1. An oligofluorene truxene based distributed feedback laser for biosensing applications
- Author
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Martin D. Dawson, Benoit Guilhabert, Nicolas Laurand, Alexander L. Kanibolotsky, Anne-Marie Haughey, Glenn A. Burley, and Peter J. Skabara
- Subjects
Materials science ,Biophysics ,Biomedical Engineering ,Biotin ,Laser ,Nanotechnology ,02 engineering and technology ,Biosensing Techniques ,010402 general chemistry ,01 natural sciences ,Sensitivity and Specificity ,chemistry.chemical_compound ,QC350 ,Oligofluorene truxene ,Electrochemistry ,Animals ,Biotinylation ,Bovine serum albumin ,Distributed feedback laser ,Fluorenes ,Organic ,biology ,business.industry ,Lasers ,Serum Albumin, Bovine ,General Medicine ,Equipment Design ,021001 nanoscience & nanotechnology ,Avidin ,0104 chemical sciences ,Highly sensitive ,chemistry ,Semiconductors ,biology.protein ,Optoelectronics ,Cattle ,0210 nano-technology ,business ,Biosensor ,Biotechnology - Abstract
The first example of an all-organic oligofluorene truxene based distributed feedback laser for the detection of a specific protein–small molecule interaction is reported. The protein avidin was detected down to View the MathML source1μgmL−1 using our biotin-labelled biosensor platform. This interaction was both selective and reversible when biotin was replaced with desthiobiotin. Avidin detection was not perturbed by Bovine Serum Albumin up to View the MathML source50,000μgmL−1. Our biosensor offers a new detection platform that is both highly sensitive, modular and potentially re-usable.
- Published
- 2014