1. Novel antibacterial cellulose diacetate-based composite 3D scaffold as potential wound dressing
- Author
-
Junyong Zhang, Yan Zhou, Mingli Jiang, Li Zhao, Yun Jiang, Meidong Lang, Xiaoming Dou, and Wencheng Liang
- Subjects
Materials science ,Polymers and Plastics ,Biocompatibility ,Composite number ,macromolecular substances ,02 engineering and technology ,010402 general chemistry ,01 natural sciences ,chemistry.chemical_compound ,Hyaluronic acid ,Materials Chemistry ,Cellulose diacetate ,Mechanical Engineering ,technology, industry, and agriculture ,Metals and Alloys ,021001 nanoscience & nanotechnology ,Electrospinning ,0104 chemical sciences ,Membrane ,chemistry ,Mechanics of Materials ,Nanofiber ,Ceramics and Composites ,0210 nano-technology ,Antibacterial activity ,Nuclear chemistry - Abstract
In this work, novel antibacterial cellulose diacetate/poly(ethylenimine)/hyaluronic acid (CDA/PEI/HA) composite three-dimension (3D) scaffolds were prepared through electrospinning and post-processing. Firstly, CDA/PEI 2D composite nanofiber membranes were prepared by electrospinning, and then the CDA/PEI/HA 3D composite scaffolds were fabricated by post-processing and freeze-drying of CDA/PEI membranes. In particular, HA was added to improve the biocompatibility of composite scaffolds. Compared with CDA/PEI scaffolds, CDA/PEI/HA composite scaffolds showed higher water absorbing rate, higher water retention rate and higher mechanical strength. Moreover, CDA/PEI/HA composite scaffolds with abundant positive charge were benefit for improving antibacterial activity. CDA/PEI/HA scaffolds with biology function of HA were benefit for improving hemocompatibility and cell proliferation of CDA/PEI scaffolds. In summary, antibacterial CDA/PEI/HA scaffolds could protect wound from bacterial infection, improve cellular behavior and accelerate wound healing. Thus, CDA/PEI/HA scaffolds could be potential application for wound dressing.
- Published
- 2021