1. Trans-to-cis photoisomerization of cyclocurcumin in different environments rationalized by computational photochemistry
- Author
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Maxime Mourer, Marco Marazzi, Antonio Francés-Monerris, Andreea Pasc, Antonio Monari, University of Alcalá / Department of Analytical Chemistry, Physical-Chemistry and Chemical Engineering, Universidad de Alcalá - University of Alcalá (UAH), Laboratoire de Physique et Chimie Théoriques (LPCT), Institut de Chimie du CNRS (INC)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Facultat de Fisica [València] (UV), Universitat de València (UV), and Laboratoire Lorrain de Chimie Moléculaire (L2CM)
- Subjects
Photoswitch ,Photoisomerization ,Chemistry ,General Physics and Astronomy ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Photochemistry ,01 natural sciences ,Fluorescence ,0104 chemical sciences ,Excited state ,[CHIM]Chemical Sciences ,Molecule ,Physical and Theoretical Chemistry ,Solvent effects ,0210 nano-technology ,Ground state ,Cis–trans isomerism - Abstract
International audience; Cyclocurcumin is a turmeric component that attracted much less attention compared to the well known curcumin. In spite of the less deep charcaterization of its properties, cyclocurcumin has shown promising anticancer effects when used in combination with curcumin. Especially, due to its peculiar molecular structure, cyclocurcumin can be regarded as an almost ideal photoswitch, whose capabilities can also be exploited for relevant biological applications. Here, by means of state-of-the-art computational methods for electronic excited-state calculations (TD-DFT, MS-CASPT2, XMS-CASPT2) we analyze in detail the absorption and photoisomerization pathways leading from the more stable trans isomer to the cis one. The different molecular surroundings, taken into account by means of electrostatic solvent effect and compared with available experimental data, have been found to be critical in describing the fate of irradiated cyclocurcumin: while in non-polar environments an excited state barrier prevents photoisomerization and favours fluorescence, in polar solvents an almost barrierless path results in a strikingly decrease of fluorescence, opening the way toward a crossing region with the ground state and thus funneling the photoproduction of the cis isomer.
- Published
- 2020