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Start Over Author "Quanming Zhou" Topic 01 natural sciences
3 results on '"Quanming Zhou"'

1. Pyridine-Embedded Phenothiazinium Dyes as Lysosome-Targeted Photosensitizers for Highly Efficient Photodynamic Antitumor Therapy

Author

Liqian Gao, Gang Liu, Wingnang Leung, Chuanshan Xu, Juan Wu, Xin Pang, Qicai Xiao, Pan Wang, Hung Kay Lee, Yue Jiang, Shao Q. Yao, Huirong Lin, Quanming Zhou, and Sheng Jiang

Subjects
Male, Light, Pyridines, medicine.medical_treatment, Antineoplastic Agents, Photodynamic therapy, 01 natural sciences, Rats, Sprague-Dawley, 03 medical and health sciences, chemistry.chemical_compound, Phenothiazines, Cell Line, Tumor, Neoplasms, Lysosome, Drug Discovery, Pyridine, medicine, Animals, Humans, Coloring Agents, 030304 developmental biology, Mice, Inbred BALB C, 0303 health sciences, Photosensitizing Agents, Light irradiation, Xenograft Model Antitumor Assays, Antitumor therapy, Combinatorial chemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, medicine.anatomical_structure, chemistry, Cell culture, Cancer cell, Molecular Medicine, Female, Lysosomes, Reactive Oxygen Species, Methylene blue
Abstract

Development of new photosensitizers (PSs) with high photodynamic efficacy and minimal side effects is of great interest in photodynamic therapy (PDT). In this work, we reported several pyridine-embedded phenothiazinium (pyridophenothiazinium) dyes, which could be conveniently synthesized in a few short steps and acted as highly efficient and potent PSs to selectively localize to lysosomes and photosensitively kill cancer cells. Among them, compound 5, which possessed the ability of promoting intracellular reactive oxygen species (ROS) upon light irradiation by almost 40-fold higher than that of methylene blue (MB, a general phenothiazinium-based PS), exhibited a remarkable phototherapeutic index (PI = 53.8) against HT29 cancer cells, leading to eradication of large solid tumors (∼300 mm3) in a xenograft mouse model without apparent side effects. These results suggest that the pyridophenothiazinium dyes developed herein, especially compound 5, may serve as promising lysosome-targeted PSs for efficient photodynamic antitumor therapy.

Published
2020

2. Development of new self-assembled cationic amino liposomes for efficient gene delivery

Author

Quanming Zhou, Gary Davidson, Liqian Gao, Yue Xiong, Pavel A. Levkin, Linxian Li, Wenbin Deng, Yihang Wu, and Ling Wang

Subjects
animal structures, Cell Survival, viruses, Biomedical Engineering, Gene delivery, 010402 general chemistry, 01 natural sciences, Cell Line, Mice, 03 medical and health sciences, Plasmid, Cations, Animals, Humans, General Materials Science, RNA, Small Interfering, Cytotoxicity, 030304 developmental biology, 0303 health sciences, Liposome, Chemistry, fungi, Gene Transfer Techniques, Cationic polymerization, RNA, Mouse Embryonic Stem Cells, DNA, Transfection, Fibroblasts, 0104 chemical sciences, Cell biology, Cell culture, Liposomes, embryonic structures, Plasmids
Abstract

A library of 83 structurally diverse cationic amino liposomes is rationally designed and parallelly synthesized for the transfection of plasmid DNA and siRNA. Our designed self-assembled liposomes not only exhibit excellent transfection efficiency in HEK 293T cells and mouse embryonic stem cells, but also show low cytotoxicity.

Published
2020

3. Recent advance on PTP1B inhibitors and their biomedical applications

Author

Liqian Gao, Jun Shen, Wei Wang, Menghua Xiang, Qicai Xiao, Laxman Pokhrel, Bigyan Sharma, Jia Yan, Quanming Zhou, Xie Liuxing, Fen Yang, Wanting Lv, Shizhe Zhou, and Wenbin Deng

Subjects
Pharmacology, Models, Molecular, Protein Tyrosine Phosphatase, Non-Receptor Type 1, 0303 health sciences, Biomedical Research, Molecular Structure, 010405 organic chemistry, Chemistry, Organic Chemistry, Cellular functions, SUPERFAMILY, General Medicine, Computational biology, 01 natural sciences, Protein Tyrosine Phosphatase 1B, 0104 chemical sciences, 03 medical and health sciences, Coordination Complexes, Drug Discovery, Humans, Enzyme Inhibitors, hormones, hormone substitutes, and hormone antagonists, 030304 developmental biology
Abstract

Protein Tyrosine Phosphatase 1B (PTP1B), as one of the most important members in PTP superfamily, plays a vital role in conducting various cellular functions. So far, PTP1B has been reported to be involved in the development of many diseases including obesity, diabetes, cancers and cardiovascular diseases. Development of potent and specific PTP1B inhibitors and studies on the structure-activity relationship (SAR) between their chemical structures and their biological activity have drawn increasing attention as they could not only modulate the PTP1B functions inside the cells but also provide useful lead compounds for the treatment of various PTP1B-associated diseases. To this end, we herein summarized the recent developments of PTP1B inhibitors, and different kinds of high-throughput screening strategies for the identification of potential PTP1B inhibitors as well as their potential biomedical applications, and we also provided some perspectives in the concluding remarks in this work.

Published
2019

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