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The ITER magnet system consists of TF coil, PF coil, CS and CCs. The bottom correction coils are one set of ITER Correction Coils (CC), which is used to reduce the range of magnetic error fields created by the other coils. Before the BCCs are finally positioned, it needs to be temporarily supported in Pit. The design and analysis of BCC temporary supports need to be considered load combinations when BCCs are placing in the Pit. The FE analysis results meet the design requirements and stress evaluation criteria. An engineering calculation, like bolt joint, assuring the integrity of the analysis work. This work could provide a necessary reference for the manufacture of BCC Temporary Supports.

ITER Bottom Correction Coils (BCCs) as an important part of the ITER magnet system, is used to compensate for the error field of other coils due to non-axial symmetry. The BCC lifting frame will be used in the process of lifting the BCC to the temporary position in the pit, the BCC lifting frame also applies to Top Correction Coils (TCCs). Considering the load combination of BCC lifting frame according to the actual working conditions, the results of finite element analysis prove that the designed BCC lifting frame meet the stress and deformation evaluation standard.

Three new quaternary Zintl phases with the "9-4-9" formula, Ae9Mn4-xAlxSb9 (Ae = Ca, Yb, Eu), have been synthesized using Pb as the metal flux, and their crystal structures have been established by single-crystal X-ray diffraction. Both Ca9Mn2.91(4)Al1.09Sb9 and Yb9Mn3.59(6)Al0.41Sb9 are isostructural with Ca9Mn4Bi9, and they crystallize in the orthorhombic space group Pbam with unit cell dimensions of a = 12.4571(8), 12.2884(16) A, b = 22.1352(16), 22.024(3) A, and c = 4.6012(3), 4.6187(6) A, respectively. Their anionic structures can be viewed as infinite ribbons based on corner-shared tetrahedrons. Also, Eu9Mn2.87(4)Al1.13Sb9 has the space group Cmca and a = 9.4883(7) A, b = 23.6895(18) A, and c = 24.4845(19) A. The structural relationships between Ca9Mn2.91(4)Al1.09Sb9 and Eu9Mn2.87(4)Al1.13Sb9 are compared and discussed as well. The successful Al3+ substitution provides additional electrons to the compounds to achieve structural stability. Magnetic susceptibility and electrical resistivity measurements, performed on single crystals of Eu9Mn2.87(4)Al1.13Sb9, indicate complex magnetic properties and semiconductor behavior. The physical properties of Yb9Mn3.59(6)Al0.41Sb9 are similar to those observed for Yb9Mn4.18(2)Sb9.

Two new steroidal glycosides oxystauntoside A (1) and oxystauntoside B (2), together with sixteen known compounds (3–18) were isolated from the 95% ethanol extract of Merrillanthus hainanensis. Their structures were characterized by extensive spectroscopic analysis including NMR and mass spectra and single crystal X-ray crystallography. The absolute configuration of 1 and 2 were further determined by ECD calculations. All of these compounds were isolated from M. hainanensis for the first time. All the fractions and compounds were tested for the anti-inflammatory activity against the TNF-α factor. The ethyl acetate fraction showed the most potent inhibition (71.3%) at 10 μg/mL and compounds 5 (78.9%) and 9 (73.4%) in this fraction with both carboxyl and phenolic hydroxyl groups showed significant inhibition at 10 μM. Our study provided the first scientific report for the medicinal value of M. hainanensis.

Hookerianones A – E (1–5), five new polyprenylated acylphloroglucinols (PPAPs), along with six known ones, were isolated from the aerial parts of Hypericum hookerianum. Their structures were elucidated by analyses of MS, NMR, chiroptical properties, biogenetic pathway, and/or single crystal X-ray diffraction. A ubiquitin-rhodamine 110 assay showed that furohyperforin and hypercalin C, two representative PPAPs in this plant, inhibited more than 90% USP7 at the concentration of 10 μM.

Perilla frutescens (L.) Britt. (Lamiaceae) is a traditionally medicinal herb in East Asian countries to treat various diseases. In present study, the low-polarity constituents of the aerial parts of P. frutescens were investigated and their anti-inflammatory effect on lipopolysaccharide (LPS)-stimulated RAW264.7 cells were assayed. Three new furanoid monoterpenoids, named as frutescenones A - C (1-3), together with thirteen known compounds (4-16) were isolated and identified on the basis of extensive spectroscopic analysis and a single-crystal X-ray diffraction study. Among these components, 1 is an unusual monoterpenoid with 2,3'-bifuran skeleton, and 3 is a rare perillaketone-adenine hybrid heterodimer, while the revised NMR arrangements of 4 were reported at the first time. Furthermore, monoterpenoid 4 and alkaloid 15 showed remarkably inhibitory effect on the production of inflammatory mediator (NO) and pro-inflammatory cytokines (TNF-α and/or IL-6) in LPS-stimulated RAW264.7 cells.

A microporous metal-organic framework containing Co(II) as nodes with a polar pore surface, {[Co(SDB)(bpdh)0.5]}n (1), was formed via reaction of a –SO2 functionalized organic connector (H2SDB = 4,4′-sulfonyldibenzoic acid) combined with (bpdh = 2,5-bis(3-pyridyl)-3,4-diaza-2,4-hexadiene), N-rich spacer under the solvothermal conditions. The diamond channels of the framework for 1 have a size of 6.1 Å along the b axis of the crystal, and the surface area of BET is 541 m2·g−1. FT-IR spectra demonstrated 5-Fu loading and ultraviolet–visible spectra showed the loading capacity of 5-Fu of 27.36%. Compared with normal tissue of pH = 7.4, the drug release in simulated cancer tissue of pH = 5.7 was gradual, showing a rational pH-responsive drug release. Clone formation experiments and CCK-8 assay confirmed the antitumor activity of 5-Fu@1a against EOMA hemangioma cells. Detection of apoptotic protein level and Annexin V-FITC/PI analysis showed that 5-Fu@1a could induce the apoptosis in caspase-dependent manner. Antitumor ability of the 5-Fu was verified by experimental data in vivo, which is consistent with the experimental data in vitro.

In this work, the host–guest interaction between calixpyridinium and anionic anticancer drug Alimta was studied in aqueous media. Spherical supramolecular amphiphilic assembly rather than simple complex was accidentally fabricated by the complexation of calixpyridinium with Alimta. It is the third kind of anionic guest to be discovered to form the higher-order assembly by the complexation of calixpyridinium besides polyanionic guest and anionic gemini surfactant guest. The finding of this assembly approach supplies a new idea to construct various self-assembly architectures in water via the complexation of calixpyridinium with anionic drugs. The resulting calixpyridinium–drug assemblies may also have the potential to adjust the effects of drugs.

Three 3D structures coordination polymers: [Ln(C2O4)(CH3COO)(H2O)]n (Ln = Gd, Eu, Tb) featuring a three-dimensional (3D) structure were synthesized with light-weight ligands. 1Gd owing to the higher magnetic density based on the large mass ratio (metal/ligands) and 3D structures, shows good MCE with −ΔSmmax = 39.5 J kg−1 K−1 at 2 K and ΔH = 7 T. Meanwhile, the luminescence properties and luminescence decay of 2Tb and 3Eu were investigated, the results showed that 2Tb and 3Eu present characteristic emissions of EuIII and TbIII ions.

In this work, a water-soluble fluorescent and colouring macrocycle deprotonated-calixpyridinium was obtained by a simple pH modulatory strategy. This type of fluorescent and colouring macrocyclic skeleton as host will be certainly applied in a large number of fields, especially in the sensing area. Herein, a near white-light emission was carried out by an innovative method of deprotonated-calixpyridinium-based host–guest interactions employing camptothecin sodium as the guest. Moreover, the pH-responsive luminescence color change of calixpyridinium–camptothecin sodium complex was further applied for the high selective detection of arginine in pure water and real samples, which is quite important in the accurate diagnosis of various disorders. The newfound pH-dependent luminescent and colouring properties of calixpyridinium will also provide an alternative idea for the development of other novel fluorescent and colorimetric macrocyclic sensors.

Soil enzyme activity during different years of reclamation and land use patterns could indicate changes in soil quality. The objective of this research is to explore the dynamics of 5 soil enzyme activities (dehydrogenase, amylase, urease, acid phosphatase and alkaline phosphatase) involved in C, N, and P cycling and their responses to changes in soil physicochemical properties resulting from long-term reclamation of coastal saline soil. Soil samples from a total of 55 sites were collected from a coastal reclamation area with different years of reclamation (0, 7, 32, 40, 63a) in this study. The results showed that both long-term reclamation and land use patterns have significant effects on soil physicochemical properties and enzyme activities. Compared with the bare flat, soil water content, soil bulk density, pH and electrical conductivity showed a decreasing trend after reclamation, whereas soil organic carbon, total nitrogen and total phosphorus tended to increase. Dehydrogenase, amylase and acid phosphatase activities initially increased and then decreased with increasing years of reclamation, whereas urease and alkaline phosphatase activities were characterized by an increase-decrease-increase trend. Moreover, urease, acid phosphatase and alkaline phosphatase activities exhibited significant differences between coastal saline soil with 63years of reclamation and bare flat, whereas dehydrogenase and amylase activities remained unchanged. Aquaculture ponds showed higher soil water content, pH and EC but lower soil organic carbon, total nitrogen and total phosphorus than rapeseed, broad bean and wheat fields. Rapeseed, broad bean and wheat fields displayed higher urease and alkaline phosphatase activities and lower dehydrogenase, amylase and acid phosphatase activities compared with aquaculture ponds. Redundancy analysis revealed that the soil physicochemical properties explained 74.5% of the variation in soil enzyme activities and that an obvious relationship existed between soil nutrients and soil enzyme activities. These results will assist governmental evaluation of the quality of reclaimed coastal soil.

In this work, the host–guest interaction between calixpyridinium and the anionic anticancer drug methotrexate disodium was explored in water. Unexpectedly, an interesting anisotropic needle-like rather than an ordinary isotropic spherical supramolecular amphiphilic assembly was fabricated by the complexation of calixpyridinium with methotrexate disodium. It is the second anionic guest to be discovered to form the non-spherical supramolecular assembly upon complexation with calixpyridinium. This discovery implies the possibility to construct various topological nanostructures based on the host–guest interactions between calixpyridinium and the anionic drugs in the future. The resulting calixpyridinium–drug assemblies with different morphologies may have the diverse potentials to adjust the efficacies of anionic drugs.

Information linking seed movement, along with changes in seed viability, is critical for understanding weed seed dynamics. Studies were conducted to examine the use of passive integrated transponder (PIT) tags placed in nylon mesh packets in combination with GPS (Global Positioning System) technology to track weed seed movement after tillage. Cylindrical PIT tags 11.5, 12, 20, and 23 mm long by 2 mm wide were evaluated in water and soil. Detection improved as tag size increased because of greater signal strength. Tags with the main axis oriented vertically were recovered at greater depths than when placed horizontally. Average detection depths for 12-mm PIT tags were 29.5 cm in water, 18.2 cm in sand, 24 cm in artificial soil, and 21.2 cm in sandy loam soil. Tests also showed that PIT tags and nylon mesh packets were resilient to intense tillage with a rototiller. No significant differences in displacement because of tillage were observed between free PIT tags and PIT-tagged packets. PIT tag performance was further tested in a 2-yr field experiment conducted between September 2003 and October 2005 at six sites in Nebraska and Wyoming. Tilled and no-till blocks were established at each site. PIT-tagged packets in the tilled block and untagged packets in the no-till block were used. Sample burial depths were 0, 2.5, 7.5, and 15 cm. Sample recovery rate did not differ between tilled and no-till blocks. Time of recovery was the main factor affecting recovery of packets buried at 0 and 2.5 cm in both blocks. Seed predation by small rodents and movement of samples beyond the area of study by tillage implements were the main sources of packet loss. Nevertheless, 2 yr after initiation of the study, more than 85% of the samples were recovered. Future development of PIT tag technology will lead to an enhanced ability to monitor seed movement.