36 results on '"Jun-Sheng Zhang"'
Search Results
2. Sequencing and analysis of the complete mitochondrial genome of Ochotona hyperborea from China and its phylogenetic analysis
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Jun-Sheng Zhang, Zhong-Wan Piao, Zhu Liu, Qi Zhang, Xin-Xu Zhao, Qian-Qian Yao, and Qiao-Jiang Yang
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0106 biological sciences ,0301 basic medicine ,Genetics ,Mitochondrial DNA ,biology ,Phylogenetic tree ,mitogenome ,Long pcr ,Coreana ,biology.organism_classification ,010603 evolutionary biology ,01 natural sciences ,Genome ,phylogenetic trees ,03 medical and health sciences ,Ochotona hyperborea ,030104 developmental biology ,Control region ,Transfer RNA ,Molecular Biology ,Gene ,Mitogenome Announcement ,Research Article - Abstract
The complete mitogenome sequence of Ochotona hyperborea was determined using long PCR. The genome was 17,063 bp in length and contained 13 protein-coding genes, two ribosomal RNA genes, 22 transfer RNA genes, one origin of L strand replication, and one control region. The overall base composition of the heavy strand is A (31.1%), C (28.7%), T (26.3%), and G (13.9%). The base compositions present clearly the A–T skew, which is most obvious in the control region and protein-coding genes. Mitochondrial genome analyses based on MP, ML, NJ, and Bayesian analyses yielded identical phylogenetic trees. This study verifies the evolutionary status of Ochotona hyperborea in Ochotonidae at the molecular level. The mitochondrial genome would be a significant supplement for the Ochotona hyperborea genetic background. The eight Ochotona species formed a monophyletic group with the high bootstrap value (100%) in all examinations.
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- 2021
3. A new tigliane-type diterpenoid from Euphorbia tirucalli
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Han-Zhuang Weng, Gui-Hua Tang, Sheng Yin, Jun-Sheng Zhang, Yang Tian, and Jia-Luo Huang
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P-glycoprotein Inhibitor ,biology ,010405 organic chemistry ,Euphorbia tirucalli ,Chemistry ,Stereochemistry ,Organic Chemistry ,Plant Science ,Ring (chemistry) ,biology.organism_classification ,01 natural sciences ,Biochemistry ,Terpenoid ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry - Abstract
Five tigliane (1−5) and one ingenane (6) diterpenoids were isolated from the ethanol extract of Euphorbia tirucalli. The structures of these compounds were identified based on analysis of their spectroscopic data. Among them, compound 12-O-(2E,4E,6E,8E-tetradecatetraenoyl)-13-O-isobutyroyl-4β-deoxyphorbol (1) was a new tigliane. The Rho123 effluxion assay showed that tiglianes with a trans-fused 5/7 ring system such as compounds 1, 2, and 4 had potent inhibitory activity against P-glycoprotein in HepG2/ADR cells.
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- 2021
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4. Prenylated indole alkaloids and lignans from the flower buds of Tussilago farfara
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Jie Bao, Jin-Hai Yu, Jun-Sheng Zhang, Xiu-Qing Song, Hua Zhang, and Jia Sun
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Circular dichroism ,China ,DPPH ,Stereochemistry ,Phytochemicals ,Tussilago ,Flowers ,Saccharomyces cerevisiae ,01 natural sciences ,Lignans ,Indole Alkaloids ,chemistry.chemical_compound ,Prenylation ,Drug Discovery ,Glycoside Hydrolase Inhibitors ,Pharmacology ,Indole test ,Lignan ,biology ,Indole alkaloid ,Molecular Structure ,010405 organic chemistry ,alpha-Glucosidases ,General Medicine ,Free Radical Scavengers ,biology.organism_classification ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry ,Chirality (chemistry) - Abstract
Six new compounds including four prenylated indole alkaloids (1–4) and two lignans (5–6), along with eight known cometabolites (7–14), were isolated from the flower buds of Tussilago farfara. Structures of the new compounds were elucidated by comparison with structurally related known analogues and also by comprehensive spectroscopic analyses. Their absolute configurations were determined by a variety of means including Mosher's method, Marfey's analysis, electronic circular dichroism (ECD) exciton chirality method and ECD calculations. Our bioassays have established that compounds 1 and 2 showed potent α-glucosidase inhibitory activity with IC50 values of 105 ± 4.7 and 35.2 ± 3.2 μM, respectively, while the known 13 and 14 exerted moderate DPPH radical scavenging activity with IC50 values of 45.2 ± 2.9 and 29.2 ± 2.0 μM, respectively.
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- 2020
5. Cytotoxic macrocyclic diterpenoids from Jatropha multifida
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Sheng Yin, Shen Li, Yao Zhang, Gui-Hua Tang, Abrar Ahmed, and Jun-Sheng Zhang
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Models, Molecular ,Macrocyclic Compounds ,Stereochemistry ,Apoptosis ,Jatropha ,Crystallography, X-Ray ,010402 general chemistry ,01 natural sciences ,Biochemistry ,Cell Line, Tumor ,Neoplasms ,Drug Discovery ,Ic50 values ,Humans ,Cytotoxic T cell ,Cytotoxicity ,Molecular Biology ,010405 organic chemistry ,Chemistry ,Cell Cycle ,Organic Chemistry ,Absolute configuration ,Cell cycle ,Antineoplastic Agents, Phytogenic ,0104 chemical sciences ,Cell culture ,Diterpenes ,Jatropha multifida - Abstract
Nine new macrocyclic diterpenoids (1–9), jatromultones A-I, along with eight known analogues (10–17) were isolated from the trunks of Jatropha multifida. The structures of the new compounds, including their absolute configurations, were elucidated by combination of spectroscopic analysis, single crystal X-ray diffraction, Rh2(OCOCF3)4-induced CD method, and chemical correlations. All compounds were screened for the cytotoxicity against five cancer cell lines, including one drug-resistant cell line, and seven compounds exhibited significant activity with IC50 values less than 10 μM. Compound 4 with IC50 values ranging from 2.69 to 6.44 μM toward all cell lines was selected for further mechanistic study, which showed that 4 could arrest cell cycle at G2/M phase and induce apoptosis. The brief structure-activity relationships (SARs) of these macrocyclic diterpenoids were also discussed.
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- 2018
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6. Monoterpene indole alkaloids from Rhazya stricta
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Ya-Qi Tang, Fang-Fang Chen, Wei Li, Sheng Yin, Gui-Hua Tang, Lin Chen, Jun-Sheng Zhang, and Abrar Ahmed
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Pharmacology ,Indole test ,Molecular Structure ,biology ,Apocynaceae ,010405 organic chemistry ,Chemistry ,Stereochemistry ,Monoterpene ,Microbial Sensitivity Tests ,General Medicine ,010402 general chemistry ,Rhazya stricta ,biology.organism_classification ,01 natural sciences ,Nmr data ,Indole Alkaloids ,0104 chemical sciences ,chemistry.chemical_compound ,Mic values ,Drug Discovery ,Monoterpenes ,Pleiocarpamine ,Candida - Abstract
Twenty-seven monoterpene indole alkaloids (MIAs) including three new ones were isolated from the plant of Rhazya stricta. Their structures were elucidated by analyses of HRMS and NMR data. Secopleiocarpamine A (1) represents a novel 2,3-seco pleiocarpamine type MIA possessing a cyano group. A possible biosynthetic pathway for 1 was postulated. All compounds were evaluated for their inhibitory activities against six Candida strains, and the results showed that 2, 5, 12, 21, 23, and 27 exhibited moderate inhibitory activities with MIC values ranging from 3.125 to 50 μg/mL.
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- 2018
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7. Anti-inflammatory Ingenane Diterpenoids from the Roots of Euphorbia kansui
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Sheng Yin, Gui-Hua Tang, Jia-Luo Huang, Han-Zhuang Weng, and Jun-Sheng Zhang
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Lipopolysaccharides ,0301 basic medicine ,Magnetic Resonance Spectroscopy ,medicine.drug_class ,Drug Evaluation, Preclinical ,Pharmaceutical Science ,Inflammation ,Pharmacology ,Nitric Oxide ,Plant Roots ,01 natural sciences ,Anti-inflammatory ,Analytical Chemistry ,Nitric oxide ,Inhibitory Concentration 50 ,Mice ,03 medical and health sciences ,chemistry.chemical_compound ,Euphorbia ,Drug Discovery ,medicine ,Animals ,Medicinal plants ,Molecular Structure ,biology ,010405 organic chemistry ,Chemistry ,Anti-Inflammatory Agents, Non-Steroidal ,Organic Chemistry ,Euphorbiaceae ,NF-κB ,biology.organism_classification ,Terpenoid ,0104 chemical sciences ,RAW 264.7 Cells ,030104 developmental biology ,Complementary and alternative medicine ,Molecular Medicine ,Diterpenes ,medicine.symptom ,Quercetin - Abstract
Bioassay-guided fractionation of the ethanolic extract of the roots of Euphorbia kansui led to the isolation of two new ingenane diterpenoids, euphorkans A (1) and B (2), together with 16 known analogues (3 – 18). Their structures were determined by combined spectral and chemical methods. All the isolates were evaluated for their inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophage cells. Compounds 1 – 6 and 10 – 13 exhibited pronounced inhibitory activity with IC50 values in the range of 2.78 – 10.6 µM, and were more potent than the positive control, quercetin (IC50 = 15.8 µM). Compounds 1 and 5 were selected for further assays toward the key inflammation mediators TNF-α and IL-6, and showed a significant inhibition in a dose-dependent manner. The preliminary mechanistic study revealed that 1 and 5 inhibited NF-κB activity, which may exert a role in their anti-inflammatory activity.
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- 2018
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8. Lindera cyclopentenedione intermediates from the roots of Lindera aggregata
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Sheng Yin, Wei Li, Lin Chen, Jun-Jie Deng, Jun-Sheng Zhang, Gui-Hua Tang, Bo Liu, and Abrar Ahmed
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Lindera ,biology ,010405 organic chemistry ,Chemistry ,Stereochemistry ,General Chemical Engineering ,General Chemistry ,010402 general chemistry ,biology.organism_classification ,01 natural sciences ,0104 chemical sciences ,Lindera aggregata ,chemistry.chemical_compound ,Monomer ,Biosynthesis ,Enantiomer - Abstract
Chromatographic fractionation of the roots of Lindera aggregata has led to the isolation of three new monomers of Lindera cyclopentenedione derivatives (1–3), a pair of new enantiomers of bi-linderone derivatives (4a/4b), and six known Lindera cyclopentenediones (5–8 and 9a/9b). Their structures were determined by NMR and MS data. The absolute configurations of the new bi-linderone derivative enantiomers (4a/4b) were determined by ECD calculation. (±)-Lindepentone A (1) presents the novel skeleton of 3,5-dioxocyclopent-1-enecarboxylate. Lindoxepines A (2) and B (3) present an unprecedented oxepine-2,5-dione derivative skeleton, which may be enlightening for the in vivo biosynthesis of the monomers of Lindera cyclopentenediones. A possible biosynthetic pathway for 1 and a plausible biosynthetic pathway from stilbenes to Lindera cyclopentenediones via the key intermediates 2 and 3 were postulated. The inhibitory activity of these compounds against three microorganisms was also evaluated.
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- 2018
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9. Chemical constituents from Tinospora sagittata and their biological activities
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De-Feng Xu, Jun-Sheng Zhang, Lei Miao, Hua Zhang, and Yin-Yin Wang
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China ,Staphylococcus aureus ,Tinospora ,Coronavirus disease 2019 (COVID-19) ,Phytochemicals ,Tinospora sagittata ,Antibacterial effect ,medicine.disease_cause ,01 natural sciences ,Triterpenoid ,Drug Discovery ,medicine ,Glycoside Hydrolase Inhibitors ,Pharmacology ,Molecular Structure ,Plant Stems ,Traditional medicine ,010405 organic chemistry ,Chemistry ,General Medicine ,Ethyl ester ,In vitro ,Anti-Bacterial Agents ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,Chemical constituents - Abstract
Six undescribed low-polarity compounds including three rare 14-methylergostane steroids (1-3), one euphane triterpenoid (4) and two octadecanoic acid ethyl esters (5 and 6), along with ten previously reported terpenyl cometabolites (7-16), were isolated from the stems of Tinospora sagittata. Their structures were determined by detailed spectroscopic analyses and comparison with structurally related known compounds, and all of them have been reported from T. sagittata for the first time. Compounds 4-6 and 16 showed potent in vitro inhibitory activity against the diabetes target α-glucosidase, while compounds 10 and 14 displayed promising antibacterial effect toward Staphylococcus aureus ATCC 25923.
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- 2021
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10. Novel degraded polycyclic polyprenylated acylphloroglucinol and new polyprenylated benzophenone from Hypericum sampsonii
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Sheng Yin, Gui-Hua Tang, Jun-Sheng Zhang, Jia-Luo Huang, Abrar Ahmed, Xin Liu, and Yi-Hong Zou
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010405 organic chemistry ,Stereochemistry ,Phloroglucinol ,Hypericum sampsonii ,Plant Science ,010402 general chemistry ,Ring (chemistry) ,01 natural sciences ,Biochemistry ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Cyclohexenone ,Benzophenone ,Organic chemistry ,Agronomy and Crop Science ,Derivative (chemistry) ,Biotechnology - Abstract
Norhypersampsone A ( 1 ), a novel degraded polycyclic polyprenylated acylphloroglucinol (PPAP) derivative, 3-(2-hydroxy-7-methyl-3-methyleneoct-6-enyl)-5-isoprenyl-2,4,6-trihydroxybenzophenone ( 2 ), a new polyprenylated benzophenone derivative, and nine known compounds ( 3 – 11 ) were isolated from Hypericum sampsonii . Their structures were elucidated by comprehensive spectroscopic techniques. Compound 1 represents a novel cyclohexenone monocyclic-PPAP formed by losing the fragment of C-2–C-4 and the side chains at C-3 and C-5 in the phloroglucinol ring. The results of the inhibitory effects of compounds 1 – 11 on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW 264.7 macrophages showed that compounds 1 , 6 – 8 , and 10 exhibited weak activities with IC 50 values in the range of 20.3–37.1 μM.
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- 2017
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11. Design, Synthesis, and Biological Evaluation of Novel Selenium-Containing Isocombretastatins and Phenstatins as Antitumor Agents
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Jun Yan, Baijiao An, Xingshu Li, Ling Huang, Lan-Lan Lou, Jun-Sheng Zhang, Yanqing Pang, and Sheng Yin
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G2 Phase ,Male ,Stereochemistry ,Mice, Nude ,chemistry.chemical_element ,Antineoplastic Agents ,010402 general chemistry ,01 natural sciences ,Rats, Sprague-Dawley ,Mice ,Selenium ,chemistry.chemical_compound ,Cell Line, Tumor ,Neoplasms ,Stilbenes ,Drug Discovery ,Animals ,Humans ,Cytotoxicity ,Cell Proliferation ,Membrane Potential, Mitochondrial ,Membrane potential ,Mice, Inbred BALB C ,010405 organic chemistry ,Cell Cycle Checkpoints ,Cell cycle ,Phosphate ,0104 chemical sciences ,chemistry ,Biochemistry ,Cell culture ,Drug Design ,Toxicity ,Molecular Medicine ,Drug Screening Assays, Antitumor ,Derivative (chemistry) - Abstract
Two series of structurally related organoselenium compounds designed by fusing the anticancer agent methyl(phenyl)selane into the tubulin polymerization inhibitors isocombretastatins or phenstatins were synthesized and evaluated for antiproliferative activity. Most of these selenium containing hybrids exhibited potent cytotoxicity against a panel of cancel cell lines, with IC50 values in the submicromolar concentration range. Among them, 11a, the 3-methylseleno derivative of isocombretastatin A-4 (isoCA-4) represented the most active compound with IC50 values of 2–34 nM against 12 cancer cell lines, including two drug-resistant cell lines. Importantly, its phosphate salt, 11ab, inhibited tumor growth in xenograft mice models with inhibitory rate of 72.9% without apparent toxicity, which was better than the reference compounds isoCA-4P (inhibitory rate 52.2%) and CA-4P (inhibitory rate 47.6%). Mechanistic studies revealed that 11a is a potent tubulin polymerization inhibitor, which could arrest cell cycle ...
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- 2017
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12. Numerical study on cnoidal wave run-up around a vertical circular cylinder
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Bin Teng and Jun-sheng Zhang
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010504 meteorology & atmospheric sciences ,Wave propagation ,Cnoidal wave ,Ocean Engineering ,Mechanics ,01 natural sciences ,Ursell number ,010305 fluids & plasmas ,Wavelength ,Nonlinear Sciences::Exactly Solvable and Integrable Systems ,Classical mechanics ,0103 physical sciences ,Stokes wave ,Boussinesq approximation (water waves) ,Mechanical wave ,Nonlinear Sciences::Pattern Formation and Solitons ,Longitudinal wave ,0105 earth and related environmental sciences ,Mathematics - Abstract
A finite element model of Boussinesq-type equations was set up, and a direct numerical method is proposed so that the full reflection boundary condition is exactly satisfied at a curved wall surface. The accuracy of the model was verified in tests. The present model was used to further examine cnoidal wave propagation and run-up around the cylinder. The results showed that the Ursell number is a nonlinear parameter that indicates the normalized profile of cnoidal waves and has a significant effect on the wave run-up. Cnoidal waves with the same Ursell number have the same normalized profile, but a difference in the relative wave height can still cause differences in the wave run-up between these waves. The maximum dimensionless run-up was predicted under various conditions. Cnoidal waves hold entirely distinct properties from Stokes waves under the influence of the water depth, and the nonlinearity of cnoidal waves enhances rather than weakens with increasing wavelength. Thus, the variations in the maximum run-up with the wavelength for cnoidal waves are completely different from those for Stokes waves, and there are even significant differences in the variation between different cnoidal waves.
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- 2017
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13. Thiophene enantiomers from the aerial parts of Eclipta prostrata
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Jie Bao, Jin-Hai Yu, Hei He, Jun-Sheng Zhang, Shu-Juan Yu, and Hua Zhang
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Pharmacology ,biology ,010405 organic chemistry ,Chemistry ,Organic Chemistry ,Pharmaceutical Science ,General Medicine ,biology.organism_classification ,01 natural sciences ,Thiophene derivatives ,0104 chemical sciences ,Analytical Chemistry ,Chiral column chromatography ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,Complementary and alternative medicine ,Drug Discovery ,Thiophene ,Molecular Medicine ,Organic chemistry ,Enantiomer ,Antibacterial activity ,Derivatization ,Eclipta prostrata - Abstract
Ten thiophene derivatives (1-10), including two previously undescribed ones (1 and 2), have been obtained and structurally characterized from the aerial parts of a traditional Chinese herb Eclipta prostrata. Six of them with one chiral center were identified to be scalemic mixtures, and the pure enantiomers of two isolates (1 and 3) were successfully separated via chemical derivatization and chiral HPLC, with the absolute configurations being established by analysis of optical rotations. All the thiophenes were subjected to a series of assays and compounds 9 and 10 exhibited mild antibacterial activity against Staphylococcus aureus.[Formula: see text].
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- 2020
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14. New antibacterial thiophenes from Eclipta prostrata
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Jie Bao, Jin-Hai Yu, Fei He, Hua Zhang, Jun-Sheng Zhang, Yin-Yin Wang, and Shu-Juan Yu
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Staphylococcus aureus ,Stereochemistry ,Cell Survival ,Dimer ,Ether ,Thiophenes ,01 natural sciences ,chemistry.chemical_compound ,Cell Line, Tumor ,Drug Discovery ,Thiophene ,Moiety ,Humans ,Eclipta prostrata ,Pharmacology ,Isovalerate ,biology ,Molecular Structure ,010405 organic chemistry ,Chemistry ,General Medicine ,Eclipta ,Plant Components, Aerial ,biology.organism_classification ,Thiophene derivatives ,0104 chemical sciences ,Anti-Bacterial Agents ,010404 medicinal & biomolecular chemistry ,Antibacterial activity - Abstract
Three new thiophene derivatives, ecliprostins A-C (1-3), have been isolated from the aerial parts of a Compositae medicinal plant Eclipta prostrata, and structures of them have been elucidated by comprehensive spectroscopic analyses. Both ecliprostins A (1) and B (2) feature an acetylenic bithiophenyl backbone and also incorporate an isovalerate moiety, while ecliprostin C (3) is a symmetrical dimer of compound 1 and represents the first example bonded via an ether bridge among the very limited natural dimers. All three compounds show antibacterial activity against Staphylococcus aureus.
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- 2019
15. Diarylheptanoids with NO production inhibitory activity from Amomum kravanh
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Jun-Sheng Zhang, Hua Zhang, Xin-Xin Cao, Zhi-Pu Yu, and Jin-Hai Yu
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Lipopolysaccharides ,Circular dichroism ,Lipopolysaccharide ,Stereochemistry ,Clinical Biochemistry ,Pharmaceutical Science ,Inhibitory postsynaptic potential ,Nitric Oxide ,01 natural sciences ,Biochemistry ,Amomum ,Nitric oxide ,chemistry.chemical_compound ,Mice ,Structure-Activity Relationship ,Diarylheptanoids ,Drug Discovery ,Animals ,Molecular Biology ,Density Functional Theory ,biology ,Dose-Response Relationship, Drug ,Molecular Structure ,010405 organic chemistry ,Macrophages ,Organic Chemistry ,Diarylheptanoid ,Stereoisomerism ,biology.organism_classification ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,RAW 264.7 Cells ,chemistry ,Fruit ,Molecular Medicine ,Zingiberaceae - Abstract
Seven new diarylheptanoids, kravanhols C−I (1–7), along with two known analogues (8 and 9), were isolated from the fruits of Amomum kravanh. The structures of compounds 1–7 were elucidated by analysis of spectroscopic data, and the absolute configurations of selective ones were determined by time-dependent density functional theory (TD-DFT) based electronic circular dichroism (ECD) calculations. All compounds were evaluated for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in murine RAW264.7 macrophage cells. Compounds 2, 5, 6 and 9 exhibited moderate inhibitory activity with IC50 values in the range of 17.4–26.5 μM, being more potent than the positive control dexamethasone (IC50 = 32.5 μM).
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- 2019
16. Euphonoids A-G, cytotoxic diterpenoids from Euphorbia fischeriana
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Jia-Luo Huang, Xue-Long Yan, Jun-Sheng Zhang, Sheng Yin, Gui-Hua Tang, Yao Zhang, and Jia-Qi Chen
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0106 biological sciences ,Models, Molecular ,Stereochemistry ,Jolkinolide B ,Molecular Conformation ,Plant Science ,Horticulture ,01 natural sciences ,Biochemistry ,Human prostate ,Structure-Activity Relationship ,Euphorbia fischeriana ,Euphorbia ,Cell Line, Tumor ,Ic50 values ,Cytotoxic T cell ,Humans ,Cytotoxicity ,Molecular Biology ,010405 organic chemistry ,Chemistry ,General Medicine ,Antineoplastic Agents, Phytogenic ,Terpenoid ,0104 chemical sciences ,Cancer cell lines ,Diterpenes ,010606 plant biology & botany - Abstract
Seven previously undescribed polycyclic diterpenoids, euphonoids A−G, including four ent-abietanes, two ent-atisanes, and one ent-kaurene, along with 26 known analogues were isolated from the roots of Euphorbia fischeriana. The structures of the undescribed compounds were elucidated by spectroscopic analysis, ECD calculations, and single crystal X-ray diffraction. Besides, the structure of a previously reported ent-abietane diterpenoid, fischeriabietane A, was revised. All the isolates were screened for the cytotoxicities against five cancer cell lines. Euphonoid A, fischeriabietane A, 11-oxo-ebracteolatanolide B, caudicifolin, jolkinolide B, and methyl-8,11-3-dihydroxy-12-oxo-ent-abietadi-13,15(17)-ene-16-oate showed significant inhibitory activities against human prostate cancer C4-2B and C4-2B/ENZR cell lines, with IC50 values being less than 10 μM. The brief structure-activity relationships (SARs) of these diterpenoids were also discussed.
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- 2019
17. Tigliane Diterpenoids as a New Type of Antiadipogenic Agents Inhibit GRα-Dexras1 Axis in Adipocytes
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Yong Rao, Zhang-Hua Sun, Gui-Hua Tang, Sheng Yin, Zhi-Shu Huang, Jun-Sheng Zhang, and Qin-Qin Song
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Cellular differentiation ,Down-Regulation ,Pharmacology ,01 natural sciences ,03 medical and health sciences ,chemistry.chemical_compound ,Mice ,Structure-Activity Relationship ,Glucocorticoid receptor ,Receptors, Glucocorticoid ,Downregulation and upregulation ,Euphorbia ,Adipocyte ,3T3-L1 Cells ,Drug Discovery ,Adipocytes ,Structure–activity relationship ,Animals ,Receptor ,Cytotoxicity ,030304 developmental biology ,EC50 ,0303 health sciences ,Adipogenesis ,Molecular Structure ,Phorbols ,0104 chemical sciences ,Molecular Docking Simulation ,010404 medicinal & biomolecular chemistry ,chemistry ,ras Proteins ,Molecular Medicine ,Anti-Obesity Agents - Abstract
The phytochemical study of Euphorbia prolifera led to the isolation of two tiglianes (1 and 2) and 23 mysrinanes (3–25). Most of these isolates showed significant antiadipogenic activity in 3T3-L1 adipocyte without apparent cytotoxicity. Subsequent structural modification yielded 10 derivatives, among which 1a, the 5-O-acetyl derivative of 1, turned out to be the most active compound with improved triglyceride-lowering activity (EC50 for 1 and 1a: 0.61 and 0.32 μM, respectively) and reduced cytotoxicity (selectivity index for 1 and 1a: 28 and 312, respectively). The structure–activity relationship study revealed that the trans-fused 5/7/6 ring system in an angular shape was important to the activity. A mechanistic study indicated that 1 and 1a could inhibit the glucocorticoid receptor α-Dexras1 axis in adipocyte, leading to the retardation of cell differentiation at the early stage. These findings may provide a new type of lipid-lowering agents for future antiobesity drug development.
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- 2019
18. Bioactive sesquiterpenoids from the flower buds of Tussilago farfara
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Xiu-Qing Song, Jun-Sheng Zhang, Jia Sun, Hua Zhang, Jin-Hai Yu, and Kai-Lu Liu
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Circular dichroism ,Magnetic Resonance Spectroscopy ,Stereochemistry ,Molecular Conformation ,Apoptosis ,Tussilago ,Flowers ,01 natural sciences ,Biochemistry ,chemistry.chemical_compound ,Cell Line, Tumor ,Drug Discovery ,Humans ,Glycoside Hydrolase Inhibitors ,Benzofuran ,Molecular Biology ,Cell Proliferation ,biology ,010405 organic chemistry ,Chemistry ,Circular Dichroism ,Organic Chemistry ,Absolute configuration ,Stereoisomerism ,alpha-Glucosidases ,Carbon-13 NMR ,biology.organism_classification ,0104 chemical sciences ,Benzopyran ,010404 medicinal & biomolecular chemistry ,S Phase Cell Cycle Checkpoints ,Enantiomer ,Sesquiterpenes ,Derivative (chemistry) - Abstract
Eleven new compounds including five bisabolane (1-5) and three oplopane (6-8) sesquiterpenoids, a pair of benzopyran enantiomers (9 & 10) and a benzofuran derivative (11), along with six known sesquiterpenoid co-metabolites (12-17), have been obtained from the flower buds of Tussilago farfara. Their structures were elucidated by comprehensive spectroscopic analyses and comparison with structurally related known analogues. The absolute configurations of all the compounds except 11 were unequivocally assigned by various techniques, including Mosher's method and time-dependent density functional theory (TD-DFT) based calculations of 13C NMR and electronic circular dichroism (ECD) data. The C-8 absolute configuration on the sidechain of this group of bisabolane sesquiterpenoids was assigned for the first time. Our bioassays have established that compounds 3, 4, 13 and 14 showed significant α-glucosidase inhibitory activities, while 6, 8 and 14 displayed moderate antiproliferative effects against two human tumor cell lines A549 and MDA-MB-231. Further flow cytometric analysis revealed that 14 effectively induced cell apoptosis and arrested cell cycle at the S/G2 phases in A549 cells, in a dose-dependent manner.
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- 2021
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19. Natural diarylfluorene derivatives: isolation, total synthesis, and phosphodiesterase-4 inhibition
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Xin Liu, Jiang Weng, Yan-Qiong Guo, Qingjiang Li, Abrar Ahmed, Jun-Sheng Zhang, Sheng Yin, and Gui-Hua Tang
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Phosphodiesterase-4 ,010405 organic chemistry ,Chemistry ,Stereochemistry ,Organic Chemistry ,Ic50 values ,Total synthesis ,010402 general chemistry ,Selaginella pulvinata ,01 natural sciences ,0104 chemical sciences - Abstract
In our previous study, selaginpulvilins A–D (1–4) featuring an unprecedented 9,9-diphenyl-1-(phenylethynyl)-9H-fluorene skeleton were identified as potent phosphodiesterase-4 (PDE4) inhibitors from Selaginella pulvinata. In the current work, a large-scale reinvestigation of the same plant led to the isolation of six additional new analogues, selaginpulvilins E–J (5–10), among which 5 features a rare 6-(4-hydroxyphenyl)-2H-pyran-2-one unit. Compounds 5–10 exhibited remarkable inhibitory activities against PDE4 with IC50 values in the range of 0.22–1.38 μM. The first total synthesis of selaginpulvilins A–F (1–6) was developed in 7–11 steps involving a Friedel–Crafts reaction as the key reaction, which provides a feasible access to this scaffold.
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- 2017
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20. New prenylated coumarins from the stems of Toddalia asiatica
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Jia-Luo Huang, Min‐Hong Jiang, You-Kai Xu, Wei Li, Jun-Sheng Zhang, Sheng Yin, Gui-Hua Tang, and Abrar Ahmed
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010405 organic chemistry ,Stereochemistry ,General Chemical Engineering ,General Chemistry ,Phenolic acid ,010402 general chemistry ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Prenylation ,Toddalia asiatica ,Ic50 values ,Enantiomer ,Derivative (chemistry) - Abstract
Eight new prenylated coumarins (1a/1b, 2a/2b, and 3–6) including two pairs of enantiomers (1a/1b and 2a/2b), a new phenolic acid derivative, methyl (E)-3,4-bis(4-hydroxyphenyl)-4-oxobut-2-enoate (7), and 33 known compounds (8–40) were isolated from the stems of Toddalia asiatica. Their structures were established from spectroscopic data and by chemical methods. The absolute configurations of two pairs of enantiomers (1a/1b and 2a/2b) were determined by X-ray diffraction analysis together with ECD and specific optical rotation calculations. The inhibitory effects of selected compounds against phosphodiesterase-4 (PDE4) were evaluated, and compounds 12, 19, 21–23, 26, 34, and 35 exhibited PDE4 inhibition activities with IC50 values less than 10 μM.
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- 2017
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21. New lanostane-type triterpenoids from the fruiting body of Ganoderma hainanense
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Gui-Hua Tang, Wei Li, Jian-Yong Zhu, Sheng Yin, Jun-Sheng Zhang, Jing-Mei Bao, Lan-Lan Lou, and An-An Liang
- Subjects
Thioredoxin-Disulfide Reductase ,Antioxidant ,Cancer chemotherapy ,Stereochemistry ,Ganoderma ,medicine.medical_treatment ,Thioredoxin reductase ,Crystallography, X-Ray ,01 natural sciences ,Lanostane ,chemistry.chemical_compound ,Triterpenoid ,Drug Discovery ,medicine ,Fruiting Bodies, Fungal ,Pharmacology ,Molecular Structure ,biology ,010405 organic chemistry ,General Medicine ,biology.organism_classification ,Triterpenes ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry ,Biochemistry - Abstract
Five new lanostane-type triterpenoids, ganoderenses A-E (1-5), two new lanostane nor-triterpenoids, ganoderenses F and G (6 and 7), along with 13 known analogues (8-20) were isolated from the fruiting body of Ganoderma hainanense. Their structures were determined by combined chemical and spectral methods, and the absolute configurations of compounds 1 and 13 were confirmed by single crystal X-ray diffraction. All compounds were evaluated for inhibitory activity against thioredoxin reductase (TrxR), a potential target for cancer chemotherapy with redox balance and antioxidant functions, but were inactive.
- Published
- 2016
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22. Pheromone-trapping the nun moth,Lymantria monacha(Lepidoptera: Lymantriidae) in Inner Mongolia, China
- Author
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Jun-Sheng Zhang, Peng Wang, Qing-He Zhang, Guo-Fa Chen, Chao Chen, Jin-Hua Zhang, and Qi Xue
- Subjects
0106 biological sciences ,biology ,Ecology ,business.industry ,Monacha ,Pest control ,Gypsy moth ,biology.organism_classification ,Pheromone trap ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,Lepidoptera genitalia ,010602 entomology ,Insect Science ,Lymantria dispar ,PEST analysis ,Larch ,business ,Agronomy and Crop Science ,Ecology, Evolution, Behavior and Systematics ,010606 plant biology & botany - Abstract
The nun moth, Lymantria monacha L., is one of the most important defoliators of Eurasian coniferous forests. Outbreaks during 2011-2015 in the natural/planted larch, and larch-birch mixed forests of the Greater Khingan Range in Inner Mongolia, China, caused tremendous timber losses from severe defoliation and tree mortality. A series of trapping experiments were conducted in these outbreak areas to evaluate the efficacy of a synthetic species-specific pheromone lure based on the female pheromone blend of European nun moth populations. Our results clearly show that the nun moth in Inner Mongolia is highly and specifically attracted to this synthetic pheromone, with few gypsy moths (Lymantria dispar) captured. Flight activity monitoring of L. monacha male moths using pheromone-baited Unitraps at 2 locations during the summer of 2015 indicated that the flight period started in mid-July, peaking in early August at both locations. Based on male moth captures, there was a strong diurnal rhythm of flight activity throughout the entire scotophase, peaking between 22:00 and 24:00. Unitraps and wing traps had significantly and surprisingly higher catches than the gypsy moth traps. Unitraps fastened to tree trunks 2 m above ground caught significantly more male moths than those at the ground level or at 5 m height. Male L. monacha moths can be attracted to pheromone-baited traps in open areas 150-200 m distant from the infested forest edge. Our data should allow improvement on the performance of pheromone-baited traps for monitoring or mass-trapping to combat outbreaks of this pest in northeastern China.
- Published
- 2016
- Full Text
- View/download PDF
23. Three new diterpenoids from Marrubium aschersonii
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Yi-Hong Zou, Ye Chen, Jing-Mei Bao, Jun-Sheng Zhang, Jing-Jun Zhao, and Gui-Hua Tang
- Subjects
biology ,010405 organic chemistry ,Chemistry ,Stereochemistry ,Marrubenol ,Plant Science ,biology.organism_classification ,01 natural sciences ,Biochemistry ,Terpenoid ,0104 chemical sciences ,Nitric oxide ,Labdane ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,Lamiaceae ,Agronomy and Crop Science ,Marrubium ,Biotechnology - Abstract
One new halimane diterpenoid, marrubasch C (1), two new labdane diterpenoids, marrubaschs D and E (2 and 3), and three known labdane diterpenoids, marrubasch F (4), marrubiin (5), and marrubenol (6), were isolated from the ethanol extract of Marrubium aschersonii Magnus (Lamiaceae). Structures of these compounds were elucidated on the basis of spectroscopic analysis. The inhibitory effects of compounds 1–6 on nitric oxide (NO) production in RAW 264.7 macrophage cells activated by lipopolysaccharide (LPS) were investigated and all the compounds showed weak activity.
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- 2016
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- View/download PDF
24. Chemical constituents from the fruits of Amomum kravanh
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Hua Zhang, Xin-Xin Cao, and Jun-Sheng Zhang
- Subjects
Lignan ,Natural product ,Traditional medicine ,010405 organic chemistry ,Biology ,biology.organism_classification ,01 natural sciences ,Biochemistry ,Amomum ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry.chemical_compound ,chemistry ,Genus ,Chemical constituents ,Zingiberaceae ,Ecology, Evolution, Behavior and Systematics - Abstract
Chemical investigation of the traditional Chinese medicine Amomum kravanh led to the isolation of a new secolignan (1), two flavonoids (2 and 3), four monoterpenoids (4–7) and six steroids (8–13). Compounds 1, 5–8 and 12–13 were isolated from the family Zingiberaceae for the first time. Compound 1 is the first lignan reported in the genus Amomum and compound 8 is firstly described as a natural product, which could be of chemotaxonomic importance for the genus Amomum and family Zingiberaceae.
- Published
- 2020
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25. Bioactive terpenoid constituents from Eclipta prostrata
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Shu-Juan Yu, Jin-yue Sun, Jun-Sheng Zhang, Jin-Hai Yu, Zhi-Pu Yu, Hua Zhang, and Xue Yan
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0106 biological sciences ,Staphylococcus aureus ,Circular dichroism ,Stereochemistry ,Phytochemicals ,Positive control ,Microbial Sensitivity Tests ,Plant Science ,Horticulture ,01 natural sciences ,Biochemistry ,Triterpenoid ,Cell Line, Tumor ,Neoplasms ,Humans ,Glycoside Hydrolase Inhibitors ,Molecular Biology ,Eclipta prostrata ,Cell Proliferation ,biology ,Plant Extracts ,Terpenes ,010405 organic chemistry ,Chemistry ,α glucosidase ,Chemical fractionation ,alpha-Glucosidases ,Eclipta ,General Medicine ,biology.organism_classification ,Terpenoid ,Anti-Bacterial Agents ,0104 chemical sciences ,Pentacyclic triterpenoid ,Drug Screening Assays, Antitumor ,Bacillus subtilis ,HeLa Cells ,010606 plant biology & botany - Abstract
Chemical fractionation of the ethanolic extract of Eclipta prostrata yielded a series of unreported terpenoid constituents, including a rare 6/6/6/6-fused tetracyclic triterpenoid, a pentacyclic triterpenoid, two pentacyclic triterpenoid saponins, a diterpenoid and a sesquiterpenoid. Structures were assigned to these compounds on the basis of comprehensive spectroscopic analyses, with the absolute configurations of the tetracyclic triterpenoid, the diterpenoid and the sesquiterpenoid being determined via explanation of electronic circular dichroism data. Screening of these isolates in an array of bioassays revealed antibacterial, cytotoxic and α-glucosidase inhibitory activities for selective compounds. Of particular interest, the tetracyclic triterpenoid showed very strong inhibition against α-glucosidase with an IC50 of 0.82 ± 0.18 μM, being 103-fold as active as the positive control acarbose.
- Published
- 2020
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- View/download PDF
26. New octadecanoid derivatives from the seeds of Ipomoea nil
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Hua Zhang, Shu-Juan Yu, Jin-Hai Yu, Xiu-Qing Song, and Jun-Sheng Zhang
- Subjects
Stereochemistry ,Positive control ,01 natural sciences ,03 medical and health sciences ,chemistry.chemical_compound ,Inhibitory Concentration 50 ,0302 clinical medicine ,Drug Discovery ,medicine ,Bioassay ,Glycoside Hydrolase Inhibitors ,Ipomoea nil ,IC50 ,Acarbose ,chemistry.chemical_classification ,ABTS ,Molecular Structure ,010405 organic chemistry ,Plant Extracts ,Fatty Acids ,Fatty acid ,General Medicine ,0104 chemical sciences ,Complementary and alternative medicine ,chemistry ,030220 oncology & carcinogenesis ,Seeds ,Enantiomer ,medicine.drug - Abstract
Four new octadecanoid derivatives (1-4) including a pair of enantiomers (1/2), along with 12 known analogues (5-16), were isolated from the seeds of Ipomoea nil. Their structures were determined by detailed spectroscopic analyses and comparison with reported data of structurally related compounds, with the absolute configurations of 1 and 2 being assigned by an in situ dimolybdenum ECD method. Our bioassays revealed that these isolates did not show ABTS radical scavenging activity while 10 and 13 displayed better α-glucosidase inhibitory activity than the positive control acarbose (IC50 167.7 ±1.55 μmol·L-1), with IC50 of 92.73 ±3.12 and 11.39 ±2.18 μmol·L-1, respectively.
- Published
- 2018
27. Cytotoxic and antibacterial triterpenoids from the roots of Morinda officinalis var. officinalis
- Author
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Hui-Juan Zhai, Hua Zhang, Qianqian Zhang, Xiu-Qing Song, Jin-Hai Yu, Jun-Sheng Zhang, Hai-Shan Liu, and Yuying Zhang
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China ,Phytochemicals ,Pentacyclic triterpenoids ,01 natural sciences ,Plant Roots ,Morinda officinalis ,Triterpenoid ,Cell Line, Tumor ,Drug Discovery ,Cytotoxic T cell ,Humans ,Morinda ,Oleanolic Acid ,Cytotoxicity ,Gram ,Pharmacology ,biology ,Traditional medicine ,Molecular Structure ,010405 organic chemistry ,Chemistry ,General Medicine ,biology.organism_classification ,Triterpenes ,0104 chemical sciences ,Anti-Bacterial Agents ,010404 medicinal & biomolecular chemistry ,Officinalis ,Two-dimensional nuclear magnetic resonance spectroscopy - Abstract
Seven new pentacyclic triterpenoids including six ursane-type, marinoids A-F (1-6), and one oleanane-type, marinoid G (7), along with five known analogues (8-12), were separated from the roots of Morinda officinalis var. officinalis. Their structures were assigned by spectroscopic means especially analysis of 2D NMR data, with the absolute configurations of 1 and 2 being determined via comparison of their experimental ECD spectra with the computed ones. Selective compounds displayed cytotoxic activity against two human osteosarcoma cell lines and also antibacterial effects against one Gram positive and one Gram negative strains.
- Published
- 2018
28. Evodialones A and B: Polyprenylated Acylcyclopentanone Racemates with a 3-Ethyl-1,1-diisopentyl-4-methylcyclopentane Skeleton from Evodia lepta
- Author
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Ya-Qi Tang, Yi-Qiu Li, Ge Zhang, Wei Li, Yi-Bo Xie, Sheng Yin, Jun-Sheng Zhang, and Lan-Lan Lou
- Subjects
Magnetic Resonance Spectroscopy ,Stereochemistry ,Pharmaceutical Science ,Cyclopentanes ,Phloroglucinol ,010402 general chemistry ,Evodia lepta ,01 natural sciences ,High-performance liquid chromatography ,Analytical Chemistry ,Evodia ,chemistry.chemical_compound ,Inhibitory Concentration 50 ,Anti-Infective Agents ,Drug Discovery ,Rutaceae ,Methylcyclopentane ,Pharmacology ,010405 organic chemistry ,Organic Chemistry ,Antimicrobial ,Skeleton (computer programming) ,0104 chemical sciences ,Complementary and alternative medicine ,chemistry ,Molecular Medicine ,Enantiomer - Abstract
Two polyprenylated acylcyclopentanone racemates, evodialones A (1) and B (2), featuring a 3-ethyl-1,1-diisopentyl-4-methylcyclopentane skeleton, were isolated from an extract of the aerial parts of Evodia lepta. Evodialone A (1) was resolved by chiral-phase HPLC to afford a pair of enantiomers, (+)- and (−)-evodialones A (1b/1a), while evodialone B (2) could not be resolved. Their structures were elucidated by spectroscopic analysis and a combination of computational techniques including gauge-independent atomic orbital calculation of 1D NMR data and experimental and TDDFT-calculated ECD spectra. A putative biosynthetic pathway of 1 and 2 starting from the monocyclic polyprenylated acylphloroglucinols is proposed. All the isolates were screened for the antimicrobial activity in vitro, and 1a and 1b showed moderate inhibitory activities against several pathogenic fungi with MICs values of 17.1–68.3 μM.
- Published
- 2018
29. Design of Prototype Magnet for Beamline System of SC200 Superconducting Proton Cyclotron
- Author
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Jin Xing Zheng, Hai Yang Liu, Jun Sheng Zhang, and Yuntao Song
- Subjects
Materials science ,business.industry ,Cyclotron ,01 natural sciences ,law.invention ,Dipole ,Optics ,Beamline ,law ,Dipole magnet ,Magnet ,0103 physical sciences ,Physics::Accelerator Physics ,010306 general physics ,Quadrupole magnet ,business ,Proton therapy ,Beam (structure) - Abstract
A proton therapy facility (SC200) which includes superconducting cyclotron, a gantry treatment room and a fixed beam room. The proton beams are transported mainly with beam transport devices, such as dipole magnets, quadrupole magnets and corrector magnets which lie on the beam transport system. The main purpose of this paper is to show the magnets prototype design of the beam transport line. Besides, main parameters of the magnets are presented and magnetic analysis work is also illustrated in this paper.
- Published
- 2018
- Full Text
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30. Polycyclic polyprenylated acylphloroglucinols: natural phosphodiesterase-4 inhibitors from Hypericum sampsonii
- Author
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Sheng Yin, Yi-Hong Zou, Zhen-Zhen Li, Gui-Hua Tang, Jun-Sheng Zhang, and Yan-Qiong Guo
- Subjects
Bicyclic molecule ,010405 organic chemistry ,Stereochemistry ,General Chemical Engineering ,Substrate (chemistry) ,General Chemistry ,010402 general chemistry ,Ring (chemistry) ,01 natural sciences ,Adenosine ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,medicine ,Nonane ,Undecane ,IC50 ,Rolipram ,medicine.drug - Abstract
Chemical investigation of the aerial parts of Hypericum sampsonii led to the isolation of seven new polycyclic polyprenylated acylphloroglucinols, hypersampsonones A–G (1–7), together with 23 known analogs (8–30). Their structures including the absolute configurations were elucidated by combined spectroscopic analysis, quantum chemical ECD calculations, and chemical methods. Compound 1 represents an unprecedented cyclocitral monoterpene-coupled bicyclo[3.3.1]nonane skeleton, while 2 features an unusual hexahydrofuro[2,3-b]furan-diepoxy ring system fused in a tricyclo[4.3.1.15,7]undecane skeleton. All the compounds were screened by using tritium-labeled adenosine 3′,5′-cyclic monophosphate ([3H]-cAMP) as substrate for their inhibitory activity against phosphodiesterase-4 (PDE4), which is a drug target for the treatment of asthma and chronic obstructive pulmonary disease. Compounds 1, 18–19, 21, and 25–30 exhibited inhibition with IC50 values less than 10 μM, in which compound 19 represented the most active compound (IC50 = 0.64 μM), being comparable to the positive control, rolipram (IC50 = 0.62 μM).
- Published
- 2016
- Full Text
- View/download PDF
31. (P)/(M)-corinepalensin A, a pair of axially chiral prenylated bicoumarin enantiomers with a rare C-5C-5' linkage from the twigs of Coriaria nepalensis
- Author
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Wei Li, Lin Chen, Sheng Yin, Jun-Sheng Zhang, Bo Liu, Gui-Hua Tang, and Fu-Liang Guo
- Subjects
Stereochemistry ,Drug target ,Stereoisomerism ,Plant Science ,Horticulture ,010402 general chemistry ,Crystallography, X-Ray ,01 natural sciences ,Biochemistry ,chemistry.chemical_compound ,Inhibitory Concentration 50 ,Magnoliopsida ,Prenylation ,Coumarins ,Ic50 values ,Humans ,heterocyclic compounds ,Molecular Biology ,biology ,Molecular Structure ,Plant Stems ,010405 organic chemistry ,General Medicine ,biology.organism_classification ,Coumarin ,0104 chemical sciences ,chemistry ,Axial chirality ,Coriaria nepalensis ,Enantiomer - Abstract
A pair of undescribed bicoumarin enantiomers, (P)/(M)-corinepalensin A, two undescribed prenylated coumarins, corinepalensins B and C, along with ten known coumarins were isolated from the twigs of Coriaria nepalensis. (P)/(M)-corinepalensin A feature a rare C-5C-5' axially chiral linkage between two prenylated coumarin monomers. Their structures were determined by a combination of spectroscopic methods, single crystal X-ray diffraction, and ECD calculations. All isolates were evaluated for the inhibitory activity against phosphodiesterase-4 (PDE4), which is a drug target for the treatment of asthma and chronic obstructive pulmonary disease. Compounds (P)-corinepalensin A, (M)-corinepalensin A, corinepalensin B, norbraylin, braylin, and nepalin C exhibited significant inhibition with IC50 values ranging from 0.43 to 7.15 μM.
- Published
- 2017
32. Biscembranoids and Cembranoids from the Soft Coral Sarcophyton elegans
- Author
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Gui-Hua Tang, Yi-Hong Zou, Yun-Shao Xu, Abrar Ahmed, Jun-Sheng Zhang, Man-Xi Ge, Lan-Lan Lou, Yunyun Chen, Sheng Yin, and Wei Li
- Subjects
South china ,Stereochemistry ,Coral ,Pharmaceutical Science ,Biology ,Crystallography, X-Ray ,Nitric Oxide ,01 natural sciences ,Article ,cembranoids ,Cell Line ,Mice ,X-Ray Diffraction ,Drug Discovery ,Ic50 values ,Animals ,Pharmacology, Toxicology and Pharmaceutics (miscellaneous) ,Molecular Structure ,Sarcophyton elegans ,010405 organic chemistry ,biscembranoids ,NO inhibition ,Anthozoa ,Cycloaddition ,0104 chemical sciences ,Biosynthetic Pathways ,010404 medicinal & biomolecular chemistry ,Diterpenes - Abstract
Two novel biscembranoids, sarelengans A and B (1 and 2), five new cembranoids, sarelengans C-G (3-7), along with two known cembranoids (8 and 9) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were determined by spectroscopic and chemical methods, and those of 1, 4, 5, and 6 were confirmed by single crystal X-ray diffraction. Compounds 1 and 2 represent the first example of biscembranoids featuring a trans-fused A/B-ring conjunction between the two cembranoid units. Their unique structures may shed light on an unusual biosynthetic pathway involving a cembranoid-∆⁸ rather than the normal cembranoid-∆¹ unit in the endo-Diels-Alder cycloaddition. Compounds 2 and 3 exhibited potential inhibitory effects on nitric oxide production in RAW 264.7 macrophages, with IC50 values being at 18.2 and 32.5 μM, respectively.
- Published
- 2017
33. Inunicosides A−K, rare polyacylated ent-kaurane diterpenoid glycosides from the flowers of Inula japonica
- Author
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Zhi-Pu Yu, Hua Zhang, Jun-Sheng Zhang, Jin-Hai Yu, and Shu-Juan Yu
- Subjects
chemistry.chemical_classification ,Inula japonica ,Inula ,Traditional medicine ,biology ,010405 organic chemistry ,Ent kaurane diterpenoid ,Organic Chemistry ,food and beverages ,Glycoside ,010402 general chemistry ,biology.organism_classification ,01 natural sciences ,Biochemistry ,Terpenoid ,0104 chemical sciences ,chemistry.chemical_compound ,chemistry ,Enzymatic hydrolysis ,Drug Discovery ,Diterpene ,Antibacterial activity - Abstract
Inunicosides A−K (1–11), eleven unusual polyacylated ent-kaurane diterpenoid glycosides, were isolated from the flowers of a traditional Chinese herbal plant Inula japonica. Their structures with absolute configurations were determined on the basis of comprehensive spectroscopic analyses, chemical degradation, enzymatic hydrolysis and ECD experiments. Among these isolates, inunicoside K (11) showed mild antibacterial activity against Staphylococcus aureus ATCC 25923. Diterpene constituents have been rarely reported in the Inula species, and thus the discovery of this panel of compounds greatly enriches the chemical diversity of metabolites from the genus Inula.
- Published
- 2019
- Full Text
- View/download PDF
34. Fringe field interference effects on field quality for quadrupole magnets
- Author
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Jun-Sheng Zhang, Wu-Quan Zhang, and Jian Zhou
- Subjects
Superconductivity ,Physics ,Nuclear and High Energy Physics ,010308 nuclear & particles physics ,business.industry ,Field homogeneity ,Cyclotron ,01 natural sciences ,law.invention ,Optics ,Beamline ,law ,0103 physical sciences ,Homogeneity (physics) ,Field quality ,010306 general physics ,business ,Quadrupole magnet ,Multipole expansion ,Instrumentation - Abstract
A study of fringe field interference effects on field quality of quadrupole magnets for a newly developed superconducting proton cyclotron beamline was presented in this paper. The integral field gradient homogeneity was better than ± 5 × 10E-4 without fringe field interference. The influence of fringe field interference on field quality and integral field degradation was analyzed with 3D simulations. The results showed that the field quality was not affected when only yoke interference was considered. Besides, the characteristics of field quality with current interference were also studied. The integral field degradation and multipole field components were analyzed to research the variation of field quality. It showed that the inhomogeneity of integral field degradation at different beam orbits was the main disturbance for integral field quality. Finally, a normalized formula of the integral field degradation with different parameters was established, which will be the data reference for the newly developed superconducting proton cyclotron beam line assembly in the near future.
- Published
- 2019
- Full Text
- View/download PDF
35. A new bisabolane sesquiterpenoid and a new abietane diterpenoid from Cephalotaxus sinensis
- Author
-
Yi-Hong Zou, Wei Li, Pek-Ha Sam, Abrar Ahmed, Sheng Yin, Jun-Sheng Zhang, and Gui-Hua Tang
- Subjects
Magnetic Resonance Spectroscopy ,Stereochemistry ,Phytochemicals ,Plant Science ,01 natural sciences ,Biochemistry ,Analytical Chemistry ,Cephalotaxus ,chemistry.chemical_compound ,Abietane ,Cephalotaxus sinensis ,biology ,Molecular Structure ,010405 organic chemistry ,Spectrum Analysis ,Organic Chemistry ,Nuclear magnetic resonance spectroscopy ,biology.organism_classification ,Terpenoid ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,chemistry ,Phytochemical ,Abietanes ,Spectrum analysis ,Sesquiterpenes - Abstract
Phytochemical investigation of Cephalotaxus sinensis has led to the isolation of a new bisabolane sesquiterpenoid (1), a new abietane diterpenoid (2), and 13 known compounds (3–15). Their structures were elucidated by extensive spectroscopic analysis (MS, UV, IR, and NMR).
- Published
- 2017
- Full Text
- View/download PDF
36. A new selaginellin derivative and a new triarylbenzophenone analog from the whole plant of Selaginella pulvinata
- Author
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You-Kai Xu, Sheng Yin, Xin Liu, Han-Zhuang Weng, Gui-Hua Tang, and Jun-Sheng Zhang
- Subjects
Selaginellaceae ,Pharmacology ,Molecular Structure ,Cyclohexanones ,010405 organic chemistry ,Stereochemistry ,Chemistry ,Biphenyl Compounds ,Organic Chemistry ,Pharmaceutical Science ,General Medicine ,01 natural sciences ,0104 chemical sciences ,Analytical Chemistry ,010404 medicinal & biomolecular chemistry ,Phosphodiesterase-4 ,Complementary and alternative medicine ,Drug Discovery ,Ic50 values ,Molecular Medicine ,Phosphodiesterase 4 Inhibitors ,Selaginella pulvinata ,Selaginellin T - Abstract
Five selaginellin derivatives (1 and 3–6) including a new one, selaginellin T (1), and a new triarylbenzophenone analog, selagibenzophenone A (2), were isolated from the whole plants of Selaginella pulvinata. Their structures were determined by 1D- and 2D-NMR and HR-ESI-MS data. Selagibenzophenone A (2) is the first example of naturally occurring triarylbenzophenone. The results of the phosphodiesterase-4 (PDE4) inhibitory screening assays showed that compounds 1−6 exhibited potent activities with the IC50 values in the range of 1.04−9.35 μM.
- Published
- 2017
- Full Text
- View/download PDF
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