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To study the effect of a stable radical on the photophysical properties of a phosphorescent Pt(II) coordination framework and the intramolecular magnetic interaction between radical ligands in the N^N Pt(II) bisacetylide complexes, we prepared a series of N^N Pt(II) bis(acetylide) complexes with oxoverdazyl radical acetylide ligands. The linker between the Pt(II) center and the spin carrier was systematically varied, to probe the effect on the sign and magnitude of the spin exchange interactions between the radical ligands and photophysical properties. The complexes were studied with steady-state and femtosecond/nanosecond transient absorption spectroscopy, continuous-wave electron paramagnetic resonance (EPR) spectroscopy, and density functional theory (DFT) computations. The transient absorption spectral studies show that the doublet excited state of the radicals are short-lived (τ

The susceptibility of a water molecule to electric fields provides fundamental and essential information for understanding the vibrational spectra of water clusters and condensed-phase water. In th...

Mitochondrial enzyme monoamine oxidase (MAO-A) is known to be overexpressed in prostate cancer (PCa) cells. Herein, we have developed a two-photon probe (PCP-1) for selectively targeting and imaging the MAO-A in PCa. Supported by enzymatic docking and in vitro experiments, PCP-1 showed efficiency to visualize MAO-A overexpressing cells and inhibit their growth and metastasis potential.

In spite of the importance of vibrational Stark effect (VSE) and many attempts, origin of VSE is still unclear in molecular level. Here, we studied on origin of VSE of hydroxyl stretching vibration in small water clusters (monomer, dimer, and tetramer) assuming that VSE can be separated by nuclear and electronic contribution. We calculated total Stark tuning rate (Δμtot) and its nuclear contribution (Δμgeom) using the ab initio method, then the electronic contribution (Δμelec) was simply obtained by the difference, Δμtot – Δμgeom. In all cases, the nuclear contribution has dominant contribution to VSE. The hydroxyl stretching mode with neighboring hydrogen acceptor showed larger Δμgeom than that of dangling bonds. Furthermore, the calculated Δμgeom became larger in larger cluster due to the hydrogen bond network. The comparison between Stark tuning rates including and excluding anharmonicity supports the importance of potential anharmonicity in VSE, as previously reported. Interestingly, a good linear rel...