometry, 0104 chemical sciences, Analytical Chemistry, Benzaldehyde, chemistry.chemical_compound, chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Oxazines, Electrode, 0210 nano-technology, Biosensor
Abstract: International audience; Carbon nanofibers (CNF) are efficient electrode modifiers in electrochemical biosensors that enhance the electrochemical active area, induce electrocatalytic effect toward the oxidation of the enzymatic cofactor nicotinamide adenine dinucleotide (reduced form, NADH), and enable the quantitative immobilization of enzymes. Combining CNF with efficient and stable mediators radically augments the speed of electron transfer between NADH and solid electrodes and leads to electrochemical sensors characterized by high sensitivity and stability. The main aim of this work was to investigate the performance of a novel mediator for NADH with advantageously low solubility in an electrochemical detector based on a screen-printed CNF electrode as well as its potential in biosensing. Using a mediator, prepared from Meldola Blue and Ni hexamine chloride, a stable and sensitive electrochemical NADH sensor is provided with a detection limit of 0.5 μmol L−1. Further on, covalent immobilization of a recently described aldehyde dehydrogenase from the Antarctic Flavobacterium PL002 strain on the surface of the mediator-modified electrode produced a stable biosensor for the detection of aldehydes. When integrated in a flow injection analysis (FIA) setup with amperometric detection at 0.1 V vs. Ag/AgCl, the measurement of benzaldehyde with a detection limit of 10 μmol L−1 over a linear range of 30–300 μmol L−1 is possible. Determination of trace benzaldehyde impurities in a pharmaceutical excipient was also demonstrated and results compared with a chromatographic method.
Published: 2020
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30. Reduced graphene oxide–based field effect transistors for the detection of E7 protein of human papillomavirus in saliva

Author: Komal Bagga, Rabah Boukherroub, Palaniappan Subramanian, Johannes Bintinger, Henri Happy, Sabine Szunerits, Wolfgang Knoll, Vladyslav Mishyn, Patrik Aspermair, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)
Subjects: Saliva, Materials science, Transistors, Electronic, Aptamer, Papillomavirus E7 Proteins, Point-of-care diagnostics, Oxide, Nanotechnology, 02 engineering and technology, Biosensing Techniques, Field effect transistors, 01 natural sciences, Biochemistry, Analytical Chemistry, law.invention, chemistry.chemical_compound, law, Limit of Detection, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Humans, Human papillomavirus, ComputingMilieux_MISCELLANEOUS, Reduced graphene oxide (rGO), Detection limit, Human papillomavirus (HPV), Human papillomavirus 16, Graphene, Spectrum Analysis, 010401 analytical chemistry, Papillomavirus Infections, Electrochemical Techniques, Aptamers, Nucleotide, 021001 nanoscience & nanotechnology, 0104 chemical sciences, 3. Good health, Tumor Virus Infections, chemistry, Surface functionalization, Feasibility Studies, Field-effect transistor, Graphite, Electronic biosensor, 0210 nano-technology, Biosensor, Research Paper
Abstract: Several challenging biological sensing concepts have been realized using electrolyte-gated reduced graphene oxide field effect transistors (rGO-FETs). In this work, we demonstrate the interest of rGO-FET for the sensing of human papillomavirus (HPV), one of the most common sexually transmitted viruses and a necessary factor for cervical carcinogenesis. The highly sensitive and selective detection of the HPV-16 E7 protein relies on the attractive semiconducting characteristics of pyrene-modified rGO functionalized with RNA aptamer Sc5-c3. The aptamer-functionalized rGO-FET allows for monitoring the aptamer-HPV-16 E7 protein binding in real time with a detection limit of about 100 pg mL-1 (1.75 nM) for HPV-16 E7 from five blank noise signals (95% confidence level). The feasibility of this method for clinical application in point-of-care technology is evaluated using HPV-16 E7 protein suspended in saliva and demonstrates the successful fabrication of a promising field effect transistor biosensor for HPV diagnosis.Graphical abstract.
Published: 2020
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31. Magnetic MnFe2O4 Core–shell nanoparticles coated with antibiotics for the ablation of pathogens

Author: Ghasem Najafpour-Darzi, Alexandre Barras, Maedeh Mohammadi, Rabah Boukherroub, Neda Akhlaghi, Sabine Szunerits, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)
Subjects: General Chemical Engineering, Nanoparticle, 02 engineering and technology, engineering.material, 010402 general chemistry, 01 natural sciences, Biochemistry, Industrial and Manufacturing Engineering, Minimum inhibitory concentration, Coating, Materials Chemistry, ComputingMilieux_MISCELLANEOUS, biology, Chemistry, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, biology.organism_classification, Grafting, Antimicrobial, Combinatorial chemistry, 0104 chemical sciences, Covalent bond, engineering, 0210 nano-technology, Bacteria, Superparamagnetism
Abstract: Emerging β-lactam antibiotic resistance necessitates the development of new therapeutic approaches. One approach to counteract this issue is the use of nanoparticles (NPs) for antimicrobial agent delivery. In this work, superparamagnetic MnFe2O4 NPs were synthesized via a simple co-precipitation method followed by coating with a SiO2 shell using tetraethoxysilane (TEOS) to prevent agglomeration and also increase the density of hydroxyl groups on the surface of MnFe2O4 NPs. The resulting MnFe2O4@SiO2 nanostructures were further functionalized with 3-aminopropyltriethoxysilane (APTES) to introduce NH2 groups on the surface of NPs for covalent grafting of ampicillin (AMP), β-lactam antibiotic. The MnFe2O4@AMP NPs proved to be highly effective for the eradication of Escherichia coli bacteria with a minimum inhibitory concentration (MIC) equivalent to 4 µg/mL of immobilized AMP, lowered by 50% compared to free AMP. The intrinsic multivalence effect of the nanostructures as well as the protection of the COO− group of the antibiotic from the attack of β-lactamase enzyme is believed to be responsible for enhanced efficiency of the hybrid compared to free AMP.
Published: 2020
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32. Enhanced electrocatalytic hydrogen evolution on a plasmonic electrode: the importance of the Ti/TiO2 adhesion layer

Author: Sabine Szunerits, Palaniappan Subramanian, Vladyslav Mishyn, Sorin Melinte, Alexandre Barras, Georgiana Sandu, Liuqing Pang, Rabah Boukherroub, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Financial support from the Centre National de la Recherche Scientifique (CNRS), the University of Lille and the Hauts-de-France region is acknowledged. P. L. thanks the Chinese government for the China Scholarship Council Award. S. M. is a Research Associate of the Belgian F.R.S. – FNRS and acknowledges financial support via the SELFPHON project., Renatech Network, and UCL - SST/ICTM/ELEN - Pôle en ingénierie électrique
Subjects: Materials science, Hydrogen, Electrolysis of water, Renewable Energy, Sustainability and the Environment, chemistry.chemical_element, 02 engineering and technology, General Chemistry, Activation energy, [CHIM.CATA]Chemical Sciences/Catalysis, [CHIM.MATE]Chemical Sciences/Material chemistry, Overpotential, 010402 general chemistry, 021001 nanoscience & nanotechnology, Electrochemistry, Electrocatalyst, 01 natural sciences, 0104 chemical sciences, [SPI]Engineering Sciences [physics], Chemical engineering, chemistry, Electrode, Water splitting, General Materials Science, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS
Abstract: The electrochemical production of hydrogen is enjoying renewed vigor due to its great promise as an environmentally friendly energy alternative. Herein, we demonstrate the capacity of nanoperforated gold films deposited on flexible substrates coated with nanometer thick Ti/TiO2 adhesion layers for electrochemical water splitting under light irradiation. The strong plasmonic induced electromagnetic field enhancement, which occurs under the illumination of plasmonic electrodes, facilitates the dissociation of water into hydrogen and improves the electrocatalytic hydrogen evolution activity beyond that of platinum. Under illumination at 980 nm at 2 W cm-2, a current density of -10 mA cm-2 was recorded at a low overpotential of h z -0.045 V (vs. RHE); under the same conditions, a Pt electrode achieved -10 mA cm-2 at h z -0.048 V (vs. RHE). Mechanistic investigations revealed that plasmon-excited perforated gold thin layers are an efficient source of hot electrons, contributing to their injection into the underlying TiO2-based adhesion layer. Direct electrochemical reduction of water appears to be a parallel reaction pathway to sustain the hydrogen evolution reaction on the interface. Both reaction pathways decrease the activation energy for the hydrogen evolution reaction similar to the benchmark Pt electrocatalyst.
Published: 2020
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33. Female role models in analytical chemistry: then, now, and in the future

Author: Antje J. Baeumner, Hua Cui, Sabine Szunerits, Maria Cruz Moreno Bondi, Universität Regensburg (UR), University of Science and Technology of China [Hefei] (USTC), Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), NanoBioInterfaces - IEMN (NBI - IEMN), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), and Projekt DEAL
Subjects: media_common.quotation_subject, ddc:540, Nobel prizes, MathematicsofComputing_GENERAL, 02 engineering and technology, 01 natural sciences, Biochemistry, GeneralLiterature_MISCELLANEOUS, Gender Role, Analytical Chemistry, [SHS.HISPHILSO]Humanities and Social Sciences/History, Philosophy and Sociology of Sciences, InformationSystems_GENERAL, Ingenuity, Professional Role, Excellence, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Humans, Chemistry (relationship), Sociology, Women in chemistry, media_common, Serendipity, 010401 analytical chemistry, Media studies, Analytical Chemistry (journal), 021001 nanoscience & nanotechnology, Creativity, Achievement, 0104 chemical sciences, Leadership, Editorial, Attitude, 540 Chemie, Female, Chemistry, Analytic, 0210 nano-technology, [SHS.GENRE]Humanities and Social Sciences/Gender studies
Abstract: International audience; “Who were your role models?” is a question we get asked seemingly at all relevant career stages of our scientific lives. Concerning women in chemistry, this question is often asked with more precision inquiring about our female role models in chemistry. This question is answered quickly—no need to think—because we have the fabulous, unparalleled in their historic successes, female chemists Marie and Irene Curie, and Rosalind Franklin, moving right along to Dorothy Hodgkin. All set! But, wait a moment, based on this superheroine foundation, we can dig deeper to answer this question with more specificity and actuality. Ada E. Yonath (2009) and Frances H. Arnold (2018), who were awarded Nobel Prizes in Chemistry for their outstanding scientific accomplishments, are more than obvious role models for so many of us. So let us keep going, because in addition we can identify with accuracy those important role models who did not inspire us from afar in history or afar from a Nobel worthy platform. Rather, they inspired us much more closely with their demonstrated ingenuity and creativity, persistence and success, and leadership accompanied with outstanding personalities. Here, choices become more personal, more focused on own fields of research, and are accompanied with the serendipity of having had a chance to meet these great women. We are talking about chemists of the caliber of Jacqueline K. Barton, Elizabeth (Lisa) A. H. Hall, Frances S. Ligler, Marja-Liisa Riekkola, Carol V. Robinson, and Dong Shaojun, to name a few of our truly outstanding female chemists who have served so many of us as role models scientifically‚ as well as personally‚ and whose excellence we aspire to emulate. Their excellence is underlined by having accomplished many “firsts” in their own universities and countries, by being recognized by their respective countries’ premier scientific academies, and by having contributed in major ways to their fields through seminal books and pioneering research.
Published: 2020
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34. Plasmon-induced photocatalytic transformations

Author: Palaniappan Subramanian, Sabine Szunerits, Rabah Boukherroub, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)
Subjects: Materials science, business.industry, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, 7. Clean energy, 6. Clean water, 0104 chemical sciences, [SPI]Engineering Sciences [physics], Semiconductor, Solar light, Photocatalysis, Water splitting, [CHIM]Chemical Sciences, Metal nanostructures, 0210 nano-technology, business, Plasmon, Electrochemical reduction of carbon dioxide
Abstract: International audience; Plasmon-induced photocatalysis has recently catapulted progress in enhancing photocatalytic efficiency under visible-light irradiation, increasing the prospect of using solar light for environmental and energy applications such as wastewater treatment, water splitting, and carbon dioxide reduction. Although widely used heterogeneous photocatalysts are semiconducting materials plasmonic metal nanostructures such as Ag, Au and Cu have been demonstrated to show significant promise in catalyzing reactions. We discuss in this chapter the concepts of plasmon-induced photochemical transformation on photocatalysts containing semiconductor and plasmonic metal nanostructures and recently reported plasmon-mediated photocatalytic reactions on these materials. We also discuss the mechanisms proposed for the plasmon-induced photocatalysis and areas that require major advancements.
Published: 2020
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35. Magneto-Optical Nanostructures for Viral Sensing

Author: Dalila Meziane, Tamazouzt Nait Saada, Rabah Boukherroub, Sabine Szunerits, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)
Subjects: magnetic nanoparticles, Coronavirus disease 2019 (COVID-19), Computer science, Sensing applications, General Chemical Engineering, Early detection, Nanotechnology, 02 engineering and technology, virus, Superparamagnetic nanoparticles, 010402 general chemistry, 01 natural sciences, Magneto optical, lcsh:Chemistry, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, General Materials Science, sensing, plasmonic, Complex matrix, Limiting, 021001 nanoscience & nanotechnology, 0104 chemical sciences, lcsh:QD1-999, Magnetic bead, Perspective, 0210 nano-technology
Abstract: International audience; The eradication of viral infections is an ongoing challenge in the medical field, as currently evidenced with the newly emerged Coronavirus disease 2019 (COVID-19) associated with severe respiratory distress. As treatments are often not available, early detection of an eventual infection and its level becomes of outmost importance. Nanomaterials and nanotechnological approaches are increasingly used in the field of viral sensing to address issues related to signal-to-noise ratio, limiting the sensitivity of the sensor. Superparamagnetic nanoparticles (MPs) present one of the most exciting prospects for magnetic bead-based viral aggregation assays and their integration into different biosensing strategies as they can be easily separated from a complex matrix containing the virus through the application of an external magnetic field. Despite the enormous potential of MPs as capture/pre-concentrating elements, they are not ideal with regard of being active elements in sensing applications as they are not the sensor element itself. Even though engineering of magneto-plasmonic nanostructures as promising hybrid materials directly applicable for sensing due to their plasmonic properties are often used in sensing, to our surprise, the literature of magneto-plasmonic nanostructures for viral sensing is limited to some examples. Considering the wide interest this topic is evoking at present, the different approaches will be discussed in more detail and put into wider perspectives for sensing of viral disease markers.
Published: 2020
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36. Core-shell Ni/NiO grafted cobalt (II) complex: An efficient inorganic nanocomposite for photocatalytic reduction of CO2 under visible light irradiation

Author: Rajkumar Yadav, Rabah Boukherroub, Anil K. Sinha, Pankaj Kumar Prajapati, Sabine Szunerits, Hari Singh, Suman L. Jain, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), and Indian Institute of Petroleum [Dehradun] (CSIR-IIP)
Subjects: Materials science, General Physics and Astronomy, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, [CHIM]Chemical Sciences, Triethylamine, ComputingMilieux_MISCELLANEOUS, Nanocomposite, Non-blocking I/O, [CHIM.CATA]Chemical Sciences/Catalysis, Surfaces and Interfaces, General Chemistry, 021001 nanoscience & nanotechnology, Condensed Matter Physics, 0104 chemical sciences, Surfaces, Coatings and Films, Organic semiconductor, chemistry, Phthalocyanine, Photocatalysis, Methanol, 0210 nano-technology, Cobalt, Nuclear chemistry
Abstract: The present paper describes the first successful synthesis of an inorganic nanocomposite by grafting of cobalt (II) phthalocyanine (CoPc) on the core-shell Ni/NiO (NNO) semiconductor for the photocatalytic reduction of CO2 to methanol under visible illumination using triethylamine as a sacrificial donor. The synthesised photocatalyst exhibited a remarkable enhancement in the yield of methanol as compared to the semiconductor Ni/NiO and CoPc for CO2 reduction under identical conditions. The maximum yield of methanol was found to be 3641.2 μmol/g with the conversion rate of 151.7 μmol g−1 h−1 which was much higher than that observed with CoPc and semiconductor alone under identical experimental conditions. Furthermore, the synthesised nanocomposite showed superior activity as compared to the previously reported organic semiconductor bound cobalt complex photocatalyst. The composite photocatalyst was found to be highly stable which showed consistent recyclability for four runs without any significant loss in activity.
Published: 2019
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37. Dual monitoring of surface reactions in real time by combined surface-plasmon resonance and field-effect transistor interrogation

Author: Bernadette Lechner, Patrik Aspermair, Sabine Szunerits, Stefan Fossati, Wolfgang Knoll, Omar Azzaroni, Jakub Dostalek, Ciril Reiner-Rozman, Johannes Bintinger, Ulrich Ramach, Sergio Moya, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Austrian Institute of Technology [Vienna] (AIT), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), 861578, ?sterreichische Forschungsf?rderungsgesellschaft, and 690836, H2020 Marie Sklodowska-Curie Actions
Subjects: Refractive index profile, 010402 general chemistry, 01 natural sciences, Biochemistry, Catalysis, law.invention, purl.org/becyt/ford/1 [https], [SPI]Engineering Sciences [physics], Colloid and Surface Chemistry, Adsorption, law, purl.org/becyt/ford/1.4 [https], surface mass, Diffusion (business), Surface plasmon resonance, Ciencias Exactas, business.industry, Chemistry, Biosensing, Transistor, field-effect transistor, Charge density, General Chemistry, Química, charge density changes, 0104 chemical sciences, Field-effect transistors, Optoelectronics, Field-effect transistor, Graphene, business, Biosensor, surface plasmon resonance, Surface-plasmon resonance spectroscopy
Abstract: By combining surface plasmon resonance (SPR) and electrolyte gated field-effect transistor (EG-FET) methods in a single analytical device we introduce a novel tool for surface investigations, enabling simultaneous measurements of the surface mass and charge density changes in real time. This is realized using a gold sensor surface that simultaneously serves as a gate electrode of the EG-FET and as the SPR active interface. This novel platform has the potential to provide new insights into (bio)adsorption processes on planar solid surfaces by directly relating complementary measurement principles based on (i) detuning of SPR as a result of the modification of the interfacial refractive index profile by surface adsorption processes and (ii) change of output current as a result of the emanating effective gate voltage modulations. Furthermore, combination of the two complementary sensing concepts allows for the comparison and respective validation of both analytical techniques. A theoretical model is derived describing the mass uptake and evolution of surface charge density during polyelectrolyte multilayer formation. We demonstrate the potential of this combined platform through the observation of layer-by-layer assembly of PDADMAC and PSS. These simultaneous label-free and real-time measurements allow new insights into complex processes at the solid-liquid interface (like non-Fickian ion diffusion), which are beyond the scope of each individual tool., Instituto de Investigaciones Fisicoquímicas Teóricas y Aplicadas
Published: 2020
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38. Plasmon-enhanced electrocatalytic oxygen reduction in alkaline media on gold nanohole electrodes

Author: Anderson G. M. da Silva, Robert Wojcieszak, Bahram Djafari-Rouhani, Sorin Melinte, Palaniappan Subramanian, Dalila Meziane, Noual Adnane, Franck Dumeignil, Sabine Szunerits, Liuqing Pang, Georgiana Sandu, Sébastien Paul, Vladyslav Mishyn, Rabah Boukherroub, Tamazouzt Nait Saada, Université de Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN], Université Mouloud Mammeri [Tizi Ouzou] [UMMTO], Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS], Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Laboratoire de Chimie appliquée & génie chimique [Tizi-Ouzou] (LCAGC), Université Mouloud Mammeri [Tizi Ouzou] (UMMTO), Institute of Chemistry [University of São Paulo] | Instituto de Química [Universidade de São Paulo], Universidade de São Paulo = University of São Paulo (USP), Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Université Mohammed Premier [Oujda], Physique - IEMN (PHYSIQUE - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Université Catholique de Louvain = Catholic University of Louvain (UCL), Unité de Catalyse et Chimie du Solide - UMR 8181 (UCCS), Université d'Artois (UA)-Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), NanoBioInterfaces - IEMN (NBI - IEMN), Institut d’Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520 (IEMN), Ecole Centrale de Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Laboratoire International associé sur les phénomènes Critiques et Supercritiques en électronique fonctionnelle, acoustique et fluidique (LIA LICS/LEMAC), Ecole Centrale de Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Ecole Centrale de Lille-Université de Lille-Université Polytechnique Hauts-de-France (UPHF)-Université Polytechnique Hauts-de-France (UPHF), UCL - SST/ICTM/ELEN - Pôle en ingénierie électrique, University of São Paulo (USP), Physique-IEMN (PHYSIQUE-IEMN), Centrale Lille Institut (CLIL)-Université d'Artois (UA)-Centrale Lille-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Lille, and Institute of Chemistry, University of São Paulo
Subjects: Materials science, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, Electrochemistry, 01 natural sciences, 7. Clean energy, Catalysis, [CHIM]Chemical Sciences, General Materials Science, Irradiation, Plasmon, ComputingMilieux_MISCELLANEOUS, Power density, Renewable Energy, Sustainability and the Environment, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, [CHIM.CATA]Chemical Sciences/Catalysis, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Wavelength, chemistry, Chemical engineering, Electrode, 0210 nano-technology, Platinum
Abstract: Plasmon-driven chemical transformation has become a promising approach for enhancing sluggish electrocatalytic reactions. Herein, an alternative enhancement strategy employing plasmon-induced hot electrons was developed and found to be competitive with oxygen reduction reaction (ORR) on platinum electrodes. We demonstrated that, by using the intertwined plasmon-catalytic-electrochemical properties of nanoperforated gold thin film electrodes, the ORR under alkaline conditions could be significantly enhanced by careful tuning of the laser wavelength and power density. Irradiation at 980 nm and 2 W cm−2 displays maximal current densities of j = −6.0 A cm−2 at 0.95 V vs. RHE, under hydrodynamic conditions, comparable to that of commercial Pt/C (40 wt%) catalysts, with good long-term stability. The wavelength-dependent electrochemical reduction confirmed that the hot carriers formed during plasmon decay are responsible for the improved electrocatalytic performance. 8;20
Published: 2020
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39. Ultrasmall CuS-BSA-Cu-3(PO4)(2) nanozyme for highly efficient colorimetric sensing of H2O2 and glucose in contact lens care solutions and human serum

Author: Abir Swaidan, Jean-Francois Tahon, Alexandre Barras, Tayssir Hamieh, Joumana Toufaily, Rabah Boukherroub, Sabine Szunerits, Ahmed Addad, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Université Libanaise, Unité Matériaux et Transformations - UMR 8207 (UMET), Centrale Lille-Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Institut de Chimie du CNRS (INC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Centrale Lille Institut (CLIL), Institut d’Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520 (IEMN), Ecole Centrale de Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Laboratoire International associé sur les phénomènes Critiques et Supercritiques en électronique fonctionnelle, acoustique et fluidique (LIA LICS/LEMAC), and Centre National de la Recherche Scientifique (CNRS)-Ecole Centrale de Lille-Université de Lille-Université Polytechnique Hauts-de-France (UPHF)-Ecole Centrale de Lille-Université de Lille-Université Polytechnique Hauts-de-France (UPHF)-Université Polytechnique Hauts-de-France (UPHF)
Subjects: CuS-BSA-Cu3(PO4)2, ENZYME, Absorption spectroscopy, H2O2, 02 engineering and technology, OXIDATION, 01 natural sciences, Biochemistry, Analytical Chemistry, HYDROGEN-PEROXIDE, Dynamic light scattering, X-ray photoelectron spectroscopy, Contact lens care solution, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, MIMICS, Spectrophotometry, medicine, Environmental Chemistry, COPPER PHOSPHATE, Fourier transform infrared spectroscopy, ComputingMilieux_MISCELLANEOUS, Spectroscopy, Detection limit, PEROXIDASE-LIKE ACTIVITY, medicine.diagnostic_test, Chemistry, 010401 analytical chemistry, Human serum, CuS-BSA-Cu-3(PO4)(2), CUS NANOPARTICLES, 021001 nanoscience & nanotechnology, Peroxidase mimic, NANOCOMPOSITES, 0104 chemical sciences, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, Blue colored, Glucose, GOLD NANOPARTICLES, Naked eye, 0210 nano-technology, FACILE PREPARATION, Colorimetric detection, Nuclear chemistry
Abstract: This work reports on the synthesis of organic-inorganic hybrid nanoscale materials, CuS-BSA-Cu-3(PO4)(2). The developed nanoparticles were characterized by various techniques, such as X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), UV-vis absorption spectrophotometry, Fourier transform infrared spectroscopy (FTIR), and dynamic light scattering (DLS). The CuS-BSA-Cu-3(PO4)(2) were successfully applied as artificial colorimetric probes in sensing H2O2, the final outcome of glucose oxidation, and proved to be efficient peroxidase mimics for the catalytic conversion of a chromogenic substrate, 3,3',5,5'-tetramethylbenzidine (TMB), into a blue colored oxidized product (oxTMB) which can be easily visualized by the naked eye and monitored by a great absorption peak at 654 nm in the UV-vis spectrophotometry. A highly efficient, rapid, sensitive, and selective determination of H2O2 and glucose have been achieved with very low detection limits of 22 nM, and 27.6 nM over 0-8 mu M and 0-1000 mu M linear ranges, respectively. Compared to CuS-BSA, CuS-BSA-Cu-3(PO4)(2) exhibited improved peroxidase-like catalytic activity. Based on these observations, the performance of this approach was successfully validated in contact lens care solutions and human serum samples. (C) 2020 Elsevier B.V. All rights reserved.
Published: 2020
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40. Cu(0) nanoparticle-decorated functionalized reduced graphene oxide sheets as artificial peroxidase enzymes: application for colorimetric detection of Cr(<scp>vi</scp>) ions

Author: Manash R. Das, Sabine Szunerits, Priyakshree Borthakur, Rabah Boukherroub, Purna K. Boruah, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)
Subjects: Oxide, Nanoparticle, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Catalysis, law.invention, chemistry.chemical_compound, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, law, Materials Chemistry, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS, Detection limit, Nanocomposite, biology, Graphene, Substrate (chemistry), [CHIM.CATA]Chemical Sciences/Catalysis, General Chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, biology.protein, Azide, 0210 nano-technology, Peroxidase, Nuclear chemistry
Abstract: Graphene oxide (GO) sheets were functionalized by a “click” chemistry approach using azide modified GO and alkynyl-terminated D(+)-glucose precursors to produce glucose terminated hydrophilic GO surfaces. This hydrophilic functionalized GO surface was utilized for the decoration of Cu(0) nanoparticles for sensitive colorimetric detection of Cr(VI) ions, which has not been explored to date. The nanocomposite exhibited excellent peroxidase mimic activity towards the colourless chromogenic substance, 3,3′,5,5′-tetramethylbenzidine (TMB), to yield a blue coloured substance 3,3′,5,5′-tetramethylbenzidinediimmine (TMBDI). In an acidic medium, Cr(VI) can decompose H2O2 to molecular O2 and H2O. Both O2 and H2O can form hydroxyl radicals (˙OH) by combining with the electron of the peroxidase substrate, resulting in enhanced TMB oxidation in the presence of Cr(VI). This colorimetric method was highly selective towards Cr(VI) ions with a limit of detection (LOD) of 67.13 nM.
Published: 2019
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41. Particle-based photodynamic therapy based on indocyanine green modified plasmonic nanostructures for inactivation of a Crohn's disease-associated Escherichia coli strain

Author: Li Chengnan, Julie Bouckaert, N. Dumitrascu, Benoit Cudennec, Rabah Boukherroub, Tetiana Dumych, Kostiantyn Turcheniuk, Roxana Jijie, Sabine Szunerits, Laurent Héliot, Charles-Henri Hage, Alexandru Ioan Cuza University of Iași [Romania], Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), XLIM (XLIM), Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 (PhLAM), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut Charles Viollette (ICV) - EA 7394 (ICV), and Université d'Artois (UA)-Institut National de la Recherche Agronomique (INRA)-Université du Littoral Côte d'Opale (ULCO)-Institut Supérieur d'Agriculture-Université de Lille
Subjects: Materials science, medicine.medical_treatment, Biomedical Engineering, Nanoparticle, Photodynamic therapy, 02 engineering and technology, 010402 general chemistry, Photochemistry, medicine.disease_cause, 01 natural sciences, chemistry.chemical_compound, medicine, General Materials Science, Photosensitizer, Escherichia coli, Singlet oxygen, General Chemistry, General Medicine, Photothermal therapy, 021001 nanoscience & nanotechnology, 0104 chemical sciences, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, chemistry, Nanorod, 0210 nano-technology, Indocyanine green
Abstract: Particle-based photodynamic therapy (PPDT) holds great promise in theranostic applications. Herein, we demonstrate that PPDT based on gold nanorods coated with an indocyanine green (ICG)-loaded silica shell allows for the inactivation of the Crohn's disease-associated adherent-invasive Escherichia coli strain LF82 (E. coli LF82) under pulsed laser light irradiation at 810 nm. Fine-tuning of the plasmonic structures together with maximizing the photosensitizer loading onto the nanostructures allowed optimizing the singlet oxygen generation capability and the PPDT efficiency. Using a nanoparticle concentration low enough to suppress photothermal heating effects, 6 log10 reduction in E. coli LF82 viability could be achieved using gold nanostructures displaying a plasmonic band at 900 nm. An additional modality of nanoparticle-based photoinactivation of E. coli is partly observed, with 3 log10 reduction of bacterial viability using Au NRs@SiO2 without ICG, due to the two-photon induced formation of reactive oxygen species. Interaction of the particles with the bacterial surface, responsible for the disruption of the bacterial integrity, together with the generation of moderate quantities of singlet oxygen could account for this behavior.
Published: 2020
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42. Preparation of magnetic, superhydrophobic/superoleophilic polyurethane sponge: Separation of oil/water mixture and demulsification

Author: Ziwen Wang, Fatima Halouane, Alexandre Barras, Shixiang Lu, Dalila Meziane, Dolci Mathias, Rabah Boukherroub, Sabine Szunerits, Tianlong Yu, Wenguo Xu, Nicolas Tiercelin, Anqi Lv, Beijing Institute of Technology (BIT), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Université Mouloud Mammeri [Tizi Ouzou] (UMMTO), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Laboratoire International associé sur les phénomènes Critiques et Supercritiques en électronique fonctionnelle, acoustique et fluidique (LIA LICS/LEMAC), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Acoustique Impulsionnelle & Magnéto-Acoustique Non linéaire - Fluides, Interfaces Liquides & Micro-Systèmes - IEMN (AIMAN-FILMS-IEMN), Institut d’Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520 (IEMN), Ecole Centrale de Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Laboratoire International associé sur les phénomènes Critiques et Supercritiques en électronique fonctionnelle, acoustique et fluidique (LIA LICS/LEMAC), Ecole Centrale de Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Ecole Centrale de Lille-Université de Lille-Université Polytechnique Hauts-de-France (UPHF)-Université Polytechnique Hauts-de-France (UPHF), Institut d’Électronique, de Microélectronique et de Nanotechnologie - Département Opto-Acousto-Électronique - UMR 8520 (IEMN-DOAE), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France)-Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-INSA Institut National des Sciences Appliquées Hauts-de-France (INSA Hauts-De-France), and Acoustique Impulsionnelle & Magnéto-Acoustique Non linéaire - Fluides, Interfaces Liquides & Micro-Systèmes - IEMN (AIMAN-FILMS - IEMN)
Subjects: Materials science, General Chemical Engineering, Composite number, 02 engineering and technology, engineering.material, 010402 general chemistry, 01 natural sciences, Industrial and Manufacturing Engineering, Contact angle, chemistry.chemical_compound, Adsorption, Coating, Environmental Chemistry, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS, Polyurethane, [SDE.IE]Environmental Sciences/Environmental Engineering, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, Chemical engineering, 13. Climate action, engineering, Magnetic nanoparticles, High-density polyethylene, Wetting, 0210 nano-technology
Abstract: Regular problems faced due to chemical leaks and oil spills have caused tremendous threats to lakes and sea water. Therefore, there is an urgent need to develop efficient strategies to remove oil and organic pollutants from water surfaces. The aim of this study is to develop a high performance magnetic, superhydrophobic/superoleophilic three-dimensional porous composite material for efficient and selective adsorption of organic pollutants from water. The composite material was fabricated by simple immersion of a commercially available polyurethane (PU) sponge into a solution of high-density polyethylene (HDPE) containing pre-synthesized magnetic (Fe3O4) nanoparticles. The composite material exhibited a water contact of ~155° and an oil contact angle of ~0°. The presence of the Fe3O4 particles allowed magnetic-controlled elimination of underwater oil, while the superhydrophobic character of the functionalized PU sponge permitted efficient separation of oil/water mixtures and demulsification of toluene/water emulsions. Moreover, the HDPE coating not only firmly immobilized the magnetic particles, but also contributed to the excellent stability of the composite sponge which withstood acid, base, salts, seawater or temperature variation from −20 °C to 105 °C. In addition, the composite material maintained its oil adsorption ability over 10 cycles. The ease of fabrication of the magnetic super wetting 3D material sponge along with its durability and reusability makes it an interesting material with potential for practical applications.
Published: 2020
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43. Interaction of cellulose and nitrodopamine coated superparamagnetic iron oxide nanoparticles with alpha-lactalbumin

Author: Marzieh Moeeni, Fakhrossadat Mohammadi, Chengnan Li, Rabah Boukherroub, Sabine Szunerits, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), and Institute for Advanced Studies in Basic Sciences [Zanjan] (IASBS)
Subjects: Superparamagnetic iron oxide nanoparticles, biology, General Chemical Engineering, Nanoparticle, 02 engineering and technology, General Chemistry, [CHIM.MATE]Chemical Sciences/Material chemistry, 010402 general chemistry, 021001 nanoscience & nanotechnology, Circular dichroism spectra, 01 natural sciences, 0104 chemical sciences, [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, chemistry.chemical_compound, Crystallography, chemistry, Alpha-lactalbumin, biology.protein, Magnetic nanoparticles, Cellulose, Amino acid residue, 0210 nano-technology, ComputingMilieux_MISCELLANEOUS
Abstract: International audience; In recent years, numerous studies have focused on the understanding of the interactions between proteins and nanoparticles (NPs). In this work, we focus on the interaction of bovine α-lactalbumin (BLA) with differently coated magnetic nanoparticles (MP): as formed MP, MPs stabilized with dopamine (MPdopamine) and nanoparticles coated with cellulose (MPcellulose). The influence of the coating on the nanoparticle–protein interaction is revealed by a set of different experiments. The binding affinity (KA) between BLA and these three structures was found to vary from 105 M−1 (for MPs) to 1011 M−1 (MPcellulose). The orientation of BLA and the involvement of amino acid residues in the process of interaction with magnetic nanoparticles were identified by molecular docking studies. In addition, circular dichroism spectra revealed that the conformation of BLA was conserved upon interaction with the magnetic nanoparticles.
Published: 2020
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44. Graphene Oxide Nanosheets for Localized Hyperthermia—Physicochemical Characterization, Biocompatibility, and Induction of Tumor Cell Death

Author: Malgorzata J. Podolska, Christoph Alexiou, Alexandre Barras, Sabine Szunerits, Benjamin Frey, Udo S. Gaipl, Christina Janko, Luis E. Muñoz, Rabah Boukherroub, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)
Subjects: Hyperthermia, Programmed cell death, Chemical Phenomena, Biocompatibility, Cell Survival, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Melanoma, Experimental, Oxide, Biocompatible Materials, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Article, law.invention, chemistry.chemical_compound, Medizinische Fakultät, law, Neoplasms, Lactate dehydrogenase, Materials Testing, Leukocytes, medicine, Humans, ddc:610, lcsh:QH301-705.5, ComputingMilieux_MISCELLANEOUS, radiotherapy, Graphene, Hyperthermia, Induced, General Medicine, hemocompatibility, Platelet Activation, 021001 nanoscience & nanotechnology, Acquired immune system, medicine.disease, hyperthermia, 0104 chemical sciences, 3. Good health, Radiation therapy, cell death, lcsh:Biology (General), chemistry, infrared, Cancer research, Nanoparticles, graphene oxide, Graphite, 0210 nano-technology
Abstract: Background: The main goals of cancer treatment are not only to eradicate the tumor itself but also to elicit a specific immune response that overcomes the resistance of tumor cells against chemo- and radiotherapies. Hyperthermia was demonstrated to chemo- and radio-sensitize cancerous cells. Many reports have confirmed the immunostimulatory effect of such multi-modal routines. Methods: We evaluated the interaction of graphene oxide (GO) nanosheets, its derivatives reduced GO and PEGylated rGO, with components of peripheral blood and evaluated its thermal conductivity to induce cell death by localized hyperthermia. Results: We confirmed the sterility and biocompatibility of the graphene nanomaterials and demonstrated that hyperthermia applied alone or in the combination with radiotherapy induced much more cell death in tumor cells than irradiation alone. Cell death was confirmed by the release of lactate dehydrogenase from dead and dying tumor cells. Conclusion: Biocompatible GO and its derivatives can be successfully used in graphene-induced hyperthermia to elicit tumor cell death.
Published: 2020
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45. Enhanced antibacterial activity of carbon dots functionalized with ampicillin combined with visible light triggered photodynamic effects

Author: Julie Bouckaert, N. Dumitrascu, Rabah Boukherroub, Roxana Jijie, Alexandre Barras, Sabine Szunerits, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), European Project: 690836,H2020,H2020-MSCA-RISE-2015,PANG(2016), Institut National de la Recherche Agronomique (INRA)-Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut d’Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520 (IEMN), Centre National de la Recherche Scientifique (CNRS)-Université de Lille-Université Polytechnique Hauts-de-France (UPHF)-Ecole Centrale de Lille-Université Polytechnique Hauts-de-France (UPHF)-Institut supérieur de l'électronique et du numérique (ISEN), Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576 (UGSF), and Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Recherche Agronomique (INRA)
Subjects: Adult, Light, Cell Survival, chemistry.chemical_element, Microbial Sensitivity Tests, 02 engineering and technology, Bactericidal activity, Conjugated system, 010402 general chemistry, 01 natural sciences, Nanomaterials, Structure-Activity Relationship, Colloid and Surface Chemistry, PDT, Ampicillin, Quantum Dots, Escherichia coli, Tumor Cells, Cultured, medicine, Carbon dots, [CHIM]Chemical Sciences, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Amines, Physical and Theoretical Chemistry, Cell Death, Dose-Response Relationship, Drug, Escherichia coli K12, [CHIM.MATE]Chemical Sciences/Material chemistry, Surfaces and Interfaces, General Medicine, 021001 nanoscience & nanotechnology, Combinatorial chemistry, Carbon, Anti-Bacterial Agents, 0104 chemical sciences, Photochemotherapy, chemistry, Female, 0210 nano-technology, Antibacterial activity, HeLa Cells, Biotechnology, Visible spectrum, medicine.drug
Abstract: International audience; In the last years, carbon-based nanomaterials have attracted considerable attention in a wide range of fields, particularly in biomedicine, owing to their remarkable photo-physical and chemical properties. In this study, we demonstrate that amine-terminated carbon dots (CDs-NH2) functionalized with ampicillin (AMP) offer a new perspective for antibacterial treatment. The amine-functionalized carbon dots were used as a carrier for immobilization and delivery of ampicillin (CDs-AMP) and as a visible light-triggered antibacterial material. Additionally, AMP immobilization on the CDs-NH2 surface improves its stability in solution as compared to free AMP. The AMP conjugated CDs platform combines the antibacterial function of AMP and conserves the intrinsic theranostic properties of CDs-NH2. Therefore, the AMP immobilized onto CDs-NH2 surface together with the generation of moderate quantities of reactive oxygen species under visible light illumination is very effective to inactivate the growth of Escherichia coli.
Published: 2018
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46. Electrochemical Aptamer-Based Biosensors for the Detection of Cardiac Biomarkers

Author: Iwona Grabowska, Rabah Boukherroub, M. Iancu, Neha Sharma, Satishchandra Ogale, G. Badea, Sabine Szunerits, Alina Vasilescu, International Centre of Biodynamics, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)
Subjects: Cardiac troponin, Protein biomarkers, Cardiac biomarkers, Chemistry, General Chemical Engineering, Aptamer, 010401 analytical chemistry, 02 engineering and technology, General Chemistry, 021001 nanoscience & nanotechnology, Brain natriuretic peptide, 01 natural sciences, Article, 0104 chemical sciences, 3. Good health, lcsh:Chemistry, lcsh:QD1-999, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, Troponin I, [CHIM]Chemical Sciences, 0210 nano-technology, Biosensor, ComputingMilieux_MISCELLANEOUS, Biomedical engineering
Abstract: Rapid and accurate diagnostic technologies for early-state identification of cardiovascular abnormalities have become of high importance to prevent and attenuate their progression. The capability of biosensors to determine an increase in the concentration of cardiovascular protein biomarkers in circulating blood immediately after a myocardial infarction makes them ideal point-of-care platforms and alternative approaches to electrocardiograms, chest X-rays, and different laboratory-based immunoassays. We report here a generic approach toward multianalyte sensing platforms for cardiac biomarkers by developing aptamer-based electrochemical sensors for brain natriuretic peptide (BNP-32) and cardiac troponin I (cTnI). For this, commercial gold-based screen-printed electrodes were modified electrophoretically with polyethyleneimine/reduced graphene oxide films. Covalent grafting of propargylacetic acid integrates propargyl groups onto the electrode to which azide-terminated aptamers can be immobilized using Cu(I)-based “click” chemistry. To ensure low biofouling and high specificity, cardiac sensors were modified with pyrene anchors carrying poly(ethylene glycol) units. In the case of BNP-32, the sensor developed has a linear response from 1 pg mL–1 to 1 μg mL–1 in serum; for cTnI, linearity is observed from 1 pg mL–1 to 10 ng mL–1 as demanded for early-stage diagnosis of heart failure. These electrochemical aptasensors represent a step further toward multianalyte sensing of cardiac biomarkers.
Published: 2018
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47. Magnetically Reusable MnFe2 O4 Nanoparticles Modified with Oxo-Peroxo Mo (VI) Schiff-Base Complexes: A High Efficiency Catalyst for Olefin Epoxidation under Solvent-Free Conditions

Author: Abolfazl Bezaatpour, Behnam Babaei, Mandana Amiri, Rabah Boukherroub, Sabine Szunerits, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), NanoBioInterfaces - IEMN (NBI - IEMN), and Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)
Subjects: Olefin fiber, Solvent free, Schiff base, 010405 organic chemistry, Nanoparticle, chemistry.chemical_element, [CHIM.CATA]Chemical Sciences/Catalysis, General Chemistry, 010402 general chemistry, 01 natural sciences, 0104 chemical sciences, 3. Good health, Catalysis, chemistry.chemical_compound, chemistry, Molybdenum, Polymer chemistry, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2018
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48. Cobalt phthalocyanine-supported reduced graphene oxide: A highly efficient catalyst for heterogeneous activation of peroxymonosulfate for rhodamine B and pentachlorophenol degradation

Author: Valentin Raditoiu, Alexandre Barras, Monaam Ben Ali, Yannick Coffinier, Sabine Szunerits, Yacine Cherifi, Cornelia Marinescu, Simona Somacescu, Rabah Boukherroub, Abderrahmane Hamdi, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), genOway, Lyon, Groupe d'Etude des Substances Végétales à Activité Biologique (GESVAB - EA 3675), and Université Bordeaux Segalen - Bordeaux 2
Subjects: Thermogravimetric analysis, Reaction mechanism, General Chemical Engineering, chemistry.chemical_element, 02 engineering and technology, 010402 general chemistry, Heterogeneous catalysis, 01 natural sciences, Industrial and Manufacturing Engineering, Catalysis, chemistry.chemical_compound, Rhodamine B, [CHIM]Chemical Sciences, Environmental Chemistry, Fourier transform infrared spectroscopy, ComputingMilieux_MISCELLANEOUS, [CHIM.CATA]Chemical Sciences/Catalysis, General Chemistry, 021001 nanoscience & nanotechnology, 6. Clean water, 0104 chemical sciences, Pentachlorophenol, chemistry, 0210 nano-technology, Cobalt, Nuclear chemistry
Abstract: In the present work, a cobalt phthalocyanine-supported reduced graphene oxide material (rGO-CoPc) was used as a catalyst for the degradation of rhodamine B (RhB) and pentachorophenol (PCP) in the presence of peroxymonosulfate (PMS). Inductively coupled plasma (ICP-OES), Raman spectroscopy, Fourier transform infrared (FTIR) spectroscopy, X-ray photoelectron spectroscopy (XPS), thermogravimetric analysis (TGA), and scanning electron microscopy (SEM) were employed to characterize the properties of the composite and Co loading in the material. The catalytic activity of the rGO1-CoPc1 catalyst (rGO:CoPc = 1:1) was evaluated by UV–vis absorption spectroscopy at varying PMS concentrations and catalyst dosages. The complete dye removal was achieved in 9 min by rGO1-CoPc1/PMS system with a high initiation rate constant of 1.019 min−1 using RhB (25 µM), PMS (0.1 mM) and rGO1-CoPc1 (0.5 mg/mL). The removal efficiency was found to be as high as 100% after 11 cycles, suggesting a long-lasting catalytic activity of the of rGO1-CoPc1/PMS system. Quenching experiments suggested that sulfate (SO4 −) radicals are the dominant species in the degradation process although hydroxyl (OH ) radicals are also involved in the reaction mechanism. Furthermore, the catalyst was successfully applied for the efficient degradation of pentachlorophenol (PCP). A full degradation of PCP (25 µM) was achieved within 20 min using rGO1-CoPc1 (0.5 mg/mL) and PMS (0.6 mM). This study demonstrated that the use of rGO-CoPc as a heterogeneous catalyst for PMS activation is useful for the advanced oxidation processes (AOP) for practical wastewater treatment.
Published: 2018
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49. Porous reduced graphene oxide modified electrodes for the analysis of protein aggregation. Part 2: Application to the analysis of calcitonin containing pharmaceutical formulation

Author: Sreekumar Kurungot, Szilveszter Gáspár, Mohamed Salah Medjram, Sabrina Lamraoui, Rabah Boukherroub, Sorin Melinte, Alina Vasilescu, Santosh K. Singh, Roxana Jijie, Ran Ye, Sabine Szunerits, Samia Boulahneche, International Centre of Biodynamics, Université Catholique de Louvain = Catholic University of Louvain (UCL), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Laboratoire de Génie Chimique et Environnement, Université 20 Août 1955 Skikda, CSIR-National Chemical Laboratory, Council of Scientific and Industrial Research (CSIR), NanoBioInterfaces - IEMN (NBI - IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), and UCL - SST/ICTM/ELEN - Pôle en ingénierie électrique
Subjects: Porous reduced graphene oxide, General Chemical Engineering, Oxide, Peptide, 02 engineering and technology, Protein aggregation, Pharmaceutical formulation, 010402 general chemistry, Electrochemistry, 01 natural sciences, law.invention, chemistry.chemical_compound, [CHIM.ANAL]Chemical Sciences/Analytical chemistry, law, [CHIM]Chemical Sciences, ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, Graphene, Calcitonin, Disposable electrodes, 021001 nanoscience & nanotechnology, 0104 chemical sciences, chemistry, Chemical engineering, Differential pulse voltammetry, Lysozyme, 0210 nano-technology
Abstract: In part 1 (A. Vasilescu et al., Porous reduced graphene oxide modified electrodes for the analysis of protein aggregation. Part 1: Lysozyme aggregation at pH 2 and 7.4 Electrochem. Acta, 254 (2017) 375–383) we proposed porous reduced graphene oxide coated glassy carbon electrode (GC/prGO) in combination with differential pulse voltammetry as a new analytical tool for aggregation studies of proteins. Lysozyme was used as a model to follow its aggregation by electrochemical means at pH 2 and pH 7.4, leading to the formation of amyloid and amorphous aggregates, respectively. Part 2 of this work widens the scope of this approach by investigating a biopharmaceutical product, as the aggregation of peptide based drugs affects their therapeutic activity and can induce allergic reactions in patients. The salmon polypeptide calcitonin (sCT) was chosen as an example of a bioactive peptide with limited pharmaceutical potential due to a tendency to form cytotoxic aggregates and amyloid fibrils. For practical applications, screen printed electrodes (SPE) and flexible electrodes (FE) modified with polydiallyldimethylammonium (PDDA) and prGO by using the layer-by-layer deposition technique have been developed for the detection of sCT. The results indicate that these electrodes can differentiate between formation of amyloid aggregates of calcitonin (2 mg mL−1) in citrate buffer to no aggregation in acetate buffer. It was further demonstrated that these electrodes are able to analyze a pharmaceutical drug product of low potency, Miacalcic (8.3 μg mL−1), where no aggregation was observed.
Published: 2018
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50. Porous reduced graphene oxide modified electrodes for the analysis of protein aggregation. Part 1: Lysozyme aggregation at pH 2 and 7.4

Author: Santosh K. Singh, Alina Vasilescu, Szilveszter Gáspár, Rabah Boukherroub, Sreekumar Kurungot, Sabine Szunerits, Abdou Aziz Diagne, Fereshteh Chekin, Mohamed Salah Medjram, and Samia Boulahneche
Subjects: Chromatography, Chemistry, Graphene, General Chemical Engineering, Size-exclusion chromatography, Oxide, 02 engineering and technology, Protein aggregation, 010402 general chemistry, 021001 nanoscience & nanotechnology, Electrochemistry, 01 natural sciences, 0104 chemical sciences, law.invention, chemistry.chemical_compound, Chemical engineering, law, Electrode, Differential pulse voltammetry, Lysozyme, 0210 nano-technology
Abstract: Protein instability due to misfolding and aggregation is of big concern for protein based therapeutics because it impacts the bioavailability and immunogenicity of such drugs. The development of simple and cost-effective methods for the analysis of pharmaceutical formulations, indicating the presence or absence of protein aggregates, is consequently of high importance. This work proposes a novel electrochemical interface based on porous reduced graphene oxide coated glassy carbon electrode (GC/prGO) allowing for the early and sensitive identification of protein aggregation by following the change in the oxidative current of the proteins. The novelty of this work lies in the exploration of the ability of GC/prGO interfaces to capture different aggregation behaviors. Lysozyme is used as a model to follow by electrochemistry its aggregation at two pH values, pH 2 and pH 7.4, leading to the formation of amyloid and amorphous aggregates, respectively. Comparing the oxidation peak of lysozyme by differential pulse voltammetry (DPV) for different electrode architectures allowed validating the higher sensitivity of the GC/prGO interface versus bare glassy electrodes or electrodes coated with non-porous reduced graphene oxide. Parallel experiments were performed by fluorescence with thioflavin T, size exclusion chromatography and Atomic Force Microscopy (AFM) imaging. These tests further highlighted the usefulness of GC/prGO electrode to visualize in a fast and reliable manner the changes in the protein structure and the differences between the processes occurring at pH 2 and pH 7.4. In particular, the ability to emphasize changes related to the first steps in aggregation that could be indicative of the aggregation course, recommend the GC/prGO electrode in combination with DPV as a new analytical tool for aggregation studies of biopharmaceuticals. Part 2 of this work will demonstrate later the utility of this approach for the analysis of a fast acting injectable human insulin formulation, Humulin R, used for diabetes treatment as well as for calcitonin.
Published: 2017
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