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Made available in DSpace on 2020-12-12T01:30:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-09-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Abstract: The increase in industrial activities to meet the growing needs of the population has led many companies to adopt environmental management (EM) policies to offset their impacts on the environment. For this reason, this article proposes a tool to identify the maturity levels of the elements of EM in industrial companies. The principles and practices of these elements were identified in the scientific literature and their practice was tested in an industrial company using the proposed tool. The main results show that the proposed tool allows to measure the maturity of the EM principles in industrial companies, making it possible to direct efforts toward EM elements with lower level of maturity. Graphic abstract: [Figure not available: see fulltext.] Production Department São Paulo State University - UNESP, Av. Dr. Ariberto Pereira da Cunha, 333 - Pedregulho Academic Areas Department Federal Institute of Education Science and Technology of Goiás Production Department São Paulo State University - UNESP, Av. Dr. Ariberto Pereira da Cunha, 333 - Pedregulho CAPES: 001 FAPESP: 2017/16768-6 FAPESP: 2017/18304-7 CNPq: 312894/2017-1

Oreochromis niloticus (Nile tilapia) is one of the most produced fish for human consumption globally; however, these fish are susceptible to exposure to toxic chemicals in the water. Pyriproxyfen is a pesticide widely used to control mosquitoes in drinking water supplies and pests in crops. The present study aimed to examine pyriproxyfen's effects on fish O. niloticus fingerlings exposed using an acute 96 h and subchronic tests for 28 days. The lethal concentration LC50−96 h for O. niloticus was 2.77 mg L−1, no observed effect concentration (NOEC), and the lowest observed effect concentration (LOEC) was 1.0 and 2.5 mg L−1, respectively. The hepatic catalase activity was significantly changed after exposure to pyriproxyfen above 0.4 mg L−1. Pyriproxyfen also induced histopathological lesions in the hepatic tissue at 28 days in a dose-dependent pattern at concentrations above 0.4 mg L−1. Pyriproxyfen above 1.2 mg L−1 reduced the locomotor behavior, distance traveled inside the tank, mean speed, and angular variation. This pesticide also decreased weight gain, food conversion, and specific growth rate at concentrations above 1.2 mg L−1. In conclusion, exposure to pyriproxyfen in water from 0.4 mg L−1 may impair O. niloticus development; consequently, pyriproxyfen may affect this fish's production and quality at higher concentrations than commonly used in water (0.01 mg L−1).