1. Two undescribed diarylheptanoids from green husk of Carya illinoinensis as acetylcholinesterase inhibitors
- Author
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Damanpreet Singh, Pamita Bhandari, Nitisha Sendri, Shinde Bhagatsing Devidas, and Shubham Nilkanth Rahmatkar
- Subjects
010405 organic chemistry ,Chemistry ,Stereochemistry ,Organic Chemistry ,Ethyl acetate ,Carya illinoinensis ,Plant Science ,Carbon-13 NMR ,DEPT ,01 natural sciences ,Biochemistry ,Husk ,food.food ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,food ,Proton NMR ,Heteronuclear single quantum coherence spectroscopy ,Diarylheptanoids - Abstract
Two undescribed diarylheptanoids, 3-(R)-acetyl-1-(3',4'-dihydroxyphenyl)-7-(4''-hydroxy-3'' -methoxyphenyl)-heptane (1) and 11-Hydroxy-1,17-epoxy-7-(2-hydroxylphenyl)-13-(16-methoxyphenyl)-heptane (2) together with known compounds, namely, 11-Oxo-1,17-epoxy-7-(2-hydroxylphenyl)-13-(16-methoxyphenyl)-heptane (3) 3,4,5-Trihydroxytetralone (4) 4,8- Dihydroxytetralone (5), 4,5-Dihydroxytetralone (6), 5,8-Dihydroxy-3-methoxytetralone (7) were isolated from ethyl acetate extract of the green husk of Carya illinoinensis. The structures of compounds were established on the basis of IR, 1H NMR, 13C NMR, DEPT, HSQC, HMBC, COSY spectroscopic and ESI-MS analysis. The isolated compounds were evaluated for AChE (acetylcholinesterase inhibition) and observed that compound 5 was potent inhibitor with IC50 of 101.48 ± 4.00 µg/mL.
- Published
- 2020