1. Identification and removal of reflection artifacts in minimally invasive photoacoustic imaging for accurate visualization of brachytherapy seeds
- Author
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Ellen M. Hendriksen, Mithun Kuniyil Ajith Singh, Srirang Manohar, Vinay Parameshwarappa, Wiendelt Steenbergen, and Biomedical Photonic Imaging
- Subjects
Materials science ,Optical fiber ,Reflection artifacts ,medicine.medical_treatment ,Brachytherapy ,Context (language use) ,01 natural sciences ,Imaging phantom ,law.invention ,010309 optics ,03 medical and health sciences ,0302 clinical medicine ,Optics ,law ,0103 physical sciences ,Ultrasound ,medicine ,Photoacoustic-guided focused ultrasound ,Photoacoustic spectroscopy ,business.industry ,Photoacoustics ,food and beverages ,Visualization ,Photoacoustic needle ,030220 oncology & carcinogenesis ,Reflection (physics) ,business - Abstract
Reflection artifacts caused by the high signal from the optical fiber/ needle tip reflecting off the seed is an important problem in minimally invasive photoacoustic imaging of brachytherapy seeds. The presence of these artifacts confounds the interpretation of images and reduces contrast. We apply a new method called PAFUSion (Photoacoustic-guided focused ultrasound) to identify and reduce reflection artifacts generated in interstitial illumination imaging of brachytherapy seeds. We present the system comprising of a US imager and linear array, with illumination provided via a cutting needle. Non-radioactive brachytherapy seeds are implanted in a tissue mimicking phantom and ex vivo porcine tissue. The PAFUSion-corrected imaging results successfully demonstrate that our approach can identify and strongly reduce reflection artifacts in the context of photoacoustic needle. The phantom result also shows that multi-spectral photoacoustics can separate signals between the seeds and other optical absorbers.
- Published
- 2017