1. Multifunctional Cationic PeptoStars as siRNA Carrier: Influence of Architecture and Histidine Modification on Knockdown Potential
- Author
-
Kaloian Koynov, Jennifer Schultze, Benjamin Weber, Jasmin Kuhn, Regina Holm, Ulrich Lächelt, David Schwiertz, and Matthias Barz
- Subjects
Small RNA ,Gene knockdown ,Drug Carriers ,Polymers and Plastics ,Chemistry ,Cationic polymerization ,Bioengineering ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,In vitro ,0104 chemical sciences ,Biomaterials ,chemistry.chemical_compound ,Cytosol ,RNA interference ,Polylysine ,Materials Chemistry ,Biophysics ,Histidine ,RNA, Small Interfering ,0210 nano-technology ,Biotechnology - Abstract
RNA interference provides enormous potential for the treatment of several diseases, including cancer. Nevertheless, successful therapies based on siRNA require overcoming various challenges, such as poor pharmacokinetic characteristics of the small RNA molecule and inefficient cytosolic accumulation. In this respect, the development of functional siRNA carrier systems is a major task in biomedical research. To provide such a desired system, the synthesis of 3-arm and 6-arm PeptoStars is aimed for. The different branched polypept(o)idic architectures share a stealth-like polysarcosine corona for efficient shielding and a multifunctional polylysine core, which can be independently varied in size and functionality for siRNA complexation-, transport and intra cellular release. The special feature of star-like polypept(o)ides is in their uniform small size (
- Published
- 2019